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  • 13th Post-ECTRIMS Meeting: review of the new developments presented at the 2020 ECTRIMS Congress (I) 
    Fernandez,Oscar; Montalban,Xavier; Aladro,Yolanda; Alonso,Ana; Arroyo,Rafael; Calles,Carmen; Castillo-Trivino,Tamara; Comabella,Manuel; Costa-Frossard,Lucienne; Forero,Lucia; Ginestal,Ricardo; Landete,Lamberto; Llaneza,Miguel; Llufriu,Sara; Luisa-Martinez (REVISTA DE NEUROLOGIA, 01/06/2021)
    Introduction. On 4 and 5 November 2022, Madrid hosted the 15th edition of the Post-ECTRIMS Meeting, where neurologists specialised in multiple sclerosis outlined the latest developments presented at the 2022 ECTRIMS Congress, ...
  • 15th Post-ECTRIMS Meeting: a review of the latest developments presented at the 2022 ECTRIMS Congress (Part I) 
    Fernandez,Oscar; Montalban,Xavier; Aguera,Eduardo; Aladro,Yolanda; Alonso,Ana; Arroyo,Rafael; Brieva,Luis; Calles,Carmen; Costa-Frossard,Lucienne; Eichau,Sara; Garcia-Dominguez,Jose-M; Hernandez,Miguel-A; Landete,Lamberto; Sara-Llufriu,Miguel-Llaneza; Mec (REVISTA DE NEUROLOGIA, 01/07/2023)
    Objective Idiopathic central precocious puberty (CPP) precipitates epiphyseal fusion of growth plates in long bones, leading to reduced adult stature. Gonadotropin-releasing hormone analogues (GnRHa) are the treatment of ...
  • A Randomized Trial of Dolutegravir Plus Darunavir/Cobicistat as a Switch Strategy in HIV-1-Infected Patients With Resistance to at Least 2 Antiretroviral Classes 
    Santos,Jose-R; Domingo,Pere; Portilla,Joaquin; Gutierrez,Felix; Imaz,Arkaitz; Vilchez,Helem; Curran,Adria; Valcarce-Pardeiro,Nieves; Payeras,Antoni; Bernal,Enrique; Montero-Alonso,Marta; Yzusqui,Miguel; Clotet,Bonaventura; Videla,Sebastia; Molto,Jose; Par (OXFORD UNIV PRESS INC, 01/11/2023)
    Background. Suppressed patients with drug-resistant HIV-1 require effective and simple antiretroviral therapy to maintain treatment adherence and viral suppression.Methods. This randomized, open-label, noninferiority, ...
  • Alpha retinal ganglion cells in pigmented mice retina: number and distribution 
    Gallego-Ortega,Alejandro; Norte-Munoz,Maria; Di-Pierdomenico,Johnny; Aviles-Trigueros,Marcelino; de-la-Villa,Pedro; Javier-Valiente-Soriano,Francisco; Vidal-Sanz,Manuel (FRONTIERS MEDIA SA, 01/12/2022)
    BackgroundUp to 30% of breast cancer (BC) patients treated with neoadjuvant chemotherapy (NCT) will relapse. Our objective was to analyze the predictive capacity of several markers associated with immune response and cell ...
  • A novel and efficient tandem CD19-and CD22-directed CAR for B cell ALL 
    Zanetti,Samanta-Romina; Velasco-Hernandez,Talia; Gutierrez-Aguera,Francisco; Diaz,Victor-M; Romecin,Paola-Alejandra; Roca-Ho,Heleia; Sanchez-Martinez,Diego; Tirado,Nestor; Baroni,Matteo-Libero; Petazzi,Paolo; Torres-Ruiz,Raul; Molina,Oscar; Bataller,Alex| (CELL PRESS, 02/02/2022)
    CD19-directed chimeric antigen receptor (CAR) T cells have yielded impressive response rates in refractory/relapse B cell acute lymphoblastic leukemia (B-ALL); however, most patients ultimately relapse due to poor CAR T ...
  • A Novel Substituted Benzo[g]quinoxaline-Based Cyclometalated Ru(II) Complex as a Biocompatible Membrane-Targeted PDT Colon Cancer Stem Cell Agent 
    Marco,Alicia; Kasparkova,Jana; Bautista,Delia; Kostrhunova,Hana; Cutillas,Natalia; Markova,Lenka; Novohradsky,Vojtech; Ruiz,Jose; Brabec,Viktor (AMER CHEMICAL SOC, 02/12/2024)
    Herein, we describe and investigate biological activity of three octahedral ruthenium(II) complexes of the type [Ru(C boolean AND N)(phen)2]+, RuL1-RuL3, containing a pi-expansive cyclometalating substituted benzo[g]quinoxaline ...
  • A multimodal approach to detect and monitor early lung disease in cystic fibrosis 
    Mondejar-Lopez,Pedro; Horsley,Alexander; Ratjen,Felix; Bertolo,Silvia; de-Vicente,Helene; Asensio-de-la-Cruz,Oscar (TAYLOR & FRANCIS LTD, 03/06/2021)
    Introduction: In the early stages, lung involvement in cystic fibrosis (CF) can be silent, with disease progression occurring in the absence of clinical symptoms. Irreversible airway damage is present in the early stages ...
  • A Body Shape Index (ABSI) achieves better mortality risk stratification than alternative indices of abdominal obesity: results from a large European cohort 
    Christakoudi,Sofia; Tsilidis,Konstantinos-K; Muller,David-C; Freisling,Heinz; Weiderpass,Elisabete; Overvad,Kim; Soederberg,Stefan; Haeggstroem,Christel; Pischon,Tobias; Dahm,Christina-C; Zhang,Jie; Tjonneland,Anne; Halkjaer,Jytte; MacDonald,Conor; Boutro (NATURE PORTFOLIO, 03/09/2020)
    Abdominal and general adiposity are independently associated with mortality, but there is no consensus on how best to assess abdominal adiposity. We compared the ability of alternative waist indices to complement body mass ...
  • An opportunity to emphasize the relevance of laboratory medicine 
    Santamaria-Gonzalez,Maria; Ruiz-Minguez,Maria-Angels; Arrebola-Ramirez,Maria-Monsalud; Filella-Pla,Xavier; Torrejon-Martinez,Maria-Jose; Morell-Garcia,Daniel; Castano-Lopez,Miguel-Angel; Allue-Palacin,Juan-Antonio; Albaladejo-Oton,Maria-Dolores; Gimenez-G (WALTER DE GRUYTER GMBH, 04/08/2021)
    Objectives Clinical practice guidelines (CPGs) are recommendations based on a systematic review of scientific evidence that are intended to help healthcare professionals and patients make the best clinical decisions. CPGs ...
  • Adult syndromology: challenges, opportunities and perspectives 
    Schmetz,Ariane; Ballesta-Martinez,Maria-Juliana; Isidor,Bertrand; Sousa,Ana-Berta; Wieczorek,Dagmar; Bramswig,Nuria-C (WALTER DE GRUYTER GMBH, 05/06/2024)
    Clinical geneticists and syndromologists have traditionally focused on identifying syndromes in children. However, there is a growing acknowledgment of the need to describe adult phenotypes. This article provides an overview ...
  • Adult height in girls with idiopathic central precocious puberty treated with triptorelin 
    Corripio,Raquel; Soriano-Guillen,Leandro; Herrero,Francisco-Javier; Castro-Feijoo,Lidia; Escribano,Aranzazu; Sol-Ventura,Paula; Espino,Rafael; Vela,Amaia; Labarta,Jose-Ignacio; Spanish-PUBERE-Grp,Jesus; Argente,Jesus (FRONTIERS MEDIA SA, 05/12/2024)
    BackgroundParkinson's disease (PD) is a progressive neurodegenerative disorder, diagnosed according to the clinical criteria that occur in already advanced stages of PD. The definition of biomarkers for the early diagnosis ...
  • A crowdsourcing database for the copy-number variation of the Spanish population 
    Lopez-Lopez,Daniel; Roldan,Gema; Fernandez-Rueda,Jose; Bostelmann,Gerrit; Carmona,Rosario; Aquino,Virginia; Perez-Florido,Javier; Ortuno,Francisco; Pita,Guillermo; Nunez-Torres,Rocio; Gonzalez-Neira,Anna; Pena-Chilet,Maria; Dopazo,Joaquin (BMC, 09/03/2023)
    Background Despite being a very common type of genetic variation, the distribution of copy-number variations (CNVs) in the population is still poorly understood. The knowledge of the genetic variability, especially at the ...
  • A cost-effectiveness analysis of hypertrophic cardiomyopathy sudden cardiac death risk algorithms for implantable cardioverter defibrillator decision-making 
    Green,Nathan; Chen,Yang; O'Mahony,Constantinos; Elliott,Perry-M; Barriales-Villa,Roberto; Monserrat,Lorenzo; Anastasakis,Aristides; Biagini,Elena; Gimeno,Juan-Ramon; Limongelli,Giuseppe; Pavlou,Menelaos; Omar,Rumana-Z (OXFORD UNIV PRESS, 09/10/2023)
    Aims To conduct a contemporary cost-effectiveness analysis examining the use of implantable cardioverter defibrillators (ICDs) for primary prevention in patients with hypertrophic cardiomyopathy (HCM).Methods A discrete-time ...
  • A spatiotemporal model of firearm ownership in the United States 
    Barak-Ventura,Roni; Marin,Manuel-Ruiz; Porfiri,Maurizio (CELL PRESS, 12/08/2022)
    Firearm injury is a major public health crisis in the United States, where more than 200 people sustain a nonfatal firearm injury and more than 100 people die from it every day. To formulate policy that minimizes firearm-related ...
  • A first-year melon/cowpea intercropping system improves soil nutrients and changes the soil microbial community 
    Cuartero,Jessica; Antonio-Pascual,Jose; Vivo,Juana-Maria; Ozbolat,Onurcan; Sanchez-Navarro,Virginia; Egea-Cortines,Marcos; Zornoza,Raul; Martinez-Mena,Maria; Garcia,Eloisa; Ros,Margarita (ELSEVIER, 15/04/2022)
    The melon/cowpea intercropping system can be a specific and efficient cropping pattern in a horticultural field. Intercropping systems contribute to the optimization of land use, fostering sustainable and efficient ...
  • Actinotignum schaalii infection: Challenges in diagnosis and treatment 
    Sahuquillo-Arce,J-M; Suarez-Urquiza,P; Hernandez-Cabezas,A; Tofan,L; Chouman-Arcas,R; Garcia-Hita,M; Sabalza-Baztan,O; Selles-Sanchez,A; Lozano-Rodriguez,N; Marti-Cunat,J; Lopez-Hontangas,J-L (CELL PRESS, 15/04/2024)
    Actinotignum schaalii affects elderly people and is associated with individuals with urologicalrelated predispositions, but can be found in a variety of locations, such as cutaneous, intraabdominal, genitourinary and ...
  • (R,S)-Equol 7-¿-D-glucuronide, but not other circulating isoflavone metabolites, modulates migration and tubulogenesis in human aortic endothelial cells targeting the VEGF pathway 
    Gimenez-Bastida,Juan-Antonio; Avila-Galvez,Maria-angeles; Martinez-Lopez,Alicia; Garcia-Moreno,Diana; Espin,Juan-Carlos; Gonzalez-Sarrias,Antonio (ROYAL SOC CHEMISTRY, 15/07/2024)
    Current knowledge indicates that the consumption of isoflavone-rich foodstuffs can have a beneficial impact on cardiovascular health. To what extent these isoflavones act as the main actors of that benefit is less clear. ...
  • 3D calcium silicophosphate porous scaffold: In vitro and in vivo response 
    Ros-Tarraga,Patricia; Martinez,Carlos-M; Rodriguez,Miguel-A; De-Aza,Piedad-N (ELSEVIER SCI LTD, 15/12/2022)
    The elderly population (65 years and older) is expected to increase from 524 million people in 2010 to 1.5 billion by 2050, with the corresponding increase in bone-related and joint damage problems. Many of these problems ...
  • 13th Post-ECTRIMS Meeting: review of the new developments presented at the 2020 ECTRIMS Congress (II) 
    Fernandez,Oscar; Montalban,Xavier; Aladro,Yolanda; Alonso,Ana; Arroyo,Rafael; Calles,Carmen; Castillo-Trivino,Tamara; Comabella,Manuel; Costa-Frossard,Lucienne; Forero,Lucia; Ginestal,Ricardo; Landete,Lamberto; Llaneza,Miguel; Llufriu,Sara; Luisa-Martinez (REVISTA DE NEUROLOGIA, 16/06/2021)
    A well-documented method and experimental design are essential to ensure the reproducibility and reliability in animal research. Experimental studies using exercise programs in animal models have experienced an exponential ...
  • 15th Post-ECTRIMS Meeting: a review of the latest developments presented at the 2022 ECTRIMS Congress (Part II) 
    Fernandez,Oscar; Montalban,Xavier; Aguera,Eduardo; Aladro,Yolanda; Alonso,Ana; Arroyo,Rafael; Brieva,Luis; Calles,Carmen; Costa-Frossard,Lucienne; Eichau,Sara; Garcia-Dominguez,Jose-M; Hernandez,Miguel-A; Landete,Lamberto; Llaneza,Miguel; Llufriu,Sara; Me (REVISTA DE NEUROLOGIA, 16/07/2023)
    Type I interferonopathies are a heterogenic group of rare diseases associated with an increase in type I interferon (IFN). The main challenge for the study of Type I interferonopathies is the lack of a well-founded animal ...