BACKGROUND: Epidemiological studies on chronic stress and cancer risk have produced inconsistent findings, likely due to challenges in measuring stress exposure. The allostatic load model offers an alternative biomarker-based ...

BACKGROUND: Robotic liver surgery (RLS) provides technical advantages over laparoscopic liver surgery, but no validated robotic-specific difficulty scoring system (DSS) exists. We evaluated the applicability of the Southampton ...

BACKGROUND: The clinical heterogeneity of atrial fibrillation (AF) challenges current classifications and risk scores, limiting their real-world applicability. AI-driven methods may enhance phenotyping and risk stratification. ...

INTRODUCTION: Bethesda III thyroid nodules represent a heterogeneous cytological category with an estimated malignancy risk of 13-30%, creating uncertainty in clinical decision-making. This study aimed to characterise ...

Colorectal cancer (CRC) is a major global health burden, whereas small intestinal cancers are rare despite arising within the same gastrointestinal tract. This disparity suggests that segment-specific epithelial programmes ...

BACKGROUND: One-carbon metabolism (1CM) regulates critical processes in carcinogenesis. However, the influence of 1CM-related nutritional and genetic factors on breast cancer (BC) risk remains unclear. OBJECTIVES: This ...

In vitro maturation (IVM) of oocytes is a key step in bovine in vitro embryo production, but concerns remain regarding its potential effects on oocyte competence and epigenetic regulation. Information on the DNA methylation ...