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Envíos recientes

03. IMIB (Instituto Murciano de Investigación Biosanitaria Pascual Parrilla): Envíos recientes

  • Two histologically colorectal carcinomas subsets from the serrated pathway show different methylome signatures and diagnostic biomarkers 
    García-Solano, José; Turpin, María-C; Torres-Moreno, Daniel; Huertas-López, Francisco; Tuomisto, Anne; Makinen, Markus-J; Conesa, Ana; Conesa-Zamora, Pablo (BMC, 2018-11-09)
    BACKGROUND: Altered methylation patterns are driving forces in colorectal carcinogenesis. The serrated adenocarcinoma (SAC) and sporadic colorectal carcinoma showing histological and molecular features of microsatellite ...
  • Mitochondrial DNA copy number variation, leukocyte telomere length, and breast cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) study 
    Campa, Daniele; Barrdahl, Myrto; Santoro, Aurelia; Severi, Gianluca; Baglietto, Laura; Omichessan, Hanane; Tumino, Rosario; Bueno-de-Mesquita, Bas; Peeters, Petra-H; Weiderpass, Elisabete; Chirlaque-López, María-Dolores; Rodríguez-Barranco, Miguel; Agudo, Antonio; Gunter, Marc; Dossus, Laure; Krogh, Vittorio; Matullo, Giuseppe; Trichopoulou, Antonia; Travis, Ruth-C; Canzian, Federico; Kaaks, Rudolf (BIOMED CENTRAL LTD, 2018-04-17)
    BACKGROUND: Leukocyte telomere length (LTL) and mitochondrial genome (mtDNA) copy number and deletions have been proposed as risk markers for various cancer types, including breast cancer (BC). METHODS: To gain a more ...
  • Correlates of circulating ovarian cancer early detection markers and their contribution to discrimination of early detection models: results from the EPIC cohort 
    Fortner, Renee-T; Vitonis, Allison-F; Schock, Helena; Huesing, Anika; Johnson, Theron; Fichorova, Raina-N; Fashemi, Titilayo; Yamamoto, Hidemi-S; Tjonneland, Anne; Hansen, Louise; Overvad, Kim; Boutron-Ruault, Marie-Christine; Kvaskoff, Marina; Severi, Gianluca; Boeing, Heiner; Trichopoulou, Antonia; Benetou, Vassiliki; La-Vecchia, Carlo; Palli, Domenico; Sieri, Sabina; Tumino, Rosario; Matullo, Giuseppe; Mattiello, Amalia; Onland-Moret, N-Charlotte; Peeters, Petra-H; Weiderpass, Elisabete; Gram, Inger-Torhild; Jareid, Mie; Quirós, José-Ramón; Duell, Eric-J; Sánchez, María-José; Chirlaque-López, María-Dolores; Ardanaz, Eva; Larrañaga, Nerea; Nodin, Bjorn; Brandstedt, Jenny; Idahl, Annika; Khaw, Kay-Tee; Allen, Naomi; Gunter, Marc; Johansson, Mattias; Dossus, Laure; Merritt, Melissa-A; Riboli, Elio; Cramer, Daniel-W; Kaaks, Rudolf; Terry, Kathryn-L (BMC, 2017-03-20)
    BACKGROUND: Ovarian cancer early detection markers CA125, CA15.3, HE4, and CA72.4 vary between healthy women, limiting their utility for screening. METHODS: We evaluated cross-sectional relationships between lifestyle and ...
  • Zebrafish modeling reveals that SPINT1 regulates the aggressiveness of skin cutaneous melanoma and its crosstalk with tumor immune microenvironment 
    Gómez-Abenza, Elena; Ibáñez-Molero, Sofia; García-Morenou, Diana; Fuentes, Inmaculada; Zon, Leonard; Mione, María-C; Cayuela-Fuentes, María-Luisa; Gabellini, Chiara; Mulero, Victoriano (BMC, 2019-09-13)
    BACKGROUND: Skin cutaneous melanoma (SKCM) is the most lethal form of skin cancer and while incidence rates are declining for most cancers, they have been steadily rising for SKCM. Serine protease inhibitor, kunitz-type, ...
  • High penetrance of acute intermittent porphyria in a Spanish founder mutation population and CYP2D6 genotype as a susceptibility factor 
    Barreda-Sánchez, María; Buendía-Martínez, Juan; Glover-López, Guillermo; Carazo-Díaz, Carmen; Ballesta-Martínez, María-Juliana; López-González, Vanesa; Sánchez-Soler, María-José; Rodríguez-Pena, Lidya; Serrano-Anton, Ana-Teresa; Gil-Ferrer, Remedios; Martínez-Romero, María-del-Carmen; Carbonell-Meseguer, Pablo; Guillén-Navarro, Encarna (BMC, 2019-02-26)
    BACKGROUND: Acute intermittent porphyria (AIP) is a low-penetrant genetic metabolic disease caused by a deficiency of hydroxymethylbilane synthase (HMBS) in the haem biosynthesis. Manifest AIP (MAIP) is considered when ...
  • Effect of NAC treatment and physical activity on neuroinflammation in subchronic Parkinsonism; is physical activity essential? 
    Gil-Martínez, Ana-Luisa; Cuenca, Lorena; Sánchez, Consuelo; Estrada, Cristina; Fernández-Villalba, Emiliano; Herrero, María-Trinidad (BMC, 2018-11-26)
    BACKGROUND: Neuroprotective strategies are becoming relevant to slow down dopaminergic cell death and inflammatory processes related to the progressive neurodegeneration in Parkinson's disease (PD). Interestingly, among ...
  • In search of an evidence-based strategy for quality assessment of human tissue samples: report of the tissue Biospecimen Research Working Group of the Spanish Biobank Network 
    Esteva-Socias, Margalida; Artiga, María-Jesús; Bahamonde, Olga; Belar, Oihana; Bermudo, Raquel; Castro, Erika; Escámez, Teresa; Fraga, Maximo; Jauregui-Mosquera, Laura; Novoa, Isabel; Peiro-Chova, Lorena; Rejon, Juan-David; Ruiz-Miro, María; Vieiro-Balo, Paula; Villar-Campo, Virginia; Zazo, Sandra; Rabano, Alberto; Villena, Cristina (BMC, 2019-11-12)
    The purpose of the present work is to underline the importance of obtaining a standardized procedure to ensure and evaluate both clinical and research usability of human tissue samples. The study, which was carried out by ...
  • Prospective analysis of circulating metabolites and breast cancer in EPIC 
    His, Mathilde; Viallon, Vivian; Dossus, Laure; Gicquiau, Audrey; Achaintre, David; Scalbert, Augustin; Ferrari, Pietro; Romieu, Isabelle; Onland-Moret, N-Charlotte; Weiderpass, Elisabete; Dahm, Christina-C; Overvad, Kim; Olsen, Anja; Tjonneland, Anne; Fournier, Agnes; Rothwell, Joseph-A; Severi, Gianluca; Kuehn, Tilman; Fortner, Renee-T; Boeing, Heiner; Trichopoulou, Antonia; Karakatsani, Anna; Martimianaki, Georgia; Masala, Giovanna; Sieri, Sabina; Tumino, Rosario; Vineis, Paolo; Panico, Salvatore; van-Gils, Carla-H; Nost, Therese-H; Sandanger, Torkjel-M; Skeie, Guri; Quirós, José-Ramón; Agudo, Antonio; Sánchez, María-José; Amiano, Pilar; Huerta-Castaño, José-María; Ardanaz, Eva; Schmidt, Julie-A; Travis, Ruth-C; Riboli, Elio; Tsilidis, Konstantinos-K; Christakoudi, Sofia; Gunter, Marc-J; Rinaldi, Sabina (BMC, 2019-09-24)
    BACKGROUND: Metabolomics is a promising molecular tool to identify novel etiologic pathways leading to cancer. Using a targeted approach, we prospectively investigated the associations between metabolite concentrations in ...
  • Childhood generalized specific phobia as an early marker of internalizing psychopathology across the lifespan: results from the World Mental Health Surveys 
    de-Vries, Ymkje-Anna; Al-Hamzawi, Ali; Alonso, Jordi; Borges, Guilherme; Bruffaerts, Ronny; Bunting, Brendan; Caldas-de-Almeida, José-Miguel; Cia, Alfredo-H; De-Girolamo, Giovanni; Dinolova, Rumyana; Esan, Oluyomi; Florescu, Silvia; Gureje, Oye; Haro, Josep-María; Hu, Chiyi; Karam, Elie-G; Karam, Aimee; Kawakami, Norito; Kiejna, Andrzej; Kovess-Masfety, Viviane; Lee, Sing; Mneimneh, Zeina; Navarro-Mateu, Fernando; Piazza, Marina; Scott, Kate; ten-Have, Margreet; Torres, Yolanda; Viana, María-Carmen; Kessler, Ronald-C; de-Jonge, Peter; Aguilar-Gaxiola, Sergio; Al-Kaisy, Mohammed-Salih; Andrade, Laura-Helena; Benjet, Corina; Bromet, Evelyn-J; Caldas-de-Almeida, José-Miguel; Cardoso, Graca; Chatterji, Somnath; Degenhardt, Louisa; Demyttenaere, Koen; de-Girolamo, Giovanni; Hinkov, Hristo; Hu, Chi-yi; Karam, Aimee-Nasser; Lepine, Jean-Pierre; Levinson, Daphna; McGrath, John; Medina-Mora, María-Elena; Moskalewicz, Jacek; Pennell, Beth-Ellen; Posada-Villa, José; Scott, Kate-M; Slade, Tim; Stagnaro, Juan-Carlos; Stein, Dan-J; Whiteford, Harvey; Williams, David-R; Wojtyniak, Bogdan (BMC, 2019-05-24)
    BACKGROUND: Specific phobia (SP) is a relatively common disorder associated with high levels of psychiatric comorbidity. Because of its early onset, SP may be a useful early marker of internalizing psychopathology, especially ...
  • Exposure to bacterial products lipopolysaccharide and flagellin and hepatocellular carcinoma: a nested case-control study 
    Fedirko, Veronika; Hao-Quang-Tran,; Gewirtz, Andrew-T; Stepien, Magdalena; Trichopoulou, Antonia; Aleksandrova, Krasimira; Olsen, Anja; Tjonneland, Anne; Overvad, Kim; Carbonnel, Franck; Boutron-Ruault, Marie-Christine; Severi, Gianluca; Kuhn, Tilman; Kaaks, Rudolf; Boeing, Heiner; Bamia, Christina; Lagiou, Pagona; Grioni, Sara; Panico, Salvatore; Palli, Domenico; Tumino, Rosario; Naccarati, Alessio; Peeters, Petra-H; Bueno-de-Mesquita, Bas; Weiderpass, Elisabete; Huerta-Castaño, José-María; Barricarte-Gurrea, Aurelio; Sánchez, María-José; Dorronsoro, Miren; Quirós, José-Ramón; Agudo, Antonio; Sjoberg, Klas; Ohlsson, Bodil; Hemmingsson, Oskar; Werner, Marten; Bradbury, Kathryn-E; Khaw, Kay-Tee; Wareham, Nick; Tsilidis, Konstantinos-K; Aune, Dagfinn; Scalbert, Augustin; Romieu, Isabelle; Riboli, Elio; Jenab, Mazda (BMC, 2017-04-04)
    BACKGROUND: Leakage of bacterial products across the gut barrier may play a role in liver diseases which often precede the development of liver cancer. However, human studies, particularly from prospective settings, are ...
  • Osteoprotegerin and breast cancer risk by hormone receptor subtype: a nested case-control study in the EPIC cohort 
    Fortner, Renee-T; Sarink, Danja; Schock, Helena; Johnson, Theron; Tjonneland, Anne; Olsen, Anja; Overvad, Kim; Affret, Aurelie; His, Mathilde; Boutron-Ruault, Marie-Christine; Boeing, Heiner; Trichopoulou, Antonia; Naska, Androniki; Orfanos, Philippos; Palli, Domenico; Sieri, Sabina; Mattiello, Amalia; Tumino, Rosario; Ricceri, Fulvio; Bueno-de-Mesquita, Bas; Peeters, Petra-H-M; Van-Gils, Carla-H; Weiderpass, Elisabete; Lund, Eiliv; Quirós, José-Ramón; Agudo, Antonio; Sánchez, María-José; Chirlaque-López, María-Dolores; Ardanaz, Eva; Dorronsoro, Miren; Key, Tim; Khaw, Kay-Tee; Rinaldi, Sabina; Dossus, Laure; Gunter, Marc; Merritt, Melissa-A; Riboli, Elio; Kaaks, Rudolf (BMC, 2017-02-08)
    BACKGROUND: Circulating osteoprotegerin (OPG), a member of the receptor activator of nuclear factor kappa-B (RANK) axis, may influence breast cancer risk via its role as the decoy receptor for both the RANK ligand (RANKL) ...
  • Clinical pilot study to evaluate the neovaginal PACIENA prosthesis® for vaginoplasty without skin grafts in women with vaginal agenesis 
    Acien, Pedro; Nohales-Alfonso, Francisco-J; Sánchez-Ferrer, María-Luisa; Sánchez-Lozano, Miguel; Navarro-Lillo, Victoria; Acien, Maribel (BMC, 2019-11-26)
    BACKGROUND: To evaluate the feasibility and clinical outcomes of vaginoplasties using a neovaginal polylactic acid prosthesis made with 3-dimensional (3D) printing technology as an intraneovaginal mould. METHODS: This was ...
  • Epidemiology of non-steroidal anti-inflammatory drugs consumption in Spain. The MCC-Spain study 
    Gómez-Acebo, Inés; Dierssen-Sotos, Trinidad; de-Pedro, María; Pérez-Gómez, Beatriz; Castaño-Vinyals, Gemma; Fernández-Villa, Tania; Palazuelos-Calderon, Camilo; Amiano, Pilar; Etxeberria, Jaione; Benavente, Yolanda; Fernández-Tardon, Guillermo; Salcedo-Bellido, Inmaculada; Capelo, Rocío; Peiro, Rosana; Marcos-Gragera, Rafael; Huerta-Castaño, José-María; Tardon, Adonina; Barricarte-Gurrea, Aurelio; Altzibar, Jone-Miren; Alonso-Molero, Jessica; Davila-Batista, Verónica; Aragonés, Nuria; Pollan, Marina; Kogevinas, Manolis; Llorca, Javier (BMC, 2018-09-21)
    BACKGROUND: Non-steroidal anti-inflammatory drugs (NSAIDs) are widely used despite their risk of gastrointestinal bleeding or cardiovascular events. We report the profile of people taking NSAIDs in Spain, and we include ...
  • The RS4939827 polymorphism in the SMAD7 GENE and its association with Mediterranean diet in colorectal carcinogenesis 
    Alonso-Molero, Jessica; González-Donquiles, Carmen; Palazuelos, Camilo; Fernández-Villa, Tania; Ramos, Elena; Pollan, Marina; Aragonés, Nuria; Llorca, Javier; Henar-Alonso, M; Tardon, Adonina; Amiano, Pilar; Jiménez-Moleon, José-Juan; Peiro-Pérez, Rosana; Capelo, Rocío; Molina, Antonio-J; Gómez-Acebo, Inés; Guevara, Marcela; Pérez-Gómez, Beatriz; Lope, Virginia; Huerta-Castaño, José-María; Castaño-Vinyals, Gemma; Kogevinas, Manolis; Moreno, Víctor; Martín, Vicente (BMC, 2017-10-30)
    BACKGROUND: The objective of our investigation is to study the relationship between the rs4939827 SNP in the SMAD7 gene, Mediterranean diet pattern and the risk of colorectal cancer. METHODS: We examined 1087 cases of ...
  • Validity of self blood pressure measurement in the control of the hypertensive patient: factors involved 
    de-Leon-Robert, Arleen; Gascón-Cánovas, Juan-José; Joaquin-Anton-Botella, José; Hidalgo-García, Isabel-María; López-Alegría, Carmen; Dilvani-Pérez-Cabrera, Yoalys; Merari-Campusano-Castellanos, Heidy (BMC, 2019-07-17)
    BACKGROUND: Improving clinical practice aimed at controlling hypertension is a pending issue in health systems. One of the methods currently used for this purpose is self blood pressure measurement (SBPM) whose use increases ...
  • CD33 (Siglec-3) Inhibitory Function: Role in the NKG2D/DAP10 Activating Pathway 
    Hernández-Caselles, Trinidad; Corral-San-Miguel, Rubén; Ruiz-Alcaraz, Antonio-José; García-Peñarrubia, Pilar (HINDAWI LTD, 2019)
    CD33 (siglec-3), a well-known target in leukemia therapy, is an inhibitory sialoadhesin expressed in human leukocytes of the myeloid lineage and some lymphoid subsets, including NK cells. It may constitute a control mechanism ...
  • Exploring causality of the association between smoking and Parkinson's disease 
    Gallo, Valentina; Vineis, Paolo; Cancellieri, Mariagrazia; Chiodini, Paolo; Barker, Roger-A; Brayne, Carol; Pearce, Neil; Vermeulen, Roel; Panico, Salvatore; Bueno-de-Mesquita, Bas; Vanacore, Nicola; Forsgren, Lars; Ramat, Silvia; Ardanaz, Eva; Arriola, Larraitz; Peterson, Jesper; Hansson, Oskar; Gavrila-Chervase, Diana; Sacerdote, Carlotta; Sieri, Sabina; Kuehn, Tilman; Katzke, Verena-A; van-der-Schouw, Yvonne-T; Kyrozis, Andreas; Masala, Giovanna; Mattiello, Amalia; Perneczky, Robert; Middleton, Lefkos; Saracci, Rodolfo; Riboli, Elio (OXFORD UNIV PRESS, 2019-06)
    BACKGROUND: The aim of this paper is to investigate the causality of the inverse association between cigarette smoking and Parkinson's disease (PD). The main suggested alternatives include a delaying effect of smoking, ...
  • Cohort Profile: Nausea and vomiting during pregnancy genetics consortium (NVP Genetics Consortium) 
    Colodro-Conde, Lucía; Cross, Simone-M; Lind, Penelope-A; Painter, Jodie-N; Gunst, Annika; Jern, Patrick; Johansson, Ada; Maegbaek, Merete-Lund; Munk-Olsen, Trine; Nyholt, Dale-R; Ordoñana, Juan-Ramón; Paternoster, Lavinia; Sánchez-Romera, Juan-F; Wright, Margaret-J; Medland, Sarah-E (OXFORD UNIV PRESS, 2017-04)
  • Gearing up to handle the mosaic nature of life in the quest for orthologs 
    Forslund, Kristoffer; Pereira, Cecile; Capella-Gutierrez, Salvador; Sousa-da-Silva, Alan; Altenhoff, Adrian; Huerta-Cepas, Jaime; Muffato, Matthieu; Patricio, Mateus; Vandepoele, Klaas; Ebersberger, Ingo; Blake, Judith; Fernández-Breis, Jesualdo-Tomás; Boeckmann, Brigitte; Gabaldon, Toni; Sonnhammer, Erik; Dessimoz, Christophe; Lewis, Suzanna (OXFORD UNIV PRESS, 2018-01-15)
    The Quest for Orthologs (QfO) is an open collaboration framework for experts in comparative phylogenomics and related research areas who have an interest in highly accurate orthology predictions and their applications. We ...
  • The role of plasma microseminoprotein-beta in prostate cancer: an observational nested case-control and Mendelian randomization study in the European prospective investigation into cancer and nutrition 
    Byrne, K-Smith; Appleby, P-N; Key, T-J; Holmes, M; Fensom, G-K; Agudo, A; Ardanaz, Eva; Boeing, H; Bueno-de-Mesquita, Bas; Chirlaque-López, María-Dolores; Kaaks, R; Larrañaga, N; Palli, D; Pérez-Cornago, A; Quirós, José-Ramón; Ricceri, F; Sánchez, M-J; Tagliabue, G; Tsilidis, K-K; Tumino, R; Fortner, R-T; Ferrari, P; Riboli, Elio; Lilja, H; Travis, R-C (OXFORD UNIV PRESS, 2019-06)
    BACKGROUND: Microseminoprotein-beta (MSP), a protein secreted by the prostate epithelium, may have a protective role in the development of prostate cancer. The only previous prospective study found a 2% reduced prostate ...

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