• BAX as a factor of susceptibility in hereditary nonpolyposis colorectal cancer 

  Ríos-Zambudio, Antonio; Rodríguez-González, José-Manuel; Parrilla-Paricio, Pascual; Carbonel, Pablo (2015-07)
• Flavonoid and lignan intake and pancreatic cancer risk in the European prospective investigation into cancer and nutrition cohort 

  Molina-Montes, Esther; Sánchez, María-José; Zamora-Ros, Raul; Romieu, Isabelle; Scalbert, Augustin; Cross, Amanda-J; Lu, Yunxia; Riboli, Elio; Bueno-de-Mesquita, H-B(as); Wark, Petra-A; Obon-Santacana, Mireia; Duell, Eric-J; Kuehn, Tilman; Katzke, Verena; Travis, Ruth-C; Ye, Weimin; Sund, Malin; Naccarati, Alessio; Mattiello, Amalia; Krogh, Vittorio; Martorana, Caterina; Masala, Giovanna; Amiano, Pilar; Huerta-Castaño, José-María; Barricarte, Aurelio; Quiros, José-Ramon; Asli, Lene-Angell; Skeie, Guri; Weiderpass, Elisabete; Ericson, Ulrika; Sonestedt, Emily; Peeters, Petra-H; Overvad, Kim; Clemens, Matthias; Boeing, Heiner; Peppa, Eleni; Vidalis, Pavlos; Trichopoulou, Antonia; Khaw, Kay-Tee; Wareham, Nick; Olsen, Anja; Tjonneland, Anne; Boutroun-Rualt, Marie-Christine; Clavel-Chapelon, Francoise (2016-10)

  Despite the potential cancer preventive effects of flavonoids and lignans, their ability to reduce pancreatic cancer risk has not been demonstrated in epidemiological studies. Our aim was to examine the association between ...
• Intraventricular injections of mesenchymal stem cells activate endogenous functional remyelination in a chronic demyelinating murine model 

  Cruz-Martínez, P; Pacheco-Torres, J; Geijo-Barrientos, E; Jones, J; González-Granero, S; Molina-Navarro, M-M; García-Verdugo, J-M; Martínez, Salvador (2016-05-12)

  Current treatments for demyelinating diseases are generally only capable of ameliorating the symptoms, with little to no effect in decreasing myelin loss nor promoting functional recovery. Mesenchymal stem cells (MSCs) ...
• Is Chronic Low Back Pain Associated with the Prevalence of Coronary Heart Disease when Genetic Susceptibility Is Considered? A Co-Twin Control Study of Spanish Twins 

  Fernández, Matt; Refshauge, Kathryn-M; Pinheiro, Marina-B; Ferreira, Paulo-H; Ordoñana, Juan-Ramón; Sánchez-Romera, Juan-Francisco; Hartvigsen, Jan; Ferreira, Manuela-L; Simpson, Stephen-J; Hopper, John-L (2016-05-12)

  OBJECTIVE: To investigate the chronic low back pain and coronary heart disease relationship, after adjusting for relevant confounders, including genetics. METHODS: In a cross-sectional design, 2148 twins were recruited ...
• Calcineurin role in porcine oocyte activation 

  Tumova, L; Chmelikova, E; Zalmanova, T; Kucerova-Chrpova, V; Dvorakova, M; Hoskova, K; Petr, J; Romar, Raquel (2016)

  Calcineurin is required for oocyte exit from meiotic block in metaphase II (MII) stage in invertebrates and also in lower vertebrates. However, the role of calcineurin in mammalian oocyte activation is still unclear. The ...
• Wheezes, crackles and rhonchi: simplifying description of lung sounds increases the agreement on their classification: a study of 12 physicians' classification of lung sounds from video recordings. 

  Melbye, Hasse; García-Marcos, Luis; Brand, Paul; Everard, Mark; Priftis, Kostas; Pasterkamp, Hans (2016-04)

  BACKGROUND: The European Respiratory Society (ERS) lung sounds repository contains 20 audiovisual recordings of children and adults. The present study aimed at determining the interobserver variation in the classification ...
• MiRNA-Based Regulation of Hemostatic Factors through Hepatic Nuclear Factor-4 Alpha 

  Salloum-Asfar, Salam; Arroyo-Rodríguez, Ana-Belén; Teruel-Montoya, Raúl; García-Barbera, Nuria; Roldán-Schilling, Vanessa; Vicente, Vicente; Martínez, Constantino; González-Conejero, Rocío (2016-05-02)

  MiRNAs have been reported as CIS-acting elements of several hemostatic factors, however, their mechanism as TRANS-acting elements mediated by a transcription factor is little known and could have important effects. HNF4? ...
• Relevance of internal time and circadian robustness for cancer patients 

  Jiménez-Movilla, María; Innominato, Pasquale-F; Ortiz-Tudela, Elisabet; Levi, Francis; Rol, María-Ángeles (2016-12)

  BACKGROUND: Adequate circadian timing of cancer treatment schedules (chronotherapy) can enhance tolerance and efficacy several-fold in experimental and clinical situations. However, the optimal timing varies according to ...
• Identification of Bovine Sperm Surface Proteins Involved in Carbohydrate-mediated Fertilization Interactions 

  Defaus, Sira; Andreu, David; Gutierrez-Gallego, Ricardo; Avilés, Manuel (2016-07)

  Glycan-protein interactions play a key role in mammalian fertilization, but data on the composition and identities of protein complexes involved in fertilization events are scarce, with the added complication that the ...
• Bird Integumentary Melanins: Biosynthesis, Forms, Function and Evolution 

  Galvan, Ismael; Solano, Francisco (2016-04-08)

  Melanins are the ubiquitous pigments distributed in nature. They are one of the main pigments responsible for colors in living cells. Birds are among the most diverse animals regarding melanin-based coloration, especially ...
• Rett Syndrome Mutant Neural Cells Lacks MeCP2 Immunoreactive Bands 

  Bueno, Carlos; Moraleda-Jiménez, José-María; Tabares-Seisdedos, Rafael; Martínez, Salvador (2016-04-11)

  Dysfunctions of MeCP2 protein lead to various neurological disorders such as Rett syndrome and Autism. The exact functions of MeCP2 protein is still far from clear. At a molecular level, there exist contradictory data. ...
• Immunosuppressive potency of mechanistic target of rapamycin inhibitors in solid-organ transplantation. 

  Baroja-Mazo, Alberto; Revilla-Nuin, Beatriz; Ramírez, Pablo; Pons-Miñano, José-Antonio (2016)

  Mammalian target of rapamycin, also known as mechanistic target of rapamycin (mTOR) is a protein kinase that belongs to the PI3K/AKT/mTOR signaling pathway, which is involved in several fundamental cellular functions such ...
• Identification of Regulatory Mutations in SERPINC1 Affecting Vitamin D Response Elements Associated with Antithrombin Deficiency 

  Toderici, Mara; de-la-Morena-Barrio, María-Eugenia; Padilla, José; Miñano, Antonia; Antón, Ana-Isabel; Vicente, Vicente; Corral, Javier; Iniesta-Valera, Juan-Antonio; Herranz-Marín, María-Teresa; Fernández, Nuria (2016-03-22)

  Antithrombin is a crucial anticoagulant serpin whose even moderate deficiency significantly increases the risk of thrombosis. Most cases with antithrombin deficiency carried genetic defects affecting exons or flanking ...
• Ion Channels in Inflammatory Processes: What Is Known and What Is Next? 

  Retamal, Mauricio-A; Bennett, Michael-V-L; Pelegrín, Pablo; Fernández, Ricardo (2016)
• Ketorolac Administration Attenuates Retinal Ganglion Cell Death After Axonal Injury 

  Nadal-Nicolás, Francisco-M; Sobrado-Calvo, Paloma; Villegas-Pérez, María-Paz; Vidal-Sanz, Manuel; Agudo-Barriuso, Marta; Rodriguez-Villagra, Esther; Bravo-Osuna, Irene; Molina-Martínez, Irene; Herrero-Vanrell, Rocio (2016-03-14)

  PURPOSE: To assess the neuroprotective effects of ketorolac administration, in solution or delivered from biodegradable microspheres, on the survival of axotomized retinal ganglion cells (RGCs). METHODS: Retinas were treated ...
• Macrophage activation and polarization modify P2X7 receptor secretome influencing the inflammatory process 

  de-Torre-Minguela, Carlos; Barberá-Cremades, María; Gómez, Ana-I; Martín-Sánchez, Fátima; Pelegrín, Pablo (2016-03-03)

  The activation of P2X7 receptor (P2X7R) on M1 polarized macrophages induces the assembly of the NLRP3 inflammasome leading to the release of pro-inflammatory cytokines and the establishment of the inflammatory response. ...
• Incidence Patterns and Trends of non-Central Nervous System Solid Tumours in Children and Adolescents. A Collaborative Study of the Spanish Population Based Cancer Registries 

  Larranaga, Nerea; José-Sánchez, Ma; Ardanaz, Eva; Felipe, Saray; Marcos-Gragera, Rafael; Ramos, María; Carulla, María; Chirlaque-López, María-Dolores; Argueelles, Marcial-V; Martos, Carmen; Mateo, Antonio; Peris-Bonet, Rafael (2016)

  OBJECTIVE: To describe incidence patterns and trends in children (0-14 years) and adolescents (15-19 age-range) with solid tumours, except those of central nervous system (CNS), in Spain. METHODS: Cases were drawn from ...
• Sever lower gastro-intestinal bleeding by CMV in a kidney transplant with low-dose immunosuppression 

  Ríos-Zambudio, Antonio; Ruiz, José; Rodríguez-González, José-Manuel; Parrilla-Paricio, Pascual (2016-07)
• Tobacco smoking-associated genome-wide DNA methylation changes in the EPIC study 

  Ambatipudi, Srikant; Cuenin, Cyrille; Hernández-Vargas, Hector; Ghantous, Akram; Le-Calvez-Kelm, Florence; Romieu, Isabelle; Herceg, Zdenko; Kaaks, Rudolf; Barrdahl, Myrto; Boeing, Heiner; Aleksandrova, Krasimira; Trichopoulou, Antonia; Lagiou, Pagona; Naska, Androniki; Palli, Domenico; Krogh, Vittorio; Polidoro, Silvia; Tumino, Rosario; Panico, Salvatore; Bueno-de-Mesquita, Bas; Peeters, Petra-H-M; Quiros, José-Ramon; Navarro, Carmen; Ardanaz, Eva; Dorronsoro, Miren; Key, Tim; Vineis, Paolo; Murphy, Neil; Riboli, Elio (2016-05)

  AIM: Epigenetic changes may occur in response to environmental stressors, and an altered epigenome pattern may represent a stable signature of environmental exposure. MATERIALS & METHODS: Here, we examined the potential ...
• The Influence of Hormonal Factors on the Risk of Developing Cervical Cancer and Pre-Cancer: Results from the EPIC Cohort 

  Bosch, F-Xavier; Roura, Esther; de-Sanjose, Silvia; Castellsague, Xavier; Travier, Noemie; Waterboer, Tim; Pawlita, Michael; Pala, Valeria; Gram, Inger-T; Lund, Eiliv; Weiderpass, Elisabete; Margall, Nuria; Dillner, Joakim; Tjonneland, Anne; Munk, Christian; Palli, Domenico; Masala, Giovanna; Khaw, Kay-Tee; Overvad, Kim; Clavel-Chapelon, Franoise; Mesrine, Sylvie; Fournier, Agnes; Fortner, Renee-T; Ose, Jennifer; Steffen, Annika; Trichopoulou, Antonia; Orfanos, Philippos; Lagiou, Pagona; Tumino, Rosario; Sacerdote, Carlotta; Polidoro, Silvia; Mattiello, Amalia; Peeters, Petra-H; Merritt, Melissa-A; Gunter, Marc-J; Riboli, Elio; Bueno-de-Mesquita, H-B(as); Quiros, J-Ramon; Sánchez, María-José; Navarro, Carmen; Barricarte, Aurelio; Larranaga, Nerea; Ekstrom, Johanna; Lindquist, David; Idahl, Annika; Travis, Ruth-C; Rinaldi, Sabina; Tommasino, Massimo; Franceschi, Silvia (2016-01-25)

  BACKGROUND: In addition to HPV, high parity and hormonal contraceptives have been associated with cervical cancer (CC). However, most of the evidence comes from retrospective case-control studies. The aim of this study is ...

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