• RAC1-Dependent ORAI1 Translocation to the Leading Edge Supports Lamellipodia Formation and Directional Persistence 

  López-Guerrero, Aida-M; Espinosa-Bermejo, Noelia; Sánchez-López, Irene; Macartney, Thomas; Pascual-Caro, Carlos; Orantos-Aguilera, Yolanda; Rodríguez-Ruiz, Lola; Pérez-Oliva, Ana-B; Mulero, Victoriano; Pozo-Guisado, Eulalia; Martín-Romero, Francisco-Javier (NATURE PORTFOLIO, 2020-04-20)

  Tumor invasion requires efficient cell migration, which is achieved by the generation of persistent and polarized lamellipodia. The generation of lamellipodia is supported by actin dynamics at the leading edge where a ...
• DNA methylation changes during preimplantation development reveal inter-species differences and reprogramming events at imprinted genes 

  Ivanova, Elena; Canovas, Sebastian; García-Martínez, Soledad; Romar, Raquel; Lopes, Jordana-S; Rizos, Dimitrios; Sánchez-Calabuig, María-J; Krueger, Felix; Andrews, Simon; Pérez-Sanz, Femando; Kelsey, Gavin; Coy, Pilar (BMC, 2020-05-11)

  Preimplantation embryos experience profound resetting of epigenetic information inherited from the gametes. Genome-wide analysis at single-base resolution has shown similarities but also species differences between human ...
• Comparative Surface Morphology, Chemical Composition, and Cytocompatibility of Bio-C Repair, Biodentine, and ProRoot MTA on hDPCs 

  Ghilotti, James; Luis-Sanz, José; López-García, Sergio; Guerrero-Gironés, Julia; Pecci-Lloret, María-P; Lozano, Adrian; Llena, Carmen; Rodríguez-Lozano, Francisco-Javier; Forner, Leopoldo; Spagnuolo, Gianrico (MDPI, 2020-05)

  Biocompatibility is an essential property for any vital pulp material that may interact with the dental pulp tissues. Accordingly, this study aimed to compare the chemical composition and ultrastructural morphology of ...
• Secondary surgical cytoreduction needs to be assessed taking into account surgical technique, completeness of cytoreduction, and extent of disease 

  Segura-Sampedro, Juan-José; Morales-Soriano, Rafael; Arjona-Sánchez, Alvaro; Cascales-Campos, Pedro-A (BMC, 2020-05-11)

  Recent evidence suggested that secondary surgical cytoreduction followed by chemotherapy does not result in longer overall survival in patients with platinum-sensitive recurrent ovarian cancer.This statement is based on a ...
• Somatic mTOR mutation in clonally expanded T lymphocytes associated with chronic graft versus host disease 

  Kim, Daehong; Park, Giljun; Huuhtanen, Jani; Lundgren, Sofie; Khajuria, Rajiv-K; Hurtado, Ana-M; Muñoz-Calleja, Cecilia; Cardenoso, Laura; Gómez-García-de-Soria, Valle; Chen-Liang, Tzu-Hua; Eldfors, Samuli; Ellonen, Pekka; Hannula, Sari; Kankainen, Matti; Bruck, Oscar; Kreutzman, Anna; Salmenniemi, Urpu; Lonnberg, Tapio; Jerez, Andrés; Itala-Remes, Maija; Myllymaki, Mikko; Keranen, Mikko-A; Mustjoki, Satu (NATURE PORTFOLIO, 2020-05-07)

  Graft versus host disease (GvHD) is the main complication of allogeneic hematopoietic stem cell transplantation (HSCT). Here we report studies of a patient with chronic GvHD (cGvHD) carrying persistent CD4(+) T cell clonal ...
• The economic benefits of increasing breastfeeding rates in Spain 

  Quesada, Juan-Antonio; Mendez, Ildefonso; Martín-Gil, Rocío (BMC, 2020)

  BACKGROUND: Interventions aimed at promoting breastfeeding rates are among the most effective possible health policies available, with an estimated return of US$35 per dollar invested. Indeed, some authors found that a 10% ...
• A Meta-Analysis of the Reliability of Four Field-Based Trunk Extension Endurance Tests 

  Martínez-Romero, María-Teresa; Ayala, Francisco; De-Ste-Croix, Mark; Vera-García, Francisco-J; Sainz-de-Baranda, Pilar; Santonja-Medina, Fernando; Sánchez-Meca, Julio (MDPI, 2020-05)

  This meta-analysis aimed to estimate the inter- and intra-tester reliability of endurance measures obtained through trunk extension field-based tests and to explore the influence of the moderators on the reliability ...
• Will neurological care change over the next 5 years due to the COVID-19 pandemic? Key informant consensus survey 

  Matias-Guiu, J; Matias-Guiu, J-A; Álvarez-Sabin, J; Ramon-Ara, J; Arenillas, J; Casado-Naranjo, I; Castellanos, M; Jiménez-Hernández, M-D; Lainez-Andres, J-M; Moral, E; Morales, A; Rodríguez-Antiguedad, A; Segura, T; Serrano-Castro, P; Diez-Tejedor, E (ELSEVIER ESPANA SLU, 2020-04)

  INTRODUCTION: The COVID-19 pandemic will give rise to long-term changes in neurological care, which are not easily predictable. MATERIAL AND METHODS: A key informant survey was used to enquire about the changes expected ...
• Alcohol Consumption and Risk of Parkinson's Disease: Data from a Large Prospective European Cohort 

  Peters, Susan; Gallo, Valentina; Vineis, Paolo; Middleton, Lefkos-T; Forsgren, Lars; Sacerdote, Carlotta; Sieri, Sabina; Kyrozis, Andreas; Chirlaque-López, María-Dolores; Zamora-Ros, Raul; Hansson, Oskar; Petersson, Jesper; Katzke, Verena; Kuehn, Tilman; Mokoroa, Olatz; Masala, Giovanna; Ardanaz, Eva; Panico, Salvatore; Bergmann, Manuela-M; Key, Timothy-J; Weiderpass, Elisabete; Ferrari, Pietro; Vermeulen, Roel (WILEY, 2020-07)

  BACKGROUND: Parkinson's disease (PD) etiology is not well understood. Reported inverse associations with smoking and coffee consumption prompted the investigation of alcohol consumption as a risk factor, for which evidence ...
• Chemopreventive effect of pomegranate and cocoa extracts on ultraviolet radiation-induced photocarcinogenesis in SKH-1 mice 

  Gómez-García, Francisco-José; López-López, Antonia; Guerrero-Sánchez, Yolanda; Sánchez-Siles, Maríano; Martínez-Diaz, Francisco; Camacho-Alonso, Fabio (PUBLIC LIBRARY SCIENCE, 2020-04-30)

  Non-melanoma skin cancer (NMSC) has a high and increasing incidence all over the world. Solar radiation is the main aetiology for humans. Although most research into photocarcinogenesis uses UVB as a source of radiation, ...
• Tracing the retina to analyze the integrity and phagocytic capacity of the retinal pigment epithelium 

  Valiente-Soriano, Francisco-Javier; Salinas-Navarro, Manuel; Di-Pierdomenico, Johnny; García-Ayuso, Diego; Lucas-Ruiz, Fernando; Pinilla, Isabel; Cuenca, Nicolas; Vidal-Sanz, Manuel; Villegas-Pérez, María-Paz; Agudo-Barriuso, Marta (NATURE PORTFOLIO, 2020-04-29)

  We have developed a new technique to study the integrity, morphology and functionality of the retinal neurons and the retinal pigment epithelium (RPE). Young and old control albino (Sprague-Dawley) and pigmented (Piebald ...
• Patterns and predictors of low physical activity in patients with stable COPD: a longitudinal study 

  Sánchez-Martínez, María-Piedad; Bernabeu-Mora, Roberto; García-Vidal, José-Antonio; Benitez-Martínez, Josép; de-Oliveira-Sousa, Silvana-Loana; Medina-Mirapeix, Francesc (SAGE PUBLICATIONS LTD, 2020-03)

  BACKGROUND: Despite the frequency and negative impact of low physical activity among patients with chronic obstructive pulmonary disease (COPD), little is known about how it persists and remits over time or the factors ...
• Changes in the Expression of Pre-Replicative Complex Genes in hTERT and ALT Pediatric Brain Tumors 

  Idilli, Aurora-Irene; Pagani, Francesca; Kerschbamer, Emanuela; Berardinelli, Francesco; Bernabé, Manuel; Cayuela, María-Luisa; Piazza, Silvano; Poliani, Pietro-Luigi; Cusanelli, Emilio; Mione, María-Caterina (MDPI, 2020-04)

  Background: The up-regulation of a telomere maintenance mechanism (TMM) is a common feature of cancer cells and a hallmark of cancer. Routine methods for detecting TMMs in tumor samples are still missing, whereas telomerase ...
• Stability and Predictors of Poor 6-min Walking Test Performance over 2 Years in Patients with COPD 

  Sánchez-Martínez, María-Piedad; Bernabeu-Mora, Roberto; Martínez-González, Maríano; Gacto-Sánchez, Maríano; Martín-San-Agustin, Rodrigo; Medina-Mirapeix, Francesc (MDPI, 2020-04)

  Poor performance in the 6-min walk test (6MWT < 350 m) is an important prognostic indicator of mortality and risk of exacerbations in patients with chronic obstructive pulmonary disease (COPD). Little is known about the ...
• Hypothalamic Pomc expression restricted to GABAergic neurons suppresses Npy overexpression and restores food intake in obese mice 

  Trotta, Milagros; Bello, Estefania-Pilar; Alsina, Ramiro; Tavella, María-Belén; Ferran, José-Luis; Rubinstein, Marcelo; Bumaschny, Viviana-Florencia (ELSEVIER, 2020-07)

  OBJECTIVE: Hypothalamic arcuate proopiomelanocortin (Arc-POMC) neurons are involved in different physiological processes such as the regulation of energy balance, glucose homeostasis, and stress-induced analgesia. Since ...
• Intramuscular Injection of Bone Marrow Stem Cells in Amyotrophic Lateral Sclerosis Patients: A Randomized Clinical Trial 

  Geijo-Barrientos, Emilio; Pastore-Olmedo, Carlos; De-Mingo, Pedro; Blanquer, Miguel; Gómez-Espuch, Joaquin; Iniesta, Francisca; García-Iniesta, Natalia; García-Hernández, Ana; Martín-Estefania, Carlos; Barríos, Laura; Moraleda, José-María; Martínez, Salvador (FRONTIERS MEDIA SA, 2020-03-24)

  BACKGROUND: Preclinical studies suggest that stem cells may be a valuable therapeutic tool in amyotrophic lateral sclerosis (ALS). As it has been demonstrated that there are molecular changes at the end-plate during the ...
• Maternal and Perinatal Outcomes Associated With Extremely High Values for the sFlt-1 (Soluble fms-Like Tyrosine Kinase 1)/PlGF (Placental Growth Factor) Ratio 

  Villalain, Cecilia; Herraiz, Ignacio; Valle, Leonor; Mendoza, Manel; Delgado, Juan-Luis; Vázquez-Fernández, María; Martínez-Uriarte, Juan; Melchor, Inigo; Caamina, Sara; Fernández-Oliva, Antoni; Villar, Olga-Patricia; Galindo, Alberto (WILEY, 2020-04)

  Background There is little knowledge about the significance of extremely high values (>655) for the ratio of sFlt-1 (soluble fms-like tyrosine kinase 1) to PlGF (placental growth factor). We aim to describe the time-to-delivery ...
• Frailty transitions and associated clinical outcomes in patients with stable COPD: A longitudinal study 

  Bernabeu-Mora, Roberto; Oliveira-Sousa, Silvana-Loana; Sánchez-Martínez, Piedad; García-Vidal, José-Antonio; Gacto-Sánchez, Maríano; Medina-Mirapeix, Francesc (PUBLIC LIBRARY SCIENCE, 2020-04-03)

  BACKGROUND: Although frailty is a frequent occurrence in chronic obstructive pulmonary disease (COPD) patients, evidence on the frequency of frailty transition is scarce. AIMS: The present study aimed to describe the frailty ...
• Subarachnoid haemorrhage with negative tomographic angiography without vasospasm: is it necessary to perform angiographic controls? 

  Paez-Granda, Diego (REVISTA DE NEUROLOGIA, 2020-04-16)

  INTRODUCTION: In about 15% of cases, the lesion causing subarachnoid haemorrhage (SAH) is not detectable by imaging studies, and some controversy exists as regards how the diagnosis should be performed in these patients. ...
• Spanish real-world experience with fingolimod in relapsing-remitting multiple sclerosis patients: MS NEXT study 

  Barrero, Francisco; Mallada-Frechin, Javier; Martínez-Gines, María-Luisa; Eugenia-Marzo, María; Meca-Lallana, Virginia; Izquierdo, Guillermo; Ramon-Ara, José; Oreja-Guevare, Celia; Meca-Lallana, José; Forero, Lucia; Sánchez-Veram, Irene; Moreno, María-José (PUBLIC LIBRARY SCIENCE, 2020-04-02)

  PURPOSE: The objective of this study was to characterize the demographic and clinical profile of RRMS patients receiving fingolimod in Spain, and to evaluate drug effectiveness and safety in clinical practice. METHODS: ...

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