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Envíos recientes

03. IMIB (Instituto Murciano de Investigación Biosanitaria Pascual Parrilla): Envíos recientes

  • Time-of-Day and Age Impact on Memory in Elevated Plus-Maze Test in Rats 
    Morales-Delgado, Nicanor; Popovic, Natalija; de-la-Cruz-Sánchez, Ernesto; Caballero-Bleda, María; Popovic, Miroljub (FRONTIERS MEDIA SA, 2018-12-06)
    The purpose of the present study was to establish the effect of daytime and aging on memory in rats in the Elevated Plus-Maze (EPM) test. Young (2-months) and aged (18-months) male Wistar rats were exposed to the EPM test, ...
  • Patterned Vascularization of Embryonic Mouse Forebrain, and Neuromeric Topology of Major Human Subarachnoidal Arterial Branches: A Prosomeric Mapping 
    Puelles, Luis; Martínez-Marin, Rafael; Melgarejo-Otalora, Pedro; Ayad, Abdelmalik; Valavanis, Antonios; Ferran, José-Luis (FRONTIERS MEDIA SA, 2019-06-19)
    The prosomeric brain model contemplates progressive regionalization of the central nervous system (CNS) from a molecular and morphological ontogenetic perspective. It defines the forebrain axis relative to the notochord, ...
  • Survey of Midbrain, Diencephalon, and Hypothalamus Neuroanatomic Terms Whose Prosomeric Definition Conflicts With Columnar Tradition 
    Puelles, Luis (FRONTIERS MEDIA SA, 2019-02-27)
    Recent neuroanatomic concepts and terms referring to the non-telencephalic forebrain are presented and discussed, in context with the present scenario in which the old columnar paradigm is being substituted by the prosomeric ...
  • The MAPT H1 Haplotype Is a Risk Factor for Alzheimer's Disease in APOE e4 Non-carriers 
    Sánchez-Juan, Pascual; Moreno, Sonia; de-Rojaso, Itziar; Hernández, Isabel; Valero, Sergi; Alegret, Montse; Montrreal, Laura; García-González, Pablo; Lage, Carmen; López-García, Sara; Rodriiguez-Rodríguez, Eloy; Orellana, Adelina; Tarraga, Lluis; Boada, Merce; Ruiz, Agustín; Abdelnour, C; Aguilera, N; Alarcón, E; Alegret, M; Boada, M; Buendía, M; Canabate, P; de-Rojas, I; Diego, S; Espinosa, A; Gailhajenet, A; García-González, P; Gil, S; Guitart, M; Hernández, I; Ibarria, M; Lafuente, A; Martín, E; Mauleon, A; Monte-Rubio, G; Montrreal, L; Moreno-Grau, S; Moreno, M; Orellana, A; Ortega, G; Pancho, A; Peleja, E; Pérez-Cordon, A; Preckler, S; Rodríguez-Gómez, O; Rosende-Roca, M; Ruiz, A; Ruiz, S; Sanabria, A; Santos-Santos, M-A; Sotolongo-Grau, O; Tarraga, L; Valero, S; Vargas, L; Quintela, I; Real, L-M; Carracedo, A; Maronas, O; Corbaton, A; Martínez, M-T; Serrano-Rios, M; González-Pérez, A; Saez, M-E; Macías, J; Pineda, J-A; Adarmes-Gómez, A-D; Buiza-Rueda, D; Carrillo, F; Carrión-Claro, M; Gómez-Garre, P; Jesús, S; Labrador-Espinosa, M-A; Macías, D; Mir, P; Perinan-Tocino, T; Blesa, R; Bullido, M-J; Calero, M; Clarimon, J; Fortea, J; Frank-García, A; Lage, C; Lleo, A; López-García, S; Martín-Montes, A; Medina, M; Pérez-Tur, J; Pinol-Ripoll, G; Rabano, A; Rodríguez-Rodríguez, E; Sánchez-Juan, P; Sastre, I; Alarcón-Martín, E; Marquie, M; Cruz-Gamero, J-M; Royo, J-L; Álvarez, I; Díez-Fairen, M; Pastor, P; Álvarez, V; Martínez, C; Menéndez-González, M; Amer-Ferrer, G; Antequera, M; Antunez, C; Legaz, A; Manzanares, S; Marin-Muñoz, J; Martínez, B; Martínez, V; Vicente, M-P; Vivancos, L; Baquero, M; Burguera, J-A; Bernal, M; Franco, E; Marín, M; Rodrigo, S; del-Ser, T; Pastor, A-B; García-Madrona, S; García-Ribas, G; Casajeros, M-J; de-Pancorbo, M-M; García-Alberca, J-M; Hevilla, S; Marín, T; López-de-Munain, A; Martínez-Lage-Álvarez, P; Mendioroz-Iriarte, M; Molinuevo, J-L; Real-de-Asua, D; sánchez-del-Valle-Díaz, R (FRONTIERS MEDIA SA, 2019-12-04)
    An ancestral inversion of 900 kb on chromosome 17q21, which includes the microtubule-associated protein tau (MAPT) gene, defines two haplotype clades in Caucasians (H1 and H2). The H1 haplotype has been linked inconsistently ...
  • WNT Signaling in Tumors: The Way to Evade Drugs and Immunity 
    Martín-Orozco, Elena; Sánchez-Fernández, Ana; Ortiz-Parra, Irene; Ayala-San-Nicolás, María (FRONTIERS MEDIA SA, 2019-12-20)
    WNT/?-catenin signaling is involved in many physiological processes. Its implication in embryonic development, cell migration, and polarization has been shown. Nevertheless, alterations in this signaling have also been ...
  • Late-Onset Cryopyrin-Associated Periodic Syndromes Caused by Somatic NLRP3 Mosaicism - UK Single Center Experience 
    Rowczenio, Dorota-M; Gomes, Sonia-Melo; Arostegui, Juan-I; Mensa-Vilaro, Anna; Omoyinmi, Ebun; Trojer, Hadija; Baginska, Anna; Baroja-Mazo, Alberto; Pelegrín, Pablo; Savic, Sinisa; Lane, Thirusha; Williams, Rene; Brogan, Paul; Lachmann, Helen-J; Hawkins, Philip-N (FRONTIERS MEDIA SA, 2017-10-31)
    Cryopyrin-associated periodic syndrome (CAPS) is caused by gain-of-function NLRP3 mutations. Recently, somatic NLRP3 mosaicism has been reported in some CAPS patients who were previously classified as "mutation-negative." ...
  • Estrogens Promote the Production of Natural Neutralizing Antibodies in Fish through G Protein-Coupled Estrogen Receptor 1 
    Rodenas, María-C; Cabas, Isabel; Gómez-González, Nuria-E; Arizcun, Marta; Meseguer, José; Mulero, Víctoriano; García-Ayala, Alfonsa (FRONTIERS MEDIA SA, 2017-06-29)
    Natural antibodies play crucial roles in pathogen elimination, B-cell survival and homeostasis, and inflammatory and autoimmune diseases. Although estrogens are able to regulate both innate and adaptive immune responses, ...
  • Saharan Dust Modeling Over the Mediterranean Basin and Central Europe: Does the Resolution Matter? 
    Palacios-Pena, Laura; Lorente-Plazas, Raquel; Montavez, Juan-Pedro; Jiménez-Guerrero, Pedro (FRONTIERS MEDIA SA, 2019-11-08)
  • Transient Sperm Starvation Improves the Outcome of Assisted Reproductive Technologies 
    Navarrete, Felipe-A; Aguila, Luis; Martín-Hidalgo, David; Tourzani, Darya-A; Luque, Guillermina-M; Ardestani, Goli; García-Vázquez, Francisco-A; Levin, Lonny-R; Buck, Jochen; Darszon, Alberto; Buffone, Mariano-G; Mager, Jesse; Fissore, Rafael-A; Salicioni, Ana-M; Gervasi, María-G; Visconti, Pablo-E (FRONTIERS MEDIA SA, 2019-11-05)
    To become fertile, mammalian sperm must undergo a series of biochemical and physiological changes known as capacitation. These changes involve crosstalk between metabolic and signaling pathways and can be recapitulated in ...
  • The Zebrafish as an Emerging Model to Study DNA Damage in Aging, Cancer and Other Diseases 
    Cayuela-Fuentes, María-Luisa; Claes, Kathleen-B-M; Ferreira, Miguel-Godinho; Henriques, Catarina-Martins; van-Eeden, Fredericus; Varga, Mate; Vierstraete, Jeroen; Mione, María-Caterina (FRONTIERS MEDIA SA, 2019-01-10)
    Cancer is a disease of the elderly, and old age is its largest risk factor. With age, DNA damage accumulates continuously, increasing the chance of malignant transformation. The zebrafish has emerged as an important ...
  • Therapeutic management and one-year outcomes in elderly patients with acute coronary syndrome 
    Orenes-Piñero, Esteban; Ruiz-Nodar, Juan-M; Esteve-Pastor, María-Asunción; Quintana-Giner, Miriam; Rivera-Caravaca, José-Miguel; Veliz, Andrea; Valdés-Chavarri, Mariano; Macías, Manuel; Pernias-Escrig, Vicente; Vicente-Ibarra, Nuria; Carrillo, Luna; Sandin-Rollan, Miriam; Candela, Elena; Lozano, Teresa; Marín, Francisco (IMPACT JOURNALS LLC, 2017-10-06)
    BACKGROUND: Elderly represents a subgroup of high-risk ACS patients due to their advanced age and other comorbidities. Unfortunately, they are also often under-represented in many studies and clinical trials. Furthermore, ...
  • Patients with chronic lymphocytic leukemia and complex karyotype show an adverse outcome even in absence of TP53/ATM FISH deletions 
    Puiggros, Anna; Collado, Rosa; Calasanz, María-José; Ortega, Margarita; Ruiz-Xiville, Neus; Rivas-Delgado, Alfredo; Luno, Elisa; González, Teresa; Navarro, Blanca; García-Malo, María-Dolores; Valiente, Alberto; Hernández, José-Ángel; Teresa-Ardanaz, María; Pinan, Maria-Ángeles; Laura-Blanco, María; Hernández-Sánchez, María; Batlle-López, Ana; Salgado, Rocío; Salido, Marta; Ferrer, Ana; Abrisqueta, Pau; Gimeno, Eva; Abella, Eugenia; Ferra, Christelle; Terol, María-José; Ortuño, Francisco; Costa, Dolors; Moreno, Carol; Carbonell, Felix; Bosch, Francesc; Delgado, Julio; Espinet, Blanca (IMPACT JOURNALS LLC, 2017-08)
    Genomic complexity identified by chromosome banding analysis (CBA) predicts a worse clinical outcome in CLL patients treated either with standard or new treatments. Herein, we analyzed the clinical impact of complex ...
  • Quality indicators in gastroscopy. Gastroscopy procedure 
    Pérez-Romero, Shirley; Alberca-de-las-Parras, Fernando; Sánchez-del-Rio, Antonio; López-Picazo-Ferrer, Julio-J; Judea-Gutiérrez, Javier; León-Molina, Joaquín (ARAN EDICIONES, S A, 2019)
    Within the project "Quality indicators in digestive endoscopy", pioneered by the Spanish Society for Digestive Diseases (SEPD), the objective of this research is to suggest the structure, process, and results procedures ...
  • Is prophylactic gastrectomy indicated for healthy carriers of CDH1 gene mutations associated with hereditary diffuse gastric cancer? 
    Munitiz, Vicente; Jimeno, Pilar; Ruiz-de-Angulo, David; Ortiz, Ángeles; Martínez-de-Haro, Luisa-Fernanda; Marín, Miguel; Cascales, Pedro; Ruiz-García, Gema; Ortiz-Ruiz, Eduardo; Parrilla-Paricio, Pascual (ARAN EDICIONES, S A, 2019)
    INTRODUCTION: hereditary diffuse gastric cancer (HDGC) is a recently reported hereditary cancer syndrome. Patients with suspected HDGC must be under surveillance via endoscopy and multiple biopsies. As an alternative, some ...
  • Neurogenic appendicopathy. A report of 8 cases 
    Ruiz, José; Ríos-Zambudio, Antonio; Oviedo, María-Isabel; Rodríguez-González, José-Manuel; Parrilla-Paricio, Pascual (ARAN EDICIONES, S A, 2017)
    INTRODUCTION: Neurogenic appendicopathy is not a very well-known disease. OBJECTIVE: To analyze the experience in the management of neurogenic appendicopathy in a tertiary hospital, assessing its clinical presentation, ...
  • USP7 and USP47 deubiquitinases regulate NLRP3 inflammasome activation 
    Palazon-Riquelme, Pablo; Worboys, Jonathan-D; Green, Jack; Valera, Ana; Martín-Sánchez, Fatima; Pellegrini, Carolina; Brough, David; López-Castejón, Gloria (WILEY, 2018-10)
    The assembly and activation of the inflammasomes are tightly regulated by post-translational modifications, including ubiquitin. Deubiquitinases (DUBs) counteract the addition of ubiquitin and are essential regulators of ...
  • Polyamine biosynthesis in Xenopus laevis: the xlAZIN2/xlODC2 gene encodes a lysine/ornithine decarboxylase 
    Lambertos, Ana; Peñafiel, Rafael (PUBLIC LIBRARY SCIENCE, 2019-09-11)
    Ornithine decarboxylase (ODC) is a key enzyme in the biosynthesis of polyamines, organic cations that are implicated in many cellular processes. The enzyme is regulated at the post-translational level by an unusual system ...
  • New insights of polyamine metabolism in testicular physiology: A role of ornithine decarboxylase antizyme inhibitor 2 (AZIN2) in the modulation of testosterone levels and sperm motility 
    Lambertos, Ana; Ramos-Molina, Bruno; López-Contreras, Andrés-J; Cremades, Asunción; Peñafiel, Rafael (PUBLIC LIBRARY SCIENCE, 2018-12-19)
    The specific role of polyamines in the testis physiology is not fully understood. Antizymes (OAZs) and antizyme inhibitors (AZINs) are modulators of ornithine decarboxylase (ODC), a key enzyme in polyamine biosynthesis and ...
  • Angiogenic role of miR-20a in breast cancer 
    Luengo-Gil, Ginés; González-Billalabeitia, Enrique; Alejo-Pérez-Henarejos, Sergio; Navarro-Manzano, Esther; Chaves-Benito, Asunción; García-Martínez, Elena; García-Garre, Elisa; Vicente, Vicente; Ayala-de-la-Peña, Francisco (PUBLIC LIBRARY SCIENCE, 2018-04-04)
    BACKGROUND: Angiogenesis is a key process for tumor progression and a target for treatment. However, the regulation of breast cancer angiogenesis and its relevance for clinical resistance to antiangiogenic drugs is still ...
  • A new insight into the three-dimensional architecture of the Golgi complex: Characterization of unusual structures in epididymal principal cells 
    Martínez-Martínez, Narcisa; Martínez-Alonso, Emma; Tomas, Mónica; Neumueller, Josef; Pavelka, Margit; Martínez-Menarguez, José-A (PUBLIC LIBRARY SCIENCE, 2017-09-28)
    Principal epididymal cells have one of the largest and more developed Golgi complex of mammalian cells. In the present study, we have used this cell as model for the study of the three-dimensional architecture of the Golgi ...

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