Repositorio Dspace

Envíos recientes

03. IMIB (Instituto Murciano de Investigación Biosanitaria Pascual Parrilla): Envíos recientes

  • Predicting long-term disease control in transplant-ineligible patients with multiple myeloma: impact of an MGUS-like signature 
    Rodríguez-Otero, Paula; Victoria-Mateos, María; Martínez-López, Joaquín; Hernández, Miguel-Teodoro; Ocio, Enrique-M; Rosinol, Laura; Martínez, Rafael; Teruel, Ana-Isabel; Gutiérrez, Norma-C; Bargay, Joan; Bengoechea, Enrique; González, Yolanda; Pérez-de-Oteyza, Jaime; Gironella, Mercedes; Núñez-Córdoba, Jorge-M; Encinas, Cristina; Martín, Jesús; Cabrera, Carmen; Palomera, Luis; de-Arriba, Felipe; Teresa-Cedena, María; Puig, Noemi; Oriol, Albert; Paiva, Bruno; Blade, Joan; Lahuerta, Juan-José; San-Miguel, Jesús-F (NATURE PUBLISHING GROUP, 2019-03-18)
    Disease control at 5 years would be a desirable endpoint for elderly multiple myeloma (MM) patients, but biomarkers predicting this are not defined. Therefore, to gain further insights in this endpoint, a population of 498 ...
  • Exome sequencing identifies germline variants in DIS3 in familial multiple myeloma 
    Pertesi, Maroulio; Vallee, Maxime; Wei, Xiaomu; Revuelta, María-V; Galia, Perrine; Demangel, Delphine; Oliver, Javier; Foll, Matthieu; Chen, Siwei; Perrial, Emeline; Garderet, Laurent; Corre, Jill; Leleu, Xavier; Boyle, Eileen-M; Decaux, Olivier; Rodon, Philippe; Kolb, Brigitte; Slama, Borhane; Mineur, Philippe; Voog, Eric; Le-Bris, Catherine; Fontan, Jean; Maigre, Michel; Beaumont, Marie; Azais, Isabelle; Sobol, Hagay; Vignon, Marguerite; Royer, Bruno; Perrot, Aurore; Fuzibet, Jean-Gabriel; Dorvaux, Veronique; Anglaret, Bruno; Cony-Makhoul, Pascale; Berthou, Christian; Desquesnes, Florence; Pegourie, Brigitte; Leyvraz, Serge; Mosser, Laurent; Frenkiel, Nicole; Augeul-Meunier, Karine; Leduc, Isabelle; Leyronnas, Cecile; Voillat, Laurent; Casassus, Philippe; Mathiot, Claire; Cheron, Nathalie; Paubelle, Etienne; Moreau, Philippe; Bignon, Yves-Jean; Joly, Bertrand; Bourquard, Pascal; Caillot, Denis; Naman, Herve; Rigaudeau, Sophie; Marit, Gerald; Macro, Margaret; Lambrecht, Isabelle; Cliquennois, Manuel; Vincent, Laure; Helias, Philippe; Avet-Loiseau, Herve; Moreno, Víctor; Reis, Rui-Manuel; Varkonyi, Judit; Kruszewski, Marcin; Vangsted, Annette-Juul; Jurczyszyn, Artur; Zaucha, Jan-Maciej; Sainz, Juan; Krawczyk-Kulis, Malgorzata; Watek, Marzena; Pelosini, Matteo; Iskierka-Jazdzewska, Elzbieta; Grzasko, Norbert; Martínez-López, Joaquín; Jerez-Cayuela, Andrés; Campa, Daniele; Buda, Gabriele; Lesueur, Fabienne; Dudzinski, Marek; García-Sanz, Ramón; Nagler, Arnon; Rymko, Marcin; Jamroziak, Krzysztof; Butrym, Aleksandra; Canzian, Federico; Obazee, Ofure; Nilsson, Bjorn; Klein, Robert-J; Lipkin, Steven-M; McKay, James-D; Dumontet, Charles (NATURE PUBLISHING GROUP, 2019-09)
  • Lytic cell death induced by melittin bypasses pyroptosis but induces NLRP3 inflammasome activation and IL-1ß release 
    Martín-Sánchez, Fatima; Martínez-García, Juan-José; Muñoz-García, María; Martínez-Villanueva, Miriam; Noguera-Velasco, José-Antonio; Andreu, David; Rivas, Luis; Pelegrín, Pablo (NATURE PUBLISHING GROUP, 2017-08)
    The nucleotide-binding domain and leucine-rich repeat-containing receptor with a pyrin domain 3 (NLRP3) inflammasome is a sensor for different types of infections and alterations of homeostatic parameters, including ...
  • Elosulfase alfa for mucopolysaccharidosis type IVA: Real-world experience in 7 patients from the Spanish Morquio-A early access program 
    Pintos-Morell, Guillem; Blasco-Alonso, Javier; Couce, María-L; Gutiérrez-Solana, Luis-G; Guillén-Navarro, Encarna; O'Callaghan, Mar; del-Toro, Mireia (ELSEVIER SCIENCE BV, 2018-06)
    There is a growing interest in evaluating the effectiveness of enzyme replacement therapy (ERT) with elosulfase alfa in patients with mucopolysaccharidosis type IVA (MPS-IVA) under real-world conditions. We present the ...
  • Are Environmental Factors for Atopic Eczema in ISAAC Phase Three due to Reverse Causation? 
    Rutter, Charlotte-E; Silverwood, Richard-J; Williams, Hywel-C; Ellwood, Philippa; Asher, Innes; García-Marcos, Luis; Strachan, David-P; Pearce, Neil; Langan, Sinead-M; Ait-Khaled, N; Anderson, H-R; Asher, MI; Beasley, R; Bjorksten, B; Brunekreef, B; Crane, J; Ellwood, P; Flohr, C; Foliaki, S; Forastiere, F; García-Marcos, Luis; Keil, U; Lai, C-K-W; Mallol, J; Mitchell, E-A; Montefort, S; Odhiambo, J; Pearce, N; Robertson, C-F; Stewart, A-W; Strachan, D; von-Mutius, E; Weiland, S-K; Weinmayr, G; Williams, H-C; Wong, G; Clayton, T-O; Ellwood, E; Baena-Cagnani, C-E; Gómez, M; Howitt, M-E; Weyler, J; Pinto-Vargas, R; da-Cunha, A-J; de-Freitas-Souza, L; Kuaban, C; Ferguson, A; Rennie, D; Standring, P; Aguilar, P; Amarales, L; Benavides, L-A; Contreras, A; Chen, Y-Z; Kunii, O; Pan, Q-Li; Zhong, N-S; Aristizabal, G; Cepeda, A-M; Ordóñez, G-A; Bustos, C; Riikjarv, M-A; Melaku, K; Sa'aga-Banuve, R; Pekkanen, J; Hypolite, I-E; Novak, Z; Zsigmond, G; Awasthi, S; Bhave, S; Hanumante, N-M; Jain, K-C; Joshi, M-K; Khatav, V-A; Mantri, S-N; Pherwani, AV; Rego, S; Sabir, M; Salvi, S; Setty, G; Sharma, S-K; Singh, V; Sukumaran, T; Babu, P-S-Suresh; Kartasasmita, C-B; Konthen, P; Suprihati, W; Masjedi, M-R; Steriu, A; Koffi, B-N; Odajima, H; al-Momen, J-A; Imanalieva, C; Kudzyte, J; Quah, B-S; Teh, K-H; Baeza-Bacab, M; Barragan-Meijueiro, M; del-Rio-Navarro, B-E; García-Almaraz, R; González-Díaz, S-N; Linares-Zapien, F-J; Merida-Palacio, JV; Ramírez-Chanona, N; Romero-Tapia, S; Romieu, I; Bouayad, Z; MacKay, R; Moyes, C; Pattemore, P; Onadeko, B-O; Cukier, G; Chiarella, P; Cua-Lim, F; Breborowicz, A; Sole, D; Sears, M; Aguirre, V; Barba, S; Shah, J; Baratawidjaja, K; Nishima, S; de-Bruyne, J; Tuuau-Potoi, N; Lai, C-K; Lee, B-W; El-Sony, A; Anderson, R (ELSEVIER SCIENCE INC, 2019-05)
    Some previously described environmental associations for atopic eczema may be due to reverse causation. We explored the role of reverse causation by comparing individual- and school-level results for multiple atopic eczema ...
  • Models of human psoriasis: Zebrafish the newly appointed player 
    Martínez-Navarro, F-J; Martínez-Menchon, T; Mulero, V; Galindo-Villegas, Jorge (ELSEVIER SCI LTD, 2019-08)
    Psoriasis is a human chronic, immune disease with severe cutaneous and systemic manifestations. Its prevalence, among the world population, highly varies with ethnicity and geography, but not sex from remarkable low levels ...
  • Fruit and vegetable intake and prostate cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) 
    Pérez-Cornago, Aurora; Travis, Ruth-C; Appleby, Paul-N; Tsilidis, Konstantinos-K; Tjonneland, Anne; Olsen, Anja; Overvad, Kim; Katzke, Verena; Kuehn, Tilman; Trichopoulou, Antonia; Peppa, Eleni; Kritikou, María; Sieri, Sabina; Palli, Domenico; Sacerdote, Carlotta; Tumino, Rosario; Bueno-de-Mesquita, Bas; Agudo, Antonio; Larrañaga, Nerea; Molina-Portillo, Elena; Ardanaz, Eva; Chirlaque-López, María-Dolores; Lasheras, Cristina; Stattin, Par; Wennberg, María; Drake, Isabel; Malm, Johan; Schmidt, Julie-A; Khaw, Kay-Tee; Gunter, Marc; Freisling, Heinz; Huybrechts, Inge; Aune, Dagfinn; Cross, Amanda-J; Riboli, Elio; Key, Timothy-J (WILEY, 2017-07-15)
    Several dietary factors have been studied in relation to prostate cancer; however, most studies have not reported on subtypes of fruit and vegetables or tumor characteristics, and results obtained so far are inconclusive. ...
  • Potential role of P2X7 receptor in neurodegenerative processes in a murine model of glaucoma 
    Pérez-de-Lara, María-J; Avilés-Trigueros, Marcelino; Guzman-Aranguez, Ana; Valiente-Soriano, Francisco-Javier; de-la-Villa, Pedro; Vidal-Sanz, Manuel; Pintor, Jesús (PERGAMON-ELSEVIER SCIENCE LTD, 2019-08)
    Glaucoma is a common cause of visual impairment and blindness, characterized by retinal ganglion cell (RGC) death. The mechanisms that trigger the development of glaucoma remain unknown and have gained significant relevance ...
  • A Systematic Review of Fitness Apps and Their Potential Clinical and Sports Utility for Objective and Remote Assessment of Cardiorespiratory Fitness 
    Muntaner-Mas, Adria; Martínez-Nicolás, Antonio; Lavie, Carl-J; Blair, Steven-N; Ross, Robert; Arena, Ross; Ortega, Francisco-B (ADIS INT LTD, 2019-04)
    BACKGROUND: Cardiorespiratory fitness (CRF) assessment provides key information regarding general health status that has high clinical utility. In addition, in the sports setting, CRF testing is needed to establish a ...
  • Effects of Social Attitude Change on Smoking Heritability 
    Mezquita, Laura; Sánchez-Romera, Juan-F; Ibáñez, Manuel-I; Morosoli, José-J; Colodro-Conde, Lucía; Ortet, Generos; Ordoñana, Juan-Ramón (SPRINGER, 2018-01)
    Societal attitudes and norms to female smoking changed in Spain in the mid-twentieth century from a restrictive to a tolerant, and an even pro-smoking, posture, while social attitudes remained stable for males. We explored ...
  • A nutrient-wide association study for risk of prostate cancer in the European Prospective Investigation into Cancer and Nutrition and the Netherlands Cohort Study 
    Papadimitriou, Nikos; Muller, David; van-den-Brandt, Piet-A; Geybels, Milan; Patel, Chirag-J; Gunter, Marc; López, David-S; Key, Timothy-J; Pérez-Cornago, Aurora; Ferrari, Pietro; Vineis, Paolo; Weiderpass, Elisabete; Boeing, Heiner; Agudo, Antonio; Sánchez, Maria-Jose; Overvad, Kim; Kuehn, Tilman; Fortner, Renee-T; Palli, Domenico; Drake, Isabel; Bjartell, Anders; Santiuste-de-Pablos, Carmen; Bueno-de-Mesquita, Bas; Krogh, Vittorio; Tjonneland, Anne; Lauritzen, Dorthe-Furstrand; Barricarte-Gurrea, Aurelio; Quirós, José-Ramón; Stattin, Par; Trichopoulou, Antonia; Martimianaki, Georgia; Karakatsani, Anna; Thysell, Elin; Johansson, Ingegerd; Ricceri, Fulvio; Tumino, Rosario; Larrañaga, Nerea; Khaw, Kay-Tee; Riboli, Elio; Tzoulaki, Ioanna; Tsilidis, Konstantinos-K (SPRINGER HEIDELBERG, 2020-10)
    PURPOSE: The evidence from the literature regarding the association of dietary factors and risk of prostate cancer is inconclusive. METHODS: A nutrient-wide association study was conducted to systematically and comprehensively ...
  • Interplay between genetic predisposition, macronutrient intake and type 2 diabetes incidence: analysis within EPIC-InterAct across eight European countries 
    Li, Sherly-X; Imamura, Fumiaki; Schulze, Matthias-B; Zheng, Jusheng; Ye, Zheng; Agudo, Antonio; Ardanaz, Eva; Aune, Dagfinn; Boeing, Heiner; Dorronsoro, Miren; Dow, Courtney; Fagherazzi, Guy; Grioni, Sara; Gunter, Marc; Huerta-Castaño, José-María; Ibsen, Daniel-B; Jakobsen, Marianne-Uhre; Kaaks, Rudolf; Key, Timothy-J; Khaw, Kay-Tee; Kyro, Cecilie; Mancini, Francesca-Romana; Molina-Portillo, Elena; Murphy, Neil; Nilsson, Peter-M; Onland-Moret, N-Charlotte; Palli, Domenico; Panico, Salvatore; Poveda, Alaitz; Quirós, J-Ramón; Ricceri, Fulvio; Sluijs, Ivonne; Spijkerman, Annemieke-M-W; Tjonneland, Anne; Tumino, Rosario; Winkvist, Anna; Langenberg, Claudia; Sharp, Stephen-J; Riboli, Elio; Scott, Robert-A; Forouhi, Nita-G; Wareham, Nicholas-J (SPRINGER, 2018-06)
    AIMS/HYPOTHESIS: Gene-macronutrient interactions may contribute to the development of type 2 diabetes but research evidence to date is inconclusive. We aimed to increase our understanding of the aetiology of type 2 diabetes ...
  • Prediagnostic circulating concentrations of plasma insulin-like growth factor-I and risk of lymphoma in the European Prospective Investigation into Cancer and Nutrition 
    Pérez-Cornago, Aurora; Appleby, Paul-N; Tipper, Sarah; Key, Timothy-J; Allen, Naomi-E; Nieters, Alexandra; Vermeulen, Roel; Roulland, Sandrine; Casabonne, Delphine; Kaaks, Rudolf; Fortner, Renee-T; Boeing, Heiner; Trichopoulou, Antonia; La-Vecchia, Carlo; Klinaki, Eleni; Hansen, Louise; Tjonneland, Anne; Bonnet, Fabrice; Fagherazzi, Guy; Boutron-Ruault, Marie-Christine; Pala, Valeria; Masala, Giovanna; Sacerdote, Carlotta; Peeters, Petra-H; Bueno-de-Mesquita, Bas; Weiderpass, Elisabete; Dorronsoro, Miren; Quirós, J-Ramón; Barricarte-Gurrea, Aurelio; Gavrila-Chervase, Diana; Agudo, Antonio; Borgquist, Signe; Rosendahl, Ann-H; Melin, Beatrice; Wareham, Nick; Khaw, Kay-Tee; Gunter, Marc; Riboli, Elio; Vineis, Paolo; Travis, Ruth-C (WILEY, 2017-03-01)
    Insulin-like growth factor (IGF)-I has cancer promoting activities. However, the hypothesis that circulating IGF-I concentration is related to risk of lymphoma overall or its subtypes has not been examined prospectively. ...
  • Saturation of acyl chains converts cardiolipin from an antagonist to an activator of Toll-like receptor-4 
    Pizzuto, Malvina; Lonez, Caroline; Baroja-Mazo, Alberto; Martínez-Banaclocha, Helios; Tourlomousis, Panagiotis; Gangloff, Monique; Pelegrín, Pablo; Ruysschaert, Jean-Marie; Gay, Nicholas-J; Bryant, Clare-E (SPRINGER BASEL AG, 2019-09)
    Cardiolipins (CLs) are tetra-acylated diphosphatidylglycerols found in bacteria, yeast, plants, and animals. In healthy mammals, CLs are unsaturated, whereas saturated CLs are found in blood cells from Barth syndrome ...
  • Pre-diagnostic circulating insulin-like growth factor-I and bladder cancer risk in the European Prospective Investigation into Cancer and Nutrition 
    Lin, Crystal; Travis, Ruth-C; Appleby, Paul-N; Tipper, Sarah; Weiderpass, Elisabete; Chang-Claude, Jenny; Gram, Inger-T; Kaaks, Rudolf; Kiemeney, Lambertus-A; Ljungberg, Borje; Tumino, Rosario; Tjonneland, Anne; Roswall, Nina; Overvad, Kim; Boutron-Ruault, Marie-Christine; Manciniveri, Francesca-Romana; Severi, Gianluca; Trichopoulou, Antonia; Masala, Giovanna; Sacerdote, Carlotta; Agnoli, Claudia; Panico, Salvatore; Bueno-de-Mesquita, Bas; Peeters, Petra-H; Salamanca-Fernández, Elena; Chirlaque-López, María-Dolores; Ardanaz, Eva; Dorronsoro, Miren; Menéndez, Virginia; Lujan-Barroso, Leila; Liedberg, Fredrik; Freisling, Heinz; Gunter, Marc; Aune, Dagfinn; Cross, Amanda-J; Riboli, Elio; Key, Timothy-J; Pérez-Cornago, Aurora (WILEY, 2018-11-15)
    Previous in vitro and case-control studies have found an association between the insulin-like growth factor (IGF)-axis and bladder cancer risk. Circulating concentrations of IGF-I have also been found to be associated with ...
  • Association Between Soft Drink Consumption and Mortality in 10 European Countries 
    Mullee, Amy; Romaguera, Dora; Pearson-Stuttard, Jonathan; Viallon, Vivian; Stepien, Magdalena; Freisling, Heinz; Fagherazzi, Guy; Mancini, Francesca-Romana; Boutron-Ruault, Marie-Christine; Kuehn, Tilman; Kaaks, Rudolf; Boeing, Heiner; Aleksandrova, Krasimira; Tjonneland, Anne; Halkjaer, Jytte; Overvad, Kim; Weiderpass, Elisabete; Skeie, Guri; Parr, Christine-L; Quirós, J-Ramón; Agudo, Antonio; Sánchez, Maria-Jose; Amiano, Pilar; Cirera-Suárez, LLuis; Ardanaz, Eva; Khaw, Kay-Tee; Tong, Tammy-Y-N; Schmidt, Julie-A; Trichopoulou, Antonia; Martimianaki, Georgia; Karakatsani, Anna; Palli, Domenico; Agnoli, Claudia; Tumino, Rosario; Sacerdote, Carlotta; Panico, Salvatore; Bueno-de-Mesquita, Bas; Verschuren, W-M-Monique; Boer, Jolanda-M-A; Vermeulen, Roel; Ramne, Stina; Sonestedt, Emily; van-Guelpen, Bethany; Holgersson, Pernilla-Lif; Tsilidis, Konstantinos-K; Heath, Alicia-K; Muller, David; Riboli, Elio; Gunter, Marc; Murphy, Neil (AMER MEDICAL ASSOC, 2019-11)
    IMPORTANCE: Soft drinks are frequently consumed, but whether this consumption is associated with mortality risk is unknown and has been understudied in European populations to date. OBJECTIVE: To examine the association ...
  • ZP4 confers structural properties to the zona pellucida essential for embryo development 
    Lamas-Toranzo, Ismael; Fonseca-Balvis, Noelia; Querejeta-Fernández, Ana; Izquierdo-Rico, María-José; González-Brusi, Leopoldo; Lorenzo, Pedro-L; García-Rebollar, Pilar; Avilés, Manuel; Bermejo-Álvarez, Pablo (ELIFE SCIENCES PUBLICATIONS LTD, 2019-10-22)
    Zona pellucida (ZP), the extracellular matrix sheltering mammalian oocytes and embryos, is composed by 3 to 4 proteins. The roles of the three proteins present in mice have been elucidated by KO models, but the function ...
  • DNA methylation and gene expression changes derived from assisted reproductive technologies can be decreased by reproductive fluids 
    Cánovas, Sebastián; Ivanova, Elena; Romar, Raquel; García-Martínez, Soledad; Soriano-Úbeda, Cristina; García-Vazquez, Francisco-A; Saadeh, Heba; Andrews, Simon; Kelsey, Gavin; Coy-Fuster, Pilar (ELIFE SCIENCES PUBLICATIONS LTD, 2017-02-01)
    The number of children born since the origin of Assisted Reproductive Technologies (ART) exceeds 5 million. The majority seem healthy, but a higher frequency of defects has been reported among ART-conceived infants, ...
  • L-Ferritin: One Gene, Five Diseases; from Hereditary Hyperferritinemia to Hypoferritinemia-Report of New Cases 
    Cadenas, Beatriz; Fita-Torro, Josep; Bermudez-Cortés, Mar; Hernández-Rodríguez, Inés; Fuster-Soler, José-Luis; Llinares, María-Esther; Galera-Miñarro, Ana-María; Romero, Julia-Lee; Pérez-Montero, Santiago; Tornador, Cristian; Sánchez, Mayka (MDPI, 2019-01-23)
    Ferritin is a multimeric protein composed of light (L-ferritin) and heavy (H-ferritin) subunits that binds and stores iron inside the cell. A variety of mutations have been reported in the L-ferritin subunit gene (FTL gene) ...
  • Vitamin D-Related Genes, Blood Vitamin D Levels and Colorectal Cancer Risk in Western European Populations 
    Fedirko, Veronika; Mandle, Hannah-B; Zhu, Wanzhe; Hughes, David-J; Siddiq, Afshan; Ferrari, Pietro; Romieu, Isabelle; Riboli, Elio; Bueno-de-Mesquita, Bas; van-Duijnhoven, Franzel-J-B; Siersema, Peter-D; Tjonneland, Anne; Olsen, Anja; Perduca, Vittorio; Carbonnel, Franck; Boutron-Ruault, Marie-Christine; Kuehn, Tilman; Johnson, Theron; Krasimira, Aleksandrova; Trichopoulou, Antonia; Makrythanasis, Periklis; Thanos, Dimitris; Panico, Salvatore; Krogh, Vittorio; Sacerdote, Carlotta; Skeie, Guri; Weiderpass, Elisabete; Colorado-Yohar, Sandra; Sala, Nuria; Barricarte-Gurrea, Aurelio; Sánchez, María-José; Quirós, José-Ramón; Amiano, Pilar; Gylling, Bjorn; Harlid, Sophia; Pérez-Cornago, Aurora; Heath, Alicia-K; Tsilidis, Konstantinos-K; Aune, Dagfinn; Freisling, Heinz; Murphy, Neil; Gunter, Marc-J; Jenab, Mazda (MDPI, 2019-08)
    Higher circulating 25-hydroxyvitamin D levels (25(OH)D) have been found to be associated with lower risk for colorectal cancer (CRC) in prospective studies. Whether this association is modified by genetic variation in genes ...

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