OBJECTIVE: This analysis describes disease activity, organ damage and health-related quality of life (HRQoL) in patients with active SLE and moderate-to-severe disease activity from the Spanish SLE Prospective Observational ...
BACKGROUND: Advanced NSCLC patients with ECOG PS ?2 are common, under-represented in pivotal trials, and have inferior outcomes with immune checkpoint inhibitors. EU label coverage for ECOG PS ?2 and PS-based dosing guidance ...
miR-146a exhibits variable expression levels in humans due to rs2431697, which is associated with cardiovascular events. However, the functional mechanisms linking this genotype with the occurrence of thrombotic events ...
Background: Flexible bronchoscopy (FB) has long been integral to pulmonology, but its bedside role in the intensive care unit (ICU) is expanding. Despite a lack of high-level evidence, FB remains a pivotal tool for airway ...
Background: The integrity of the alveolar ridge is compromised by tooth loss or trauma, initiating chronic resorption that alters bone morphology. Vertical bone augmentation (VBA) is a complex procedure required to ...
Background/Objectives: Provisional restorations are widely used in fixed prosthodontics, and polymethyl methacrylate (PMMA) remains one of the most commonly used materials. Discoloration during intraoral service may ...
BACKGROUND: Peptide receptor radionuclide therapy (PRRT) has become a cornerstone in the management of neuroendocrine tumors (NETs), yet optimal sequencing and patient selection remain unsettled. This study aimed to develop ...
Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) is a challenging condition with limited effective treatments. We report a case of a 44-year-old man with refractory CP/CPPS treated with a home-based prostatic ...
OBJECTIVES: Proteoforms affect biological and clinical processes and are anticipated to play a major role in establishing precision medicine. However, mass spectrometry-based proteoform tests generate complex data which ...
Chronic pain is a highly prevalent condition with major impact on disability, quality of life, and healthcare system sustainability. The reductionist biomedical paradigm, focused on tissue injury and pharmacological ...
Purpose: To explore anatomically adjusted point-to-point relationships between macular sensitivity and intraretinal layer thickness in healthy and glaucomatous eyes using combined optical coherence tomography (OCT) and ...
OBJECTIVE: This study investigated the effects of eldecalcitol (ELD), a synthetic analog of vitamin D(3), with immunomodulatory and osteogenic modulatory properties, on the biological behavior of human dental pulp stem ...
BACKGROUND: Intravascular adenomyomatosis (IA), characterised by endometrial-type glands or stroma embedded within smooth muscle tissue inside myometrial vessels, is a rare variant within the spectrum of uterine intravenous ...
The Transplant Conditioning Intensity (TCI) score is a novel tool aiming to stratify conditioning intensity more effectively than the existing nomenclature. TCI is predictive of early nonrelapse mortality (NRM), 2-year NRM ...
BACKGROUND: Assigning the ECOG performance status is critical for decision-making in oncology, but it poses challenges in hospitalized patients due to lower concordance and potential alteration by factors related to ...
Background/Objectives: The biologically oriented preparation technique (BOPT) is a vertical tooth preparation approach that eliminates a conventional finish line and positions the prosthetic margin within the gingival ...