Repositorio Dspace

Envíos recientes

03. IMIB (Instituto Murciano de Investigación Biosanitaria Pascual Parrilla): Envíos recientes

  • The Immediate and Late Effects of Thyroid Hormone (Triiodothyronine) on Murine Coagulation Gene Transcription 
    Reitsma, Pieter-H; van-Vlijmen, Bart-J-M; Salloum-Asfar, Salam; Boelen, Anita (2015-05-26)
    Thyroid dysfunction is associated with changes in coagulation. The aim of our study was to gain more insight into the role of thyroid hormone in coagulation control. C57Black/6J mice received a low-iodine diet and drinking ...
  • Molecular anatomy of the thalamic complex and the underlying transcription factors 
    Wegierski, Tomasz; Kuznicki, Jacek; Nagalski, Andrzej; Wisniewska, Marta-B; Puelles, Luis; Dabrowski, Michal (2016-06)
    Thalamocortical loops have been implicated in the control of higher-order cognitive functions, but advances in our understanding of the molecular underpinnings of neocortical organization have not been accompanied by similar ...
  • Novel biomarkers in cardiology: MicroRNAs in atrial fibrillation. 
    Orenes-Piñero, Esteban; Quintana-Giner, Miriam; Romero-Aniorte, Ana-Isabel; Valdés-Chavarri, Mariano; Marín, Francisco (2015-07)
    Atrial fibrillation (AF) is the most common sustained chronic cardiac arrhythmia in clinical practice, which increases the risk of stroke and thromboembolism and is an independent predictor of mortality. The underlying ...
  • Retinal aging in the diurnal Chilean rodent (Octodon degus): histological, ultrastructural and neurochemical alterations of the vertical information processing pathway 
    Szabadfi, Krisztina; Gabriel, Robert; Estrada, Cristina; Fernández-Villalba, Emiliano; Tarragon, Ernesto; Izura, Virginia; Herrero, María-Trinidad; Setalo, Gyorgy, Jr; Reglodi, Dora; Tamas, Andrea (2015-04-21)
    The retina is sensitive to age-dependent degeneration. To find suitable animal models to understand and map this process has particular importance. The degu (Octodon degus) is a diurnal rodent with dichromatic color vision. ...
  • Dysregulated cholinergic network as a novel biomarker of poor prognostic in patients with head and neck squamous cell carcinoma 
    Castillo-González, Ana-Cristina; Nieto-Cerón, Susana; Noguera-Velasco, José-Antonio; López-Moreno, María-Fuensanta; Cabezas-Herrera, Juan; Pelegrín-Hernández, Juan-Pablo; Hellín-Meseguer, Diego; Montenegro, María-Fernanda; Rodríguez-López, José-Neptuno; Vidal, Cecilio-J (2015-12)
    BACKGROUND: In airways, a proliferative effect is played directly by cholinergic agonists through nicotinic and muscarinic receptors activation. How tumors respond to aberrantly activated cholinergic signalling is a key ...
  • Molecular codes defining rostrocaudal domains in the embryonic mouse hypothalamus 
    Ferran, José-L; Puelles, Luis; Rubenstein, John-L-R (2015-04-17)
    The prosomeric model proposes that the hypothalamus is a rostral forebrain entity, placed ventral to the telencephalon and rostral to the diencephalon. Gene expression markers differentially label molecularly distinct ...
  • IL-4 Up-Regulates MiR-21 and the MiRNAs Hosted in the CLCN5 Gene in Chronic Lymphocytic Leukemia 
    Ruiz-Lafuente, Natalia; Alcaraz-García, María-José; Sebastián-Ruiz, Silvia; García-Serna, Azahara-María; Gómez-Espuch, Joaquín; Moraleda-Jiménez, José-María; Minguela-Puras, Alfredo; García-Alonso, Ana-María; Parrado, Antonio (2015-04-24)
    Interleukin 4 (IL-4) induces B-cell differentiation and survival of chronic lymphocytic leukemia (CLL) cells. MicroRNAs (miRNAs) regulate mRNA and protein expression, and several miRNAs, deregulated in CLL, might play roles ...
  • Inflammation in Parkinson's disease: role of glucocorticoids 
    Herrero, María-Trinidad; Estrada, Cristina; Maatouk, Layal; Vyas, Sheela (2015)
    Chronic inflammation is a major characteristic feature of Parkinson's disease (PD). Studies in PD patients show evidence of augmented levels of potent pro-inflammatory molecules e.g., TNF-?, iNOS, IL-1? whereas in experimental ...
  • Differential requirements for Gli2 and Gli3 in the regional specification of the mouse hypothalamus 
    Haddad-Tovolli, Roberta; Zhang, Yuanfeng; Zhou, Xunlei; Alvarez-Bolado, Gonzalo; Paul, Fabian-A; Blaess, Sandra; Theil, Thomas; Puelles, Luis (2015-03-25)
    Secreted protein Sonic hedgehog (Shh) ventralizes the neural tube by modulating the crucial balance between activating and repressing functions (GliA, GliR) of transcription factors Gli2 and Gli3. This balance-the Shh-Gli ...
  • A new scenario of hypothalamic organization: rationale of new hypotheses introduced in the updated prosomeric model 
    Puelles, Luis; Rubenstein, John-L-R (2015-03-19)
    In this essay, we aim to explore in depth the new concept of the hypothalamus that was presented in the updated prosomeric model (Puelles et al., 2012b; Allen Developing Mouse Brain Atlas). Initial sections deal with the ...
  • Effects of Ocular Hypertension in the Visual System of Pigmented Mice 
    Valiente-Soriano, Francisco-Javier; Salinas-Navarro, Manuel; Jiménez-López, Manuel; Alarcón-Martínez, Luis; Ortín-Martínez, Arturo; Bernal-Garro, José-M; Avilés-Trigueros, Marcelino; Agudo-Barriuso, Marta; Villegas-Pérez, María-Paz; Vidal-Sanz, Manuel (2015-03-26)
    To study the effects of ocular hypertension (OHT) on the visual system of C57BL/6 pigmented mice, the limbal and episcleral veins of the left eye were laser photocoagulated (LP). LP increased the intraocular pressure during ...
  • Retino-retinal projection in juvenile and young adult rats and mice 
    Nadal-Nicolás, Francisco-M; Valiente-Soriano, Francisco-Javier; Salinas-Navarro, Manuel; Jiménez-López, Manuel; Vidal-Sanz, Manuel; Agudo-Barriuso, Marta (2015-05)
    Identification of retino-retinal projecting RGCs (ret-ret RGCs) has been accomplished by tracing RGCs in one retina after intravitreal injection of different tracers in the other eye. In mammals, rabbit and rat, ret-ret ...
  • Mesencephalic basolateral domain specification is dependent on Sonic Hedgehog 
    Martínez-López, Jesus-E; Moreno-Bravo, Juan-A; Pilar-Madrigal, M; Puelles, Eduardo; Martínez, Salvador (2015)
    In the study of central nervous system morphogenesis, the identification of new molecular markers allows us to identify domains along the antero-posterior and dorso-ventral (DV) axes. In the past years, the alar and basal ...
  • Origin and early development of the chicken adenohypophysis 
    Sánchez-Arrones, Luisa; Ferran, José-L; Puelles, Luis; Hidalgo-Sánchez, Matias (2015-02-17)
    The adenohypophysis (ADH) is an important endocrine organ involved in the regulation of many physiological processes. The late morphogenesis of this organ at neural tube stages is well known: the epithelial ADH primordium ...
  • Effects of Body Mass Index on the Lipid Profile and Biomarkers of Inflammation and a Fibrinolytic and Prothrombotic State 
    Orenes-Piñero, Esteban; Hernández-Romero, Diana; Tello-Montoliu, Antonio; Valdés-Chavarri, Mariano; Marín, Francisco; Pineda, Javier; Marco, Pascual; Sogorb, Francisco; Roldán-Schilling, Vanessa; Lip, Gregory-Y-H (2015)
    AIM: Both an overweight status and obesity are associated with high cardiovascular morbidity and mortality. The aim of this study was to examine the effects of obesity on different underlying mechanisms, i.e. inflammation, ...
  • Methods for monitoring the functional status of the circadian system in dietary surveys studies: application criteria and interpretation of results 
    Garaulet, Marta; Madrid, Juan-Antonio (2015-02-26)
    To evaluate the circadian system status of the subject may be of special interest in nutrition. Particularly for those studies related to the assessment of diseases related to malnutrition, as it is the case of most of the ...
  • Red nucleus and rubrospinal tract disorganization in the absence of Pou4f1 
    Martínez-López, Jesus-E; Moreno-Bravo, Juan-A; Pilar-Madrigal, M; Puelles, Eduardo; Martínez, Salvador (2015-02-05)
    The red nucleus (RN) is a neuronal population that plays an important role in forelimb motor control and locomotion. Histologically it is subdivided into two subpopulations, the parvocellular RN (pRN) located in the ...
  • Alcoholic Beverage Preference and Dietary Habits in Elderly across Europe: Analyses within the Consortium on Health and Ageing: Network of Cohorts in Europe and the United States (CHANCES) Project 
    Sluik, Diewertje; Geelen, Anouk; Kromhout, Daan; de-Groot, Lisette-C-P-G-M; Feskens, Edith-J-M; Jankovic, Nicole; O'Doherty, Mark-G; Kee, Frank; Schoettker, Ben; Rolandsson, Olov; Eriksson, Sture; Kiefte-de-Jong, Jessica-C; Franco, Oscar-H; Ferrieres, Jean; Bamia, Christina; Trichopoulou, Antonia; Fransen, Heidi-P; Boer, Jolanda-M-A; Martínez, Begona; Huerta-Castaño, José-María; Boffetta, Paolo (2016-08-22)
    INTRODUCTION: The differential associations of beer, wine, and spirit consumption on cardiovascular risk found in observational studies may be confounded by diet. We described and compared dietary intake and diet quality ...
  • 'Atherothrombosis-associated microRNAs in Antiphospholipid syndrome and Systemic Lupus Erythematosus patients' 
    Perez-Sánchez, C; Aguirre, M-A; Ruiz-Limon, P; Barbarroja, N; Jiménez-Gomez, Y; de-la-Rosa, I-Arias; Rodriguez-Ariza, A; Collantes-Estevez, E; Segui, P; Velasco, F; López-Pedrera, Ch; Cuadrado, M-J; Teruel-Montoya, Raúl; González-Conejero, Rocío; Martínez, C (2016-08-09)
    MicroRNAs markedly affect the immune system, and have a relevant role in CVD and autoimmune diseases. Yet, no study has analyzed their involvement in atherothrombosis related to APS and SLE patients. This study intended ...
  • Trends in socioeconomic inequalities in mortality in small areas of 33 Spanish cities 
    Gotsens, Merce; Palencia, Laia; Rodriguez-Sanz, Maica; Mari-Dell'Olmo, Marc; Martínez-Beneito, Miguel-A; Ballesta-Ruiz, Mónica; Cirera-Suárez, Lluís; Salmerón-Martínez, Diego; Calvo, Montse; Daponte, Antonio; Dominguez-Berjon, Felicitas; Gandarillas, Ana; Izco-Goni, Natividad; Martos, Carmen; Moreno-Iribas, Conchi; Nolasco, Andreu; Taracido, Margarita; Borrell, Carme (2016-12)
    BACKGROUND: In Spain, several ecological studies have analyzed trends in socioeconomic inequalities in mortality from all causes in urban areas over time. However, the results of these studies are quite heterogeneous ...

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