https://sms.carm.es/ricsmur/handle/123456789/17166 2026-04-06T22:12:52Z https://sms.carm.es/ricsmur/handle/123456789/25777 A critical analysis of the IMWG multiple myeloma complete response criterion in the era of mass spectrometry Puig, Noemi; Agullo, Cristina; Paiva, Bruno; Cedeña, María-Teresa; Rosinol, Laura; Contreras, Teresa; Martínez-lopez, Joaquín; Oriol, Albert; Blanchard, María-Jesús; Ríos-tamayo, Rafael; Sureda, Anna; Lakhwani, Sunil; de-La-Rubia, Javier; Cabanas-Perianes, Valentín; de-Arriba-de-la-Fuente, Felipe; Paricio, Miguel; Inigo, María-Belén; González-calle, Verónica; Ocio, Enrique-M; Castro, Sergio; Bargay, Joan; Blade, Joan; San-Miguel, Jesus-F; Lahuerta, Juan-José; Mateos, María-Victoria 2026-02-01T00:00:00Z https://sms.carm.es/ricsmur/handle/123456789/25776 Large language model-assisted structured reporting in Radiology residents: an implementation pilot study in Emergency Radiology. García-Hidalgo, Clemente; Consentino-Hernández, José-Antonio; Cayuela-Espí, José-Vicente; Pagán-Vicente, Gonzalo; Plasencia-Martínez, Juana-María; Blanco-Barrio, Ana; Pérez-Hernández, Gloria; Moreno-Pastor, Ana 2026-01-19T00:00:00Z https://sms.carm.es/ricsmur/handle/123456789/25774 Optimizing GRIDSS for clinical use: A targeted NGS filtering strategy for germline structural variant detection Munte, Elisabet; Rofes, Paula; Millan-Castillo, Miriam; Solanes, Ares; Muñoz, Xavier; Campos, Olga; Alay, Ania; Ajenjo-Bauza, María; Navarro, Esther; de-la-Morena-Barrio, Belén; Salinas, Mónica; Vargas-Parra, Gardenia; Cuesta, Raquel; Moreno-Cabrera, José-Marcos; Cordero, David; Pineda, Marta; del-Valle, Jesus; Lazaro, Conxi; Feliubadalo, Lidia Detecting intermediate-sized structural variants (SVs) remains challenging in diagnostics, as tools for single-nucleotide and copy-number variants, particularly read-depth-based methods, are often insufficient. GRIDSS addresses this gap by integrating paired-end mapping, split-read analysis, and assembly-based approaches. However, its use in targeted sequencing and diagnostic workflows remains complex. NGS panel data from 9726 patients with suspected hereditary cancer were analyzed using GRIDSS. A filtering strategy was developed to prioritize clinically relevant germline SVs. Multiple parameter settings were tested to optimize performance. The initial dataset of 1,307,592 variants was reduced to 89 candidates after applying the selected filtering strategy. Of these, 24 had been previously detected by routine callers and were not further analyzed. Among the remaining 65, 13 were considered likely true positives after visual inspection using IGV. Experimental validation was performed by Sanger/Nanopore long-read sequencing for these variants, all of which were confirmed. Eight were classified as (likely) pathogenic, including two frameshift duplications in MSH6, one splicing variant in BARD1, and five mobile element insertions in APC, BRCA2, and PALB2. Altogether, GRIDSS implementation increased diagnostic yield while maintaining feasibility for diagnostic workflows. Comprehensive workflow scheme for germline structural variant detection and results in our diagnostic setting. 2026-03-16T00:00:00Z https://sms.carm.es/ricsmur/handle/123456789/25773 Correction: PARP inhibitors-associated thrombosis in patients with ovarian cancer: a study of the Spanish Society of Medical Oncology (SEOM) thrombosis and cancer group. Sánchez-Cánovas, Manuel; López-Robles, Javier; García-Verdejo, Francisco-José; Cacho-Lavin, Diego; Olivares, Helena; Garrido-Fernández, Alberto; Coma-Salvans, Eva; Quintanar-Verduguez, Teresa; Salvador-Coloma, Carmen; Fernández-Garay, David; Cumplido, José-David; Ferrer-Pérez, Ana-Isabel; Carbó-Bagué, Anna; Teigell-Munoz, Francisco-Javier; García-López, Rubén; Martínez-Marín, Andrea; Muñoz-Martín, Andrés-J 2025-11-03T00:00:00Z