BACKGROUND: Advanced NSCLC patients with ECOG PS ?2 are common, under-represented in pivotal trials, and have inferior outcomes with immune checkpoint inhibitors. EU label coverage for ECOG PS ?2 and PS-based dosing guidance ...

miR-146a exhibits variable expression levels in humans due to rs2431697, which is associated with cardiovascular events. However, the functional mechanisms linking this genotype with the occurrence of thrombotic events ...

Background: The integrity of the alveolar ridge is compromised by tooth loss or trauma, initiating chronic resorption that alters bone morphology. Vertical bone augmentation (VBA) is a complex procedure required to ...

BACKGROUND: Peptide receptor radionuclide therapy (PRRT) has become a cornerstone in the management of neuroendocrine tumors (NETs), yet optimal sequencing and patient selection remain unsettled. This study aimed to develop ...

OBJECTIVES: Proteoforms affect biological and clinical processes and are anticipated to play a major role in establishing precision medicine. However, mass spectrometry-based proteoform tests generate complex data which ...

Purpose: To explore anatomically adjusted point-to-point relationships between macular sensitivity and intraretinal layer thickness in healthy and glaucomatous eyes using combined optical coherence tomography (OCT) and ...

BACKGROUND: Intravascular adenomyomatosis (IA), characterised by endometrial-type glands or stroma embedded within smooth muscle tissue inside myometrial vessels, is a rare variant within the spectrum of uterine intravenous ...

BACKGROUND: Assigning the ECOG performance status is critical for decision-making in oncology, but it poses challenges in hospitalized patients due to lower concordance and potential alteration by factors related to ...

Patients with end-stage lung diseases awaiting lung transplant frequently experience severe hypoxemia, dyspnea, and functional limitations that may compromise survival and transplant eligibility. Optimizing noninvasive ...

BACKGROUND: Laser technology is increasingly used in dentistry due to its minimally invasive properties. Among its applications, caries removal has gained attention. The most frequently used lasers in this context are ...