NPM1-mutated acute myeloid leukemia is genetically heterogeneous, and risk assessment remains focused exclusively on FLT3-ITD despite the potential role of other co-mutations. We retrospectively analyzed 1,360 adults from ...
Triple-negative essential thrombocythemia (TN-ET) represents a diagnostic and therapeutic challenge. The aim of the present study was to identify prognostic factors useful for tailoring treatment. 241 TN-ET patients with ...
Background Diagnostic yield (DY) of small bowel capsule endoscopy (SBCE) is limited by the presence of intestinal content. An objective assessment of the cleanliness grade of the small bowel (SB) is currently lacking. We ...
Susceptibility to pulmonary infection depends not only on the patient's clinical condition but also on the characteristics of the microorganism, such as its virulence and transmissibility, which are influenced by environmental ...
OBJECTIVE: This study aims to evaluate the content, structure, and alignment with international standards of Diabetes Self-Management Education guidelines across Spain's regional healthcare systems. It focuses on comparing ...
PURPOSE: Dientamoeba fragilis is a cosmopolitan intestinal protist with an insufficiently understood life cycle and pathogenicity. Diagnosis by light microscopy is challenging, leading to significant underdiagnosis. Two ...
BackgroundNeonatal nursing care requires ethical competence alongside technical expertise. Despite progress in Spain, disparities persist in ethical training and professional autonomy in neonatal units.ObjectiveTo examine ...
Chronic kidney disease (CKD) remains a hidden epidemic, under-recognized and under-diagnosed, despite widespread recognition of the benefits of systematic screening of at-risk individuals and early diagnosis. CKD is an ...
Chronic spontaneous urticaria (CSU) remains difficult to manage in patients refractory to antihistamines and omalizumab. Although dupilumab has recently been approved and incorporated into international guidelines, real-world ...
García-Torralba, Esmeralda; Buque, Aitziber; Galluzzi, Lorenzo(TAYLOR & FRANCIS INC, 2026-12-31)
The clinical management of patients with breast cancer is largely dictated by tumor stage, disease subtype and (at least in some settings) specific molecular features thereof (e.g., BRCA1 mutations, PD-L1 positivity). ...
Recent studies suggest that copy number variants (CNVs) may contribute to the missing heritability of complex diseases such as Alzheimer's disease (AD) and related dementias (ADRD). We performed a CNV analysis using ...
BACKGROUND: The current standard of care for resectable locally advanced colon cancer (LACC) is based on upfront surgery followed by adjuvant chemotherapy (AC). This study aimed to evaluate the safety and efficacy of ...
Essential thrombocythemia (ET) is a myeloproliferative neoplasm in which JAK2, CALR, and MPL mutations are associated with distinct clinical phenotypes. Here, we analyzed the platelet proteome of ET patients by MS, combined ...
PURPOSE: Menopause increases cardiometabolic risk via dyslipidaemia, oxidative stress, and low-grade inflammation. Polyphenols may modulate these processes, but human evidence is inconsistent. We investigated the effects ...
Studying the global distribution of the pathogenic variant c.40_42delAGA;p.(Arg14del) in the phospholamban (PLN) gene is highly important for raising awareness among healthcare providers and may help uncover factors ...
INTRODUCTION: The first wave of Coronavirus disease 2019 (COVID-19), driven by the global emergence of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), severely affected Spain with high infection and mortality ...
Measurable residual disease assessment in bone marrow (BM-MRD) is a crucial prognostic factor in multiple myeloma (MM), but its clinical use has some caveats, such as invasiveness, poor spatial representativity, and serial ...