Repositorio Dspace

Envíos recientes

03. IMIB (Instituto Murciano de Investigación Biosanitaria Pascual Parrilla): Envíos recientes

  • Primary results of the Spanish Cryoballoon Ablation Registry: acute and long-term outcomes of the RECABA study 
    Ferrero-De-Loma-Osorio, Angel; Cozar, Rocio; García-Alberola, Arcadi; Valles, Ermengol; Barrera, Alberto; Toquero, Jorge; Miguel-Ormaetxe, José; Martínez-Sánchez, Juan; Ruiz-Granell, Ricardo; Bastos-Amador, Pablo; Manuel-Rubio, José; Marti-Amor, Julio; Pascual, Patricia; Molina, Irene; Daniel-Martínez-Alday, Jesus (NATURE PORTFOLIO, 2021-08-26)
    Cryoablation is safe and effective for the treatment of atrial fibrillation (AF) in controlled clinical trials, but contemporary real-world usage and outcomes are limited. The Report of the Spanish Cryoballoon Ablation ...
  • Extracellular NLRP3 inflammasome particles are internalized by human coronary artery smooth muscle cells and induce pro-atherogenic effects 
    Gaul, Susanne; Schaeffer, Karen-Marie; Opitz, Lena; Maeder, Christina; Kogel, Alexander; Uhlmann, Luisa; Kalwa, Hermann; Wagner, Ulf; Haas, Jan; Behzadi, Amirhossein; Pelegrín, Pablo; Boeckel, Jes-Niels; Laufs, Ulrich (NATURE PORTFOLIO, 2021-07)
    Inflammation driven by intracellular activation of the NLRP3 inflammasome is involved in the pathogenesis of a variety of diseases including vascular pathologies. Inflammasome specks are released into the extracellular ...
  • PRMT1-dependent methylation of BRCA1 contributes to the epigenetic defense of breast cancer cells against ionizing radiation 
    Montenegro, María-F; González-Guerrero, Rebeca; Sánchez-del-Campo, Luis; Pinero-Madrona, Antonio; Cabezas-Herrera, Juan; Neptuno-Rodríguez-López, Jose (NATURE PORTFOLIO, 2020-08-06)
    The therapeutic effect of irradiation is thought to come from DNA damage that affects rapidly proliferating cancer cells; however, resistant cells rapidly initiate mechanisms to repair such damage. While DNA repair mechanisms ...
  • Ambulatory circadian monitoring in sleep disordered breathing patients and CPAP treatment 
    Martínez-Nicolas, Antonio; Guaita, Marc; Santamaria, Joan; Montserrat, Josep-M; Antonio-Madrid, Juan; Angeles-Rol, María (NATURE PORTFOLIO, 2021-07)
    Our aim was to evaluate the circadian rhythm of motor activity, body position and integrated variable TAP (composed by wrist Temperature, motor Activity and body Position) in Sleep Disordered Breathing (SDB), its relation ...
  • Prediction of quality of life in early breast cancer upon completion of adjuvant chemotherapy 
    Carmona-Bayonas, Alberto; Calderon, Caterina; Hernández, Raquel; Montes, Ana-Fernández; Castelo, Beatriz; Ciria-Suárez, Laura; Antonanzas, Monica; Rogado, Jacobo; Pacheco-Barcia, Vilma; Martínez, Elena-Asensio; Ivars, Alejandra; de-la-Pena, Francisco-Ayala; Jiménez-Fonseca, Paula (NATURE PORTFOLIO, 2021-07)
    Quality of life (QoL) is a complex, ordinal endpoint with multiple conditioning factors. A predictive model of QoL after adjuvant chemotherapy can support decision making or the communication of information about the range ...
  • Prediction of survival in patients with advanced, refractory colorectal cancer in treatment with trifluridine/tipiracil: real-world vs clinical trial data 
    Fernández-Montes, Ana; Carmona-Bayonas, Alberto; Jiménez-Fonseca, Paula; Vazquez-Rivera, Francisca; Martínez-Lago, Nieves; Covela-Rua, Marta; Cousillas-Castineiras, Antia; González-Villarroel, Paula; De-la-Camara-Gómez, Juan; Carlos-Mendez-Mendez, José; Carriles-Fernández, Carmen; Sánchez-Canovas, Manuel; García-García, Teresa (NATURE PORTFOLIO, 2021-07)
    Trifluridine/tipiracil increases overall survival (OS) in patients with refractory, metastatic colorectal cancer (mCRC). A post hoc exploratory analysis of the RECOURSE randomized clinical trial (RCT) established two ...
  • Gasdermins mediate cellular release of mitochondrial DNA during pyroptosis and apoptosis 
    de-Torre-Minguela, Carlos; Gómez, Ana-I; Couillin, Isabelle; Pelegrín, Pablo (WILEY, 2021-08)
    Pyroptosis and intrinsic apoptosis are two forms of regulated cell death driven by active caspases where plasma membrane permeabilization is induced by gasdermin pores. Caspase-1 induces gasdermin D pore formation during ...
  • Exhaled volatilome analysis as a useful tool to discriminate asthma with other coexisting atopic diseases in women of childbearing age 
    Sola-Martínez, Rosa-A; Lozano-Terol, Gema; Gallego-Jara, Julia; Morales, Eva; Cantero-Cano, Esther; Sánchez-Solis, Manuel; García-Marcos, Luis; Jiménez-Guerrero, Pedro; Noguera-Velasco, José-A; Canovas-Diaz, Manuel; de-Diego-Puente, Teresa (NATURE PORTFOLIO, 2021-07)
    The prevalence of asthma is considerably high among women of childbearing age. Most asthmatic women also often have other atopic disorders. Therefore, the differentiation between patients with atopic diseases without asthma ...
  • Clinical Features and Outcomes of Streptococcus anginosus Group Infective Endocarditis: A Multicenter Matched Cohort Study 
    Escrihuela-Vidal, Francesc; Eduardo-López-Cortes, Luis; Escola-Verge, Laura; De-Alarcon-González, Aristides; Cuervo, Guillermo; Sánchez-Porto, Antonio; Fernández-Hidalgo, Nuria; Luque, Rafael; Montejo, Miguel; Miro, José-M; Angel-Goenaga, Miguel; Munoz, Patricia; Valerio, Maricela; Ripa, Marco; Sousa-Regueiro, Dolores; Gurgui, Merce; Carmen-Farinas-Alvarez, María; Mateu, Lourdes; García-Vazquez, Elisa; Galvez-Acebal, Juan; Carratala, Jordi (OXFORD UNIV PRESS INC, 2021-06)
    BACKGROUND: Although Streptococcus anginosus group (SAG) endocarditis is considered a severe disease associated with abscess formation and embolic events, there is limited evidence to support this assumption. METHODS: We ...
  • Timing of chocolate intake affects hunger, substrate oxidation, and microbiota: A randomized controlled trial 
    Hernández-González, Teresa; González-Barrio, Rocio; Escobar, Carolina; Antonio-Madrid, Juan; Jesus-Periago, María; Carmen-Collado, María; Scheer, Frank-AJL; Garaulet, Marta (WILEY, 2021-07)
    Eating chocolate in the morning or in the evening/at night, may differentially affect energy balance and impact body weight due to changes in energy intake, substrate oxidation, microbiota (composition/function), and ...
  • Identification of differentially expressed genes profiles in a combined mouse model of Parkinsonism and colitis 
    Gil-Martínez, AL; Cuenca-Bermejo, L; González-Cuello, AM; Sánchez-Rodrigo, C; Parrado, A; Vyas, S; Fernández-Villalba, E; Herrero, MT (NATURE PORTFOLIO, 2020-08-04)
    Different cellular mechanisms have been described as being potentially involved in the progression of neurodegeneration in Parkinson's disease, although their role is still unclear. The present study aimed to identify in ...
  • Disparity between central and peripheral refraction inheritance in twins 
    Pusti, Dibyendu; Benito, Antonio; Madrid-Valero, Juan-J; Ordonana, Juan-R; Artal, Pablo (NATURE PORTFOLIO, 2021-06)
    The last decades have witnessed a sudden increase in myopia incidence among youngsters that have been related to modern lifestyle along with the use of emerging technologies affecting visual exposure. Increasing exposures ...
  • Cardiovascular risk factors, cardiovascular disease, and COVID-19: an umbrella review of systematic reviews 
    Harrison, Stephanie-L; Buckley, Benjamin-JR; Miguel-Rivera-Caravaca, José; Zhang, Juqian; Lip, Gregory-YH (OXFORD UNIV PRESS, 2021-10)
    AIMS: To consolidate evidence to determine (i) the association between cardiovascular risk factors and health outcomes with coronavirus 2019 (COVID-19); and (ii) the impact of COVID-19 on cardiovascular health. METHODS AND ...
  • Differentiation of human adult-derived stem cells towards a neural lineage involves a dedifferentiation event prior to differentiation to neural phenotypes 
    Bueno, Carlos; Martínez-Morga, Marta; García-Bernal, David; Moraleda-Jiménez, José-María; Martínez, Salvador (NATURE PORTFOLIO, 2021-06)
    Although it has been reported that mesenchymal stem cells isolated from adult tissues can be induced to overcome their mesenchymal fate and transdifferentiate into neural cells, the findings and their interpretation have ...
  • Evidence of haptoglobin in the porcine female genital tract during oestrous cycle and its effect on in vitro embryo production 
    García-Vazquez, Francisco-A; Moros-Nicolas, Carla; López-Ubeda, Rebeca; Rodríguez-Tobon, Ernesto; Guillen-Martínez, Ascension; Ross, Jason-W; Luongo, Chiara; Matas, Carmen; Hernández-Caravaca, Ivan; Aviles, Manuel; José-Izquierdo-Rico, Ma (NATURE PORTFOLIO, 2021-06)
    Recent evidence supports involvement of the acute phase protein haptoglobin in numerous events during mammalian reproduction. The present study represents an in-depth investigation of haptoglobin expression and secretion ...
  • Decoding empagliflozin's molecular mechanism of action in heart failure with preserved ejection fraction using artificial intelligence 
    Bayes-Genis, Antoni; Iborra-Egea, Oriol; Spitaleri, Giosafat; Domingo, Mar; Revuelta-López, Elena; Codina, Pau; Cediel, German; Santiago-Vacas, Evelyn; Cserkoova, Adriana; Pascual-Figal, Domingo-Andrés; Nunez, Julio; Lupon, Josep (NATURE PORTFOLIO, 2021-06)
    The use of sodium-glucose co-transporter 2 inhibitors to treat heart failure with preserved ejection fraction (HFpEF) is under investigation in ongoing clinical trials, but the exact mechanism of action is unclear. Here ...
  • Sleep duration and napping in relation to colorectal and gastric cancer in the MCC-Spain study 
    Papantoniou, Kyriaki; Castano-Vinyals, Gemma; Espinosa, Ana; Turner, Michelle-C; Martín-Sánchez, Vicente; Casabonne, Delphine; Aragones, Nuria; Gómez-Acebo, Ines; Ardanaz, Eva; Jiménez-Moleon, José-Juan; Amiano, Pilar; Molina-Barcelo, Ana; Alguacil, Juan; Fernández-Tardon, Guillermo; María-Huerta, José; Hernández-Segura, Natalia; Pérez-Gómez, Beatriz; Llorca, Javier; Vidan-Alli, Juana; Olmedo-Requena, Rocio; Gil, Leire; Castanon-López, Carmen; Pollan, Marina; Kogevinas, Manolis; Moreno, Victor (NATURE PORTFOLIO, 2021-06)
    Sleep duration is a novel and potentially modifiable risk factor for cancer. We evaluated the association of self-reported sleep duration and daytime napping with odds of colorectal and gastric cancer. We included 2008 ...
  • Changes in antibiotic prescription following an education strategy for acute respiratory infections 
    Delsors, Eloisa; Monso, Francisco; López-Roman, Francisco-Javier; Menárguez-Puche, Juan-Francisco; González-Barbera, María; Hukelova, Hana; Martínez-Ros, María-Teresa; López-Santiago, Asensio (NATURE RESEARCH, 2021-06)
    The objective of this study was to assess the impact of an education intervention for primary health care physicians, based on the knowledge of clinical practice guidelines and availability of rapid antigen detection test ...
  • Genetic and environmental variation in educational attainment: an individual-based analysis of 28 twin cohorts 
    Silventoinen, Karri; Jelenkovic, Aline; Sund, Reijo; Latvala, Antti; Honda, Chika; Inui, Fujio; Tomizawa, Rie; Watanabe, Mikio; Sakai, Norio; Rebato, Esther; Busjahn, Andreas; Tyler, Jessica; Hopper, John-L; Ordonana, Juan-R; Sánchez-Romera, Juan-F; Colodro-Conde, Lucia; Calais-Ferreira, Lucas; Oliveira, Vinicius-C; Ferreira, Paulo-H; Medda, Emanuela; Nistico, Lorenza; Toccaceli, Virgilia; Derom, Catherine-A; Vlietinck, Robert-F; Loos, Ruth-JF; Siribaddana, Sisira-H; Hotopf, Matthew; Sumathipala, Athula; Rijsdijk, Fruhling; Duncan, Glen-E; Buchwald, Dedra; Tynelius, Per; Rasmussen, Finn; Tan, Qihua; Zhang, Dongfeng; Pang, Zengchang; Magnusson, Patrik-KE; Pedersen, Nancy-L; Aslan, Anna-KDahl; Hwang, Amie-E; Mack, Thomas-M; Krueger, Robert-F; McGue, Matt; Pahlen, Shandell; Brandt, Ingunn; Nilsen, Thomas-S; Harris, Jennifer-R; Martín, Nicholas-G; Medland, Sarah-E; Montgomery, Grant-W; Willemsen, Gonneke; Bartels, Meike; van-Beijsterveldt, Catharina-EM; Franz, Carol-E; Kremen, William-S; Lyons, Michael-J; Silberg, Judy-L; Maes, Hermine-H; Kandler, Christian; Nelson, Tracy-L; Whitfield, Keith-E; Corley, Robin-P; Huibregtse, Brooke-M; Gatz, Margaret; Butler, David-A; Tarnoki, Adam-D; Tarnoki, David-L; Park, Hang-A; Lee, Jooyeon; Lee, Soo-Ji; Sung, Joohon; Yokoyama, Yoshie; Sorensen, Thorkild-IA; Boomsma, Dorret, I; Kaprio, Jaakko (NATURE PORTFOLIO, 2020-07)
    We investigated the heritability of educational attainment and how it differed between birth cohorts and cultural-geographic regions. A classical twin design was applied to pooled data from 28 cohorts representing 16 ...
  • NLRP3 at the crossroads between immune/inflammatory responses and enteric neuroplastic remodelling in a mouse model of diet-induced obesity 
    Pellegrini, Carolina; Fornai, Matteo; Benvenuti, Laura; Colucci, Rocchina; Caputi, Valentina; Palazon-Riquelme, Pablo; Giron, María-Cecilia; Nericcio, Anna; Garelli, Francesca; D'Antongiovanni, Vanessa; Segnani, Cristina; Ippolito, Chiara; Nannipieri, Monica; López-Castejon, Gloria; Pelegrín, Pablo; Hasko, Gyorgy; Bernardini, Nunzia; Blandizzi, Corrado; Antonioli, Luca (WILEY, 2021-10)
    BACKGROUND AND PURPOSE: Enteric neurogenic/inflammation contributes to bowel dysmotility in obesity. We examined the role of NLRP3 in colonic neuromuscular dysfunctions in mice with high-fat diet (HFD)-induced obesity. ...

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