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Envíos recientes

03. IMIB (Instituto Murciano de Investigación Biosanitaria Pascual Parrilla): Envíos recientes

  • Hypothalamic Pomc expression restricted to GABAergic neurons suppresses Npy overexpression and restores food intake in obese mice 
    Trotta, Milagros; Bello, Estefania-Pilar; Alsina, Ramiro; Tavella, María-Belén; Ferran, José-Luis; Rubinstein, Marcelo; Bumaschny, Viviana-Florencia (ELSEVIER, 2020-07)
    OBJECTIVE: Hypothalamic arcuate proopiomelanocortin (Arc-POMC) neurons are involved in different physiological processes such as the regulation of energy balance, glucose homeostasis, and stress-induced analgesia. Since ...
  • In search of common developmental and evolutionary origin of the claustrum and subplate 
    Bruguier, Hannah; Suárez, Rodrigo; Manger, Paul; Hoerder-Suabedissen, Anna; Shelton, Andrew-M; Oliver, David-K; Packer, Adam-M; Ferran, José-L; García-Moreno, Fernando; Puelles, Luis; Molnar, Zoltan (WILEY, 2020-12-01)
    The human claustrum, a major hub of widespread neocortical connections, is a thin, bilateral sheet of gray matter located between the insular cortex and the striatum. The subplate is a largely transient cortical structure ...
  • Intramuscular Injection of Bone Marrow Stem Cells in Amyotrophic Lateral Sclerosis Patients: A Randomized Clinical Trial 
    Geijo-Barrientos, Emilio; Pastore-Olmedo, Carlos; De-Mingo, Pedro; Blanquer, Miguel; Gómez-Espuch, Joaquin; Iniesta, Francisca; García-Iniesta, Natalia; García-Hernández, Ana; Martín-Estefania, Carlos; Barríos, Laura; Moraleda, José-María; Martínez, Salvador (FRONTIERS MEDIA SA, 2020-03-24)
    BACKGROUND: Preclinical studies suggest that stem cells may be a valuable therapeutic tool in amyotrophic lateral sclerosis (ALS). As it has been demonstrated that there are molecular changes at the end-plate during the ...
  • Frailty transitions and associated clinical outcomes in patients with stable COPD: A longitudinal study 
    Bernabeu-Mora, Roberto; Oliveira-Sousa, Silvana-Loana; Sánchez-Martínez, Piedad; García-Vidal, José-Antonio; Gacto-Sánchez, Maríano; Medina-Mirapeix, Francesc (PUBLIC LIBRARY SCIENCE, 2020-04-03)
    BACKGROUND: Although frailty is a frequent occurrence in chronic obstructive pulmonary disease (COPD) patients, evidence on the frequency of frailty transition is scarce. AIMS: The present study aimed to describe the frailty ...
  • Spanish real-world experience with fingolimod in relapsing-remitting multiple sclerosis patients: MS NEXT study 
    Barrero, Francisco; Mallada-Frechin, Javier; Martínez-Gines, María-Luisa; Eugenia-Marzo, María; Meca-Lallana, Virginia; Izquierdo, Guillermo; Ramon-Ara, José; Oreja-Guevare, Celia; Meca-Lallana, José; Forero, Lucia; Sánchez-Veram, Irene; Moreno, María-José (PUBLIC LIBRARY SCIENCE, 2020-04-02)
    PURPOSE: The objective of this study was to characterize the demographic and clinical profile of RRMS patients receiving fingolimod in Spain, and to evaluate drug effectiveness and safety in clinical practice. METHODS: ...
  • Coordinated Intervention of Microglial and Muller Cells in Light-Induced Retinal Degeneration 
    Di-Pierdomenico, Johnny; Martínez-Vacas, Ana; Hernández-Muñoz, Daniel; Gómez-Ramírez, Ana-M; Valiente-Soriano, Francisco-Javier; Agudo-Barriuso, Marta; Vidal-Sanz, Manuel; Villegas-Pérez, María-Paz; García-Ayuso, Diego (ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 2020-03)
    PURPOSE: To analyze the role of microglial and Müller cells in the formation of rings of photoreceptor degeneration caused by phototoxicity. METHODS: Two-month-old Sprague-Dawley rats were exposed to light and processed ...
  • Salivary Biomarkers and Their Correlation with Pain and Stress in Patients with Burning Mouth Syndrome 
    López-Jornet, Pia; Castillo-Felipe, Candela; Pardo-Marin, Luis; Ceron, José-J; Pons-Fuster, Eduardo; Tvarijonaviciute, Asta (MDPI, 2020-04)
    OBJECTIVE: To evaluate a panel of salivary analytes involving biomarkers of inflammation, stress, immune system and antioxidant status in patients with burning mouth syndrome (BMS) and to study their relationship with ...
  • Photoprotection and Skin Pigmentation: Melanin-Related Molecules and Some Other New Agents Obtained from Natural Sources 
    Solano, Francisco (MDPI, 2020-04)
    Direct sun exposure is one of the most aggressive factors for human skin. Sun radiation contains a range of the electromagnetic spectrum including UV light. In addition to the stratospheric ozone layer filtering the most ...
  • Changes in individual and contextual socio-economic level influence on reproductive behavior in Spanish women in the MCC-Spain study 
    Gómez-Acebo, Ines; Dierssen-Sotos, Trinidad; Palazuelos, Camilo; Castano-Vinyals, Gemma; Pérez-Gómez, Beatriz; Amiano, Pilar; Fernández-Villa, Tania; Ardanaz, Eva; Suárez-Calleja, Claudia; Alguacil, Juan; Molina-Barcelo, Ana; Jiménez-Moleon, José-J; Molero, Jessica-Alonso; Roca-Barcelo, Aina; Chirlaque-López, María-Dolores; Fernández-Vázquez, José-Pedro; Molinuevo, Amaia; Aragonés, Nuria; Serra, María-Sala; Binefa, Gemma; Moreno, Victor; Pollan, Marina; Kogevinas, Manolis; Llorca, Javier (BMC, 2020-04-15)
    BACKGROUND: The association between socioeconomic level and reproductive factors has been widely studied. For example, it is well known that women with lower socioeconomic status (SES) tend to have more children, the age ...
  • New approach for estimating risk of miscarriage after chorionic villus sampling 
    Gil, M-M; Molina, F-S; Rodríguez-Fernández, M; Delgado, J-L; Carrillo, M-P; Jani, J; Plasencia, W; Stratieva, V; Maiz, N; Carretero, P; Lismonde, A; Chaveeva, P; Burgos, J; Santacruz, B; Zamora, J; De-Paco-Matallana, Catalina (WILEY, 2020-11)
    OBJECTIVE: To estimate the risk of miscarriage associated with chorionic villus sampling (CVS). METHODS: This was a retrospective cohort study of women attending for routine ultrasound examination at 11 + 0 to 13 + 6 weeks' ...
  • Aortic valve stenosis provides complementary information to bleeding risk scores in non-valvular atrial fibrillation patients initiating anticoagulation 
    Elvira-Ruiz, Gines; Caro-Martínez, Cesar; Flores-Blanco, Pedro-José; Cerezo-Manchado, Juan-José; Albendin-Iglesias, Helena; Lova-Navarro, Alejandro; Arregui-Montoya, Francisco; Muñoz-Franco, Francisca-María; García-Iniesta, Natalia; García-Alberola, Arcadio; Bailén-Lorenzo, José-Luis; Pascual-Figal, Domingo-Andrés; Manzano-Fernández, Sergio (TSINGHUA UNIV PRESS, 2020)
    BACKGROUND: The identification of modifiable bleeding risk factors may be of relevance. The aim is to evaluate if aortic stenosis (AS) provides additional information to bleeding risk scores for predicting major bleeding ...
  • Bi-allelic missense disease-causing variants in RPL3L associate neonatal dilated cardiomyopathy with muscle-specific ribosome biogenesis 
    Ganapathi, Mythily; Argyriou, Loukas; Martínez-Azorin, Francisco; Morlot, Susanne; Yigit, Gokhan; Lee, Teresa-M; Auber, Bernd; von-Gise, Alexander; Petrey, Donald-S; Thiele, Holger; Cyganek, Lukas; Sabater-Molina, María; Ahimaz, Priyanka; Cabezas-Herrera, Juan; Sorli-García, Moises; Zibat, Arne; Siegelin, Markus-D; Burfeind, Peter; Buchovecky, Christie-M; Hasenfuss, Gerd; Honig, Barry; Li, Yun; Iglesias, Alejandro-D; Wollnik, Bernd (SPRINGER, 2020-11)
    Dilated cardiomyopathy (DCM) belongs to the most frequent forms of cardiomyopathy mainly characterized by cardiac dilatation and reduced systolic function. Although most cases of DCM are classified as sporadic, 20-30% of ...
  • Hypothalamic Crh/Avp, Plasmatic Glucose and Lactate Remain Unchanged During Habituation to Forced Exercise 
    Toval, Ángel; Vicente-Conesa, Francisco; Martínez-Ortega, Paloma; Kutsenko, Yevheniy; Morales-Delgado, Nicanor; Garrigos, Daniel; Alonso, Antonia; Ribeiro-Do-Couto, Bruno; Popovic, Miroljub; Luis-Ferran, José (FRONTIERS MEDIA SA, 2020-05-15)
    It has been demonstrated that physical activity contributes to a healthier life. However, there is a knowledge gap regarding the neural mechanisms producing these effects. One of the keystones to deal with this problem is ...
  • Participant-funded clinical trials on rare diseases 
    Dal-Re, Rafael; Palau, Francesc; Guillén-Navarro, Encarna; Ayuso, Carmen (EDICIONES DOYMA S A, 2020-10)
    The development of medicines for certain rare diseases can be frustrated by lack of funding. In certain cases the patients themselves, or their relatives, occasionally fund the clinical trial in which they will be treated ...
  • Genetic Factors Involved in Cardiomyopathies and in Cancer 
    Sabater-Molina, María; Navarro-Penalver, Marina; Muñoz-Esparza, Carmen; Esteban-Gil, Ángel; Santos-Mateo, Juan-José; Gimeno, Juan-R (MDPI, 2020-06)
    Cancer therapy-induced cardiomyopathy (CCM) manifests as left ventricular (LV) dysfunction and heart failure (HF). It is associated withparticular pharmacological agents and it is typically dose dependent, but significant ...
  • Allogeneic Bone Marrow Mesenchymal Stem Cell Transplantation in Tooth Extractions Sites Ameliorates the Incidence of Osteonecrotic Jaw-Like Lesions in Zoledronic Acid-Treated Rats 
    Rodríguez-Lozano, Francisco-Javier; Oñate-Sánchez, Ricardo-E; Gonzalvez-García, Mar; Valles-Bergada, Marta; Martínez, Carlos-M; Revilla-Nuin, Beatriz; Guerrero-Gironés, Julia; Moraleda, José-María; García-Bernal, David (MDPI, 2020-06)
    Medication-related osteonecrosis of the jaw (MRONJ) is defined as the exposed necrotic bone involving the maxillofacial structures in bisphosphonate treated patients, and the pathophysiology of this disease remains unclear. ...
  • The Role of the Gut Microbiome in Colorectal Cancer Development and Therapy Response 
    Sánchez-Alcoholado, Lidia; Ramos-Molina, Bruno; Otero, Ana; Laborda-Illanes, Aurora; Ordonez, Rafael; Medina, José-Antonio; Gómez-Millan, Jaime; Queipo-Ortuno, María-Isabel (MDPI, 2020-06)
    Colorectal cancer (CRC) is the third most common cancer worldwide and the leading cause of cancer-related deaths. Recently, several studies have demonstrated that gut microbiota can alter CRC susceptibility and progression ...
  • TMEM95 is a sperm membrane protein essential for mammalian fertilization 
    Lamas-Toranzo, Ismael; Hamze, Julieta-G; Bianchi, Enrica; Fernández-Fuertes, Beatriz; Pérez-Cerezales, Serafin; Laguna-Barraza, Ricardo; Fernández-González, Raul; Lonergan, Pat; Gutiérrez-Adan, Alfonso; Wright, Gavin-J; Jiménez-Movilla, María; Bermejo-Álvarez, Pablo (ELIFE SCIENCES PUBLICATIONS LTD, 2020)
    The fusion of gamete membranes during fertilization is an essential process for sexual reproduction. Despite its importance, only three proteins are known to be indispensable for sperm-egg membrane fusion: the sperm proteins ...
  • Activation of adenosine A3 receptor protects retinal ganglion cells from degeneration induced by ocular hypertension 
    Boia, Raquel; Salinas-Navarro, Manuel; Gallego-Ortega, Alejandro; Galindo-Romero, Caridad; Aires, Ines-D; Agudo-Barriuso, Marta; Ambrosio, Antonio-Francisco; Vidal-Sanz, Manuel; Santiago, Ana-Raquel (NATURE PUBLISHING GROUP, 2020-05-27)
    Glaucoma is a progressive chronic retinal degenerative disease and a leading cause of global irreversible blindness. This disease is characterized by optic nerve damage and retinal ganglion cell (RGC) death. The current ...
  • Seminal Plasma Induces Overexpression of Genes Associated with Embryo Development and Implantation in Day-6 Porcine Blastocysts 
    Martínez, Cristina-A; Cambra, Josép-M; Gil, María-A; Parrilla, Inmaculada; Álvarez-Rodríguez, Manuel; Rodríguez-Martínez, Heriberto; Cuello, Cristina; Martínez, Emilio-A (MDPI, 2020-05)
    The infusion of boar seminal plasma (SP) before artificial insemination (AI) positively alters the expression of endometrial genes and pathways involved in embryo development. This study aimed to determine which transcriptome ...

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