NPM1-mutated acute myeloid leukemia is genetically heterogeneous, and risk assessment remains focused exclusively on FLT3-ITD despite the potential role of other co-mutations. We retrospectively analyzed 1,360 adults from ...
Triple-negative essential thrombocythemia (TN-ET) represents a diagnostic and therapeutic challenge. The aim of the present study was to identify prognostic factors useful for tailoring treatment. 241 TN-ET patients with ...
Chronic kidney disease (CKD) remains a hidden epidemic, under-recognized and under-diagnosed, despite widespread recognition of the benefits of systematic screening of at-risk individuals and early diagnosis. CKD is an ...
Chronic spontaneous urticaria (CSU) remains difficult to manage in patients refractory to antihistamines and omalizumab. Although dupilumab has recently been approved and incorporated into international guidelines, real-world ...
García-Torralba, Esmeralda; Buque, Aitziber; Galluzzi, Lorenzo(TAYLOR & FRANCIS INC, 2026-12-31)
The clinical management of patients with breast cancer is largely dictated by tumor stage, disease subtype and (at least in some settings) specific molecular features thereof (e.g., BRCA1 mutations, PD-L1 positivity). ...
Essential thrombocythemia (ET) is a myeloproliferative neoplasm in which JAK2, CALR, and MPL mutations are associated with distinct clinical phenotypes. Here, we analyzed the platelet proteome of ET patients by MS, combined ...
INTRODUCTION: The first wave of Coronavirus disease 2019 (COVID-19), driven by the global emergence of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), severely affected Spain with high infection and mortality ...
Measurable residual disease assessment in bone marrow (BM-MRD) is a crucial prognostic factor in multiple myeloma (MM), but its clinical use has some caveats, such as invasiveness, poor spatial representativity, and serial ...
Gomes, Bruno; Esquinas-Rodríguez, Antonio; Alwajeeh, Fares-N(FRONTIERS MEDIA SA, 2026-06-04)
Madelung's disease (Launois-Bensaude syndrome) presents a critical challenge when managing acute respiratory failure (ARF) due to the high risk of difficult airway and failed intubation posed by symmetric cervical lipomatosis. ...
Failure of non-invasive respiratory support represents a major and unresolved clinical challenge in critically ill patients, both after extubation and during non-invasive ventilation or high-flow oxygen therapy used as ...
INTRODUCTION: Chronic obstructive pulmonary disease (COPD) is a progressive lung disorder characterized by persistent symptoms such as dyspnea and cough, as well as exacerbations. Triple therapy with budesonide/glycopyrr ...
INTRODUCTION: Patients with moderate-to-severe atopic dermatitis (AD) and significant comorbidities are frequently excluded from randomized clinical trials, limiting the applicability of evidence to these clinically complex ...
Immune checkpoint inhibitors (ICIs) have signifi-cantly improved oncologiconcological outcomes. However, ICIs can elicit immune-mediated adverse effects that may require treatment discontinuation and potentially affect ...
BACKGROUND: Imprinting disorders are caused by epigenetic alterations leading to abnormal gene expression from imprinted loci. Pseudohypoparathyroidism type 1B is characterized by methylation defects at the GNAS locus, ...
INTRODUCTION: Endothelial dysfunction is key in COVID-19 pathogenesis. This randomized, double-blind phase IIb trial investigated continuous intravenous infusion of defibrotide in patients hospitalized with SARS-CoV-2 ...
AIM: The aim of this review is to present a qualitative synthesis of various studies concerning the presence of caries in people with ASD. METHODS AND RESULTS: A review of scientific articles was carried out by consulting ...