Repositorio Dspace

Envíos recientes

03. IMIB (Instituto Murciano de Investigación Biosanitaria Pascual Parrilla): Envíos recientes

  • Androgen receptor gene status in plasma DNA associates with worse outcome on enzalutamide or abiraterone for castration-resistant prostate cancer: a multi-institution correlative biomarker study 
    Conteduca, V; Wetterskog, D; Sharabiani, M-T-A; Grande, E; Fernández-Pérez, M-P; Jayaram, A; Salvi, S; Castellano, D; Romanel, A; Lolli, C; Casadio, V; Gurioli, G; Amadori, D; Font, A; Vazquez-Estevez, S; González-del-Alba, A; Mellado, B; Fernández-Calvo, O; Méndez-Vidal, M-J; Climent, M-A; Duran, I; Gallardo, E; Rodríguez, A; Santander, C; Saez, M-I; Puente, J; Tandefelt, D-Gasi; Wingate, A; Dearnaley, D; Demichelis, F; De-Giorgi, U; González-Billalabeitia, Enrique; Attard, G (OXFORD UNIV PRESS, 2017-07)
    BACKGROUND: There is an urgent need to identify biomarkers to guide personalized therapy in castration-resistant prostate cancer (CRPC). We aimed to clinically qualify androgen receptor (AR) gene status measurement in ...
  • Disease-causing mutations in the serpin antithrombin reveal a key domain critical for inhibiting protease activities 
    Aguila, Sonia; Izaguirre, Gonzalo; Martínez-Martínez, Irene; Vicente, Vicente; Olson, Steven-T; Corral, Javier (AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC, 2017-10-06)
    Antithrombin mainly inhibits factor Xa and thrombin. The reactive center loop (RCL) is crucial for its interactions with its protease targets and is fully inserted into the A-sheet after its cleavage, causing translocation ...
  • Significant Hypo-Responsiveness to GPVI and CLEC-2 Agonists in Pre-Term and Full-Term Neonatal Platelets and following Immune Thrombocytopenia 
    Hardy, Alexander-T; Palma-Barqueros, Verónica; Watson, Stephanie-K; Malcor, Jean-Daniel; Eble, Johannes-A; Gardiner, Elizabeth-E; Blanco-Carnero, José-Eliseo; Guijarro-Campillo, Rafael; Delgado-Marín, Juan-Luis; Lozano, María-Luisa; Teruel-Montoya, Raúl; Vicente, Vicente; Watson, Steve-P; Rivera, José; Ferrer-Marín, Francisca (GEORG THIEME VERLAG KG, 2018-06)
    Neonatal platelets are hypo-reactive to the tyrosine kinase-linked receptor agonist collagen. Here, we have investigated whether the hypo-responsiveness is related to altered levels of glycoprotein VI (GPVI) and integrin ...
  • Regulation of TFPIa expression by miR-27a/b-3p in human endothelial cells under normal conditions and in response to androgens 
    Arroyo-Rodríguez, Ana-B; Salloum-Asfar, Salam; Pérez-Sánchez, Carlos; Teruel-Montoya, Raúl; Navarro, Silvia; García-Barbera, Nuria; Luengo-Gil, Ginés; Roldán-Schilling, Vanessa; Hansen, John-Bjarne; López-Pedrera, Chary; Vicente, Vicente; González-Conejero, Rocío; Martínez, Constantino (NATURE PORTFOLIO, 2017-02-27)
    The increased risk of cardiovascular events in older men is multifactorial, but the significant reduction of testosterone levels has been involved. As this hormone regulates the expression of TFPI by unknown mechanisms, ...
  • Risk Model for Colorectal Cancer in Spanish Population Using Environmental and Genetic Factors: Results from the MCC-Spain study 
    Ibáñez-Sanz, Gemma; Diez-Villanueva, Anna; Henar-Alonso, M; Rodríguez-Moranta, Francisco; Pérez-Gómez, Beatriz; Bustamante, Mariona; Martín, Vicente; Llorca, Javier; Amiano, Pilar; Ardanaz, Eva; Tardon, Adonina; Jiménez-Moleon, José-Juan; Peiro, Rosana; Alguacil, Juan; Navarro, Carmen; Guino, Elisabet; Binefa, Gemma; Fernández-Navarro, Pablo; Espinosa, Anna; Davila-Batista, Verónica; Molina, Antonio-José; Palazuelos, Camilo; Castaño-Vinyals, Gemma; Aragonés, Nuria; Kogevinas, Manolis; Pollan, Marina; Moreno, Víctor (NATURE PORTFOLIO, 2017-02-24)
    Colorectal cancer (CRC) screening of the average risk population is only indicated according to age. We aim to elaborate a model to stratify the risk of CRC by incorporating environmental data and single nucleotide ...
  • Does von Willebrand factor improve the predictive ability of current risk stratification scores in patients with atrial fibrillation? 
    García-Fernández, Amaya; Roldán-Schilling, Vanessa; Rivera-Caravaca, José-Miguel; Hernández-Romero, Diana; Valdés-Chavarri, Mariano; Vicente, Vicente; Lip, Gregory-Y-H; Marín, Francisco (NATURE PORTFOLIO, 2017-01-30)
    Von Willebrand factor (vWF) is a biomarker of endothelial dysfunction. We investigated its role on prognosis in anticoagulated atrial fibrillation (AF) patients and determined whether its addition to clinical risk ...
  • Molecular regionalization of the developing amphioxus neural tube challenges major partitions of the vertebrate brain 
    Albuixech-Crespo, Beatriz; López-Blanch, Laura; Burguera, Demian; Maeso, Ignacio; Sánchez-Arrones, Luisa; Moreno-Bravo, Juan-Antonio; Somorjai, Ildiko; Pascual-Anaya, Juan; Puelles, Eduardo; Bovolenta, Paola; García-Fernández, Jordi; Puelles, Luis; Irimia, Manuel; Ferran, José-Luis (PUBLIC LIBRARY SCIENCE, 2017-04)
    All vertebrate brains develop following a common Bauplan defined by anteroposterior (AP) and dorsoventral (DV) subdivisions, characterized by largely conserved differential expression of gene markers. However, it is still ...
  • Radial glia fibers translate Fgf8 morphogenetic signals to generate a thalamic nuclear complex protomap in the mantle layer 
    Botella-López, Arancha; García-López, Raquel; Pombero, Ana; Martínez, Salvador (SPRINGER HEIDELBERG, 2019-03)
    Thalamic neurons are distributed between different nuclear groups of the thalamic multinuclear complex; they develop topologically ordered specific projections that convey information on voluntary motor programs and sensory ...
  • Nuclear derivatives and axonal projections originating from rhombomere 4 in the mouse hindbrain 
    Di-Bonito, María; Studer, Michele; Puelles, Luis (SPRINGER HEIDELBERG, 2017-11)
    The r4-derived territory is located in the pontine region of the brainstem, forming a wedge-shaped slice that broadens from the choroidal roof to the ventral midline. R4-derived neuronal populations migrate radially inside ...
  • Galectin-3 as a marker of interstitial atrial remodelling involved in atrial fibrillation 
    Hernández-Romero, Diana; Vílchez, Juan-Antonio; Lahoz, Alvaro; Romero-Aniorte, Ana-I; Jover, Eva; García-Alberola, Arcadio; Jara-Rubio, Rubén; Martínez, Carlos-M; Valdés-Chavarri, Mariano; Marín, Francisco (NATURE PORTFOLIO, 2017-01-12)
    Remodelling in the atria could appear as a result of hypertension, diabetes or ischaemic heart disease. Galectin-3 (Gal-3) is a mediator of profibrotic pathways and a potential biomarker of cardiac remodelling. We prospectively ...
  • Sequence data and association statistics from 12,940 type 2 diabetes cases and controls (vol 4, 170179, 2017) 
    Flannick, Jason; Fuchsberger, Christian; Mahajan, Anubha; Teslovich, Tanya-M; Agarwala, Vineeta; Gaulton, Kyle-J; Caulkins, Lizz; Koesterer, Ryan; Ma, Clement; Moutsianas, Loukas; McCarthy, Davis-J; Rivas, Manuel-A; Perry, John-R-B; Sim, Xueling; Blackwell, Thomas-W; Robertson, Neil-R; Rayner, N-William; Cingolani, Pablo; Locke, Adam-E; Tajes, Juan-Fernández; Highland, Heather-M; Dupuis, Josee; Chines, Peter-S; Lindgren, Cecilia-M; Hartl, Christopher; Jackson, Anne-U; Chen, Han; Huyghe, Jeroen-R; van-de-Bunt, Martijn; Pearson, Richard-D; Kumar, Ashish; Mueller-Nurasyid, Martina; Grarup, Niels; Stringham, Heather-M; Gamazon, Eric-R; Lee, Jaehoon; Chen, Yuhui; Scott, Robert-A; Below, Jennifer-E; Chen, Peng; Huang, Jinyan; Go, Min-Jin; Stitzel, Michael-L; Pasko, Dorota; Parker, Stephen-C-J; Varga, Tibor-V; Green, Todd; Beer, Nicola-L; Day-Williams, Aaron-G; Ferreira, Teresa; Fingerlin, Tasha; Horikoshi, Momoko; Hu, Cheng; Huh, Iksoo; Ikram, Mohammad-Kamran; Kim, Bong-Jo; Kim, Yongkang; Kim, Young-Jin; Kwon, Min-Seok; Lee, Juyoung; Lee, Selyeong; Lin, Keng-Han; Maxwell, Taylor-J; Nagai, Yoshihiko; Wang, Xu; Welch, Ryan-P; Yoon, Joon; Zhang, Weihua; Barzilai, Nir; Voight, Benjamín-F; Han, Bok-Ghee; Jenkinson, Christopher-P; Kuulasmaa, Teemu; Kuusisto, Johanna; Manning, Alisa; Ng, Maggie-C-Y; Palmer, Nicholette-D; Balkau, Beverley; Stancakova, Alena; Abboud, Hanna-E; Boeing, Heiner; Giedraitis, Vilmantas; Prabhakaran, Dorairaj; Gottesman, Omri; Scott, James; Carey, Jason; Kwan, Phoenix; Grant, George; Smith, Joshua-D; Neale, Benjamín-M; Purcell, Shaun; Butterworth, Adam-S; Howson, Joanna-M-M; Lee, Heung-Man; Lu, Yingchang; Kwak, Soo-Heon; Zhao, Wei; Danesh, John; Lam, Vincent-K-L; Park, Kyong-Soo; Saleheen, Danish; So, Wing-Yee; Tam, Claudia-H-T; Afzal, Uzma; Aguilar, David; Arya, Rector; Aung, Tin; Chan, Edmund; Navarro, Carmen; Cheng, Ching-Yu; Palli, Domenico; Correa, Adolfo; Curran, Joanne-E; Rybin, Dennis; Farook, Vidya-S; Fowler, Sharon-P; Freedman, Barry-I; Griswold, Michael; Hale, Daniel-Esten; Hicks, Pamela-J; Khor, Chiea-Chuen; Kumar, Satish; Lehne, Benjamín; Thuillier, Dorothee; Lim, Wei-Yen; Liu, Jianjun; Loh, Marie; Musani, Solomon-K; Puppala, Sobha; Scott, William-R; Yengo, Loic; Tan, Sian-Tsung; Taylor, Herman-A; Thameem, Farook; Wilson, Gregory; Wong, Tien-Yin; Njolstad, Pal-Rasmus; Levy, Jonathan-C; Mangino, Massimo; Bonnycastle, Lori-L; Schwarzmayr, Thomas; Fadista, Joao; Surdulescu, Gabriela-L; Herder, Christian; Groves, Christopher-J; Wieland, Thomas; Bork-Jensen, Jette; Brandslund, Ivan; Christensen, Cramer; Koistinen, Heikki-A; Doney, Alex-S-F; Kinnunen, Leena; Esko, Tonu; Farmer, Andrew-J; Hakaste, Liisa; Hodgkiss, Dylan; Kravic, Jasmina; Lyssenko, Valeriya; Hollensted, Mette; Jorgensen, Marit-E; Jorgensen, Torben; Ladenvall, Claes; Justesen, Johanne-Marie; Karajamaki, Annemari; Kriebel, Jennifer; Rathmann, Wolfgang; Lannfelt, Lars; Lauritzen, Torsten; Narisu, Narisu; Linneberg, Allan; Melander, Olle; Milani, Lili; Neville, Matt; Orho-Melander, Marju; Qi, Lu; Qi, Qibin; Roden, Michael; Rolandsson, Olov; Swift, Amy; Rosengren, Anders-H; Stirrups, Kathleen; Wood, Andrew-R; Mihailov, Evelin; Blancher, Christine; Carneiro, Mauricio-O; Maguire, Jared; Poplin, Ryan; Shakir, Khalid; Fennell, Timothy; DePristo, Mark; de-Ángelis, Martin-Hrabe; Deloukas, Panos; Gjesing, Anette-P; Jun, Goo; Nilsson, Peter-M; Murphy, Jacquelyn; Onofrio, Robert; Thorand, Barbara; Hansen, Torben; Meisinger, Christa; Hu, Frank-B; Isomaa, Bo; Karpe, Fredrik; Liang, Liming; Peters, Annette; Huth, Cornelia; O'Rahilly, Stephen-P; Palmer, Colin-N-A; Pedersen, Oluf; Rauramaa, Rainer; Tuomilehto, Jaakko; Salomaa, Veikko; Watanabe, Richard-M; Syvanen, Ann-Christine; Bergman, Richard-N; Bharadwaj, Dwaipayan; Bottinger, Erwin-P; Cho, Yoon-Shin; Chandak, Giriraj-R; Chan, Juliana-Cn; Chia, Kee-Seng; Daly, Mark-J; Ebrahim, Shah-B; Langenberg, Claudia; Elliott, Paul; Jablonski, Kathleen-A; Lehman, Donna-M; Jia, Weiping; Ma, Ronald-C-W; Pollin, Toni-I; Sandhu, Manjinder; Tandon, Nikhil; Froguel, Philippe; Barroso, Inés; Teo, Yik-Ying; Zeggini, Eleftheria; Loos, Ruth-J-F; Small, Kerrin-S; Ried, Janina-S; DeFronzo, Ralph-A; Grallert, Harald; Glaser, Benjamín; Metspalu, Andrés; Wareham, Nicholas-J; Walker, Mark; Banks, Eric; Gieger, Christian; Ingelsson, Erik; Im, Hae-Kyung; Illig, Thomas; Franks, Paul-W; Buck, Gemma; Trakalo, Joseph; Buck, David; Prokopenko, Inga; Magi, Reedik; Lind, Lars; Farjoun, Yossi; Owen, Katharine-R; Gloyn, Anna-L; Strauch, Konstantin; Tuomi, Tiinamaija; Kooner, Jaspal-Singh; Lee, Jong-Young; Park, Taesung; Donnelly, Peter; Morris, Andrew-D; Hattersley, Andrew-T; Bowden, Donald-W; Collins, Francis-S; Atzmon, Gil; Chambers, John-C; Spector, Timothy-D; Laakso, Markku; Strom, Tim-M; Bell, Graeme-I; Blangero, John; Duggirala, Ravindranath; Tai, EShyong; McVean, Gilean; Hanis, Craig-L; Wilson, James-G; Seielstad, Mark; Frayling, Timothy-M; Meigs, James-B; Cox, Nancy-J; Sladek, Rob; Lander, Eric-S; Gabriel, Stacey; Mohlke, Karen-L; Meitinger, Thomas; Groop, Leif; Abecasis, Goncalo; Scott, Laura-J; Morris, Andrew-P; Kang, Hyun-Min; Altshuler, David; Burtt, Noel-P; Florez, José-C; Boehnke, Michael; McCarthy, Mark-I (NATURE PUBLISHING GROUP, 2018-01-23)
    This corrects the article DOI: 10.1038/sdata.2017.179.
  • Data Descriptor: Sequence data and association statistics from 12,940 type 2 diabetes cases and controls 
    Flannick, Jason; Fuchsberger, Christian; Mahajan, Anubha; Teslovich, Tanya-M; Agarwala, Vineeta; Gaulton, Kyle-J; Caulkins, Lizz; Koesterer, Ryan; Ma, Clement; Moutsianas, Loukas; McCarthy, Davis-J; Rivas, Manuel-A; Perry, John-R-B; Sim, Xueling; Blackwell, Thomas-W; Robertson, Neil-R; Rayner, N-William; Cingolani, Pablo; Locke, Adam-E; Tajes, Juan-Fernández; Highland, Heather-M; Dupuis, Josee; Chines, Peter-S; Lindgren, Cecilia-M; Hartl, Christopher; Jackson, Anne-U; Chen, Han; Huyghe, Jeroen-R; De-Bunt, Martijn-Van; Pearson, Richard-D; Kumar, Ashish; Muller-Nurasyid, Martina; Grarup, Niels; Stringham, Heather-M; Gamazon, Eric-R; Lee, Jaehoon; Chen, Yuhui; Scott, Robert-A; Below, Jennifer-E; Chen, Peng; Huang, Jinyan; Go, Min-Jin; Stitzel, Michael-L; Pasko, Dorota; Parker, Stephen-C-J; Varga, Tibor-V; Green, Todd; Beer, Nicola-L; Day-Williams, Aaron-G; Ferreira, Teresa; Fingerlin, Tasha; Horikoshi, Momoko; Hu, Cheng; Huh, Iksoo; Ikram, Mohammad-Kamran; Kim, Bong-Jo; Kim, Yongkang; Kim, Young-Jin; Kwon, Min-Seok; Lee, Juyoung; Lee, Selyeong; Lin, Keng-Han; Maxwell, Taylor-J; Nagai, Yoshihiko; Wang, Xu; Welch, Ryan-P; Yoon, Joon; Zhang, Weihua; Barzilai, Nir; Voight, Benjamín-F; Han, Bok-Ghee; Jenkinson, Christopher-P; Kuulasmaa, Teemu; Kuusisto, Johanna; Manning, Alisa; Ng, Maggie-C-Y; Palmer, Nicholette-D; Balkau, Beverley; Stancakova, Alena; Abboud, Hanna-E; Boeing, Heiner; Giedraitis, Vilmantas; Prabhakaran, Dorairaj; Gottesman, Omri; Scott, James; Carey, Jason; Kwan, Phoenix; Grant, George; Smith, Joshua-D; Neale, Benjamín-M; Purcell, Shaun; Butterworth, Adam-S; Howson, Joanna-M-M; Lee, Heung-Man; Lu, Yingchang; Kwak, Soo-Heon; Zhao, Wei; Danesh, John; Lam, Vincent-K-L; Park, Kyong-Soo; Saleheen, Danish; So, Wing-Yee; Tam, Claudia-H-T; Afzal, Uzma; Aguilar, David; Arya, Rector; Aung, Tin; Chan, Edmund; Navarro, Carmen; Cheng, Ching-Yu; Palli, Domenico; Correa, Adolfo; Curran, Joanne-E; Rybin, Dennis; Farook, Vidya-S; Fowler, Sharon-P; Freedman, Barry-I; Griswold, Michael; Hale, Daniel-Esten; Hicks, Pamela-J; Khor, Chiea-Chuen; Kumar, Satish; Lehne, Benjamín; Thuillier, Dorothee; Lim, Wei-Yen; Liu, Jianjun; Loh, Marie; Musani, Solomon-K; Puppala, Sobha; Scott, William-R; Yengo, Loic; Tan, Sian-Tsung; Taylor, Herman-A; Thameem, Farook; Wilson, Gregory; Wong, Tien-Yin; Njolstad, Pal-Rasmus; Levy, Jonathan-C; Mangino, Massimo; Bonnycastle, Lori-L; Schwarzmayr, Thomas; Fadista, Joao; Surdulescu, Gabriela-L; Herder, Christian; Groves, Christopher-J; Wieland, Thomas; Bork-Jensen, Jette; Brandslund, Ivan; Christensen, Cramer; Koistinen, Heikki-A; Doney, Alex-S-F; Kinnunen, Leena; Esko, Tonu; Farmer, Andrew-J; Hakaste, Liisa; Hodgkiss, Dylan; Kravic, Jasmina; Lyssenko, Valeriya; Hollensted, Mette; Jorgensen, Marit-E; Jorgensen, Torben; Ladenvall, Claes; Justesen, Johanne-Marie; Karajamaki, Annemari; Kriebel, Jennifer; Rathmann, Wolfgang; Lannfelt, Lars; Lauritzen, Torsten; Narisu, Narisu; Linneberg, Allan; Melander, Olle; Milani, Lili; Neville, Matt; Orho-Melander, Marju; Qi, Lu; Qi, Qibin; Roden, Michael; Rolandsson, Olov; Swift, Amy; Rosengren, Anders-H; Stirrups, Kathleen; Wood, Andrew-R; Mihailov, Evelin; Blancher, Christine; Carneiro, Mauricio-O; Maguire, Jared; Poplin, Ryan; Shakir, Khalid; Fennell, Timothy; DePristo, Mark; De-Ángelis, Martin-Hrabe; Deloukas, Panos; Gjesing, Anette-P; Jun, Goo; Nilsson, Peter-M; Murphy, Jacquelyn; Onofrio, Robert; Thorand, Barbara; Hansen, Torben; Meisinger, Christa; Hu, Frank-B; Isomaa, Bo; Karpe, Fredrik; Liang, Liming; Peters, Annette; Huth, Cornelia; O'Rahilly, Stephen-P; Palmer, Colin-N-A; Pedersen, Oluf; Rauramaa, Rainer; Tuomilehto, Jaakko; Salomaa, Veikko; Watanabe, Richard-M; Syvanen, Ann-Christine; Bergman, Richard-N; Bharadwaj, Dwaipayan; Bottinger, Erwin-P; Cho, Yoon-Shin; Chandak, Giriraj-R; Chan, Juliana-Cn; Chia, Kee-Seng; Daly, Mark-J; Ebrahim, Shah-B; Langenberg, Claudia; Elliott, Paul; Jablonski, Kathleen-A; Lehman, Donna-M; Jia, Weiping; Ma, Ronald-Cw; Pollin, Toni-I; Sandhu, Manjinder; Tandon, Nikhil; Froguel, Philippe; Barroso, Inés; Teo, Yik-Ying; Zeggini, Eleftheria; Loos, Ruth-J-F; Small, Kerrin-S; Ried, Janina-S; DeFronzo, Ralph-A; Grallert, Harald; Glaser, Benjamín; Metspalu, Andrés; Wareham, Nicholas-J; Walker, Mark; Banks, Eric; Gieger, Christian; Ingelsson, Erik; Im, Hae-Kyung; Illig, Thomas; Franks, Paul-W; Buck, Gemma; Trakalo, Joseph; Buck, David; Prokopenko, Inga; Magi, Reedik; Lind, Lars; Farjoun, Yossi; Owen, Katharine-R; Gloyn, Anna-L; Strauch, Konstantin; Tuomi, Tiinamaija; Kooner, Jaspal-Singh; Lee, Jong-Young; Park, Taesung; Donnelly, Peter; Morris, Andrew-D; Hattersley, Andrew-T; Bowden, Donald-W; Collins, Francis-S; Atzmon, Gil; Chambers, John-C; Spector, Timothy-D; Laakso, Markku; Strom, Tim-M; Bell, Graeme-I; Blangero, John; Duggirala, Ravindranath; Tai, EShyong; McVean, Gilean; Hanis, Craig-L; Wilson, James-G; Seielstad, Mark; Frayling, Timothy-M; Meigs, James-B; Cox, Nancy-J; Sladek, Rob; Lander, Eric-S; Gabriel, Stacey; Mohlke, Karen-L; Meitinger, Thomas; Groop, Leif; Abecasis, Goncalo; Scott, Laura-J; Morris, Andrew-P; Kang, Hyun-Min; Altshuler, David; Burtt, Noel-P; Florez, José-C; Boehnke, Michael; McCarthy, Mark-I (NATURE PORTFOLIO, 2017-12-19)
    To investigate the genetic basis of type 2 diabetes (T2D) to high resolution, the GoT2D and T2D-GENES consortia catalogued variation from whole-genome sequencing of 2,657 European individuals and exome sequencing of 12,940 ...
  • Non-proliferative neurogenesis in human periodontal ligament stem cells 
    Bueno, Carlos; Martínez-Morga, Marta; Martínez, Salvador (NATURE PORTFOLIO, 2019-12-02)
    Understanding the sequence of events from undifferentiated stem cells to neuron is not only important for the basic knowledge of stem cell biology, but also for therapeutic applications. In this study we examined the ...
  • Mammalian spermatozoa and cumulus cells bind to a 3D model generated by recombinant zona pellucida protein-coated beads 
    Gabriela-Hamze, Julieta; Canha-Gouveia, Analuce; Algarra, Blanca; Gómez-Torres, María-José; Concepcion-Olivares, María; Romar, Raquel; Jiménez-Movilla, María (NATURE PORTFOLIO, 2019-11-29)
    The egg is a spherical cell encapsulated by the zona pellucida (ZP) which forms a filamentous matrix composed of several glycoproteins that mediate gamete recognition at fertilization. Studies on molecular mechanisms of ...
  • Neutrophil-lymphocyte ratio in metastatic breast cancer is not an independent predictor of survival, but depends on other variables 
    Ivars-Rubio, Alejandra; Yufera, Juan-Carlos; de-la-Morena, Pilar; Fernández-Sánchez, Ana; Navarro-Manzano, Esther; García-Garre, Elisa; García-Martínez, Elena; Marín-Zafra, Gema; Sánchez-Cánovas, Manuel; García-Torralba, Esmeralda; Ayala-de-la-Peña, Francisco (NATURE PORTFOLIO, 2019-11-18)
    The prognostic impact of neutrophil-lymphocyte ratio (NLR) in metastatic breast cancer (MBC) has been previously evaluated in early and metastatic mixed breast cancer cohorts or without considering other relevant prognostic ...
  • The first comprehensive phylogenetic and biochemical analysis of NADH diphosphatases reveals that the enzyme from Tuber melanosporum is highly active towards NAD+ 
    García-Saura, Antonio-Ginés; Zapata-Pérez, Rubén; Martínez-Moñino, Ana-Belén; Hidalgo, José-Francisco; Morte, Asunción; Pérez-Gilabert, Manuela; Sánchez-Ferrer, Álvaro (NATURE PORTFOLIO, 2019-11-14)
    Nudix (for nucleoside diphosphatases linked to other moieties, X) hydrolases are a diverse family of proteins capable of cleaving an enormous variety of substrates, ranging from nucleotide sugars to NAD(+)-capped RNAs. ...
  • The ant Lasius niger is a new source of bacterial enzymes with biotechnological potential for bleaching dye 
    Diez-Méndez, Alexandra; García-Fraile, Paula; Solano, Francisco; Rivas, Raúl (NATURE PORTFOLIO, 2019-10-23)
    Industrial synthetic dyes cause health and environmental problems. This work describes the isolation of 84 bacterial strains from the midgut of the Lasius niger ant and the evaluation of their potential application in dye ...
  • The effect of surface electromyography biofeedback on the activity of extensor and dorsiflexor muscles in elderly adults: a randomized trial 
    Belén-Gamez, Ana; Hernández-Morante, Juan-José; Martínez-Gil, José-Luis; Esparza, Francisco; Martínez, Carlos-Manuel (NATURE PORTFOLIO, 2019-09-11)
    Surface electromyography-biofeedback (sEMG-B) is a technique employed for the rehabilitation of patients with neurological pathologies, such as stroke-derived hemiplegia; however, little is known about its effectiveness ...
  • Antibody responses to flagellin C and Streptococcus gallolyticus pilus proteins in colorectal cancer 
    Butt, Julia; Fernández-de-Larrea, Nerea; Tjalsma, Harold; Roelofs, Rian; Kato, Ikuko; Martín, Vicente; Pérez-Gómez, Beatriz; Moreno, Víctor; Dierssen-Sotos, Trinidad; Castilla, Jess; Fernández-Tardon, Guillermo; Amiano, Pilar; Salas, Dolores; Alguacil, Juan; Juan-Jiménez-Moleon, José; Huerta-Castaño, José-María; de-Sanjose, Silvia; del-Campo, Rosa; Kogevinas, Manolis; Pollan, Marina; Pawlita, Michael; Waterboer, Tim; Boleij, Annemarie; Aragonés, Nuria (NATURE PORTFOLIO, 2019-07-26)
    Antibodies to Streptococcus gallolyticus subspecies gallolyticus (SGG) have been associated with colorectal cancer (CRC). Because SGG may correlate with impaired gut epithelia, we assessed the association of antibodies to ...
  • Galectin-3 and ß-trace protein concentrations are higher in clinically unaffected patients with Fabry disease 
    Hernández-Romero, Diana; Sánchez-Quinones, Jessica; Vílchez, Juan-Antonio; Rivera-Caravaca, José-Miguel; de-la-Morena-Valenzuela, Gonzalo; Lip, Gregory-Y-H; Climent, Vicente; Marín, Francisco (NATURE PORTFOLIO, 2019-04-17)
    Current therapies have not shown benefit in organ damage reversal in Fabry disease (FD), but biomarkers could help risk stratification and prognosis. We investigated if several biomarkers of cardiac fibrosis, cardiac wall ...

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