• In search of common developmental and evolutionary origin of the claustrum and subplate 

  Bruguier, Hannah; Suárez, Rodrigo; Manger, Paul; Hoerder-Suabedissen, Anna; Shelton, Andrew-M; Oliver, David-K; Packer, Adam-M; Ferran, José-L; García-Moreno, Fernando; Puelles, Luis; Molnar, Zoltan (WILEY, 2020-12-01)

  The human claustrum, a major hub of widespread neocortical connections, is a thin, bilateral sheet of gray matter located between the insular cortex and the striatum. The subplate is a largely transient cortical structure ...
• Intramuscular Injection of Bone Marrow Stem Cells in Amyotrophic Lateral Sclerosis Patients: A Randomized Clinical Trial 

  Geijo-Barrientos, Emilio; Pastore-Olmedo, Carlos; De-Mingo, Pedro; Blanquer, Miguel; Gómez-Espuch, Joaquin; Iniesta, Francisca; García-Iniesta, Natalia; García-Hernández, Ana; Martín-Estefania, Carlos; Barríos, Laura; Moraleda, José-María; Martínez, Salvador (FRONTIERS MEDIA SA, 2020-03-24)

  BACKGROUND: Preclinical studies suggest that stem cells may be a valuable therapeutic tool in amyotrophic lateral sclerosis (ALS). As it has been demonstrated that there are molecular changes at the end-plate during the ...
• Frailty transitions and associated clinical outcomes in patients with stable COPD: A longitudinal study 

  Bernabeu-Mora, Roberto; Oliveira-Sousa, Silvana-Loana; Sánchez-Martínez, Piedad; García-Vidal, José-Antonio; Gacto-Sánchez, Maríano; Medina-Mirapeix, Francesc (PUBLIC LIBRARY SCIENCE, 2020-04-03)

  BACKGROUND: Although frailty is a frequent occurrence in chronic obstructive pulmonary disease (COPD) patients, evidence on the frequency of frailty transition is scarce. AIMS: The present study aimed to describe the frailty ...
• Spanish real-world experience with fingolimod in relapsing-remitting multiple sclerosis patients: MS NEXT study 

  Barrero, Francisco; Mallada-Frechin, Javier; Martínez-Gines, María-Luisa; Eugenia-Marzo, María; Meca-Lallana, Virginia; Izquierdo, Guillermo; Ramon-Ara, José; Oreja-Guevare, Celia; Meca-Lallana, José; Forero, Lucia; Sánchez-Veram, Irene; Moreno, María-José (PUBLIC LIBRARY SCIENCE, 2020-04-02)

  PURPOSE: The objective of this study was to characterize the demographic and clinical profile of RRMS patients receiving fingolimod in Spain, and to evaluate drug effectiveness and safety in clinical practice. METHODS: ...
• Coordinated Intervention of Microglial and Muller Cells in Light-Induced Retinal Degeneration 

  Di-Pierdomenico, Johnny; Martínez-Vacas, Ana; Hernández-Muñoz, Daniel; Gómez-Ramírez, Ana-M; Valiente-Soriano, Francisco-Javier; Agudo-Barriuso, Marta; Vidal-Sanz, Manuel; Villegas-Pérez, María-Paz; García-Ayuso, Diego (ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 2020-03)

  PURPOSE: To analyze the role of microglial and Müller cells in the formation of rings of photoreceptor degeneration caused by phototoxicity. METHODS: Two-month-old Sprague-Dawley rats were exposed to light and processed ...
• Salivary Biomarkers and Their Correlation with Pain and Stress in Patients with Burning Mouth Syndrome 

  López-Jornet, Pia; Castillo-Felipe, Candela; Pardo-Marin, Luis; Ceron, José-J; Pons-Fuster, Eduardo; Tvarijonaviciute, Asta (MDPI, 2020-04)

  OBJECTIVE: To evaluate a panel of salivary analytes involving biomarkers of inflammation, stress, immune system and antioxidant status in patients with burning mouth syndrome (BMS) and to study their relationship with ...
• Photoprotection and Skin Pigmentation: Melanin-Related Molecules and Some Other New Agents Obtained from Natural Sources 

  Solano, Francisco (MDPI, 2020-04)

  Direct sun exposure is one of the most aggressive factors for human skin. Sun radiation contains a range of the electromagnetic spectrum including UV light. In addition to the stratospheric ozone layer filtering the most ...
• Effectiveness of Fingolimod versus Natalizumab as Second-Line Therapy for Relapsing-Remitting Multiple Sclerosis in Spain: Second-Line GATE Study 

  Meca-Lallana, José; Ayuso, Teresa; Martínez-Yelamos, Sergio; Duran, Carmen; Contreras-Martín, Yessica; Herrera-Navarro, Nicolas; Pérez-Sempere, Ángel; Álvarez-Cermeno, José-C; Millán-Pascual, Jorge; Meca-Lallana, Virginia; Romero-Sevilla, Raul; Ricart, Javier (KARGER, 2020-05)

  BACKGROUND: There is a lack of head-to-head studies comparing the efficacy of fingolimod (FIN) and natalizumab (NTZ) as second-line therapy for relapsing-remitting multiple sclerosis (RRMS). METHODS: Multicenter, observational ...
• Time course of bilateral microglial activation in a mouse model of laser-induced glaucoma 

  Ramírez, Ana; de-Hoz, Rosa; Fernández-Albarral, José-A; Salobrar-García, Elena; Rojas, Blanca; Valiente-Soriano, Francisco-Javier; Aviles-Trigueros, Marcelino; Villegas-Pérez, María-Paz; Vidal-Sanz, Manuel; Trivino, Alberto; Ramírez, José-M; Salazar, Juan-J (NATURE PORTFOLIO, 2020-03-17)

  Microglial activation is associated with glaucoma. In the model of unilateral laser-induced ocular hypertension (OHT), the time point at which the inflammatory process peaks remains unknown. Different time points (1, 3, ...
• Biology and Therapeutic Targets of Colorectal Serrated Adenocarcinoma; Clues for a Histologically Based Treatment against an Aggressive Tumor 

  Alburquerque-González, Begoña; López-Calderón, Fernando-F; López-Abellan, María-Dolores; Esteban-Gil, Ángel; García-Solano, José; Conesa-Zamora, Pablo (MDPI, 2020-03)

  Serrated adenocarcinoma (SAC) is a tumor recognized by the WHO as a histological subtype accounting for around 9% of colorectal carcinomas. Compared to conventional carcinomas, SACs are characterized by a worse prognosis, ...
• Influence of Preformed Antibodies in Liver Transplantation 

  Legaz, Isabel; Boix, Francisco; López, Manuela; Alfaro, Rafael; Galian, José-A; Llorente, Santiago; Campillo, José-A; Botella, Carmen; Ramírez, Pablo; Sánchez-Bueno, Francisco; Pons, José-A; Moya-Quiles, María-R; Minguela, Alfredo; Muro, Manuel (MDPI, 2020-03)

  The significance of human leukocyte antigen (HLA) matching and preformed donor-specific antibodies (DSAs) in liver transplantation remains unclear. The aim of this study was to analyze the presence of DSAs in a large cohort ...
• Genome-wide plasma DNA methylation features of metastatic prostate cancer 

  Wu, Anjui; Cremaschi, Paolo; Wetterskog, Daniel; Conteduca, Vincenza; Franceschini, Gian-Marco; Kleftogiannis, Dimitrios; Jayaram, Anuradha; Sandhu, Shahneen; Wong, Stephen-Q; Benelli, Matteo; Salvi, Samanta; Gurioli, Giorgia; Feber, Andrew; Pereira, Maríana-Buongermino; Wingate, Anna-María; González-Billalebeitia, Enrique; De-Giorgi, Ugo; Demichelis, Francesca; Lise, Stefano; Attard, Gerhardt (AMER SOC CLINICAL INVESTIGATION INC, 2020-04-01)

  Tumor DNA circulates in the plasma of cancer patients admixed with DNA from noncancerous cells. The genomic landscape of plasma DNA has been characterized in metastatic castration-resistant prostate cancer (mCRPC) but the ...
• Spatial and Pregnancy-Related Changes in the Protein, Amino Acid, and Carbohydrate Composition of Bovine Oviduct Fluid 

  Rodríguez-Alonso, Beatriz; Maillo, Verónica; Salvador-Acuna, Omar; López-Ubeda, Rebeca; Torrecillas, Alejandro; Simintiras, Constantine-A; Sturmey, Roger; Aviles, Manuel; Lonergan, Patrick; Rizos, Dimitrios (MDPI, 2020-03)

  Knowledge of how the biochemical composition of the bovine oviduct is altered due to the oviduct anatomy or the presence of an embryo is lacking. Thus, the aim of this study was to assess the effect of (?) oviduct anatomy ...
• A New Treatment for Mammillary Fistulas Using Ultrasound-Guided Percutaneous Needle Electrolysis 

  Berna-Serna, Juan-de-Dios; García-Vidal, José-Antonio; Escolar-Reina, María-P; Medina-Mirapeix, Francesc; Guzman-Aroca, Florentina; Piñero-Madrona, Antonio; Berna-Mestre, Juan-de-Dios (MDPI, 2020-03)

  The aim of this study was to investigate the efficacy of ultrasound-guided percutaneous needle electrolysis (PNE) in mammillary fistulas (MFs). A prospective study was performed in 18 patients with MF who were treated with ...
• Expression of tert Prevents ALT in Zebrafish Brain Tumors 

  Idilli, Aurora-Irene; Cusanelli, Emilio; Pagani, Francesca; Berardinelli, Francesco; Bernabé, Manuel; Cayuela, María-Luisa; Poliani, Pietro-Luigi; Mione, María-Caterina (FRONTIERS MEDIA SA, 2020-02-11)

  The activation of a telomere maintenance mechanism (TMM) is an essential step in cancer progression to escape replicative senescence and apoptosis. Alternative lengthening of telomeres (ALT) is found in a subset of malignant ...
• Child Head Circumference and Placental MFSD2a Expression Are Associated to the Level of MFSD2a in Maternal Blood During Pregnancy 

  Sánchez-Campillo, María; Ruiz-Palacios, María; Ruiz-Alcaraz, Antonio-J; Prieto-Sánchez, María-Teresa; Blanco-Carnero, José-Eliseo; Zornoza, Matilde; Ruiz-Pastor, María-José; Demmelmair, Hans; Sánchez-Solis, Manuel; Koletzko, Berthold; Larque, Elvira (FRONTIERS MEDIA SA, 2020)

  Gestational diabetes mellitus (GDM) is a world-wide health challenge, which prevalence is expected to increase in parallel to the epidemic of obesity. Children born from GDM mothers have lower levels of docosahexaenoic ...
• Living Without Temporal Cues: A Case Study 

  Bonmati-Carrion, María-Ángeles; Revell, Victoria-L; Cook, Tom-J; Welch, Thomas-R-E; Rol, María-Ángeles; Skene, Debra-J; Madrid, Juan-Antonio (FRONTIERS MEDIA SA, 2020-02-07)

  Isolation from external time cues allows endogenous circadian rhythmicity to be demonstrated. In this study, also filmed as a television documentary, we assessed rhythmic changes in a healthy man time isolated in a bunker ...
• Urban air pollution and hospital admissions for asthma and acute respiratory disease in Murcia city (Spain) 

  Ortega-García, Juan-Antonio; Martínez-Hernández, Indra; Boldo, Elena; Cárceles-Álvarez, Alberto; Solano-Navarro, Carmen; Ramis, Rebeca; Aguilar-Ros, Estefania; Sánchez-Solis, Manuel; López-Hernández, Fernando (EDICIONES DOYMA S A, 2020-08)

  INTRODUCTION: Urban air pollution is a major threat to child and adolescent health. Children are more vulnerable to its effects, being associated with higher morbidity and mortality due to acute and chronic diseases, ...
• Non-Pharmacological Interventions for Reducing Anxiety in Patients with Potentially Malignant Oral Disorders 

  López-Yufera, Elia; López-Jornet, Pia; Toralla, Oscar; Pons-Fuster-López, Eduardo (MDPI, 2020-03)

  OBJECTIVE: To evaluate the effect of a music intervention upon anxiety, blood pressure, and heart rate in adult patients with potentially malignant oral disorders. METHODS: Eighty consecutive adults (mean age: 68.3 years) ...
• Genome-wide Association Analysis in Humans Links Nucleotide Metabolism to Leukocyte Telomere Length 

  Li, Chen; Stoma, Svetlana; Lotta, Luca-A; Warner, Sophie; Albrecht, Eva; Allione, Alessandra; Arp, Pascal-P; Broer, Linda; Buxton, Jessica-L; Alves, Alexessander-Da-Silva-Couto; Deelen, Joris; Fedko, Iryna-O; Gordon, Scott-D; Jiang, Tao; Karlsson, Robert; Kerrison, Nicola; Loe, Taylor-K; Mangino, Massimo; Milaneschi, Yuri; Miraglio, Benjamin; Pervjakova, Natalia; Russo, Alessia; Surakka, Ida; van-der-Spek, Ashley; Verhoeven, Josine-E; Amin, Najaf; Beekman, Marían; Blakemore, Alexandra; Canzian, Federico; Hamby, Stephen-E; Hottenga, Jouke-Jan; Jones, Peter-D; Jousilahti, Pekka; Magi, Reedik; Medland, Sarah-E; Montgomery, Grant-W; Nyholt, Dale-R; Perola, Markus; Pietilainen, Kirsi-H; Salomaa, Veikko; Sillanpaa, Elina; Suchiman, H-Eka; van-Heemst, Diana; Willemsen, Gonneke; Agudo, Antonio; Boeing, Heiner; Boomsma, Dorret; Chirlaque-López, María-Dolores; Fagherazzi, Guy; Ferrari, Pietro; Franks, Paul; Gieger, Christian; Eriksson, Johan-Gunnar; Gunter, Marc; Hagg, Sara; Hovatta, Iiris; Imaz, Liher; Kaprio, Jaakko; Kaaks, Rudolf; Key, Timothy-J; Krogh, Vittorio; Martín, Nicholas-G; Melander, Olle; Metspalu, Andrés; Moreno, Concha; Onland-Moret, N-Charlotte; Nilsson, Peter; Ong, Ken-K; Overvad, Kim; Palli, Domenico; Panico, Salvatore; Pedersen, Nancy-L; Penninx, Brenda-W-J-H; Ramon-Quiros, J; Riitta-Jarvelin, Marjo; Rodríguez-Barranco, Miguel; Scott, Robert-A; Severi, Gianluca; Slagboom, P-Eline; Spector, Tim-D; Tjonneland, Anne; Trichopoulou, Antonia; Tumino, Rosario; Uitterlinden, Andre-G; van-der-Schouw, Yvonne-T; van-Duijn, Cornelia-M; Weiderpass, Elisabete; Denchi, Eros-Lazzerini; Matullo, Giuseppe; Butterworth, Adam-S; Danesh, John; Samani, Nilesh-J; Wareham, Nicholas-J; Nelson, Christopher-P; Langenberg, Claudia; Codd, Veryan (CELL PRESS, 2020-03-05)

  Leukocyte telomere length (LTL) is a heritable biomarker of genomic aging. In this study, we perform a genome-wide meta-analysis of LTL by pooling densely genotyped and imputed association results across large-scale ...

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