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Envíos recientes

03. IMIB (Instituto Murciano de Investigación Biosanitaria Pascual Parrilla): Envíos recientes

  • Epididymal and ejaculated sperm differ on their response to the cryopreservation and capacitation processes in mouflon (Ovis musimon) 
    Martínez-Fresneda, Lucía; Castaño, Cristina; Boveda, Paula; Tesfaye, Dawit; Schellander, Karl; Santiago-Moreno, Julián; García-Vázquez, Francisco-A (NATURE PORTFOLIO, 2019-10-30)
    Spermatozoa must undergo the process of capacitation to fertilize the egg which involves a cell destabilizing process. Capacitation-like changes such as protein tyrosine phosphorylation (PTP) are associated with cryopreservation. ...
  • Association of current and former smoking with body mass index: A study of smoking discordant twin pairs from 21 twin cohorts 
    Piirtola, Maarit; Jelenkovic, Aline; Latvala, Antti; Sund, Reijo; Honda, Chika; Inui, Fujio; Watanabe, Mikio; Tomizawa, Rie; Iwatani, Yoshinori; Ordoñana, Juan-Ramón; Sánchez-Romera, Juan-F; Colodro-Conde, Lucía; Tarnoki, Adam-D; Tarnoki, David-L; Martín, Nicholas-G; Montgomery, Grant-W; Medland, Sarah-E; Rasmussen, Finn; Tynelius, Per; Tan, Qihua; Zhang, Dongfeng; Pang, Zengchang; Rebato, Esther; Stazi, María-A; Fagnani, Corrado; Brescianini, Sonia; Busjahn, Andreas; Harris, Jennifer-R; Brandt, Ingunn; Nilsen, Thomas-Sevenius; Cutler, Tessa-L; Hopper, John-L; Corley, Robin-P; Huibregtse, Brooke-M; Sung, Joohon; Kim, Jina; Lee, Jooyeon; Lee, Sooji; Gatz, Margaret; Butler, David-A; Franz, Carol-E; Kremen, William-S; Lyons, Michael-J; Magnusson, Patrik-K-E; Pedersen, Nancy-L; Aslan, Anna-K-Dahl; Oncel, Sevgi-Y; Aliev, Fazil; Derom, Catherine-A; Vlietinck, Robert-F; Loos, Ruth-J-F; Silberg, Judy-L; Maes, Hermine-H; Boomsma, DorretI; Sorensen, Thorkild-I-A; Korhonen, Tellervo; Kaprio, Jaakko; Silventoinen, Karri (PUBLIC LIBRARY SCIENCE, 2018-07-12)
    BACKGROUND: Smokers tend to weigh less than never smokers, while successful quitting leads to an increase in body weight. Because smokers and non-smokers may differ in genetic and environmental family background, we analysed ...
  • Crystal structure of the C-terminal four-helix bundle of the potassium channel KCa3.1 
    Ji, Tianyang; Corbalán-García, Senena; Hubbard, Stevan-R (PUBLIC LIBRARY SCIENCE, 2018-06-28)
    KCa3.1 (also known as SK4 or IK1) is a mammalian intermediate-conductance potassium channel that plays a critical role in the activation of T cells, B cells, and mast cells, effluxing potassium ions to maintain a negative ...
  • Expression of LAIR-1 (CD305) on Human Blood Monocytes as a Marker of Hepatic Cirrhosis Progression 
    Martínez-Esparza, María; Ruiz-Alcaraz, Antonio-José; Carmona-Martínez, Violeta; Fernández-Fernández, María-Dolores; Anton, Gonzalo; Muñoz-Tornero, María; Lencina, Miriam; Pagan, Inmaculada; de-la-Pena, Jesús; García-Penarrubia, Pilar (HINDAWI LTD, 2019)
    BACKGROUND AND AIM: The presumed role of the inhibitory receptor LAIR-1 (CD305) in the inflammatory response suggests that it might contribute to the pathophysiology of chronic inflammatory diseases such as liver cirrhosis. ...
  • Microglia in Health and Disease: A Double-Edged Sword 
    Santiago, Ana-Raquel; Bernardino, Liliana; Agudo-Barriuso, Marta; Goncalves, Joana (THIEME MEDICAL PUBL INC, 2017)
  • Association between birthweight and later body mass index: an individual-based pooled analysis of 27 twin cohorts participating in the CODATwins project 
    Jelenkovic, Aline; Yokoyama, Yoshie; Sund, Reijo; Pietilainen, Kirsi-H; Hur, Yoon-Mi; Willemsen, Gonneke; Bartels, Meike; van-Beijsterveldt, Toos-C-E-M; Ooki, Syuichi; Saudino, Kimberly-J; Stazi, María-A; Fagnani, Corrado; D'Ippolito, Cristina; Nelson, Tracy-L; Whitfield, Keith-E; Knafo-Noam, Ariel; Mankuta, David; Abramson, Lior; Heikkila, Kauko; Cutler, Tessa-L; Hopper, John-L; Wardle, Jane; Llewellyn, Clare-H; Fisher, Abigail; Corley, Robin-P; Huibregtse, Brooke-M; Derom, Catherine-A; Vlietinck, Robert-F; Loos, Ruth-J-F; Bjerregaard-Andersen, Morten; Beck-Nielsen, Henning; Sodemann, Morten; Tarnoki, Adam-D; LTarnoki, David; Burt, S-Alexandra; Klump, Kelly-L; Ordoñana, Juan-Ramón; Sánchez-Romera, Juan-F; Colodro-Conde, Lucía; Dubois, Lise; Boivin, Michel; Brendgen, Mara; Dionne, Ginette; Vitaro, Frank; Harris, Jennifer-R; Brandt, Lngunn; Nilsen, Thomas-Sevenius; Craig, Jeffrey-M; Saffery, Richard; Rasmussen, Finn; Tynelius, Per; Bayasgalan, Gombojav; Narandalai, Danshiitsoodol; Haworth, Claire-M-A; Plomin, Robert; Ji, Fuling; Ning, Feng; Pang, Zengchang; Rebato, Esther; Krueger, Robert-F; Mcgue, Matt; Pahlen, Shandell; Boomsma, Dorret-I; Sorensen, Thorkild-I-A; Kaprio, Jaakko; Silventoinen, Karri (OXFORD UNIV PRESS, 2017-10)
    BACKGROUND: There is evidence that birthweight is positively associated with body mass index (BMI) in later life, but it remains unclear whether this is explained by genetic factors or the intrauterine environment. We ...
  • Comparison of diffusion, cytotoxicity and tissue inflammatory reactions of four commercial bleaching products against human dental pulp stem cells 
    Llena, Carmen; Collado-González, Mar; García-Bernal, D; Onate-Sánchez, R-E; Martínez, C-M; Moraleda-Jiménez, José-María; Rodríguez-Lozano, Francisco-Javier; Forner, L (NATURE PORTFOLIO, 2019-05-23)
    Multiple side effects related to bleaching were found to occur in the dental pulp tissue, including decreased cell metabolism and viability. In this work we evaluated the in vitro diffusion capacity, cytotoxicity and ...
  • Prevention of hatching of porcine morulae and blastocysts by liquid storage at 20 °C 
    Martínez-Serrano, Cristina-A; Cambra, Josep-M; Nohalez, Alicia; Parrilla, Inmaculada; Roca, Jordi; Vázquez, José-L; Rodríguez-Martínez, Heriberto; Gil, María-Antonia; Martínez, Emilio-A; Cuello, Cristina (NATURE PORTFOLIO, 2019-04-17)
    Vitrification is the ideal method for long-lasting storage of porcine embryos. However, both strict airline regulations for transport of liquid nitrogen dewars and the technical problems experienced when vitrified embryos ...
  • Establishing a Twin Register: An Invaluable Resource for (Behavior) Genetic, Epidemiological, Biomarker, and "Omics' Studies 
    Odintsova, Veronika-V; Willemsen, Gonneke; Dolan, Conor-V; Hottenga, Jouke-Jan; Martín, Nicholas-G; Slagboom, P-Eline; Ordoñana, Juan-Ramón; Boomsma, Dorret-I (CAMBRIDGE UNIV PRESS, 2018-06)
    Twin registers are wonderful research resources for research applications in medical and behavioral genetics, epidemiology, psychology, molecular genetics, and other areas of research. New registers continue to be launched ...
  • Human Wharton's jelly mesenchymal stem cells protect axotomized rat retinal ganglion cells via secretion of anti-inflammatory and neurotrophic factors 
    Millan-Rivero, José-E; Nadal-Nicolás, Francisco-M; García-Bernal, David; Sobrado-Calvo, Paloma; Blanquer-Blanquer, Miguel; Moraleda-Jiménez, José-María; Vidal-Sanz, Manuel; Agudo-Barriuso, Marta (NATURE PORTFOLIO, 2018-11-02)
    Mesenchymal stem cell (MSC) transplantation is emerging as an ideal tool to restore the wounded central nervous system (CNS). MSCs isolated from extra-embryonic tissues have some advantages compared to MSCs derived from ...
  • Circadian monitoring as an aging predictor 
    Martínez-Nicolás, A; Madrid, J-A; García, F-J; Campos, M; Moreno-Casbas, M-T; Almaida-Pagan, P-F; Lucas-Sánchez, A; Rol, M-A (NATURE PORTFOLIO, 2018-10-09)
    The ageing process is associated with sleep and circadian rhythm (SCR) frailty, as well as greater sensitivity to chronodisruption. This is essentially due to reduced day/night contrast, decreased sensitivity to light, ...
  • Characterization of human peritoneal monocyte/macrophage subsets in homeostasis: Phenotype, GATA6, phagocytic/oxidative activities and cytokines expression 
    Ruiz-Alcaraz, Antonio-José; Carmona-Martínez, Violeta; Tristan-Manzano, María; Machado-Linde, Francisco; Sánchez-Ferrer, María-Luisa; García-Penarrubia, Pilar; Martínez-Esparza, María (NATURE PORTFOLIO, 2018-08-24)
    Peritoneal macrophages play a critical role in the control of infectious and inflammatory diseases. Although recent progress on murine peritoneal macrophages has revealed multiple aspects on their origin and mechanisms ...
  • An Adult Zebrafish Model Reveals that Mucormycosis Induces Apoptosis of Infected Macrophages 
    López-Muñoz, Azucena; Nicolás, Francisco-E; García-Moreno, Diana; Pérez-Oliva, Ana-Belén; Navarro-Mendoza, María-I; Hernández-Onate, Miguel-A; Herrera-Estrella, Alfredo; Torres-Martínez, Santiago; Ruiz-Vázquez, Rosa-M; Garre, Victoriano; Mulero, Víctoriano (NATURE PORTFOLIO, 2018-08-24)
    Mucormycosis is a life-threatening fungal infection caused by various ubiquitous filamentous fungi of the Mucorales order, although Rhizopus spp. and Mucor spp. are the most prevalent causal agents. The limited therapeutic ...
  • Heritability of siesta and night-time sleep as continuously assessed by a circadian-related integrated measure 
    López-Mínguez, J; Morosoli, J-J; Madrid, J-A; Garaulet, Marta; Ordoñana, Juan-Ramón (NATURE PORTFOLIO, 2017-09-26)
    Siesta is a relevant aspect of sleep due to its posited relationship with health or cognitive function. However, unlike night-time sleep, studies about daytime-sleep determinants and characteristics are scarce, and the ...
  • Importance of time in therapeutic range on bleeding risk prediction using clinical risk scores in patients with atrial fibrillation 
    Rivera-Caravaca, José-Miguel; Roldán-Schilling, Vanessa; Esteve-Pastor, María-Asunción; Valdés-Chavarri, Mariano; Vicente, Vicente; Lip, Gregory-Y-H; Marín, Francisco (NATURE PORTFOLIO, 2017-09-21)
    Bleeding risk with vitamin K antagonists (VKAs) is closely related to the quality of anticoagulation in atrial fibrillation (AF) patients, reflected by time in therapeutic range (TTR). Here we compared the discrimination ...
  • The overlaying oil type influences in vitro embryo production: differences in composition and compound transfer into incubation medium between oils 
    Martínez-Serrano, Cristina-A; Nohalez, Alicia; Parrilla, Inmaculada; Motas, Miguel; Roca, Jordi; Romero, Inmaculada; García-González, Diego-L; Cuello, Cristina; Rodríguez-Martínez, Heriberto; Martínez, Emilio-A; Gil, María-Antonia (NATURE PORTFOLIO, 2017-09-05)
    The oil overlay micro-drop system is widely used for cultures of mammalian gametes and embryos. We evaluated hereby the effects of two unaltered commercial oils- Sigma mineral oil (S-MO) and Nidoil paraffin oil (N-PO)-on ...
  • P2X7 receptor induces mitochondrial failure in monocytes and compromises NLRP3 inflammasome activation during sepsis 
    Martínez-García, Juan-José; Martínez-Banaclocha, Helios; Angosto-Bazarra, Diego; de-Torre-Minguela, Carlos; Baroja-Mazo, Alberto; Alarcón-Vila, Cristina; Martínez-Alarcón, Laura; Amores-Iniesta, Joaquín; Martín-Sánchez, Fatima; Ercole, Giovanni-A; Martínez, Carlos-M; González-Lisorge, Ada; Fernández-Pacheco, José; Martínez-Gil, Piedad; Adriouch, Sahil; Koch-Nolte, Friedrich; Lujan, Juan; Acosta-Villegas, Francisco; Parrilla-Paricio, Pascual; García-Palenciano, Carlos; Pelegrín, Pablo (NATURE PORTFOLIO, 2019-06-20)
    Sepsis is characterized by a systemic inflammatory response followed by immunosuppression of the host. Metabolic defects and mitochondrial failure are common in immunocompromised patients with sepsis. The NLRP3 inflammasome ...
  • PTEN self-regulates through USP11 via the PI3K-FOXO pathway to stabilize tumor suppression 
    Park, Mi-Kyung; Yao, Yixin; Xia, Weiya; Setijono, Stephanie-Rebecca; Kim, Jae-Hwan; Vila, Isabelle-K; Chiu, Hui-Hsuan; Wu, Yun; Billalabeitia, Enrique-Gonzalez; Lee, Min-Gyu; Kalb, Robert-G; Hung, Mien-Chie; Pandolfi, Pier-Paolo; Song, Su-Jung; Song, Min-Sup (NATURE PUBLISHING GROUP, 2019-02-07)
    PTEN is a lipid phosphatase that antagonizes the PI3K/AKT pathway and is recognized as a major dose-dependent tumor suppressor. The cellular mechanisms that control PTEN levels therefore offer potential routes to therapy, ...
  • Comprehensive long-term efficacy and safety of recombinant human alpha-mannosidase (velmanase alfa) treatment in patients with alpha-mannosidosisKeywords 
    Lund, Allan-M; Borgwardt, Line; Cattaneo, Federica; Ardigo, Diego; Geraci, Silvia; Gil-Campos, Mercedes; de-Meirleir, Linda; Laroche, Cecile; Dolhem, Philippe; Cole, Duncan; Tylki-Szymanska, Anna; López-Rodríguez, Mónica; Guillén-Navarro, Encarna; Dali, Christine-I; Heron, Benedicte; Fogh, Jens; Muschol, Nicole; Phillips, Dawn; Van-den-Hout, J-M-Hannerieke; Jones, Simon-A; Amraoui, Yasmina; Harmatz, Paul; Guffon, Nathalie (SPRINGER, 2018-12)
    INTRODUCTION: Long-term outcome data provide important insights into the clinical utility of enzyme replacement therapies. Such data are presented for velmanase alfa in the treatment of alpha-mannosidosis (AM). METHODS: ...
  • Evaluating radiological response in pancreatic neuroendocrine tumours treated with sunitinib: comparison of Choi versus RECIST criteria (CRIPNET_ GETNE1504 study) 
    Pilar-Solis-Hernández, María; Fernández-del-Valle, Ana; Carmona-Bayonas, Alberto; García-Carbonero, Rocío; Custodio, Ana; Benavent, Marta; Alonso-Gordoa, Teresa; Núñez-Valdovino, Barbara; Sánchez-Cánovas, Manuel; Matos, Ignacio; Alonso, Vicente; López, Carlos; Viudez, Antonio; Izquierdo, Marta; Calvo-Temprano, David; Grande, Enrique; Capdevila, Jaume; Jiménez-Fonseca, Paula (NATURE PUBLISHING GROUP, 2019-10-01)
    BACKGROUND: The purpose of our study was to analyse the usefulness of Choi criteria versus RECIST in patients with pancreatic neuroendocrine tumours (PanNETs) treated with sunitinib. METHOD: A multicentre, prospective study ...

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