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Envíos recientes

02.06.01. Investigación y comunicación científica: Envíos recientes

  • Recovery of Renal Function and Late Withdrawal of Hemodialysis in IgD Multiple Myeloma: A Case Report 
    Vigueras-Hernández, María-Rosa; Sirvent-Pedreño, Ana-Esther; Enriquez, Ricardo; Pérez-Pérez, Antonio; de-Arriba-de-la-Fuente, Felipe; Andreu-Muñoz, Alberto (SCIENTIFIC SCHOLAR LLC, 2025-10-08)
  • Association of Cutaneous Immune-related Adverse Events with Overall Survival and Progression-free Survival in Oncology Patients Receiving Immune Checkpoint Inhibitors: A Prospective Study of 189 Patients in a Spanish Tertiary Care Hospital 
    Juan-Carpena, Gloria; Martínez-Banaclocha, Natividad; Carlos-Palazon-Cabanes, Juan; Niveiro-de-Jaime, María; Betlloch-mas, Isabel; Blanes-Martínez, Mar (ACTA DERMATO-VENEREOLOGICA, 2025-01-03)
    Cutaneous immune-related adverse events (cirAEs) may be associated with tumoral response and survival in patients using immune checkpoint inhibitors, but this relationship remains unclear because previous reports on the ...
  • Optimizing therapeutic approaches for HR+/HER2advanced breast cancer: clinical perspectives on biomarkers and treatment strategies post-CDK4/6 inhibitor progression 
    Andular, Juan-Miguel-Cejalvo; Ayala-de-la-Peña, Francisco; Vila, Mireia-Margeli; Pascual, Javier; Tolos, Pablo; Pages, Cristina; Cuenca, Nica; Guerrero-Zotano, Ángel (OAE PUBLISHING INC, 2025-01-22)
    This review offers an expert perspective on biomarkers, CDK4/6 inhibitor efficacy, and therapeutic approaches for managing hormone receptor-positive (HR+), human epidermal growth factor receptor-negative (HER2-) advanced ...
  • Nirsevimab Effectiveness Against Severe Respiratory Syncytial Virus Infection in the Primary Care Setting 
    López-Lacort, Mónica; Muñoz-Quiles, Cintia; Mira-Iglesias, Ainara; Xavier-López-Labrador, F; Garces-Sánchez, María; Escribano-López, Begoña; Zornoza-Moreno, Matilde; Pérez-Martín, Jaime-Jesús; Alfayate-Miguelez, Santiago; Iofrío-de-Arce, Antonio; Pastor-Villalba, Eliseo; Lluch-Rodrigo, José-Antonio; Diez-Domingo, Javier; Orrico-Sánchez, Alejandro; MEDIPRIM-Network (AMER ACAD PEDIATRICS, 2025-01-01)
    OBJECTIVES: This study assesses the effectiveness of nirsevimab, a monoclonal antibody, in preventing medically attended respiratory syncytial virus-lower respiratory tract infections (RSV-LRTIs) in a large primary care ...
  • Assessing therapeutic decisions in generalized myasthenia gravis: Study protocol 
    Gutiérrez-Gutiérrez, Gerardo; Gómez-Ballesteros, Rocío; Sotoca, Javier; Ares, Adrián; Villaverde-González, Ramón; Reyes, Virginia; Armangue, Thais; Salas, Elisa; Díaz-Abos, Paola; Rebollo, Pablo; Sarmiento, Mónica; Escobar, Iratxe; Maurino, Jorge; Querol, Luis (PUBLIC LIBRARY SCIENCE, 2025-04-22)
    BACKGROUND: The therapeutic landscape in generalized myasthenia gravis (gMG) has been continuously evolving in recent years, with over five products approved, each with different efficacy, safety, and administration profiles. ...
  • Transcriptional analysis of metastatic hormone-naïve prostate cancer primary tumor biopsies reveals a relevant role for SOX11 in prostate cancer cell dissemination 
    Martín-Martin, Natalia; García-Longarte, Saioa; Corres-Mendizabal, Jon; Lazcano, Uxue; Astobiza, Ianire; Bozal-Basterra, Laura; Herranz, Nicolas; van-Splunder, Hielke; Carlevaris, Onintza; Pujana-Vaquerizo, Mikel; Blasco, María-Teresa; Aransay, Ana-M; Rosino-Sánchez, Antonio; Tudela-Pallarés, Julián; Jiménez, Daniel; Martínez, Alberto; Salca, Andrei; Santos-Martin, Aida; Rey, Sofia; Ugalde-Olano, Aitziber; Gonzalo, David; Graupera, Mariona; Gomis, Roger-R; Mateo, Joaquín; Unda, Miguel; González-Billalabeitia, Enrique; Loizaga-Iriarte, Ana; Mendizabal, Isabel; Carracedo, Arkaitz (BMC, 2025-06-03)
    BACKGROUND: Metastatic hormone-naïve prostate cancer (mHNPC) is an infrequent form of this tumor type that is characterized by metastasis at the time of diagnosis and accounts for up to 50% of prostate cancer-related deaths. ...
  • Evaluating the effect of heart and respiratory rate measurement errors on the ability to predict the outcome of high flow nasal cannula therapy: a multi-centre study 
    Yu, Hang; Saffaran, Sina; Tonelli, Roberto; Laffey, John-G; Zhang, Qingchen; Esquinas-Rodríguez, Antonio; Martins-de-Lima, Lucas; Kawano-Dourado, Leticia; Maia, Israel-S; Cavalcanti, Alexandre-Biasi; Clini, Enrico; Bates, Declan-G (BMC, 2025-11-22)
    BACKGROUND: The respiratory rate oxygenation (ROX) index, and machine learning (ML) models, are promising approaches to help clinicians identify earlier those patients at risk of failing high flow nasal cannula (HFNC) ...
  • Machine learning models compared with current clinical indices to predict the outcome of high flow nasal cannula therapy in acute hypoxemic respiratory failure 
    Yu, Hang; Saffaran, Sina; Tonelli, Roberto; Laffey, John-G; Esquinas-Rodríguez, Antonio; Martins-de-Lima, Lucas; Kawano-Dourado, Leticia; Maia, Israel-S; Cavalcanti, Alexandre-Biasi; Clini, Enrico; Bates, Declan-G (BMC, 2025-03-07)
    BACKGROUND: Early identification of patients with acute hypoxemic respiratory failure (AHRF) who are at risk of failing high-flow nasal cannula (HFNC) therapy could facilitate closer monitoring, and timely adjustment/escalation ...
  • Development and validation of checklists for standardized patients in dental education for special care health needs patients 
    Guerrero-Gironés, Julia; Mellinas-Martínez, Irene; Pecci-Lloret, Miguel-Ramón; Adánez-Martínez, Gracia; Pecci-Lloret, María-Pilar (BMC, 2025-12-19)
    BACKGROUND: Traditionally, checklists or evaluation templates have been utilized to assess psychological and health-related issues in fields like psychology and pediatrics. Currently, their use has expanded, particularly ...
  • Clinical simulation as an effective teaching model in the Special Needs Dentistry course 
    Mellinas-Martínez, Irene; Pecci-Lloret, María-Pilar; Pecci-Lloret, Miguel-Ramón; Adánez-Martínez, Gracia; Guerrero-Gironés, Julia (BMC, 2025-10-17)
    BACKGROUND: Clinical simulation is a teaching-learning methodology that shows positive results in clinical learning, emphasizing the importance of active learning due to its proximity to real-life professional settings. ...
  • Tinzaparin for the prevention of thromboembolic events in ambulatory patients with metastatic colorectal cancer receiving first line treatment: a randomised, clinical trial design 
    Salgado, Mercedes; de-la-Camara-Gómez, Juan; García-Escobar, Ignacio; Álvarez-Llosa, Renata-Carola; González-Villarroel, Paula; Fernández-Garay, David; Pampols-Felip, Montse; Guillot-Morales, Mónica; Pelegrin-Mateo, Francisco-José; Jiménez-Orozco, Encarnación; Sastre, Javier; Martínez-de-Castro, Eva; Coma, Eva; Paris-Bouzas, Lorena; Ferrer-Pérez, Ana-Isabel; Momprade-Olive, Elisabet; Cousillas-Castineiras, Antia; Covela-Rua, Marta; Rojas, Maríam; Querol, Rosa; Díaz, Luis-Robles; Merino, Marta; Gil, Mireia; Sánchez-Cánovas, Manuel; Elias, Teresa; Marrupe-González, David; Sánchez-Gil, Belén; Carmona-Campos, Marta; García-Ferron, María; Soria, José-Manuel; Muñoz, Andrés (BMC, 2025-11-17)
    BACKGROUND: Colorectal cancer (CRC) is the third most commonly diagnosed cancer worldwide. CRC leads to increased activation of the clotting system. Since CRC patients present a higher rate of bleeding, careful evaluation ...
  • Co-infections during SARS-CoV-2 infection in hematologic patients and cell therapy recipients in the omicron era: a Spanish hematopoietic stem cell transplantation and cell therapy group study 
    Chorao, Pedro; Avendano, Alex; Heras-Fernando, Inmaculada; Aiello, Francesco; Mico-Cerda, Mireia; Arrufat-Bel, Ana; García-Gutiérrez, Valentín; Olave, María-Teresa; Acera-Gómez, Marina; Espigado, Ildefonso; Cuesta-Casas, María-Ángeles; González-Santillana, Clara; Hernández-Rivas, José-Ángel; Roldan-Pérez, Alicia; Labrador, Jorge; Villalba, Marta; Vázquez, Lourdes; García-Vidal, Carolina; Martino, Rodrigo; López-Jiménez, Javier; Cedillo, Ángel; Solano, Carlos; García-Cadenas, Irene; Pinana, José-Luis; Spanish-Hematopoietic-Stem-Cell-Transplantation-Cell-Therapy-Grp-GETH-TC (BMC, 2025-07-25)
    BACKGROUND: Although SARS-Cov-2 outcomes have improved in the Omicron era, the synergistic or additive effects between SARS-CoV-2 Omicron variants and other microbiological agents in adult hematologic patients have been ...
  • Internal fixation versus revision arthroplasty for Vancouver B2-B3 fractures: mortality and functional outcomes in frail patients. Insights from the PIPPAS study of 485 patients 
    Moreta, Jesús; Aguado, Hector-J; Castillon-Bernal, Pablo; Muñoz-Vives, Josep-M; Camacho, Pilar; Jornet-Gibert, Montsant; Teixidor, Jordi; Pereda-Manso, Adela; García-Sánchez, Yaiza; Ojeda-Thies, Cristina; García-Portabella, Pablo; Álvarez, Elvira-Mateos; Noriega-González, David; Muñoz-Moreno, María-Fe; Arroyo-Hernantes, Irene; Álvarez-Ramos, Begoña-Aranzazu; García-Medrano, Belén; Martínez-Selles, Carmen; Marín-Jiménez, Sergio; García-Virto, Virginia; Pais-Ortega, Sergio; Acha, Adriana; Tomas-Hernández, Jordi; Selga-Marsa, Jordi; Andrés-Peiro, José-Vicente; Piedra-Calle, Carlos; Blasco-Casado, Ferran; Guerra-Farfan, Ernesto; Querolt-Coll, Jordi; Triana-López-de-Santamaria, Guillermo; Hernández, José-M; Renau-Cerrillo, Marina; Gil-Aliberas, Carles; Carreras-Castaner, Anna; Vives-Barquiel, Marian; Ajuria-Fernández, Eliam; Fernández-Manzano, Eugenia; García-de-Cortazar, Unai; Arrieta, Mirentxu; Escobar, Daniel; Castrillo, Estibaliz; Balvis-Balvis, Patricia; Denisiuk, Maciej; Castro-Menéndez, Manuel; Pastor, Sonsoles; Larrazabal, Ane; Olias-López, Beatriz; Amaya-Espinosa, Patricia; Boluda-Mengod, Juan; González-Martín, David; López-Dorado, Daniel; Borras-Cebrian, Juan-Carlos; Martínez-Pérez, Carles; Freile-Pazmino, Patricio-Andrés; Calavia-Cale, Pablo; Suárez-Suárez, Miguel-Ángel; Lanuza-Lagunilla, Lucía; García-Arias, Antonio; Cabria-Fernández, Julián; García-Coiradas, Javier; Valle-Cruz, José; Sánchez-del-Saz, Jaime; Mora-Fernández, Jesús; Lalueza-Andreu, Pedro; Bonome-Roel, César; Cano-Leira, María-Ángeles; Benjumea-Carrasco, Antonio; López-de-Pariza, Ana; Fernández-Juan, Alexis; Sevillano-de-la-Puente, Carmen; Juldain-Mondragon, Miren; Guiadilla-Arsuaga, Jorge; Saura-Sánchez, Eladio; Giménez-Ibánez, Sandra; Sánchez-Gómez, Plácido; Ricon-Recarey, F-Javier; García-García, Elena-María; Cuadrado-Abajo, Francisco; Pérez-Núñez, María-Isabel; del-Pozo-Manrique, Pedro; García-Navas-García, Francisco-Manuel; García-Paredero, Ester; Guijarro-Valtuena, Ainhoa; Beteta-Robles, Teresa; Navas-Pernia, Inés; De-Villasante-Jiron, Ignasi; Serra-Porta, Teresa; Carrasco-Becerra, Carmen; Otero-Naveiro, Victor; Paz, Silvia-Pena; Fernández-Billón-Castrillo, Inés; Fernández-Dorado, Fátima; Martínez-Menduina, Amaia; Vaquerizo-García, Victor; Murcia-Asensio, Antonio; Galián-Muñoz, Elena; Marín-Martínez, Carmelo; Muñoz-Vicente, Adrián; Plaza-Salazar, Nuria; Gamez-Asuncion, Carla; Benito-Santamaria, Jennifer; Salgado-Tarrida, Paula; Prats-Puente, Oriol; Cuenca-Copete, Alejandro; González-Montero, Blas; Giraldo-Vegas, Luis-Alejandro; Mingo-Robinet, Juan; Briso-Montiano, Ricardo; Barberia-Biurrun, Amaya; Escudero-Martínez, Emma; Chouza-Montero, Laura; Naharro-Tobio, María; Gasset-Teixidor, Alfons; Domínguez-Ibarrola, Andrea; Peñalver, J-M; Serrano-Sanz, Jorge; Roche-Albero, Adrián; Martín-Hernández, Carlos; Macho-Mier, María; Salo-Cuenca, José-Carlos; Espona-Rosello, Jordi; Criado-Albillos, Guillermo; Cabello-Benavides, Hugo-Gabriel; Alonso-Nestar, David; González-Bernal, Jeronimo; González-Santos, Josefa; Cunchillos-Pascual, Jorge; Martínez-Íñiguez-Blasco, Jorge; Bogallo-Dorado, José-Manuel; Ramírez-Roldan, Alicia; Cano-Porras, Juan-Ramón; Marques-López, Fernando; Martínez-Díaz, Santos; Slullitel, Pablo-I; Carabelli, Guido-S; Astore, Ignacio; Boietti, Bruno-Rafael; Cordova-Peralta, Julio-César; Hernández-Pascual, Carlos; Rodríguez-Gangoso, Alfredo; Dot-Pascuet, Iván; Pineiro-Borrero, Ana; Pérez-Sánchez, José-María; Mandia-Martínez, Alfonso; De-Caso-Rodríguez, Julio; Martín-Marcuello, Jordi; Benito-Mateo, Miguel; Alda-Gastiain, Oiane; Corcuera-Elosegui, Irene; González-Panisello, María-Rosa; Elizalde-Pérez-Salazar, Nicolás; De-Sande-Díaz, María (SPRINGER, 2025-12-22)
    BACKGROUND: Periprosthetic femoral fractures following hip arthroplasty (FH-PPF) represent a severe complication, especially in elderly patients with compromised health. Traditionally, revision arthroplasty is recommended ...
  • Identification of 4 autophagy-related genetic variants as risk factors for chronic lymphocytic leukemia 
    Cabrera-Serrano, Antonio-José; Sánchez-Maldonado, José-Manuel; Rodríguez-Sevilla, Juan-José; Reyes-Zurita, Fernando-Jesús; Collado, Rosa; Puiggros, Anna; Cornejo-Calvo, Elena; García-Martin, Paloma; Ter-Horst, Rob; Benavente, Yolanda; Jerez-Cayuela, Andrés; Landi, Stefano; Espinet, Blanca; Maffei, Rossana; López-Nevot, Miguel-Ángel; Ramos-Campoy, Silvia; González-Olmedo, Carmen; Chen-Liang, Tzu-Hua; Moreno, Victor; Jannus, Fatin; Marcos-Gragera, Rafael; Carretero-Fernández, María; Sampaio-Marques, Belem; Gamez, Irene; García-Álvarez, María; Camp, Nicola-J; Dierssen-Sotos, Trinidad; Kamaso, Joanna; Pérez, Eva-María; Norman, Aaron-D; Luppi, Mario; Li, Yang; Alcoceba, Miguel; Campa, Daniele; de-San-Jose, Silvia; Marasca, Roberto; Ludovico, Paula; Clay-Gilmour, Alyssa; Canzian, Federico; Ibáñez, Marian; Netea, Mihai-G; McKay, James; Casabonne, Delphine; Berndt, Sonja-I; Slager, Susan-L; Sainz, Juan (ELSEVIER, 2025-12-09)
    We investigated the influence of 55 583 autophagy-related single-nucleotide polymorphisms (SNPs) on chronic lymphocytic leukemia (CLL) risk across 4 independent populations comprising 5472 CLL cases and 726 465 controls. ...
  • Tafasitamab plus lenalidomide as salvage therapy in diffuse large B-cell lymphoma: real-world experience from GELTAMO 
    Gutiérrez, Antonio; Zeberio, Izaskun; Peñalver, Francisco-Javier; Martínez-Barranco, Pilar; Pérez, Sandra; Morillo, Daniel; Martin, Xabier; Nicolás, Concepción; Ferrero, Ainara; Jiménez-Ubieto, Ana; Bastos-Oreiro, Mariana; Dávila-Valls, Julio; Calle, María-Victoria; Pérez, María; Rodríguez, Guillermo; Alonso, Aranzazu; García-Noblejas, Ana; Sánchez-Argüello, Diana; Knight, Teresa; Fernández, Ángeles; López, Javier; Pérez-de-Oteyza, Jaime; González-de-Villambrosia, Sonia; Pérez, Elena; Marín, Alejandro; Navarro, María-Belén; Fernández, Rubén; Gómez, Pilar; Hueso, José-Antonio; Peñarrubia-Ponce, María-Jesús; Bravo, Pilar; García-Belmonte, Daniel; de-la-Nuez, Haridian; Nistal, Sara; Abrisqueta, Pau; Iban, Fernanda; Palomera, Luis; Donato, Eva; Provencio, Andrea; Infante, María-Stefania; González-Barca, Eva (ELSEVIER, 2025-10-14)
    Relapsed/refractory diffuse large B-cell lymphoma (R/R DLBCL) remains challenging to treat, especially in patients ineligible for intensive therapy or chimeric antigen receptor T cells. Tafasitamab plus lenalidomide (T/L) ...
  • Autologous stem cell transplantation for relapsed/refractory large B-cell lymphoma: a multicenter GETH-TC/GELTAMO study 
    Bento, Leyre; Gutiérrez, Antonio; Martínez, Carmen; Orti-Verdet, María-Consejo; Sorribes, Marina; Caballero, Ana-Carolina; Peña, Marta; Pérez, Ariadna; Jiménez-Ubieto, Ana; Medina, Lucía; Bastos-Oreiro, Mariana; Fernández-Caldas-González, Paula; Navarro, Belén; Salcedo, Isabel; Abrisqueta, Pau; Español-Morales, Ignacio; Cornago, Javier; Martín-Moro, Fernando; García, Lucía; Gómez, Pilar; Varela, María-Rosario; Puente, María; Zanabili, Joud; Zudaire, Teresa; Zeberio, Izaskun; del-Campo, Raquel; González, Leslie; González, Pedro; Blázquez, Cristina; Rovira, Jordina; Sitges, Marta; Franch-Sarto, Mireia; Cabero, Almudena; Mussetti, Alberto; Montoro, Juan; Sampol, Antonia; Sureda, Anna; Caballero, Dolores; Martín-García-Sancho, Alejandro (ELSEVIER, 2025-07-08)
    We performed a retrospective multicenter study including 791 patients with relapsed/refractory (R/R) large B-cell lymphoma (LBCL) who underwent autologous stem cell transplantation (ASCT). After a median follow-up of 74 ...
  • AML typical mutations ( CEBPA, FLT3, NPM1) identify a high-risk chronic myelomonocytic leukemia independent of CPSS molecular 
    Castaño-Diez, Sandra; López-Guerra, Mónica; Zugasti, Inés; Calvo, Xavier; Schulz, Felicitas-Isabel; Avendano, Alejandro; Mora, Elvira; Falantes, José; Azaceta, Gemma; Ibáñez, Maríam; Chen-Liang, Tzu-Hua; Notano, Cristina; Amer, Neus; Palomo, Laura; Pomares, Helena; Vila, Jordi; Bernal-del-Castillo, Teresa; Jiménez-Vicente, Carlos; Esteban, Daniel; Guijarro, Francesca; Álamo, José; Cortés-Bullich, Albert; Torrecillas-Mayayo, Victor; Triguero, Ana; Mont-de-Torres, Lucía; Carcelero, Ester; Cardus, Aina; Germing, Ulrich; Betz, Beate; Rozman, María; Arenillas, Leónor; Zamora, Lurdes; Diez-Campelo, María; Xicoy, Blanca; Esteve, Jordi; Díaz-Bey, Marina (ELSEVIER, 2025-01-14)
    Mutations commonly associated with acute myeloid leukemia (AML), such as CEBPA, FLT3, IDH1/2, and NPM1, are rarely found in chronic myelomonocytic leukemia (CMML), and their prognostic significance in CMML has not been ...
  • Revisiting Alma Ata: A Blueprint for Cancer Care 
    Benítez-Fuentes, Javier-David; Lastra-del-Prado, Rodrigo; Borregón-Rivilla, Miguel; de-Luna-Aguilar, Alicia; Lázaro-Sánchez, Antonio-David; Ferrandez-Arias, Asia; Rodríguez-Payá, Paula; Grau-Mirete, Beatriz; Quintanar-Verduguez, Teresa; Asensio-Martínez, Elena; Iranzo, Patricia; Callejo, Ana; Cruellas-Lapena, Mara; Gómez-Ulla, Jacobo; Rodríguez-Lescure, Álvaro (SAGE PUBLICATIONS INC, 2025-08)
    Despite significant advances in oncology, cancer care globally continues to face critical challenges, including stark disparities in access, insufficient preventive focus, fragmented primary health care (PHC) integration, ...
  • Inborn errors of immunity underlie clonal T cell expansions in large granular lymphocyte leukemia 
    Bravo-Pérez, Carlos; Gurnari, Carmelo; Huuhtanen, Jani; Kawashima, Naomi; Guarnera, Luca; Mandala, Aashray; Williams, Nakisha-D; Haddad, Christopher; Witt, Michaela; Unlu, Serhan; Brady, Zachary; Ogbue, Olisaemeka; Orland, Mark; Ahmed, Arooj; Kubota, Yasuo; Pagliuca, Simona; Durmaz, Arda; Mustjoki, Satu; Visconte, Valeria; Maciejewski, Jaroslaw-P (AMER SOC CLINICAL INVESTIGATION INC, 2025-05-01)
    BACKGROUNDT cell large granular lymphocyte leukemia (T-LGLL) is a lymphoproliferative disorder of cytotoxic T lymphocytes (CTLs), often with gain-of-function STAT3 mutations. T-LGLL represents a unique model for the study ...
  • Neoadjuvant Abemaciclib plus Letrozole vs. Chemotherapy in patients with HR+/HER2- Highly Proliferative Breast Cancer. 
    Martin, Miguel; Guerrero-Zotano, Ángel; Pérez-López, María-E; Ruiz-Borrego, Manuel; Martínez-Janez, Noelia; Chacon, José-I; Gil-Gil, Miguel; Andrés, Raquel; Bermejo, Begoña; Sánchez-Rovira, Pedro; Del-Barco, Sonia; Ponce, José-J; Fernández, Isaura; Martínez-de-Duenas, Eduardo; Hinojo-Gonzale, Carmen; González, Marta; García-Garre, Elisa; Hernando, Blanca; de-la-Haba-Rodríguez, Juan; Álvarez, Isabel-M; González-Santiago, Santiago; García-Saenz, José-A; Santaballa, Ana; Casas, Maribel; Bezares, Susana; Caballero, Rosalía; Rojo, Federico; Alba, Emilio (AACR JOURNALS, 2026-01-22)
    PURPOSE: Neoadjuvant chemotherapy is standard for high-risk hormone receptor-positive and human epidermal growth factor receptor 2-negative (HR+/HER2-) breast cancer. This study evaluates whether 12 months of letrozole ...

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