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Envíos recientes

03. IMIB (Instituto Murciano de Investigación Biosanitaria Pascual Parrilla): Envíos recientes

  • Early endosome autoantigen 1 regulates IL-1ß release upon caspase-1 activation independently of gasdermin D membrane permeabilization 
    Baroja-Mazo, Alberto; Compan, Vincent; Martín-Sánchez, Fatima; Tapia-Abellán, Ana; Couillin, Isabelle; Pelegrín, Pablo (NATURE PORTFOLIO, 2019-04-08)
    Unconventional protein secretion represents an important process of the inflammatory response. The release of the pro-inflammatory cytokine interleukin (IL)-1? which burst during pyroptosis as a consequence of gasdermin D ...
  • An uncharacterized FMAG_01619 protein from Fusobacterium mortiferum ATCC 9817 demonstrates that some bacterial macrodomains can also act as poly-ADP-ribosylhydrolases 
    García-Saura, Antonio-Ginés; Zapata-Pérez, Rubén; Hidalgo, José-Francisco; Cabanes, Juana; Gil-Ortiz, Fernando; Sánchez-Ferrer, Álvaro (NATURE PORTFOLIO, 2019-03-01)
    Macrodomains constitute a conserved fold widely distributed that is not only able to bind ADP-ribose in its free and protein-linked forms but also can catalyse the hydrolysis of the latter. They are involved in the regulation ...
  • Comparative inhibitory profile and distribution of bacterial PARPs, using Clostridioides difficile CD160 PARP as a model 
    García-Saura, Antonio-Ginés; Zapata-Pérez, Rubén; Hidalgo, José-Francisco; Sánchez-Ferrer, Álvaro (NATURE PORTFOLIO, 2018-05-23)
    Poly-ADP-ribose polymerases (PARPs) are involved in the regulation of important cellular processes, such as DNA repair, aging and apoptosis, among others. They have been considered as promising therapeutic targets, since ...
  • Role of Kupffer cells in the progression of CRC liver metastases after the first stage of ALPPS 
    García-Pérez, Rocío; Ferrer-Fabrega, Joana; Varona-Bosque, Aranzazu; Martínez, Carlos-Manuel; Revilla-Nuin, Beatriz; Cabellos, Laia; Pena, Romina; Vilana, Ramón; González-Abos, Carolina; García-Valdecasas, Juan-Carlos; Fuster-Obregon, José (NATURE PORTFOLIO, 2018-05-24)
    Associated liver partition and portal vein ligation for staged hepatectomy (ALPPS) has been suggested as a potential therapy for extensive bilobar liver tumors, although in some circumstances this technique may induce tumor ...
  • Alcohol consumption and risk of urothelial cell bladder cancer in the European prospective investigation into cancer and nutrition cohort 
    Botteri, E; Ferrari, P; Roswall, N; Tjonneland, A; Hjartaker, A; Huerta-Castaño, José-María; Fortner, R-T; Trichopoulou, A; Karakatsani, A; La-Vecchia, C; Pala, V; Pérez-Cornago, A; Sonestedt, E; Liedberg, F; Overvad, K; Sánchez, M-J; Gram, I-T; Stepien, M; Trijsburg, L; Borje, L; Johansson, M; Kuehn, T; Panico, S; Tumino, R; Bueno-de-Mesquita, Bas; Weiderpass, E (WILEY, 2017-11-15)
    Findings on the association between alcohol consumption and bladder cancer are inconsistent. We investigated that association in the European Prospective Investigation into Cancer and Nutrition cohort. We included 476,160 ...
  • Possible role of chondroitin sulphate and glucosamine for primary prevention of colorectal cancer. Results from the MCC-Spain study 
    Ibáñez-Sanz, Gemma; Diez-Villanueva, Anna; Vilorio-Marqués, Laura; Gracia, Esther; Aragonés, Nuria; Olmedo-Requena, Rocío; Llorca, Javier; Vidan, Juana; Amiano, Pilar; Nos, Pilar; Fernández-Tardon, Guillermo; Rada, Ricardo; Chirlaque-López, María-Dolores; Guino, Elisabet; Davila-Batista, Verónica; Castaño-Vinyals, Gemma; Pérez-Gómez, Beatriz; Miron-Pozo, Benito; Dierssen-Sotos, Trinidad; Etxeberria, Jaione; Molinuevo, Amaia; Álvarez-Cuenllas, Begoña; Kogevinas, Manolis; Pollan, Marina; Moreno, Víctor (NATURE PORTFOLIO, 2018-02-01)
    A safe and effective colorectal cancer (CRC) chemoprevention agent remains to be discovered. We aim to evaluate the association between the use of glucosamine and/or chondroitin sulphate and risk of colorectal cancer (CRC) ...
  • Amniotic membrane promotes focal adhesion remodeling to stimulate cell migration 
    Bernabé-García, Ángel; Liarte, Sergio; Moraleda-Jiménez, José-María; Castellanos, Gregorio; Nicolás, Francisco-José (NATURE PORTFOLIO, 2017-11-10)
    During wound healing, the migration of keratinocytes onto newly restored extracellular matrix aims to reestablish continuity of the epidermis. The application of amniotic membrane (AM) to chronic, deep traumatic, non-healing ...
  • Light color importance for circadian entrainment in a diurnal (Octodon degus) and a nocturnal (Rattus norvegicus) rodent 
    Bonmatí-Carrión, María-Ángeles; Baño-Otalora, Beatriz; Madrid, Juan-Antonio; Rol, María-Ángeles (NATURE PORTFOLIO, 2017-08-18)
    The central circadian pacemaker (Suprachiasmatic Nuclei, SCN) maintains the phase relationship with the external world thanks to the light/dark cycle. Light intensity, spectra, and timing are important for SCN synchronisation. ...
  • ColPortal, an integrative multiomic platform for analysing epigenetic interactions in colorectal cancer 
    Esteban-Gil, Ángel; Pérez-Sanz, Fernando; García-Solano, José; Alburquerque-González, Begoña; Parreno-González, María-Antonia; Legaz-García, María-Del-Carmen; Fernández-Breis, Jesualdo-Tomás; Rodríguez-Braun, Edith; Pimentel, Paola; Tuomisto, Anne; Makinen, Markus; Slaby, Ondrej; Conesa-Zamora, Pablo (NATURE PORTFOLIO, 2019-10-31)
    Colorectal cancer (CRC) is the third leading cause of cancer mortality worldwide. Different pathological pathways and molecular drivers have been described and some of the associated markers are used to select effective ...
  • NLRP3 lacking the leucine-rich repeat domain can be fully activated via the canonical inflammasome pathway 
    Hafner-Bratkovic, Iva; Susjan, Petra; Lainscek, Dusko; Tapia-Abellán, Ana; Cerovic, Kosta; Kadunc, Lucija; Angosto-Bazarra, Diego; Pelegrín, Pablo; Jerala, Roman (NATURE PUBLISHING GROUP, 2018-12-05)
    NLRP3 is a cytosolic sensor triggered by different pathogen- and self-derived signals that plays a central role in a variety of pathological conditions, including sterile inflammation. The leucine-rich repeat domain is ...
  • Generation and characterization of a novel knockin minipig model of Hutchinson-Gilford progeria syndrome 
    Dorado, Beatriz; Grunnet-Ploen, Gro; Barettino, Ana; Macias, Alvaro; Gonzalo, Pilar; Andres-Manzano, María-Jesús; González-Gómez, Cristina; Galan-Arriola, Carlos; Alfonso, José-Manuel; Lobo, Manuel; López-Martin, Gonzalo-J; Molina, Antonio; Sánchez-Sánchez, Raúl; Gadea, Joaquín; Sánchez-González, Javier; Liu, Ying; Callesen, Henrik; Filgueiras-Rama, David; Ibáñez, Borja; Sorensen, Charlotte-Brandt; Andrés, Vicente (NATURE PUBLISHING GROUP, 2019-03-19)
    Hutchinson-Gilford progeria syndrome (HGPS) is an extremely rare genetic disorder for which no cure exists. The disease is characterized by premature aging and inevitable death in adolescence due to cardiovascular ...
  • The NADPH oxidase NOX4 represses epithelial to amoeboid transition and efficient tumour dissemination 
    Crosas-Molist, E; Bertran, E; Rodríguez-Hernández, I; Herraiz, C; Cantelli, G; Fabra, A; Sanz-Moreno, V; Fabregat, I (NATURE PUBLISHING GROUP, 2017-05-25)
    Epithelial to mesenchymal transition is a common event during tumour dissemination. However, direct epithelial to amoeboid transition has not been characterized to date. Here we provide evidence that cells from hepatocellular ...
  • Bone marrow biopsy superiority over PET/CT in predicting progression-free survival in a homogeneously-treated cohort of diffuse large B-cell lymphoma 
    Chen-Liang, Tzu-Hua; Martín-Santos, Taida; Jerez-Cayuela, Andrés; Rodríguez-García, Guillermo; Senent, Leonor; Martínez-Millan, Cristina; Muina, Begoña; Orero, Mayte; Teruel, Anabel; Martín, Alejandro; Gómez-Espuch, Joaquín; Kennedy, Kyra; Benet, Carmen; Raya, José-María; Fernández-González, Marta; de-la-Cruz, Fatima; Guinot, Marta; Villegas, Carolina; Ballester, Isabel; Baile, Monica; Moya, María; López-Jiménez, Javier; Frutos, Laura; Navarro, José-Luis; Una, Jon; Fernández-López, Rosa; Igua, Carolina; Contreras, José; Sánchez-Vano, Raquel; del-Puig-Cozar, María; Tamayo, Pilar; Mucientes, Jorge; Sánchez-Blanco, José-Javier; Pérez-Ceballos, Elena; Ortuño, Francisco-José (WILEY, 2017-11)
    Several studies have reported uneven results when evaluating the prognostic value of bone marrow biopsy (BMB) and PET/CT as part of the staging of diffuse large B-cell lymphoma (DLBCL). The heterogeneity of the inclusion ...
  • Association between physical activity and risk of hepatobiliary cancers: A multinational cohort study 
    Baumeister, Sebastian-E; Schlesinger, Sabrina; Aleksandrova, Krasimira; Jochem, Carmen; Jenab, Mazda; Gunter, Marc-J; Overvad, Kim; Tjonneland, Anne; Boutron-Ruault, Marie-Christine; Carbonnel, Franck; Fournier, Agnes; Kuehn, Tilman; Kaaks, Rudolf; Pischon, Tobias; Boeing, Heiner; Trichopoulou, Antonia; Bamia, Christina; La-Vecchia, Carlo; Masala, Giovanna; Panico, Salvatore; Fasanelli, Francesca; Tumino, Rosario; Grioni, Sara; Bueno-de-Mesquita, Bas; Vermeulen, Roel; May, Anne-M; Borch, Kristin-B; Oyeyemi, Sunday-O; Ardanaz, Eva; Rodríguez-Barranco, Miguel; Chirlaque-López, María-Dolores; Felez-Nobrega, Mireia; Sonestedt, Emily; Ohlsson, Bodil; Hemmingsson, Oskar; Werner, Marten; Pérez-Cornago, Aurora; Ferrari, Pietro; Stepien, Magdalena; Freisling, Heinz; Tsilidis, Konstantinos-K; Ward, Heather; Riboli, Elio; Weiderpass, Elisabete; Leitzmann, Michael-F (ELSEVIER, 2019-05)
    BACKGROUND & AIMS: To date, evidence on the association between physical activity and risk of hepatobiliary cancers has been inconclusive. We examined this association in the European Prospective Investigation into Cancer ...
  • Plasma Androgen Receptor and Docetaxel for Metastatic Castration-resistant Prostate Cancer 
    Conteduca, Vincenza; Jayaram, Anuradha; Romero-Laorden, Nuria; Wetterskog, Daniel; Salvi, Samanta; Gurioli, Giorgia; Scarpi, Emanuela; Castro, Elena; Marín-Aguilera, Mercedes; Lolli, Cristian; Schepisi, Giuseppe; Maugeri, Antonio; Wingate, Anna; Farolfi, Alberto; Casadio, Valentina; Medina, Ana; Puente, Javier; Méndez-Vidal, María-José; Morales-Barrera, Rafael; Villa-Guzmán, José-C; Hernando, Susana; Rodríguez-Vida, Alejo; González-del-Alba, Aranzazu; Mellado, Begoña; González-Billalabeitia, Enrique; Olmos, David; Attard, Gerhardt; De-Giorgi, Ugo (ELSEVIER SCIENCE BV, 2019-03)
    Plasma androgen receptor (AR) gain identifies metastatic castration-resistant prostate cancer (mCRPC) patients with worse outcome on abiraterone/enzalutamide, but its relevance in the context of taxane chemotherapy is ...
  • ECLIM-SEHOP, a new platform to set up and develop international academic clinical trials for childhood cancer and blood disorders in Spain 
    Bautista, F; Canete, A; Ramírez-Villar, G-L; Fernández, J-M; Fuster-Soler, José-Luis; Díaz-de-Heredia, C; Astigarraga, I; García-Ariza, M; Rives, S; Dapena, J-L; Márquez, C; Molines, A; Bermudez, M-del-M; Gallego, S; Andrés, M-del-M; Verdu-Amoros, J; Hernández, C; López, M; Catala, A; Lassaletta, A; Cruz, O; Ramírez, M; Lendinez, F; Carbone, A; Gómez-Sirvent, J; Tallon, M; Acha, T; Moreno, L; Fernández-Teijeiro, A (SPRINGER INTERNATIONAL PUBLISHING AG, 2019-12)
    INTRODUCTION: Cancer and blood disorders in children are rare. The progressive improvement in survival over the last decades largely relies on the development of international academic clinical trials that gather the ...
  • SEOM clinical practice guideline: management and prevention of febrile neutropenia in adults with solid tumors (2018) 
    Carmona-Bayonas, Alberto; Jiménez-Fonseca, Paula; de-Castro, E-M; Mata, E; Biosca, M; Custodio, A; Espinosa, J; Vazquez, E-G; Henao, F; Ayala-de-la-Peña, Francisco (SPRINGER INTERNATIONAL PUBLISHING AG, 2019-01)
    Febrile neutropenia (FN) is a common dose-limiting toxicity of chemotherapy, with a profound impact on the evolution of patients with cancer, due to the potential development of serious complications, mortality, delays, ...
  • Cirugía de las metástasis hepáticas 
    López-López, Víctor; López-Conesa, Asunción; Brusadin, Roberto; Ferreras, David; Robles-Campos, Ricardo (Arán Ediciones, 2022)
  • Comparación del grosor y dificultad de contracción del músculo transverso abdominal en la maniobra de ahuecamiento abdominal(ADIM) aislada versuscombinada con TheraPEP®: un estudio piloto 
    Cano-del-Águila, E; Poveda-Pagán, E; León-Morillas, F; Oliveira-Sousa, Silvana-Loana (Sociedad Andaluza de Fisioterapia. SOFIA., 2022)
  • Randomized phase II study of weekly carfilzomib 70 mg/m2 and dexamethasone with or without cyclophosphamide in relapsed and/or refractory multiple myeloma patients 
    Puertas, Borja; González-Calle, Verónica; Sureda, Anna; Moreno, María-José; Oriol, Albert; González, Esther; Rosiñol, Laura; López, Jordi; Escalante, Fernando; Martínez-López, Joaquín; Carrillo, Estrella; Clavero, Esther; Ríos-Tamayo, Rafael; Rey-Bua, Beatriz; González-Rodríguez, Ana-Pilar; Dourdil, Victoria; de-Arriba-de-la-Fuente, Felipe; González, Sonia; Pérez-de-Oteyza, Jaime; Hernández-García, Miguel-Teodoro; García-Mateo, Aranzazu; Bargay, Joan; Blade, Joan; Lahuerta, Juan-José; San-Miguel, Jesus-F; Ocio, Enrique-M; Mateos, María-Victoria (FERRATA STORTI FOUNDATION, 2023-10)
    In this randomized phase II study (GEM-KyCyDex, clinicaltrials gov. Identifier: NCT03336073), the combination of weekly carfilzomib 70 mg/m2, cyclophosphamide and dexamethasone (KCd) was compared to carfilzomib and ...

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