• Generation of Calpain-3 knock-out porcine embryos by CRISPR-Cas9 electroporation and intracytoplasmic microinjection of oocytes before insemination 

  Navarro-Serna, Sergio; Dehesa-Etxebeste, Martxel; Piñeiro-Silva, Celia; Romar, Raquel; Lopes, Jordana-S; López-de-Munain, Adolfo; Gadea, Joaquín (Elsevier Inc., 2022)

  Limb girdle muscular dystrophy type R1 (LGMDR1) is an autosomal recessive myopathy described in humans resulting from a deficiency of calpain-3 protein (CAPN3). This disease lacks effective treatment and an appropriate ...
• Reductions in blood concentrations of persistent organic pollutants in the general population of Barcelona from 2006 to 2016 

  Porta, Miquel; Pumarega, José; Henriquez-Hernández, Luis-A; Gasull, Magda; Bartoll, Xavier; Arrebola, Juan-P; Morales, Eva; Ibarluzea, Jesús; Alguacil, Juan; Bilal, Usama; Luzardo, Octavio-P (ELSEVIER, 2021-07)
• Prognostic role of pre-diagnostic circulating inflammatory biomarkers in breast cancer survival: evidence from the EPIC cohort study 

  Castro-Espín, Carlota; Cairat, Manon; Navionis, Anne-Sophie; Dahm, Christina-C; Antoniussen, Christian-S; Tjonneland, Anne; Mellemkjaer, Lene; Mancini, Francesca-Romana; Hajji-Louati, Mariem; Severi, Gianluca; Le-Cornet, Charlotte; Kaaks, Rudolf; Schulze, Matthias-B; Masala, Giovanna; Agnoli, Claudia; Sacerdote, Carlotta; Crous-Bou, Marta; Sánchez, María-José; Amiano, Pilar; Chirlaque-López, María-Dolores; Guevara, Marcela; Smith-Byrne, Karl; Heath, Alicia-K; Christakoudi, Sofía; Gunter, Marc-J; Rinaldi, Sabina; Agudo, Antonio; Dossus, Laure (SPRINGERNATURE, 2024-11)

  BACKGROUND: Inflammation influences tumour progression and cancer prognosis, but its role preceding breast cancer (BC) and its prognostic implications remain inconclusive. METHODS: We studied pre-diagnostic plasma inflammatory ...
• Peds1 deficiency in zebrafish results in myeloid cell apoptosis and exacerbated inflammation 

  Arroyo, Ana-B; Tyrkalska, Sylwia-D; Bastida-Martínez, Eva; Monera-Girona, Antonio-J; Canton-Sandoval, Joaquín; Bernal-Carrión, Martín; García-Moreno, Diana; Elías-Arnanz, Montserrat; Mulero, Víctoriano (SPRINGERNATURE, 2024-08-29)

  Plasmalogens are glycerophospholipids with a vinyl ether bond that confers unique properties. Recent identification of the gene encoding PEDS1, the desaturase generating the vinyl ether bond, enables evaluation of the role ...
• Pyroptosis leads to loss of centrosomal integrity in macrophages 

  Bai, Siyi; Martín-Sánchez, Fatima; Brough, David; López-Castejon, Gloria (SPRINGERNATURE, 2024-08-08)

  NLRP3 forms a multiprotein inflammasome complex to initiate the inflammatory response when macrophages sense infection or tissue damage, which leads to caspase-1 activation, maturation and release of the inflammatory ...
• Estrogen receptor-? signaling in tanycytes lies at the crossroads of fertility and metabolism 

  Fernandois, Daniela; Rusidze, Maríam; Mueller-Fielitz, Helge; Sauve, Florent; Deligia, Eleonora; Silva, Mauro-SB; Evrard, Florence; Franco-García, Aurelio; Mazur, Daniele; Martínez-Corral, Inés; Jouy, Nathalie; Rasika, S; Maurage, Claude-Alain; Giacobini, Paolo; Nogueiras, Rubén; Dehouck, Benedicte; Schwaninger, Markus; Lenfant, Francoise; Prevot, Vincent (W B SAUNDERS CO-ELSEVIER INC, 2024-09)

  BACKGROUND: Estrogen secretion by the ovaries regulates the hypothalamic-pituitary-gonadal axis during the reproductive cycle, influencing gonadotropin-releasing hormone (GnRH) and luteinizing hormone (LH) secretion, and ...
• Detection of inflammasome activation in liver tissue during the donation process as potential biomarker for liver transplantation 

  Mateo, Sandra-V; Vidal-Correoso, Daniel; Muñoz-Morales, Ana-M; Jover-Aguilar, Marta; Alconchel-Gago, Felipe; de-la-Peña, Jesús; Martínez-Alarcón, Laura; López-López, Víctor; Ríos-Zambudio, Antonio; Cascales, Pedro; Pons, José-A; Ramírez, Pablo; Pelegrín, Pablo; Baroja-Mazo, Alberto (SPRINGERNATURE, 2024-05)

  Deceased donor liver transplantation (LT) is a crucial lifesaving option for patients with end-stage liver diseases. Although donation after brain death (DBD) remains the main source of donated organs, exploration of ...
• The genomic profiling of high-risk smoldering myeloma patients treated with an intensive strategy unveils potential markers of resistance and progression 

  Medina-Herrera, A; Vázquez, I; Cuenca, I; Rosa-Rosa, JM; Ariceta, B; Jiménez, C; Fernández-Mercado, M; Larrayoz, MJ; Gutiérrez, NC; Fernández-Guijarro, M; González-Calle, V; Rodríguez-Otero, P; Oriol, A; Rosiñol, L; Alegre, A; Escalante, F; de-la-Rubia, J; Teruel, AI; de-Arriba, F; Hernández, MT; López-Jiménez, J; Ocio, EM; Puig, N; Paiva, B; Lahuerta, JJ; Blade, J; San-Miguel, JF; Mateos, MV; Martínez-López, J; Calasanz, MJ; García-Sanz, R; Rios, R; Sureda, A; Blanchard, MJ; Martínez-Martínez, R; Moraleda, JM; Bargay, J; Gironella, M; Palomera, L; González-Montes, Y; Marti, JM; Krsnik, I; Arguinano, JM; González, ME; González, AP; Casado, LF (SPRINGERNATURE, 2024-04-29)

  Smoldering multiple myeloma (SMM) precedes multiple myeloma (MM). The risk of progression of SMM patients is not uniform, thus different progression-risk models have been developed, although they are mainly based on clinical ...
• Penetrance of Dilated Cardiomyopathy in Genotype-Positive Relatives 

  Cabrera-Romero, Eva; Ochoa, Juan-Pablo; Barriales-Villa, Roberto; Bermúdez-Jiménez, Francisco-José; Climent-Paya, Vicente; Zorio, Esther; Espinosa, María-Ángeles; Gallego-Delgado, María; Navarro-Peñalver, Marina; Arana-Achaga, Xabier; Piqueras-Flores, Jesús; Espejo-Bares, Victoria; Rodríguez-Palomares, José-F; Lacuey-Lecumberri, Gemma; López, Javier; Tiron, Coloma; Pena-Pena, María-Luisa; García-Pinilla, José-M; Lorca, Rebeca; Ripoll-Vera, Tomás; Diez-López, Carles; Mogollon, María-Victoria; García-Álvarez, Ana; Martínez-Dolz, Luis; Brion, María; Larranaga-Moreira, José-María; Jiménez-Jaimez, Juan; García-Álvarez, María-Isabel; Vilches, Silvia; Villacorta, Eduardo; Sabater-Molina, María; Solla-Ruiz, Itziar; Royuela, Ana; Domínguez, Fernando; Mirelis, Jesús-G; García-Pavia, Pablo (ELSEVIER SCIENCE INC, 2024-04-30)

  BACKGROUND: Disease penetrance in genotype-positive (G+) relatives of families with dilated cardiomyopathy (DCM) and the characteristics associated with DCM onset in these individuals are unknown. OBJECTIVES: This study ...
• Novel Re(I) Complexes as Potential Selective Theranostic Agents in Cancer Cells and In Vivo in Caenorhabditis elegans Tumoral Strains 

  Marco, Alicia; Ashoo, Pezhman; Hernández-García, Samanta; Martínez-Rodríguez, Pedro; Cutillas, Natalia; Vollrath, Annette; Jordan, Dustin; Janiak, Christoph; Gandía-Herrero, Fernando; Ruiz, José (AMER CHEMICAL SOC, 2024-03)

  A series of rhenium(I) complexes of the type fac-[Re(CO)(3)(N^N)L](0/+), Re1-Re9, was synthesized, where N^N = benzimidazole-derived bidentate ligand with an ester functionality and L = chloride or pyridine-type ligand. ...
• Photoactivatable Ruthenium Complexes Containing Minimal Straining Benzothiazolyl-1,2,3-triazole Chelators for Cancer Treatment 

  Ballester, Francisco-J; Hernández-García, Alba; Santana, MDolores; Bautista, Delia; Ashoo, Pezhman; Ortega-Forte, Enrique; Barone, Giampaolo; Ruiz, José (AMER CHEMICAL SOC, 2024-02)

  Ruthenium(II) complexes containing diimine ligands have contributed to the development of agents for photoactivated chemotherapy. Several approaches have been used to obtain photolabile Ru(II) complexes. The two most ...
• Oocyte electroporation prior to in vitro fertilization is an efficient method to generate single, double, and multiple knockout porcine embryos of interest in biomedicine and animal production 

  Navarro-Serna, Sergio; Piñeiro-Silva, Celia; Fernández-Martín, Irene; Dehesa-Etxebeste, Martxel; López-de-Munain, Adolfo; Gadea, Joaquín (ELSEVIER SCIENCE INC, 2024-04-01)

  Genetically modified pigs play a critical role in mimicking human diseases, xenotransplantation, and the development of pigs resistant to viral diseases. The use of programmable endonucleases, including the CRISPR/Cas9 ...
• Novel 2-(5-Arylthiophen-2-yl)-benzoazole Cyclometalated Iridium(III) dppz Complexes Exhibit Selective Phototoxicity in Cancer Cells by Lysosomal Damage and Oncosis 

  Kasparkova, Jana; Hernández-García, Alba; Kostrhunova, Hana; Goicuria, Marta; Novohradsky, Vojtech; Bautista, Delia; Markova, Lenka; Santana, María-Dolores; Brabec, Viktor; Ruiz, José (AMER CHEMICAL SOC, 2023-12-23)

  A second-generation series of biscyclometalated 2-(5-aryl-thienyl)-benzimidazole and -benzothiazole Ir(III) dppz complexes [Ir(C^N)(2)(dppz)](+), Ir1-Ir4, were rationally designed and synthesized, where the aryl group ...
• Urinary concentrations of bisphenol A, parabens and benzophenone-type ultra violet light filters in relation to sperm DNA fragmentation in young men: A chemical mixtures approach 

  Kiwitt-Cardenas, Jonathan; Arense-Gonzalo, Julián-J; Adoamnei, Evdochia; Sarabia-Cos, Laura; Vela-Soria, Fernando; Fernández, Mariana-F; Gosalvezi, Jaime; Mendiola, Jaime; Torres-Cantero, Alberto-M (ELSEVIER, 2024-02)

  People are daily exposed to multiple endocrine disruptor compounds (EDCs) that may interfere with different molecular and cellular processes, promoting a potential estrogenic, androgenic, or anti-androgenic state. However, ...
• Targeting protein methylation in pancreatic cancer cells results in KRAS signaling imbalance and inhibition of autophagy 

  Montenegro, María-F; Marti-Diaz, Roman; Navarro, Ana; Tolivia, Jorge; Sánchez-del-Campo, Luis; Cabezas-Herrera, Juan; Rodríguez-López, José-Neptuno (SPRINGERNATURE, 2023-11)

  Pancreatic cancer cells with mutant KRAS require strong basal autophagy for viability and growth. Here, we observed that some processes that allow the maintenance of basal autophagy in pancreatic cancer cells are controlled ...
• State of the scientific evidence and recommendations for the management of older patients with gastric cancer 

  Paredero-Pérez, Irene; Jiménez-Fonseca, Paula; Cano, Juana-María; Arrazubi, Virginia; Carmona-Bayonas, Alberto; Covela-Rua, Marta; Fernández-Montes, Ana; Martín-Richard, Marta; Gironés-Sarrio, Regina (ELSEVIER, 2024-04)

  Gastric cancer is one of the most frequent and deadly tumours worldwide. However, the evidence that currently exists for the treatment of older adults is limited and is derived mainly from clinical trials in which older ...
• Telomerase RNA-based aptamers restore defective myelopoiesis in congenital neutropenic syndromes 

  Martínez-Balsalobre, Elena; García-Castillo, Jesús; García-Moreno, Diana; Naranjo-Sánchez, Elena; Fernández-Lajarin, Miriam; Blasco, María-A; Alcaraz-Pérez, Francisca; Mulero, Víctoriano; Cayuela, María-L (NATURE PORTFOLIO, 2023-09)

  Telomerase RNA (TERC) has a noncanonical function in myelopoiesis binding to a consensus DNA binding sequence and attracting RNA polymerase II (RNA Pol II), thus facilitating myeloid gene expression. The CR4/CR5 domain of ...
• Large T cell clones expressing immune checkpoints increase during multiple myeloma evolution and predict treatment resistance 

  Botta, Cirino; Pérez, Cristina; Larrayoz, Marta; Puig, Noemi; Cedena, María-Teresa; Termini, Rosalinda; Goicoechea, Ibai; Rodríguez, Sara; Zabaleta, Aintzane; López, Aitziber; Sarvide, Sarai; Blanco, Laura; Papetti, Daniele-M; Nobile, Marco-S; Besozzi, Daniela; Gentile, Massimo; Correale, Pierpaolo; Siragusa, Sergio; Oriol, Albert; González-García, María-Esther; Sureda, Anna; de-Arriba, Felipe; Rios-Tamayo, Rafael; Moraleda-Jiménez, José-María; Gironella, Mercedes; Hernández, Miguel-T; Bargay, Joan; Palomera, Luis; Pérez-Montana, Albert; Goldschmidt, Hartmut; Avet-Loiseau, Herve; Roccaro, Aldo; Orfao, Alberto; Martínez-López, Joaquín; Rosiñol, Laura; Lahuerta, Juan-José; Blade, Joan; Mateos, María-Victoria; San-Miguel, Jesús-F; Martínez-Climent, José-Ángel; Paiva, Bruno (NATURE PORTFOLIO, 2023-09)

  Tumor recognition by T cells is essential for antitumor immunity. A comprehensive characterization of T cell diversity may be key to understanding the success of immunomodulatory drugs and failure of PD-1 blockade in tumors ...
• Scalable production of tissue-like vascularized liver organoids from human PSCs 

  Harrison, Sean-P; Siller, Richard; Tanaka, Yoshiaki; Chollet, María-Eugenia; de-la-Morena-barrio, María-Eugenia; Xiang, Yangfei; Patterson, Benjamin; Andersen, Elisabeth; Bravo-Pérez, Carlos; Kempf, Henning; Asrud, Kathrine-S; Lunov, Oleg; Dejneka, Alexandr; Mowinckel, Marie-Christine; Stavik, Benedicte; Sandset, Per-Morten; Melum, Espen; Baumgarten, Saphira; Bonanini, Flavio; Kurek, Dorota; Mathapati, Santosh; Almaas, Runar; Sharma, Kulbhushan; Wilson, Steven-R; Skottvoll, Froydis-S; Boger, Ida-C; Bogen, Inger-Lise; Nyman, Tuula-A; Wu, Jun-Jie; Bezrouk, Ales; Cizkova, Dana; Corral, Javier; Mokry, Jaroslav; Zweigerdt, Robert; Park, In-Hyun; Sullivan, Gareth-J (SPRINGERNATURE, 2023-09)

  The lack of physiological parity between 2D cell culture and in vivo culture has led to the development of more organotypic models, such as organoids. Organoid models have been developed for a number of tissues, including ...
• Neuroblastoma RAS viral oncogene homolog (N-RAS) deficiency aggravates liver injury and fibrosis 

  Zheng, Kang; Hao, Fengjie; Medrano-García, Sandra; Chen, Chaobo; Guo, Feifei; Moran-Blanco, Laura; Rodríguez-Perales, Sandra; Torres-Ruiz, Raúl; Peligros, María-Isabel; Vaquero, Javier; Banares, Rafael; del-Moral, Manuel-Gómez; Regueiro, José-R; Martínez-Naves, Eduardo; Mohamed, Mohamed-Ramadan; Gallego-Duran, Rocio; Maya, Douglas; Ampuero, Javier; Romero-Gómez, Manuel; Gilbert-Ramos, Albert; Guixe-Muntet, Sergi; Fernández-Iglesias, Anabel; Gracia-Sancho, Jordi; Coll, Mar; Graupera, Isabel; Gines, Pere; Ciudin, Andreea; Rivera-Esteban, Jesús; Pericas, Juan-M; Frutos, María-Dolores; Molina, Bruno-Ramos; Herranz, José-María; Ávila, Matias-A; Nevzorova, Yulia-A; Fernández-Malave, Edgar; Cubero, Francisco-Javier (SPRINGERNATURE, 2023-08-10)

  Progressive hepatic damage and fibrosis are major features of chronic liver diseases of different etiology, yet the underlying molecular mechanisms remain to be fully defined. N-RAS, a member of the RAS family of small ...

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