Repositorio Dspace

Envíos recientes

03. IMIB (Instituto Murciano de Investigación Biosanitaria Pascual Parrilla): Envíos recientes

  • Immunotherapy with CAR-T cells in paediatric haematology-oncology 
    Mirones, Isabel; Moreno, Lucas; Patino-García, Ana; Lizeaga, Garbine; Moraleda, José-María; Lozano, María-Luisa; Pérez-Martínez, Antonio (EDICIONES DOYMA S A, 2020-07)
    Despite being a rare disease, cancer is the first cause of mortality due to disease during the paediatric age in the developed countries. The current, great increase in new treatments, such as immunotherapy, constitutes a ...
  • The associations of major foods and fibre with risks of ischaemic and haemorrhagic stroke: a prospective study of 418 329 participants in the EPIC cohort across nine European countries 
    Tong, Tammy-Y-N; Appleby, Paul-N; Key, Timothy-J; Dahm, Christina-C; Overvad, Kim; Olsen, Anja; Tjonneland, Anne; Katzke, Verena; Kuhn, Tilman; Boeing, Heiner; Karakatsani, Anna; Peppa, Eleni; Trichopoulou, Antonia; Weiderpass, Elisabete; Masala, Giovanna; Grioni, Sara; Panico, Salvatore; Tumino, Rosario; Boer, Jolanda-M-A; Verschuren, W-M-Monique; Quiros, J-Ramon; Agudo, Antonio; Rodríguez-Barranco, Miguel; Imaz, Liher; Chirlaque-López, María-Dolores; Moreno-Iribas, Conchi; Engstrom, Gunnar; Sonestedt, Emily; Lind, Marcus; Otten, Julia; Khaw, Kay-Tee; Aune, Dagfinn; Riboli, Elio; Wareham, Nicholas-J; Imamura, Fumiaki; Forouhi, Nita-G; di-Angelantonio, Emanuele; Wood, Ángela-M; Butterworth, Adam-S; Pérez-Cornago, Aurora (OXFORD UNIV PRESS, 2020-07-21)
    AIM: To investigate the associations between major foods and dietary fibre with subtypes of stroke in a large prospective cohort. METHODS AND RESULTS: We analysed data on 418 329 men and women from nine European countries, ...
  • New role of the antidepressant imipramine as a Fascin1 inhibitor in colorectal cancer cells 
    Alburquerque-González, Begoña; Bernabé-García, Manuel; Montoro-García, Silvia; Bernabé-García, Ángel; Rodrigues, Priscila-Campioni; Ruiz-Sanz, Javier; López-Calderón, Fernando-F; Luque, Irene; Nicolas, Francisco-José; Cayuela, María-Luisa; Salo, Tuula; Pérez-Sánchez, Horacio; Conesa-Zamora, Pablo (SPRINGERNATURE, 2020-02)
    Serrated adenocarcinoma (SAC) is more invasive, has worse outcomes than conventional colorectal carcinoma (CRC), and is characterized by frequent resistance to anti-epidermal growth factor receptor (EGFR) and overexpression ...
  • Improvement of the Flavanol Profile and the Antioxidant Capacity of Chocolate Using a Phenolic Rich Cocoa Powder 
    González-Barrio, Rocío; Nunez-Gómez, Vanesa; Cienfuegos-Jovellanos, Elena; García-Alonso, Francisco-Javier; Periago-Caston, Ma-Jesús (MDPI, 2020-02)
    Chocolate is made from cocoa, which is rich in (poly)phenols that have a high antioxidant capacity and are associated with the prevention of chronic diseases. In this study, a new production process was evaluated in order ...
  • Melatonin as an Agent for Direct Pulp-Capping Treatment 
    Guerrero-Gironés, Julia; Alcaina-Lorente, Antonia; Ortiz-Ruiz, Clara; Ortiz-Ruiz, Eduardo; Pecci-Lloret, María-P; Rodríguez-Lozano, Francisco-Javier; Martínez, Carlos-M; Ortiz-Ruiz, Antonio-José (MDPI, 2020)
    Melatonin plays an essential role in the regulation of bone growth. The actions that melatonin exerts on odontoblasts may be similar to its action on osteoblasts. This research aimed to evaluate the pulp response to melatonin ...
  • Role of TGF-? in Skin Chronic Wounds: A Keratinocyte Perspective 
    Liarte, Sergio; Bernabé-García, Ángel; Nicolas, Francisco-J (MDPI, 2020-02)
    Chronic wounds are characterized for their incapacity to heal within an expected time frame. Potential mechanisms driving this impairment are poorly understood and current hypotheses point to the development of an unbalanced ...
  • ALPPS for Locally Advanced Intrahepatic Cholangiocarcinoma: Did Aggressive Surgery Lead to the Oncological Benefit? An International Multi-center Study 
    Li, Jun; Moustafa, Mohamed; Linecker, Michael; Lurje, Georg; Capobianco, Ivan; Baumgart, Janine; Ratti, Francesca; Rauchfuss, Falk; Balci, Deniz; Fernandes, Eduardo; Montalti, Roberto; Robles-Campos, Ricardo; Bjornsson, Bergthor; Topp, Stefan-A; Fronek, Jiri; Liu, Chao; Wahba, Roger; Bruns, Christiane; Brunner, Stefan-M; Schlitt, Hans-J; Heumann, Asmus; Stueben, Bjoern-Ole; Izbicki, Jakob-R; Bednarsch, Jan; Gringeri, Enrico; Fasolo, Elisa; Rolinger, Jens; Kristek, Jakub; Hernández-Alejandro, Roberto; Schnitzbauer, Andreas; Nuessler, Natascha; Schoen, Michael-R; Voskanyan, Sergey; Petrou, Athanasios-S; Hahn, Oszkar; Soejima, Yuji; Vicente, Emilio; Castro-Benitez, Carlos; Adam, Rene; Tomassini, Federico; Troisi, Roberto-Ivan; Kantas, Alexandros; Oldhafer, Karl-Juergen; Ardiles, Victoria; de-Santibanes, Eduardo; Malago, Massimo; Clavien, Pierre-Alain; Vivarelli, Marco; Settmacher, Utz; Aldrighetti, Luca; Neumann, Ulf; Petrowsky, Henrik; Cillo, Umberto; Lang, Hauke; Nadalin, Silvio (SPRINGER, 2020-05)
    BACKGROUND: ALPPS is found to increase the resectability of primary and secondary liver malignancy at the advanced stage. The aim of the study was to verify the surgical and oncological outcome of ALPPS for intrahepatic ...
  • Controlled donation after circulatory death up to 80 years for liver transplantation: Pushing the limit again 
    Cascales-Campos, Pedro-A; Ferreras, David; Alconchel, Felipe; Febrero, Beatriz; Royo-Villanova, Mario; Martínez, María; Rodríguez, José-M; Fernández-Hernández, Juan-A; Ríos-Zambudio, Antonio; Pons, José-A; Sánchez-Bueno, Francisco; Robles-Campos, Ricardo; Martínez-Barba, Enrique; Martínez-Alarcón, Laura; Parrilla, Pascual; Ramírez, Pablo (WILEY, 2020-01)
    Our main objective was to compare liver transplant (LT) results between donation after circulatory death (DCD) and donation after brainstem death (DBD) in our hospital and to analyze, within the DCD group, the influence ...
  • CDCA7 finely tunes cytoskeleton dynamics to promote lymphoma migration and invasion 
    Martín-Cortazar, Carla; Chiodo, Yuri; Jiménez-P, Raul; Bernabé, Manuel; Cayuela, María-Luisa; Iglesias, Teresa; Campanero, Miguel-R (FERRATA STORTI FOUNDATION, 2020-03-01)
    Metastases, the major cause of death from cancer, require cells' acquisition of the ability to migrate and involve multiple steps, including local tumor cell invasion and basement membrane penetration. Certain lymphoid ...
  • Multilayer intraclonal heterogeneity in chronic myelomonocytic leukemia 
    Beke, Allan; Laplane, Lucie; Riviere, Julie; Yang, Qin; Torres-Martín, Miguel; Dayris, Thibault; Rameau, Philippe; Saada, Veronique; Bilhou-Nabera, Chrystele; Hurtado, Ana; Lordier, Larissa; Vainchenker, William; Figueroa, María-E; Droin, Nathalie; Solary, Eric (FERRATA STORTI FOUNDATION, 2020-01-01)
    The functional diversity of cells that compose myeloid malignancies, i.e., the respective roles of genetic and epigenetic heterogeneity in this diversity, remains poorly understood. This question is addressed in chronic ...
  • Physical activity and risks of breast and colorectal cancer: a Mendelian randomisation analysis 
    Papadimitriou, Nikos; Dimou, Niki; Tsilidis, Konstantinos-K; Banbury, Barbara; Martín, Richard-M; Lewis, Sarah-J; Kazmi, Nabila; Robinson, Timothy-M; Albanes, Demetrius; Aleksandrova, Krasimira; Berndt, Sonja-I; Bishop, D-Timothy; Brenner, Hermann; Buchanan, Daniel-D; Bueno-de-Mesquita, Bas; Campbell, Peter-T; Castellvi-Bel, Sergi; Chan, Andrew-T; Chang-Claude, Jenny; Ellingjord-Dale, Merete; Figueiredo, Jane-C; Gallinger, Steven-J; Giles, Graham-G; Giovannucci, Edward; Gruber, Stephen-B; Gsur, Andrea; Hampe, Jochen; Hampel, Heather; Harlid, Sophia; Harrison, Tabitha-A; Hoffmeister, Michael; Hopper, John-L; Hsu, Li; Huerta, José-María; Huyghe, Jeroen-R; Jenkins, Mark-A; Keku, Temitope-O; Kuehn, Tilman; La-Vecchia, Carlo; Le-Marchand, Loic; Li, Christopher-I; Li, Li; Lindblom, Annika; Lindor, Noralane-M; Lynch, Brigid; Markowitz, Sanford-D; Masala, Giovanna; May, Anne-M; Milne, Roger; Monninkhof, Evelyn; Moreno, Lorena; Moreno, Victor; Newcomb, Polly-A; Offit, Kenneth; Perduca, Vittorio; Pharoah, Paul-D-P; Platz, Elizabeth-A; Potter, John-D; Rennert, Gad; Riboli, Elio; Sánchez, María-José; Schmit, Stephanie-L; Schoen, Robert-E; Severi, Gianluca; Sieri, Sabina; Slattery, Martha-L; Song, Mingyang; Tangen, Catherine-M; Thibodeau, Stephen-N; Travis, Ruth-C; Trichopoulou, Antonia; Ulrich, Cornelia-M; van-Duijnhoven, Franzel-J-B; Van-Guelpen, Bethany; Vodicka, Pavel; White, Emily; Wolk, Alicja; Woods, Michael-O; Wu, Anna-H; Peters, Ulrike; Gunter, Marc-J; Murphy, Neil (NATURE PORTFOLIO, 2020-01-30)
    Physical activity has been associated with lower risks of breast and colorectal cancer in epidemiological studies; however, it is unknown if these associations are causal or confounded. In two-sample Mendelian randomisation ...
  • Patterns in metabolite profile are associated with risk of more aggressive prostate cancer: A prospective study of 3,057 matched case-control sets from EPIC 
    Schmidt, Julie-A; Fensom, Georgina-K; Rinaldi, Sabina; Scalbert, Augustin; Appleby, Paul-N; Achaintre, David; Gicquiau, Audrey; Gunter, Marc-J; Ferrari, Pietro; Kaaks, Rudolf; Kuhn, Tilman; Boeing, Heiner; Trichopoulou, Antonia; Karakatsani, Anna; Peppa, Eleni; Palli, Domenico; Sieri, Sabina; Tumino, Rosario; Bueno-de-Mesquita, Bas; Agudo, Antonio; Sánchez, María-José; Chirlaque-López, María-Dolores; Ardanaz, Eva; Larranaga, Nerea; Pérez-Cornago, Aurora; Assi, Nada; Riboli, Elio; Tsilidis, Konstantinos-K; Key, Timothy-J; Travis, Ruth-C (WILEY, 2020-02-01)
    Metabolomics may reveal novel insights into the etiology of prostate cancer, for which few risk factors are established. We investigated the association between patterns in baseline plasma metabolite profile and subsequent ...
  • Consensus statement on the use of alemtuzumab in daily clinical practice in Spain 
    Meca-Lallana, J-E; Fernández-Prada, M; García-Vázquez, E; Moreno-Guillén, S; Otero-Romero, S; Rus-Hidalgo, M; Villar-Guimerans, L-M; Eichau-Madueno, S; Fernández-Fernández, O; Izquierdo-Ayuso, G; Álvarez-Cermeno, José-C; Arnal-García, C; Arroyo-González, R; Brieva-Ruiz, L; Calles-Hernández, C; García-Merino, A; González-Platas, M; Hernández-Pérez, M-A; Moral-Torres, E; Olascoaga-Urtaza, J; Oliva-Nacarino, P; Oreja-Guevara, C; Ortiz-Castillo, R; Oterino, A; Prieto-González, J-M; Ramio-Torrenta, L; Rodríguez-Antiguedad, A; Saiz, A; Tintore, M; Montalban-Gairin, X (ELSEVIER ESPANA SLU, 2022-10)
    INTRODUCTION: Alemtuzumab is a highly effective drug approved by the European Medicines Agency as a disease-modifying drug for the treatment of relapsing-remitting multiple sclerosis. OBJECTIVE: A consensus document was ...
  • Human Skin Keratinocytes on Sustained TGF-? Stimulation Reveal Partial EMT Features and Weaken Growth Arrest Responses 
    Liarte, Sergio; Bernabé-García, Ángel; Nicolas, Francisco-J (MDPI, 2020-01)
    Defects in wound closure can be related to the failure of keratinocytes to re-epithelize. Potential mechanisms driving this impairment comprise unbalanced cytokine signaling, including Transforming Growth Factor-? (TFG-?). ...
  • Nutrient-wide association study of 92 foods and nutrients and breast cancer risk 
    Heath, Alicia-K; Muller, David-C; van-den-Brandt, Piet-A; Papadimitriou, Nikos; Critselis, Elena; Gunter, Marc; Vineis, Paolo; Weiderpass, Elisabete; Fagherazzi, Guy; Boeing, Heiner; Ferrari, Pietro; Olsen, Anja; Tjonneland, Anne; Arveux, Patrick; Boutron-Ruault, Marie-Christine; Mancini, Francesca-Romana; Kuehn, Tilman; Turzanski-Fortner, Renee; Schulze, Matthias-B; Karakatsani, Anna; Thriskos, Paschalis; Trichopoulou, Antonia; Masala, Giovanna; Contiero, Paolo; Ricceri, Fulvio; Panico, Salvatore; Bueno-de-Mesquita, Bas; Bakker, Marije-F; van-Gils, Carla-H; Olsen, Karina-Standahl; Skeie, Guri; Lasheras, Cristina; Agudo, Antonio; Rodríguez-Barranco, Miguel; Sánchez, María-José; Amiano, Pilar; Chirlaque-López, María-Dolores; Barricarte-Gurrea, Aurelio; Drake, Isabel; Ericson, Ulrika; Johansson, Ingegerd; Winkvist, Anna; Key, Tim; Freisling, Heinz; His, Mathilde; Huybrechts, Inge; Christakoudi, Sofia; Ellingjord-Dale, Merete; Riboli, Elio; Tsilidis, Konstantinos-K; Tzoulaki, Ioanna (BMC, 2020-01-13)
    BACKGROUND: Several dietary factors have been reported to be associated with risk of breast cancer, but to date, unequivocal evidence only exists for alcohol consumption. We sought to systematically assess the association ...
  • Experience with tocilizumab in patients with neuromyelitis optica spectrum disorders 
    Carreon-Guarnizo, Ester; Hernández-Clares, R; Castillo-Trivino, T; Meca-Lallana, V; Arocas-Casan, V; Iniesta-Martínez, F; Olascoaga-Urtaza, J; Meca-Lallana, J-E (ELSEVIER ESPANA SLU, 2022-04)
    INTRODUCTION: Neuromyelitis optica spectrum disorders (NMOSD) are immune-mediated inflammatory disorders of the central nervous system involving astrocytes, B lymphocytes, anti-aquaporin 4, and such inflammatory mediators ...
  • Lifestyle factors and risk of multimorbidity of cancer and cardiometabolic diseases: a multinational cohort study 
    Freisling, Heinz; Viallon, Vivian; Lennon, Hannah; Bagnardi, Vincenzo; Ricci, Cristian; Butterworth, Adam-S; Sweeting, Michael; Muller, David; Romieu, Isabelle; Bazelle, Pauline; Kvaskoff, Marina; Arveux, Patrick; Severi, Gianluca; Bamia, Christina; Kuehn, Tilman; Kaaks, Rudolf; Bergmann, Manuela; Boeing, Heiner; Tjonneland, Anne; Olsen, Anja; Overvad, Kim; Dahm, Christina-C; Menéndez, Virginia; Agudo, Antonio; Sánchez, María-José; Amiano, Pilar; Santiuste, Carmen; Barricarte-Gurrea, Aurelio; Tong, Tammy-Y-N; Schmidt, Julie-A; Tzoulaki, Ioanna; Tsilidis, Konstantinos-K; Ward, Heather; Palli, Domenico; Agnoli, Claudia; Tumino, Rosario; Ricceri, Fulvio; Panico, Salvatore; Picavet, H-Susan-J; Bakker, Marije; Monninkhof, Evelyn; Nilsson, Peter; Manjer, Jonas; Rolandsson, Olov; Thysell, Elin; Weiderpass, Elisabete; Jenab, Mazda; Riboli, Elio; Vineis, Paolo; Danesh, John; Wareham, Nick-J; Gunter, Marc-J; Ferrari, Pietro (BMC, 2020-01-10)
    BACKGROUND: Although lifestyle factors have been studied in relation to individual non-communicable diseases (NCDs), their association with development of a subsequent NCD, defined as multimorbidity, has been scarcely ...
  • Validation of self-reported perception of proximity to industrial facilities: MCC-Spain study 
    Castello, Adela; Pérez-Gómez, Beatriz; Lora-Pablos, David; Lope, Virginia; Castano-Vinyals, Gemma; Vitelli-Storelli, Facundo; Dierssen-Sotos, Trinidad; Amiano, Pilar; Guevara, Marcela; Moreno, Victor; Lozano-Lorca, Macarena; Tardon, Adonina; Alguacil, Juan; Hernández-García, Marta; Marcos-Gragera, Rafael; Chirlaque-López, María-Dolores; Ardanaz, Eva; Ibarluzea, Jesús; Gómez-Acebo, Ines; Molina, Antonio-J; O'Callaghan-Gordo, Cristina; Aragonés, Nuria; Kogevinas, Manolis; Pollan, Marina; García-Pérez, Javier (PERGAMON-ELSEVIER SCIENCE LTD, 2020-02)
    BACKGROUND: Self-reported data about environmental exposures can lead to measurement error. OBJECTIVES: To validate the self-reported perception of proximity to industrial facilities. METHODS: MCC-Spain is a population-based ...
  • Retrospective Multicenter Study of Extracorporeal Photopheresis in Steroid-Refractory Acute and Chronic Graft-versus-Host Disease 
    Oarbeascoa, Gillen; Lozano, María-Luisa; Guerra, Luisa-María; Amunarriz, Cristina; Andon-Saavedra, Concepcion; García-Gala, José-María; Viejo, Aurora; Revilla, Nuria; Acosta-Fleitas, Cynthia; Luis-Arroyo, José; Martínez-Revuelta, Eva; Galego, Andrea; Hernández-Maraver, Dolores; Kwon, Mi; Diez-Martín, José-Luis; Pascual, Cristina (ELSEVIER SCIENCE INC, 2020-04)
    Extracorporeal photopheresis (ECP) is an established treatment strategy in steroid-refractory graft-versus-host disease (GVHD). This study's main objective was to analyze the clinical response and impact of ECP therapy in ...
  • A new regulatory mechanism of protein phosphatase 2A activity via SET in acute myeloid leukemia 
    Arriazu, Elena; Vicente, Carmen; Pippa, Raffaella; Peris, Irene; Martínez-Balsalobre, Elena; García-Ramírez, Patricia; Marcotegui, Nerea; Igea, Ana; Alignani, Diego; Rifon, José; Mateos, María-C; Cayuela, María-Luisa; Nebreda, Ángel-R; Odero, María-D (NATURE PUBLISHING GROUP, 2020-01-08)
    Acute myeloid leukemia (AML) is an aggressive hematologic malignancy. Although novel emerging drugs are available, the overall prognosis remains poor and new therapeutic approaches are required. PP2A phosphatase is a key ...

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