Repositorio Dspace

Envíos recientes

03. IMIB (Instituto Murciano de Investigación Biosanitaria Pascual Parrilla): Envíos recientes

  • Ir(III) Compounds Containing a Terdentate Ligand Are Potent Inhibitors of Proliferation and Effective Antimetastatic Agents in Aggressive Triple-Negative Breast Cancer Cells 
    Novohradsky, Vojtech; Marco, Alicia; Markova, Lenka; Cutillas, Natalia; Ruiz, José; Brabec, Viktor (AMER CHEMICAL SOC, 2023-07)
    Herein, we report a series of new octahedral iridium(III) complexes Ir1-Ir9 of the type [Ir(N^N^N)(C^N)Cl]PF(6) (N^N^N = 4'-(p-tolyl)-2,2':6',2"-terpyridine; C^N = deprotonated 2-arylbenzimidazole backbone) to introduce ...
  • Exploring Structure-Activity Relationships in Photodynamic Therapy Anticancer Agents Based on Ir(III)-COUPY Conjugates 
    Rovira, Anna; Ortega-Forte, Enrique; Hally, Cormac; Jorda-Redondo, Mireia; Abad-Montero, Diego; Vigueras, Gloria; Martínez, Jesús-I; Bosch, Manel; Nonell, Santi; Ruiz, José; Marchan, Vicente (AMER CHEMICAL SOC, 2023-06)
    Photodynamic therapy holds great promise as a non-invasive anticancer tool against drug-resistant cancers. However, highly effective, non-toxic, and reliable photosensitizers with operability under hypoxic conditions remain ...
  • Durvalumab plus tremelimumab for the treatment of advanced neuroendocrine neoplasms of gastroenteropancreatic and lung origin 
    Capdevila, J; Hernando, J; Teule, A; López, C; García-Carbonero, R; Benavent, M; Custodio, A; García-Álvarez, A; Cubillo, A; Alonso, V; Carmona-Bayonas, Alberto; Alonso-Gordoa, T; Crespo, G; Jiménez-Fonseca, P; Blanco, M; Viudez, A; La-Casta, A; Sevilla, I; Segura, A; Llanos, M; Landolfi, S; Nuciforo, P; Manzano, JL (NATURE PORTFOLIO, 2023-05)
    Single immune checkpoint blockade in advanced neuroendocrine neoplasms (NENs) shows limited efficacy; dual checkpoint blockade may improve treatment activity. Dune (NCT03095274) is a non-randomized controlled multicohort ...
  • Rats conserve passive avoidance retention level throughout the light phase of diurnal cycle 
    Popovic, Natalija; Morales-Delgado, Nicanor; de-la-Cruz-Sánchez, Ernesto; Popovic, Miroljub (PERGAMON-ELSEVIER SCIENCE LTD, 2023-09)
    Emotions and memory formation are sensible to circadian rhythm. Here we study whether the time of day during the light phase of the diurnal cycle affects emotional memory in male Wistar rats using the passive avoidance ...
  • Cryotop vitrification of large batches of pig embryos simultaneously provides excellent postwarming survival rates and minimal interference with gene expression 
    González-Plaza, Alejandro; Cambra, Josep-M; García-Canovas, Manuela; Parrilla, Inmaculada; Gil, María-A; Martínez, Emilio-A; Rodríguez-Martínez, Heriberto; Martínez, Cristina-A; Cuello, Cristina (ELSEVIER SCIENCE INC, 2023-08)
    The most commonly used technique to vitrify pig embryos is the super open pulled straw (SOPS), where a maximum of 6 embryos can be vitrified simultaneously per device without compromising the minimum volume necessary for ...
  • Cyclometalated Benzimidazole Osmium(II) Complexes with Antiproliferative Activity in Cancer Cells Disrupt Calcium Homeostasis 
    Hernández-García, Alba; Markova, Lenka; Santana, María-Dolores; Pracharova, Jitka; Bautista, Delia; Kostrhunova, Hana; Novohradsky, Vojtech; Brabec, Viktor; Ruiz, José; Kasparkova, Jana (AMER CHEMICAL SOC, 2023-04-24)
    We present the synthesis and characterization of six new heteroleptic osmium(II) complexes of the type [Os(C^N)(N^N)(2)]OTf (N^N = 2,2'-bipyridine and dipyrido[3,2-d:2',3'-f]quinoxaline; C^N = deprotonated methyl ...
  • Impact of particulate matter on the incidence of atrial fibrillation and the risk of adverse clinical outcomes: A review 
    Mandaglio-Collados, Dario; López-Gálvez, Raquel; José-Ruiz-Alcaraz, Antonio; López-García, Cecilia; Roldan-Schilling, Vanesa; Lip, Gregory-YH; Marín, Francisco; Rivera-Caravaca, José-Miguel (ELSEVIER, 2023-07)
    BACKGROUND: Atrial fibrillation (AF) is common and increases the risk of stroke and mortality. Previous studies have suggested that air pollution is an important risk factor for new-onset AF. Herein, we review the evidence ...
  • Food processing and cancer risk in Europe: results from the prospective EPIC cohort study 
    Kliemann, Nathalie; Rauber, Fernanda; Levy, Renata-Bertazzi; Viallon, Vivian; Vamos, Eszter-P; Cordova, Reynalda; Freisling, Heinz; Casagrande, Corinne; Nicolás, Genevieve; Aune, Dagfinn; Tsilidis, Konstantinos-K; Heath, Alicia; Schulze, Matthias-B; Jannasch, Franziska; Srour, Bernard; Kaaks, Rudolf; Rodríguez-Barranco, Miguel; Tagliabue, Giovanna; Agudo, Antonio; Panico, Salvatore; Ardanaz, Eva; Chirlaque-López, María-Dolores; Vineis, Paolo; Tumino, Rosario; Pérez-Cornago, Aurora; Andersen, Julie-Louise-Munk; Tjonneland, Anne; Skeie, Guri; Weiderpass, Elisabete; Monteiro, Carlos-Augusto; Gunter, Marc-J; Millett, Christopher; Huybrechts, Inge (ELSEVIER SCI LTD, 2023-03)
    BACKGROUND: Food processing has been hypothesised to play a role in cancer development; however, data from large-scale epidemiological studies are scarce. This study investigated the association between dietary intake ...
  • The impact of the covid-19 pandemic on diabetes care: the perspective of healthcare providers across Europe 
    Van-Grondelle, SE; Van-Bruggen, S; Rauh, SP; Van-der-Zwan, M; Cebrian, A; Seidu, S; Rutten, GEHM; Vos, HMM; Numans, ME; Vos, RC (ELSEVIER SCI LTD, 2023-04)
    AIMS: Covid-19 caused changes on the delivery of diabetes care. This study aimed to explore perceptions of healthcare providers across Europe concerning 1) the impact of covid-19 on delivery of diabetes care; 2) impact of ...
  • Dietary patterns related to biological mechanisms and survival after breast cancer diagnosis: results from a cohort study 
    Castro-Espín, Carlota; Bonet, Catalina; Crous-Bou, Marta; Katzke, Verena; Le-Cornet, Charlotte; Jannasch, Franziska; Schulze, Matthias-B; Olsen, Anja; Tjonneland, Anne; Dahm, Christina-C; Antoniussen, Christian-S; Sánchez, María-José; Amiano, Pilar; Chirlaque-López, María-Dolores; Guevara, Marcela; Agnoli, Claudia; Tumino, Rosario; Sacerdote, Carlotta; de-Magistris, María-Santucci; Sund, Malin; Boden, Stina; Jensen, Torill-Enget; Olsen, Karina-Standahl; Skeie, Guri; Gunter, Marc-J; Rinaldi, Sabina; González-Gil, Esther-M; Weiderpass, Elisabete; Christakoudi, Sofía; Heath, Alicia-K; Dossus, Laure; Agudo, Antonio (SPRINGERNATURE, 2023-03)
    BACKGROUND: Inflammatory, insulin and oestrogenic pathways have been linked to breast cancer (BC). We aimed to examine the relationship between pre-diagnostic dietary patterns related to these mechanisms and BC survival. ...
  • von Willebrand factor links primary hemostasis to innate immunity 
    Drakeford, Clive; Aguila, Sonia; Roche, Fiona; Hokamp, Karsten; Fazavana, Judicael; Cervantes, Mariana-P; Curtis, Annie-M; Hawerkamp, Heike-C; Dhami, Sukhraj-Pal-Singh; Charles-Messance, Hugo; Hackett, Emer-E; Chion, Alain; Ward, Soracha; Ahmad, Azaz; Schoen, Ingmar; Breen, Eamon; Keane, Joe; Murphy, Ross; Preston, Roger-JS; O'Sullivan, Jamie-M; Sheedy, Frederick-J; Fallon, Padraic; O'Donnell, James-S (NATURE PORTFOLIO, 2022-11)
    The plasma multimeric glycoprotein von Willebrand factor (VWF) plays a critical role in primary hemostasis by tethering platelets to exposed collagen at sites of vascular injury. Recent studies have identified additional ...
  • Identification of ALK-positive patients with advanced NSCLC and real-world clinical experience with crizotinib in Spain (IDEALK study) 
    Aguado-de-la-Rosa, Carlos; Cruz-Castellanos, Patricia; Lázaro-Quintela, Martín; Domine, Manuel; Vázquez-Estevez, Sergio; López-Vivanco, Guillermo; Firvida-Pérez, José-Luis; Alonso-Romero, José-Luis; Ferrera-Delgado, Lioba; García-Giron, Carlos; Diz-Tain, Pilar; Álvarez-Álvarez, Rosa; Sanchis, Pilar-Mut; Fernández-Canton, Inmaculada; Manrique-Abos, Isabel; Martínez-Aguillo, Maite; Gómez-Aldaravi-Gutiérrez, Lorenzo; Ortega-Granados, Ana-Laura; Álvarez-Cabellos, Ruth; García-Sebastian, Arancha; García-Sifuentes, Luis-Fernando; Reguart, Noemi (ELSEVIER IRELAND LTD, 2022-11)
    OBJECTIVES: To determine the incidence of ALK translocations in patients with advanced/metastatic NSCLC in Spain, to describe the clinical characteristics of these patients, and to evaluate the effectiveness and safety of ...
  • Erectile dysfunction, phosphodiesterase-5 inhibitor use and risk of cardiovascular disease and mortality in people with diabetes: A systematic review and meta-analysis 
    Seidu, Samuel; Cebrian, Ana; Kunutsor, Setor-K; Khunti, Kamlesh (ELSEVIER SCI LTD, 2022-10)
    BACKGROUND: Phosphodiesterase-5 inhibitors (PDE5-Is), used in the management of erectile dysfunction (ED), have potential cardioprotective benefits. The impact of PDE5-Is on reducing adverse cardiovascular outcomes in ...
  • Genetic polymorphisms associated with telomere length and risk of developing myeloproliferative neoplasms 
    Giaccherini, Matteo; Macauda, Angélica; Sgherza, Nicola; Sainz, Juan; Gemignani, Federica; Maldonado, José-Manuel-Sánchez; Jurado, Manuel; Tavano, Francesca; Mazur, Grzegorz; Jerez-Cayuela, Andrés; Gora-Tybor, Joanna; Golos, Aleksandra; Mohedo, Francisca-Hernández; López, Joaquín-Martínez; Varkonyi, Judit; Spadano, Raffaele; Butrym, Aleksandra; Canzian, Federico; Campa, Daniele (NATURE PUBLISHING GROUP, 2020-09)
    Telomere length measured in leukocyte (LTL) has been found to be associated with the risk of developing several cancer types, including myeloproliferative neoplasms (MPNs). LTL is genetically determined by, at least, 11 ...
  • Comorbidity within mental disorders: a comprehensive analysis based on 145 990 survey respondents from 27 countries 
    McGrath, JJ; Lim, CCW; Plana-Ripoll, O; Holtz, Y; Agerbo, E; Momen, NC; Mortensen, PB; Pedersen, CB; Abdulmalik, J; Aguilar-Gaxiola, S; Al-Hamzawi, A; Alonso, J; Bromet, EJ; Bruffaerts, R; Bunting, B; de-Almeida, JMC; de-Girolamo, G; de-Vries, YA; Florescu, S; Gureje, O; Haro, JM; Harris, MG; Hu, C; Karam, EG; Kawakami, N; Kiejna, A; Kovess-Masfety, V; Lee, S; Mneimneh, Z; Navarro-Mateu, Fernando; Orozco, R; Posada-Villa, J; Roest, AM; Saha, S; Scott, KM; Stagnaro, JC; Stein, DJ; Torres, Y; Viana, MC; Ziv, Y; Kessler, RC; de-Jonge, P (CAMBRIDGE UNIV PRESS, 2020)
    AIMS: Epidemiological studies indicate that individuals with one type of mental disorder have an increased risk of subsequently developing other types of mental disorders. This study aimed to undertake a comprehensive ...
  • Plasma tumour DNA as an early indicator of treatment response in metastatic castration-resistant prostate cancer 
    Conteduca, Vincenza; Wetterskog, Daniel; Scarpi, Emanuela; Romanel, Alessandro; Gurioli, Giorgia; Jayaram, Anuradha; Lolli, Cristian; Tandefelt, Delila-Gasi; Schepisi, Giuseppe; Casadei, Chiara; Wingate, Anna; Matteucci, Federica; Paganelli, Giovanni; González-Billalabeitia, Enrique; Demichelis, Francesca; de-Giorgi, Ugo; Attard, Gerhardt (SPRINGERNATURE, 2020-09)
    BACKGROUND: Plasma tumour DNA (ptDNA) levels on treatment are associated with response in a variety of cancers. However, the role of ptDNA in prostate cancer monitoring remains largely unexplored. Here we characterised ...
  • Natural History of MYH7-Related Dilated Cardiomyopathy 
    de-Frutos, Fernando; Pablo-Ochoa, Juan; Navarro-Peñalver, Marina; Baas, Annette; Bjerre, Jesper-Vandborg; Zorio, Esther; Mendez, Irene; Lorca, Rebeca; Verdonschot, Job-AJ; Elpidio-García-Granja, Pablo; Bilinska, Zofia; Fatkin, Diane; Fuentes-Canamero, MEugenia; García-Pinilla, José-M; García-Álvarez, María-I; Girolami, Francesca; Barriales-Villa, Roberto; Diez-López, Carles; Lopes, Luis-R; Wahbi, Karim; García-Álvarez, Ana; Rodríguez-Sánchez, Ibon; Rekondo-Olaetxea, Javier; Rodríguez-Palomares, José-F; Gallego-Delgado, María; Meder, Benjamin; Kubanek, Milos; Hansen, Frederikke-G; Alejandra-Restrepo-Cordoba, María; Palomino-Doza, Julian; Ruiz-Guerrero, Luis; Sarquella-Brugada, Georgia; José-Pérez-Pérez, Alberto; José-Bermúdez-Jiménez, Francisco; Ripoll-Vera, Tomás; Rasmussen, Torsten-Bloch; Jansen, Mark; Sabater-Molina, María; Elliot, Perry-M; García-Pavia, Pablo (ELSEVIER SCIENCE INC, 2022-10)
    BACKGROUND: Variants in myosin heavy chain 7 (MYH7) are responsible for disease in 1% to 5% of patients with dilated cardiomyopathy (DCM); however, the clinical characteristics and natural history of MYH7-related DCM are ...
  • Overall and stage-specific survival of patients with screen-detected colorectal cancer in European countries: A population-based in 9 countries 
    Cardoso, Rafael; Guo, Feng; Heisser, Thomas; de-Schutter, Harlinde; Van-Damme, Nancy; Nilbert, Mef-Christina; Christensen, Jane; Bouvier, Anne-Marie; Bouvier, Veronique; Launoy, Guy; Woronoff, Anne-Sophie; Cariou, Melanie; Robaszkiewicz, Michel; Delafosse, Patricia; Poncet, Florence; Walsh, Paul-M; Senore, Carlo; Rosso, Stefano; Lemmens, Valery-EPP; Elferink, Marloes-AG; Tomsic, Sonja; Zagar, Tina; Marques, Arantza-López-de-Munain; Marcos-Gragera, Rafael; Puigdemont, Montse; Galceran, Jaume; Carulla, María; Sánchez-Gil, Antonia; Chirlaque-López, María-Dolores; Hoffmeister, Michael; Brenner, Hermann (ELSEVIER, 2022-10)
    BACKGROUND: An increasing proportion of colorectal cancers (CRCs) are detected through screening due to the availability of organised population-based programmes. We aimed to analyse survival probabilities of patients with ...
  • Maternal urinary concentrations of bisphenol A during pregnancy are associated with global DNA methylation in cord blood of newborns in the "NELA" birth cohort 
    Navarro-Lafuente, Fuensanta; Adoamnei, Evdochia; Arense-Gonzalo, Julián-J; Prieto-Sánchez, María-T; Sánchez-Ferrer, María-L; Parrado, Antonio; Fernández, Mariana-F; Suarez, Beatriz; López-Acosta, Antonia; Sánchez-Guillamon, Antonio; García-Marcos, Luis; Morales, Eva; Mendiola, Jaime; Torres-Cantero, Alberto-M (ELSEVIER, 2022-09)
    Endocrine disrupting chemicals (EDCs) set a public health risk through disruption of normal physiological processes. The toxicoepigenetic mechanisms of developmental exposure to common EDCs, such as bisphenol A (BPA), are ...
  • Lateral gain is impaired in macular degeneration and can be targeted to restore vision in mice 
    Rizzi, M; Powell, K; Robinson, MR; Matsuki, T; Hoke, J; Maswood, RN; Georgiadis, A; Georgiou, M; Jones, PR; Ripamonti, C; Nadal-Nicolás, FM; Michaelides, M; Rubin, GS; Smith, AJ; Ali, RR (NATURE PORTFOLIO, 2022-04-20)
    Macular degeneration is a leading cause of blindness. Treatments to rescue vision are currently limited. Here, we study how loss of central vision affects lateral feedback to spared areas of the human retina. We identify ...

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