Repositorio Dspace

Envíos recientes

03. IMIB (Instituto Murciano de Investigación Biosanitaria Pascual Parrilla): Envíos recientes

  • Linking Nutri-Score dietary profiles to metabolic biomarkers in a cross-sectional study within the multinational EPIC cohort. 
    Deschasaux-Tanguy, Melanie; Meirhaeghe, Aline; Julia, Chantal; Hercberg, Serge; Srour, Bernard; Kesse-Guyot, Emmanuelle; Biessy, Carine; Nicolas, Genevieve; Murphy, Neil; Jenab, Mazda; Weiderpass, Elisabete; Ferrari, Pietro; Eriksen, Anne-Kirstine; Kyro, Cecilie; Correia, Emmanuelle; Hajji, Mariem; Katzke, Verena; Schulze, Matthias-B; Masala, Giovanna; Gargano, Giuliana; Fordellone, Mario; Buscema, Federica; Vineis, Paolo; Colizzi, Chiara; van-der-Schouw, Yvonne-T; Crous-Bou, Marta; Sánchez, María-José; Jiménez-Zabala, Ana; Rodríguez-Palacios, Daniel; Guevara, Marcela; Riboli, Elio; Gunter, Marc-J; Huybrechts, Inge; Touvier, Mathilde (SPRINGERNATURE, 2026-05-13)
    The front-of-pack label Nutri-Score has been implemented in several European countries since 2017 to guide consumers towards foods of higher nutritional value. A few studies reported associations between Nutri-Score dietary ...
  • Circadian system functional status and sleep in blind subjects with and without conscious light perception (vol 17, 1787735, 2026) 
    Martínez-Martínez, David; González-Romero, Pedro; Rodríguez-Morilla, Beatriz; Bonmati-Carrion, María-Ángeles; Rol, María-Ángeles; Almaida-Pagán, Pedro-Francisco (FRONTIERS MEDIA SA, 2026-04-27)
    [This corrects the article DOI: 10.3389/fphys.2026.1787735.].
  • Circadian system functional status and sleep in blind subjects with and without conscious light perception 
    Martínez-Martínez, David; González-Romero, Pedro; Rodríguez-Morilla, Beatriz; Bonmati-Carrion, María-Ángeles; Rol, María-Ángeles; Almaida-Pagán, Pedro-Francisco (FRONTIERS MEDIA SA, 2026-04-13)
    To understand circadian rhythms and sleep in an understudied population, which is particularly prone to suffer chronodisruption (CD), eighteen blind volunteers of 51.5 ± 3.6 years (Mean ± SEM) and 26 volunteers (51.8 ± ...
  • Phase IIB, Randomized, Double-Blind, Placebo-Controlled Clinical Trial of Intravenous Defibrotide for the Prevention and Treatment of Respiratory Distress and Cytokine Release Syndrome in COVID-19 
    Jara-Rubio, Rubén; Martínez-Mellado, Antonio-José; Kiwitt-Cardenas, Jonathan; Clavel, José-G; García-Pérez, Bartolomé; Castro, Pedro; Díaz-Ricart, Maribel; Carrillo-Alcaraz, Andrés; López-Bernus, Amparo; Bernal-Morell, Enrique; Roura, Aychel; Marín, Sonia; Ruiz-López, Francisco-José; Solana-Martínez, Elena; Martínez-Baño, Domingo; Albacete-Moreno, Carlos-L; Andreu-Soler, Enriqueta; Tellez-Santoyo, Adrián; Fernández-Méndez, Sara; Noguera-Velasco, José-Antonio; Cebreiros-López, Iria; Parrilla, Andrés; Espuny-Miró, Alberto; García-Bernal, David; Blanquer-Blanquer, Miguel; Sánchez-Salinas, Andrés; Iniesta-Martínez, Francisca; Hernández-García, Cristina; Muro-Amador, Manuel; Minguela-Puras, Alfredo; Moreno-Docón, Antonio; Torres-Cantero, Alberto; Muñoz-García, María; Serrano, Manuel; Iacobelli, Massimo; Carlo-Stella, Carmelo; Wei, Lee-Jen; Richardson, Paul-G; Moraleda-Jiménez, José-María (WILEY, 2026-05-12)
    INTRODUCTION: Endothelial dysfunction is key in COVID-19 pathogenesis. This randomized, double-blind phase IIb trial investigated continuous intravenous infusion of defibrotide in patients hospitalized with SARS-CoV-2 ...
  • Internal connectivity of the mouse mesocortical ring and functional implications 
    Puelles, Luis; García-Calero, Elena (SPRINGER HEIDELBERG, 2026-05-08)
    The mammalian mesocortex (MCx) was redefined recently as a complete ring intercalated between the allo- and iso-cortex, attending to the consistent expression of 46 selective gene markers. The MCx exhibits various other ...
  • PARP2 deficiency impairs pancreatic cancer progression by promoting genomic instability and antitumor immunity 
    Martínez-Bosch, Neus; Manero-RuPérez, Noemi; Vázquez-Bellon, Nuria; Nickell-Hernández, Bennett; Ventura-Blanch, Cristina; Lutfi, Nura; Lechuga, Carmen-G; Martínez, Carlos; Moreno, Mireia; Ampurdanes, Coral; Abad, Etna; Iglesias, Mar; Muñoz-Escribano, María; Janic, Ana; Rovira, Meritxell; Guerra, Carmen; Rabinovich, Gabriel-A; Yelamos, José; Navarro, Pilar (AMER ASSOC ADVANCEMENT SCIENCE, 2026-05-08)
    Pancreatic cancer represents one of the most lethal tumors, characterized by an immunosuppressive microenvironment and a lack of cytotoxic immune cell infiltrates, which confer resistance to immunotherapy. Here, we demonstrate ...
  • The ERA Registry Annual Report 2023: epidemiology of kidney replacement therapy in Europe, with a focus on age comparisons 
    Hoekstra, Marin-W-F; Boenink, Rianne; Bonthuis, Marjolein; Boerstra, Brittany-A; Astley, Megan-E; Montez-de-Sousa, Iris-R; Gjorgjievski, Nikola; Resic, Halima; Mitsides, Nicos; Hommel, Kristine; Guidotti, Rebecca; Marín-Sánchez, Inmaculada; Slon-Roblero, María-F; Artamendi, Marta; Beckerman, Pazit; Buchwinkler, Lukas; Gellert, Ryszard; Kuzema, Viktorija; Oksa, Adrián; Comas, Jordi; Heylen, Line-M-T-J; Lassalle, Mathilde; Hernández-Ramírez, Sara; Santhakumaran, Shalini; Seyahi, Nurhan; Asberg, Anders; Weekers, Laurent-E; Muñoz-Terol, José-M; Trujillo-Alemán, Sara; Memeti-Smaili, Fatime; Ots-Rosenberg, Mai; Indridason, Olafur-S; Komissarov, Kirill-S; ten-Dam, Marc-A-G-J; Stendahl, María; Galvao, Ana-A; Ortiz, Alberto; Stel, Vianda-S; Kramer, Anneke (OXFORD UNIV PRESS, 2026-05-01)
    The European Renal Association (ERA) Registry collects data on patients with kidney failure receiving kidney replacement therapy (KRT). This paper presents a summary of the ERA Registry Annual Report 2023, and focuses ...
  • Postmortem genetic testing in sudden death: clinical and medico-legal implications 
    Sabater-Molina, María; Nicolás-Rocamora, Elisa; Munteanu, Serena; Fuentes-Bermejo, María-Dolores; Osuna-Carrillo-Albornoz, Eduardo; Pérez-Cárceles, María-Dolores; Pastor-Quirante, Francisco; Gimeno-Blanes, Juan-Ramón; Hernández-del-Rincón, Juan-Pedro (SPRINGER, 2026-05-08)
    BACKGROUND: Anatomopathological autopsy and postmortem genetic testing play a crucial role in forensic medicine, particularly in elucidating the causes of sudden death (SD) that remain unexplained by conventional methods. ...
  • Prevalence and risk factors of asthma, rhinoconjunctivitis and eczema in the very extreme environment of Naryn, Kyrgyzstan 
    Sulaimanov, Shaiirbek-A; Martínez-Torres, A-Elena; García-Marcos, Luis; Asheraliev, Mukhtar-E; Moidunov, Artur-A; Brimkulov, Nurlan-N; Muratova, Zhanara-K; Omusheva, Saltanat-E; Tynybekov, Kubanych-T; Narkoziev, Baktybek-E (ELSEVIER, 2026-05)
    BACKGROUND: There is not much information about the prevalence of allergic diseases in high altitudes in central Asia; and even less on their potential risk of protective factors. METHODS: A survey using the Global Asthma ...
  • Lessons of nature from trisomy-8 myeloid neoplasia: the riddle of oncogenic clonal drives. 
    Awada, Hussein; Durmaz, Arda; Guarnera, Luca; Brady, Zachary; Kubota, Yasuo; Unlu, Serhan; Gurnari, Carmelo; Bravo-Pérez, Carlos; Awada, Hassan; Haferlach, Torsten; Maciejewski, Jaroslaw-P; Visconte, Valeria (FERRATA STORTI FOUNDATION, 2026-05-07)
    Not available.
  • CVOT Summit Report 2025: advances along the cardiovascular-kidney-metabolic disease continuum 
    Schnell, Oliver; Agarwal, Arnav; Azizi, Michel; Ballwieser, Dennis; Barnard-Kelly, Katharine; Battelino, Tadej; Bluher, Matthias; Bugianesi, Elisabetta; Cebrián-Cuenca, Ana-María; Ceriello, Antonio; Choudhary, Pratik; Danne, Thomas; Dayan, Colin-M; del-Prato, Stefano; Eckel, Robert-H; Fioretto, Paola; Garvey, Timothy; Green, Jennifer-B; Heerspink, Hiddo-J-L; Holman, Rury-R; Itzhak, Baruch; Jacob, Stephan; Jhund, Pardeep-S; Ji, Linong; Judge, Parminder-K; Khunti, Kamlesh; Korenjak, Marko; Krentz, Andrew-J; Lambrinou, Ekaterini; Libby, Peter; Mader, Julia-K; Mann, Johannes-F-E; Marx, Nikolaus; Mathieu, Chantal; McMurray, John-J-V; Muller-Wieland, Dirk; Papanas, Nikolaos; Patel, Dipesh-C; Pfeiffer, Andreas-F-H; Reger-Tan, Susanne; Rodbard, Helena-W; Rosano, Giuseppe-M-C; Saboo, Banshi; Sato, Naoki; Solomon, Scott-D; Standl, Eberhard; Tacke, Frank; Topsever, Pinar; Wanner, Christoph; Wharton, Sean; Young, Veronika (SPRINGER, 2026-05-06)
    The 11th Cardiovascular Outcome Trial (CVOT) Summit: Congress on Cardiovascular, Kidney, and Metabolic Outcomes was held virtually on November 20-21, 2025. The Summit provided a multidisciplinary forum to review and discuss ...
  • Smoking, GAD65 autoimmunity, genetic susceptibility to type 1 diabetes and incident adult-onset diabetes in the EPIC-InterAct case-cohort study. 
    Keysendal, Emmy; Carlsson, Sofia; Lampousi, Anna-Maria; Hampe, Christiane-S; Huerta-Castaño, José-María; Kerrison, Nicola; Nilsson, Peter-M; Pala, Valeria; Schulze, Matthias-B; Sharp, Stephen-J; Rolandsson, Olov; Wareham, Nicholas-J (SPRINGERNATURE, 2026-04-16)
    AIMS/HYPOTHESIS: Smoking increases the risk of type 2 diabetes, but its role in autoimmune diabetes remains unclear. We investigated whether smoking is associated with being GAD65 autoantibody (GAD65Ab) positive or the ...
  • Redefining safety standards: a large-scale comparative analysis of bovine versus murine models for medical device embryotoxicity testing 
    Romar, Raquel; Romero-Aguirregomezcorta, Jon; Maroto, María; Gutiérrez-Adan, Alfonso; Coy-Fuster, Pilar (SPRINGER/PLENUM PUBLISHERS, 2026-06)
    PURPOSE: To overcome the limited sensitivity of the standard mouse embryo assay (MEA) for embryotoxicity screening of assisted reproduction devices and to assess the bovine embryo assay (BEA) as a suitable alternative. ...
  • Real-world characterization of PD-L1 expression in patients with advanced esophagogastric adenocarcinoma in Spain 
    Jiménez-Fonseca, Paula; Díez-García, Marc; Catoya-Villa, Juan-Luis; Pérez-Wert, Pablo; Visa, Laura; Carmona-Bayonas, Alberto; Limón, María-Luisa; Fernández-Montes, Ana; Reboredo, Margarita; Vidal-Tocino, Rosario; Gallego-Plazas, Javier; Mendoza, Guillermo-Eduardo; Landolfi, Stefania; Teijo, Ana; Guerra-Pastrian, Laura; Nieto, Andrés; Domínguez-Miranda, José-Luis; López-Vega, María-Luisa; Rodríguez-González, Marta; Illán-Gambín, Francisco-José; Martínez-de-Castro, Eva; Hierro, Cinta; Gil-Raga, Mireia; Robles-González, María; Moreno-Gutiérrez, María-Elena; Vilanova, David; Iglesias-Coma, Mar (SPRINGER INT PUBL AG, 2026-04-28)
    PURPOSE: Epidemiological data from Sapin are lacking, especially in a publication relating Spanish data and prevalence of programmed cell death ligand-1 (PD-L1) expression. This study aimed to evaluate the prevalence of ...
  • Real-World Effectiveness and Safety of Upadacitinib in Crohn's Disease: Insights From the Eneida Registry 
    Iborra, M; Botella, B; Martin-Arranz, M-D; Ceballos, D; Martínez-Pascual, C; Garrido, A; Varela, P; Moreta, M; Brunet-Mas, Eduard; González-Lama, Y; Rodríguez-González, E; Vicuna, M; Gisbert, J-P; Ordas, I; Arguelles-Arias, F; Tosca-Cuquerella, J; Vicente-Lidon, R; Sierra-Ausin, M; Rodríguez-Lago, I; Martin-Rodríguez, D; Paredes, JM; Sicilia, B; García-de-la-Filia, I; Jiménez, N; Barreiro-de-Acosta, M; Betore, E; Ferrer-Bradley, I; García-Alles, L; Huguet, JM; Castellet-Farrus, S; García, M-J; Gutiérrez-Casbas, A; Ponferrada-Díaz, A; Ramos, L; Calafat, M; Vera, I; Suárez-Ferrer, Consuelo; Fernández-Velado, E; Rodríguez-Sánchez, S; Mínguez, A; Mancebo, A; Barrio, J; Lario, S; de-La-Cruz, D-R; Hernández-Camba, Alejandro; Rodríguez-Gutiérrez, C; Chaparro, M; Ricart, E; Almenara-Michelena, L; Balaguer, A; Domenech, E; Nos, P (WILEY, 2026-05)
    BACKGROUND: Upadacitinib (UPA) is the first oral Janus kinase (JAK) inhibitor approved for the treatment of Crohn's disease (CD). Real-world data, particularly from large nationwide cohorts, remain limited. This study aimed ...
  • Functional, biochemical, and clinical characterization of natural mutations affecting arginine residues in the heparin-binding site of antithrombin 
    Cifuentes-Riquelme, Rosa; de-la-Morena-Barrio, María-Eugenia; Miñano, Antonia; Garrido-Rodríguez, Pedro; Velasco, Francisco; Rojo-Carrillo, Juan-José; López-Correas, Paloma; Zaragoza-Huesca, David; Padilla, José; Lozano-Almela, María-Luisa; Bravo-Pérez, Carlos; Corral, Javier (WILEY, 2026-04)
    Arginine residues in antithrombin are essential for heparin binding and for the activation of this key anticoagulant serpin. Mutations affecting these residues may cause antithrombin deficiency, specifically Type II ...
  • Machine learning-based prediction models for noninvasive respiratory support failure in acute respiratory failure: a systematic review and meta-analysis 
    Akgun, Kadir-Burak; Al-Otaibi, Hajed-M; Chiappa, Gaspar-R; Alqarni, Abdullah-A; Troxell, David; Przybylski, Franciszek; Esquinas-Rodríguez, Antonio (FRONTIERS MEDIA SA, 2026-04-10)
    BACKGROUND: Early identification of noninvasive respiratory support (NIRS) failure in acute respiratory failure (ARF) is clinically relevant, as delayed intubation is associated with worse outcomes. Machine learning-based ...
  • Diagnosis and therapeutic management of psoriatic arthritis: summary of 2024 update of the Spanish clinical practice guideline (ESPOGUIA) 
    Ramírez, Julio; López-Medina, Clementina; Montilla, Carlos; Moreno, Mireia; Moreno-Ramos, Manuel-José; Navarro, Victoria; Díaz, David; Fernández-Clotet, Agnes; Riera-Monroig, Josep; Díaz-del-Campo, Petra; Canete, Juan-D; Queiro, Rubén (SAGE PUBLICATIONS LTD, 2026-04)
    Psoriatic arthritis (PsA) is a heterogeneous chronic inflammatory disease affecting peripheral and axial joints, entheses, skin, and nails, requiring coordinated multidisciplinary management. Since the 2018 edition of ...
  • Predicting disease progression in multiple sclerosis with clinically accessible information and technology 
    Fuchs, Tom-A-N; Schoonheim, Menno-M; Strijbis, Eva-M-M; Jelgerhuis, Julia-R; Horakova, Dana; Havrdova, Eva-K; Uher, Tomas; Zivadinov, Robert; Ozakbas, Serkan; Girard, Marc; Alroughani, Raed; Grammond, Pierre; Lugaresi, Alessandra; Tomassini, Valentina; Kalincik, Tomas; Roos, Izanne; Gerlach, Oliver; van-der-Walt, Anneke; Khoury, Samia-J; van-Pesch, Vincent; Surcinelli, Andrea; Foschi, Matteo; Sa, María-José; D'amico, Emanuele; Kuhle, Jens; Cartechini, Elisabetta; Maimone, Davide; Karabudak, Rana; Soysal, Aysun; Spitaleri, Daniele; Laureys, Guy; Taylor, Bruce; D'hooghe, Marie; Ampapa, Radek; Castillo-Triviño, Tamara; Altintas, Ayse; Gray, Orla; Gouider, Riadh; Meca-Lallana, José-Eustasio; Kermode, Allan-G; Fabis-Pedrini, Marzena; Carroll, William-M; de-Gans, Koen; Sánchez-Menoyo, José-Luis; Etemadifar, Masoud; Al-Asmi, Abdullah; McCombe, Pamela; Simu, Mihaela; Yetkin, Mehmet-Fatih; Al-Harbi, Talal; Csepany, Tunde; Lalive, Patrice; Hardy, Todd-A; Ramanathan, Sudarshini; Willekens, Barbara; Pérez-Sempere, Ángel; Cárdenas-Robledo, Simón; Habek, Mario; Singhal, Bhim; Grigoriadis, Nikolaos; Simo, Magdolna; Shaygannejad, Vahid; Blanco, Yolanda; Agüera-Morales, Eduardo; Garber, Justin; Solaro, Claudio; Shuey, Neil; Khurana, Dheeraj; Decoo, Danny; Moghadasi, Abdorreza-Naser; Buzzard, Katherine; Skibina, Olga; John, Nevin; Petersen, Thor; Weinstock-Guttman, Bianca (SPRINGER HEIDELBERG, 2026-05)
    BACKGROUND: Predicting disease progression at the individual level is essential for personalized medicine. We previously developed machine-learning tools to estimate 5-year progression risk in people with multiple sclerosis ...
  • Gene editing of the GJB2 locus in porcine embryos using CRISPR/Cas9 and cytosine base editors: toward a model of congenital deafness 
    Pineiro-Silva, Celia; Bermejo-Álvarez, Pablo; García-Purrinos, Francisco-José; Gadea-Mateos, Joaquín (SPRINGERNATURE, 2026-04-18)
    Mutations in the GJB2 gene, which encodes Connexin 26 (Cx26), are responsible for the majority of cases of non-syndromic congenital hearing loss in humans. While murine GJB2 knockout models have provided mechanistic insight, ...

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