Repositorio Dspace

Envíos recientes

03. IMIB (Instituto Murciano de Investigación Biosanitaria Pascual Parrilla): Envíos recientes

  • Presence of rare potential pathogenic variants in subjects under 65 years old with very severe or fatal COVID-19 
    López-Rodríguez, Rosario; del-Pozo-Valero, Marta; Corton, Marta; Minguez, Pablo; Ruiz-Hornillos, Javier; Elena-Pérez-Tomás, María; Barreda-Sánchez, María; Mancebo, Esther; Villaverde, Cristina; Nunez-Moreno, Gonzalo; Romero, Raquel; Paz-Artal, Estela; Guillén-Navarro, Encarna; Almoguera, Berta; Ayuso, Carmen (NATURE PORTFOLIO, 2022-06)
    Rare variants affecting host defense against pathogens could be involved in COVID-19 severity and may help explain fatal outcomes in young and middle-aged patients. Our aim was to report the presence of rare genetic variants ...
  • Bee pollen in zebrafish diet affects intestinal microbiota composition and skin cutaneous melanoma development 
    Di-Chiacchio, Isabela-M; Gómez-Abenza, Elena; Paiva, Isadora-M; de-Abreu, Danilo-JM; Rodríguez-Vidal, Juan-Francisco; Carvalho, Elisangela-EN; Carvalho, Stephan-M; Solis-Murgas, Luis-David; Mulero, Victoriano (NATURE PORTFOLIO, 2022-06)
    Bee pollen is recommended as dietary supplement due to immunostimulating functions including antioxidant, anti-inflammatory and anti-carcinogenic properties. Nevertheless, the effectiveness of such properties is still not ...
  • Physiological and pathophysiological functions of NLRP6: pro- and anti-inflammatory roles 
    Angosto-Bazarra, Diego; Molina-López, Cristina; Pelegrín, Pablo (NATURE PORTFOLIO, 2022-06)
    The nucleotide-binding oligomerization and leucine-rich repeat receptor (NLR) protein family consists of important immune sensors that form inflammasomes, a cytosolic multi-protein platform that induces caspase-1 activation ...
  • Urolithins: potential biomarkers of gut dysbiosis and disease stage in Parkinson's patients 
    Romo-Vaquero, María; Fernández-Villalba, Emiliano; Gil-Martínez, Ana-Luisa; Cuenca-Bermejo, Lorena; Carlos-Espin, Juan; Trinidad-Herrero, María; Victoria-Selma, María (ROYAL SOC CHEMISTRY, 2022-06)
    Gut microbiota alteration (gut dysbiosis) occurs during the onset and progression of Parkinson's disease. Gut dysbiosis biomarkers could be relevant to prodromal disease. Urolithins, anti-inflammatory metabolites produced ...
  • Hematic Antegrade Repriming Reduces Emboli on Cardiopulmonary Bypass: A Randomized Controlled Trial 
    Blanco-Morillo, Juan; Salmerón-Martínez, Diego; Morillo-Cuadrado, Daniel-Vicente; Arribas-Leal, José-M; Puis, Luc; Verdu-Verdu, Alicia; Martínez-Molina, Mercedes; Tormos-Ruiz, Encarnacion; Sornichero-Caballero, Angel; Ramírez-Romero, Pablo; Farina, Piero; Cánovas-López, Sergio (LIPPINCOTT WILLIAMS & WILKINS, 2023-03)
    Particulate and gaseous microemboli (GME) are side effects of cardiac surgery that interfere with postoperative recovery by causing endothelial dysfunction and vascular blockages. GME sources during surgery are multiple, ...
  • Prediagnosis Leisure-Time Physical Activity and Lung Cancer Survival: A Pooled Analysis of 11 Cohorts 
    Yang, Jae-Jeong; Yu, Danxia; White, Emily; Lee, Dong-Hoon; Blot, William; Robien, Kim; Sinha, Rashmi; Park, Yikyung; Takata, Yumie; Gao, Yu-Tang; Smith-Byrne, Karl; Monninkhof, Evelyn-M; Kaaks, Rudolf; Langhammer, Arnulf; Borch, Kristin-Benjaminsen; Al-Shaar, Laila; Lan, Qing; Sorgjerd, Elin-Pettersen; Zhang, Xuehong; Zhu, Clair; Chirlaque-López, María-Dolores; Severi, Gianluca; Overvad, Kim; Sacerdote, Carlotta; Aune, Dagfinn; Johansson, Mattias; Smith-Warner, Stephanie-A; Zheng, Wei; Shu, Xiao-Ou (OXFORD UNIV PRESS, 2022-03)
    BACKGROUND: Little is known about the association between physical activity before cancer diagnosis and survival among lung cancer patients. In this pooled analysis of 11 prospective cohorts, we investigated associations ...
  • Intravitreal and subretinal syngeneic bone marrow mononuclear stem cell transplantation improves photoreceptor survival but does not ameliorate retinal function in two rat models of retinal degeneration 
    Di-Pierdomenico, Johnny; Gallego-Ortega, Alejandro; Martínez-Vacas, Ana; García-Bernal, David; Vidal-Sanz, Manuel; Villegas-Pérez, María-P; García-Ayuso, Diego (WILEY, 2022-09)
    PURPOSE: To study and compare effects of syngeneic bone marrow mononuclear stem cells (BM-MNCs) transplants on inherited retinal degeneration in two animal models with different etiologies: the RCS and the P23H-1 rats. To ...
  • CA 15-3 prognostic biomarker in SARS-CoV-2 pneumonia 
    Ros-Lucas, José-Antonio; Pascual-Figal, Domingo-Andrés; Noguera-Velasco, José-Antonio; Hernández-Vicente, Alvaro; Cebreiros-López, Iria; Arnaldos-Carrillo, María; Martínez-Ardil, Isabel-M; García-Vazquez, Elisa; Aparicio-Vicente, Mario; Solana-Martínez, Elena; Ruiz-Martínez, Sheyla-Yolany; Fernández-Mula, Laura; Andujar-Espinosa, Ruben; Fernández-Suárez, Beatriz; Sánchez-Caro, María-Dolores; Penalver-Mellado, Carlos; Ruiz-López, Francisco-Jose (NATURE PORTFOLIO, 2022-04-25)
    The severity of lung involvement is the main prognostic factor in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Carbohydrate antigen 15-3 (CA 15-3), a marker of lung damage and fibrosis, could ...
  • Spontaneous and ART-induced large offspring syndrome: similarities and differences in DNA methylome 
    Li, Yahan; Lopes, Jordana-Sena; Fuster, Pilar-Coy; Rivera, Rocio-Melissa (TAYLOR & FRANCIS INC, 2022-11)
    Large/abnormal offspring syndrome (LOS/AOS) is a congenital overgrowth syndrome reported in ruminants produced by assisted reproduction (ART-LOS) which exhibit global disruption of the epigenome and transcriptome. LOS/AOS ...
  • Body Size at Different Ages and Risk of 6 Cancers: A Mendelian Randomization and Prospective Cohort Study 
    Mariosa, Daniela; Smith-Byrne, Karl; Richardson, Tom-G; Ferrari, Pietro; Gunter, Marc-J; Papadimitriou, Nikos; Murphy, Neil; Christakoudi, Sofia; Tsilidis, Konstantinos-K; Riboli, Elio; Muller, David; Purdue, Mark-P; Chanock, Stephen-J; Hung, Rayjean-J; Amos, Christopher, I; O'Mara, Tracy-A; Amiano, Pilar; Pasanisi, Fabrizio; Rodríguez-Barranco, Miguel; Krogh, Vittorio; Tjonneland, Anne; Halkjaer, Jytte; Pérez-Cornago, Aurora; Chirlaque-López, María-Dolores; Skeie, Guri; Rylander, Charlotta; Borch, Kristin-Benjaminsen; Aune, Dagfinn; Heath, Alicia-K; Ward, Heather-A; Schulze, Matthias; Bonet, Catalina; Weiderpass, Elisabete; Smith, George-Davey; Brennan, Paul; Johansson, Mattias (OXFORD UNIV PRESS INC, 2022-09)
    It is unclear if body weight in early life affects cancer risk independently of adult body weight. To investigate this question for 6 obesity-related cancers, we performed univariable and multivariable analyses using 1) ...
  • Do Antiangiogenics Promote Clot Instability? Data from the TESEO Prospective Registry and Caravaggio Clinical Trial 
    Carmona-Bayonas, Alberto; Verso, Melina; Sánchez-Canovas, Manuel; Rubio-Pérez, Jaime; García-de-Herreros, Marta; Martínez-del-Prado, Purificacion; Fernández-Pérez, Isaura; Quintanar-Verduguez, Teresa; Obispo-Portero, Berta; Pachon-Olmos, Vanessa; Gómez, David; Ortega, Laura; Serrano-Moyano, Marta; MBrozos, Elena; Biosca, Mercedes; Antonio-Rebollo, Maite; Teijeira-Sánchez, Lucia; Hernández-Pérez, Carolina; David-Cumplido-Buron, José; Martínez-Lago, Nieves; García-Pérez, Estefania; Munoz-Langa, José; Pérez-Segura, Pedro; Martínez-de-Castro, Eva; Jiménez-Fonseca, Paula; Agnelli, Giancarlo; Munoz, Andres (GEORG THIEME VERLAG KG, 2022-10)
    BACKGROUND: Venous thromboembolism (VTE) is a common complication in cancer patients. Much of its morbidity stems from the development of fatal pulmonary embolisms (PE). Little is known about the factors involved in clot ...
  • Position Statement on the Diagnosis, Treatment, and Response Evaluation to Systemic Therapies of Advanced Neuroendocrine Tumors, With a Special Focus on Radioligand Therapy 
    Capdevila, Jaume; Grande, Enrique; García-Carbonero, Rocio; Simo, Marc; del-Olmo-García, Ma-Isabel; Jiménez-Fonseca, Paula; Carmona-Bayonas, Alberto; Pubul, Virginia (OXFORD UNIV PRESS, 2022-04-05)
    BACKGROUND: The aim of this study was to provide a guidance for the management of neuroendocrine tumors (NETs) in clinical practice. MATERIAL AND METHODS: Nominal group and Delphi techniques were used. A steering committee ...
  • How Accurately Can We Recall the Timing of Food Intake? A Comparison of Food Times from Recall-Based Survey Questions and Daily Food Records 
    Gioia, Siena-C; Guirette, Melanie; Chen, Angela; Tucker, Chandler; Gray, Brianna-E; Vetter, Celine; Garaulet, Marta; Scheer, Frank-AJL; Saxena, Richa; Dashti, Hassan-S (OXFORD UNIV PRESS INC, 2022-02)
    BACKGROUND: There currently are no standard, low-cost, and validated methods to assess the timing of food intake. OBJECTIVES: The aim of this study was to validate simple, recall-based questions that can characterize food ...
  • Novel valproate half-sandwich rhodium and iridium conjugates to fight against multidrug-resistant Gram-positive bacteria 
    Marco, Alicia; Vigueras, Gloria; Busto, Natalia; Cutillas, Natalia; Bautista, Delia; Ruiz, José (ROYAL SOC CHEMISTRY, 2023-10)
    New valproate Ir(III) and Rh(III) half-sandwich conjugates containing a C,N-phenylbenzimidazole chelated ligand have been synthesized and characterized. The valproic acid conjugation to organometallic fragments seems to ...
  • Antithrombin Deficiency Is Associated with Prothrombotic Plasma Fibrin Clot Phenotype 
    Natorska, Joanna; Corral, Javier; de-la-Morena-Barrio, María-Eugenia; Bravo-Pérez, Carlos; Bagoly, Zsuzsa; Bereczky, Zsuzsanna; Trelinski, Jacek; Witkowski, Michal; Klajmon, Adrianna; Undas, Anetta; Zabczyk, Michal (GEORG THIEME VERLAG KG, 2023-09)
    BACKGROUND: Deficiency of antithrombin increases risk of venous thromboembolism. We hypothesized that antithrombin deficiency affects fibrin clot structure and function. METHODS: We evaluated 148 patients (age: 38 [32-50] ...
  • Expert Consideration on Regulatory Aspects for Perinatal Derivatives in Clinical Settings 
    Hofmann, Nicola; Lafarge, Xavier; Antica, Maríastefania; Ferry, Nicolas; Girandon, Lenart; Gramignoli, Roberto; Jurga, Marcin; Kerdjoudj, Halima; Navakauskiene, Ruta; Schiavi, Jessica; Shablii, Volodymyr; Nicolas, Francisco-J; Gindraux, Florelle (OXFORD UNIV PRESS, 2023-05)
    Perinatal derivatives (PnD) are drawing growing interest among the scientific community as an unrestricted source of multipotent stem cells, secretome, and biological matrices. They are useful for the treatment of diseases ...
  • Usefulness of PIVKA-II for monitoring after liver transplantation in patients with hepatocellular carcinoma 
    Villalba-López, Francisco; Saenz-Mateos, Luis-Francisco; Sánchez-Lorencio, María-Isabel; De-La-Orden-García, Virginia; Alconchel-Gago, Felipe; Cascales-Campos, Pedro-Antonio; García-Bernardo, Carmen; Noguera-Velasco, José-Antonio; Baroja-Mazo, Alberto; Ramírez-Romero, Pablo (NATURE PORTFOLIO, 2023-04-06)
    The high morbidity and mortality of hepatocellular carcinoma (HCC) has encouraged the search for new biomarkers to be used alongside alpha-foetoprotein (AFP) and imaging tests. The aim of this study was to evaluate the ...
  • Intraductal papillary neoplasms of the bile duct: a European retrospective multicenter observational study (EUR-IPNB study) 
    Lluis, Nuria; Serradilla-Martín, Mario; Achalandabaso, Mar; Jehaes, Francois; Dasari, Bobby-VM; Mambrilla-Herrero, Sara; Sparrelid, Ernesto; Balakrishnan, Anita; Hoogwater, Frederik-JH; Amaral, María-J; Andersson, Bodil; Berrevoet, Frederik; Doussot, Alexandre; López-López, Victor; Alsammani, Mohammedsuror; Detry, Olivier; Domingo-del-Pozo, Carlos; Machairas, Nikolaos; Pekli, Damjan; Alcazar-López, Candido-F; Asbun, Horacio; Bjornsson, Bergthor; Christophides, Thalis; Diez-Caballero, Alberto; Francart, David; Noel, Colin-B; Sousa-Silva, Donzilia; Toledo-Martínez, Enrique; Tzimas, George-N; Yaqub, Sheraz; Cauchy, Francois; Prieto-Calvo, Mikel; D'Souza, Melroy-A; Spiers, Harry-VM; van-den-Heuvel, Marius-C; Charco, Ramon; Lesurtel, Mickael; Ramia, José-M (LIPPINCOTT WILLIAMS & WILKINS, 2023-04)
    BACKGROUND/PURPOSE: Intraductal papillary neoplasm of the bile duct (IPNB) is a rare disease in Western countries. The main aim of this study was to characterize current surgical strategies and outcomes in the mainly ...
  • GALE variants associated with syndromic manifestations, macrothrombocytopenia, bleeding, and platelet dysfunction 
    Marin-Quilez, Ana; Di-Buduo, Christian-A; Benito, Rocio; Balduini, Alessandra; Rivera, José; Bastida, José-María (TAYLOR & FRANCIS INC, 2023-12-31)
    GALE gene encodes the uridine diphosphate [UDP]-galactose-4-epimerase, which catalyzes the bidirectional interconversion of UDP-glucose to UDP-galactose, and UDP-N-acetyl-glucosamine to UDP-N-acetyl-galactosamine. In that ...
  • Gaucher disease protects against tuberculosis 
    Fan, Jingwen; Hale, Victoria-L; Lelieveld, Lindsey-T; Whitworth, Laura-J; Busch-Nentwich, Elisabeth-M; Troll, Mark; Edelstein, Paul-H; Cox, Timothy-M; Roca, Francisco-J; Aerts, Johannes-MFG; Ramakrishnan, Lalita (NATL ACAD SCIENCES, 2023-02)
    Biallelic mutations in the glucocerebrosidase (GBA1) gene cause Gaucher disease, characterized by lysosomal accumulation of glucosylceramide and glucosylsphingosine in macrophages. Gaucher and other lysosomal diseases occur ...

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