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Envíos recientes

03. IMIB (Instituto Murciano de Investigación Biosanitaria Pascual Parrilla): Envíos recientes

  • Prevention of hatching of porcine morulae and blastocysts by liquid storage at 20 °C 
    Martínez-Serrano, Cristina-A; Cambra, Josep-M; Nohalez, Alicia; Parrilla, Inmaculada; Roca, Jordi; Vázquez, José-L; Rodríguez-Martínez, Heriberto; Gil, María-Antonia; Martínez, Emilio-A; Cuello, Cristina (NATURE PORTFOLIO, 2019-04-17)
    Vitrification is the ideal method for long-lasting storage of porcine embryos. However, both strict airline regulations for transport of liquid nitrogen dewars and the technical problems experienced when vitrified embryos ...
  • Establishing a Twin Register: An Invaluable Resource for (Behavior) Genetic, Epidemiological, Biomarker, and "Omics' Studies 
    Odintsova, Veronika-V; Willemsen, Gonneke; Dolan, Conor-V; Hottenga, Jouke-Jan; Martín, Nicholas-G; Slagboom, P-Eline; Ordoñana, Juan-Ramón; Boomsma, Dorret-I (CAMBRIDGE UNIV PRESS, 2018-06)
    Twin registers are wonderful research resources for research applications in medical and behavioral genetics, epidemiology, psychology, molecular genetics, and other areas of research. New registers continue to be launched ...
  • Human Wharton's jelly mesenchymal stem cells protect axotomized rat retinal ganglion cells via secretion of anti-inflammatory and neurotrophic factors 
    Millan-Rivero, José-E; Nadal-Nicolás, Francisco-M; García-Bernal, David; Sobrado-Calvo, Paloma; Blanquer-Blanquer, Miguel; Moraleda-Jiménez, José-María; Vidal-Sanz, Manuel; Agudo-Barriuso, Marta (NATURE PORTFOLIO, 2018-11-02)
    Mesenchymal stem cell (MSC) transplantation is emerging as an ideal tool to restore the wounded central nervous system (CNS). MSCs isolated from extra-embryonic tissues have some advantages compared to MSCs derived from ...
  • Circadian monitoring as an aging predictor 
    Martínez-Nicolás, A; Madrid, J-A; García, F-J; Campos, M; Moreno-Casbas, M-T; Almaida-Pagan, P-F; Lucas-Sánchez, A; Rol, M-A (NATURE PORTFOLIO, 2018-10-09)
    The ageing process is associated with sleep and circadian rhythm (SCR) frailty, as well as greater sensitivity to chronodisruption. This is essentially due to reduced day/night contrast, decreased sensitivity to light, ...
  • Characterization of human peritoneal monocyte/macrophage subsets in homeostasis: Phenotype, GATA6, phagocytic/oxidative activities and cytokines expression 
    Ruiz-Alcaraz, Antonio-José; Carmona-Martínez, Violeta; Tristán-Manzano, María; Machado-Linde, Francisco; Sánchez-Ferrer, María-Luisa; García-Penarrubia, Pilar; Martínez-Esparza, María (NATURE PORTFOLIO, 2018-08-24)
    Peritoneal macrophages play a critical role in the control of infectious and inflammatory diseases. Although recent progress on murine peritoneal macrophages has revealed multiple aspects on their origin and mechanisms ...
  • An Adult Zebrafish Model Reveals that Mucormycosis Induces Apoptosis of Infected Macrophages 
    López-Muñoz, Azucena; Nicolás, Francisco-E; García-Moreno, Diana; Pérez-Oliva, Ana-Belén; Navarro-Mendoza, María-I; Hernández-Onate, Miguel-A; Herrera-Estrella, Alfredo; Torres-Martínez, Santiago; Ruiz-Vázquez, Rosa-M; Garre, Victoriano; Mulero, Víctoriano (NATURE PORTFOLIO, 2018-08-24)
    Mucormycosis is a life-threatening fungal infection caused by various ubiquitous filamentous fungi of the Mucorales order, although Rhizopus spp. and Mucor spp. are the most prevalent causal agents. The limited therapeutic ...
  • Heritability of siesta and night-time sleep as continuously assessed by a circadian-related integrated measure 
    López-Mínguez, J; Morosoli, J-J; Madrid, J-A; Garaulet, Marta; Ordoñana, Juan-Ramón (NATURE PORTFOLIO, 2017-09-26)
    Siesta is a relevant aspect of sleep due to its posited relationship with health or cognitive function. However, unlike night-time sleep, studies about daytime-sleep determinants and characteristics are scarce, and the ...
  • Importance of time in therapeutic range on bleeding risk prediction using clinical risk scores in patients with atrial fibrillation 
    Rivera-Caravaca, José-Miguel; Roldán-Schilling, Vanessa; Esteve-Pastor, María-Asunción; Valdés-Chavarri, Mariano; Vicente, Vicente; Lip, Gregory-Y-H; Marín, Francisco (NATURE PORTFOLIO, 2017-09-21)
    Bleeding risk with vitamin K antagonists (VKAs) is closely related to the quality of anticoagulation in atrial fibrillation (AF) patients, reflected by time in therapeutic range (TTR). Here we compared the discrimination ...
  • The overlaying oil type influences in vitro embryo production: differences in composition and compound transfer into incubation medium between oils 
    Martínez-Serrano, Cristina-A; Nohalez, Alicia; Parrilla, Inmaculada; Motas, Miguel; Roca, Jordi; Romero, Inmaculada; García-González, Diego-L; Cuello, Cristina; Rodríguez-Martínez, Heriberto; Martínez, Emilio-A; Gil, María-Antonia (NATURE PORTFOLIO, 2017-09-05)
    The oil overlay micro-drop system is widely used for cultures of mammalian gametes and embryos. We evaluated hereby the effects of two unaltered commercial oils- Sigma mineral oil (S-MO) and Nidoil paraffin oil (N-PO)-on ...
  • P2X7 receptor induces mitochondrial failure in monocytes and compromises NLRP3 inflammasome activation during sepsis 
    Martínez-García, Juan-José; Martínez-Banaclocha, Helios; Angosto-Bazarra, Diego; de-Torre-Minguela, Carlos; Baroja-Mazo, Alberto; Alarcón-Vila, Cristina; Martínez-Alarcón, Laura; Amores-Iniesta, Joaquín; Martín-Sánchez, Fatima; Ercole, Giovanni-A; Martínez, Carlos-M; González-Lisorge, Ada; Fernández-Pacheco, José; Martínez-Gil, Piedad; Adriouch, Sahil; Koch-Nolte, Friedrich; Lujan, Juan; Acosta-Villegas, Francisco; Parrilla-Paricio, Pascual; García-Palenciano, Carlos; Pelegrín, Pablo (NATURE PORTFOLIO, 2019-06-20)
    Sepsis is characterized by a systemic inflammatory response followed by immunosuppression of the host. Metabolic defects and mitochondrial failure are common in immunocompromised patients with sepsis. The NLRP3 inflammasome ...
  • PTEN self-regulates through USP11 via the PI3K-FOXO pathway to stabilize tumor suppression 
    Park, Mi-Kyung; Yao, Yixin; Xia, Weiya; Setijono, Stephanie-Rebecca; Kim, Jae-Hwan; Vila, Isabelle-K; Chiu, Hui-Hsuan; Wu, Yun; Billalabeitia, Enrique-Gonzalez; Lee, Min-Gyu; Kalb, Robert-G; Hung, Mien-Chie; Pandolfi, Pier-Paolo; Song, Su-Jung; Song, Min-Sup (NATURE PUBLISHING GROUP, 2019-02-07)
    PTEN is a lipid phosphatase that antagonizes the PI3K/AKT pathway and is recognized as a major dose-dependent tumor suppressor. The cellular mechanisms that control PTEN levels therefore offer potential routes to therapy, ...
  • Comprehensive long-term efficacy and safety of recombinant human alpha-mannosidase (velmanase alfa) treatment in patients with alpha-mannosidosisKeywords 
    Lund, Allan-M; Borgwardt, Line; Cattaneo, Federica; Ardigo, Diego; Geraci, Silvia; Gil-Campos, Mercedes; de-Meirleir, Linda; Laroche, Cecile; Dolhem, Philippe; Cole, Duncan; Tylki-Szymanska, Anna; López-Rodríguez, Mónica; Guillén-Navarro, Encarna; Dali, Christine-I; Heron, Benedicte; Fogh, Jens; Muschol, Nicole; Phillips, Dawn; Van-den-Hout, J-M-Hannerieke; Jones, Simon-A; Amraoui, Yasmina; Harmatz, Paul; Guffon, Nathalie (SPRINGER, 2018-12)
    INTRODUCTION: Long-term outcome data provide important insights into the clinical utility of enzyme replacement therapies. Such data are presented for velmanase alfa in the treatment of alpha-mannosidosis (AM). METHODS: ...
  • Evaluating radiological response in pancreatic neuroendocrine tumours treated with sunitinib: comparison of Choi versus RECIST criteria (CRIPNET_ GETNE1504 study) 
    Pilar-Solis-Hernández, María; Fernández-del-Valle, Ana; Carmona-Bayonas, Alberto; García-Carbonero, Rocío; Custodio, Ana; Benavent, Marta; Alonso-Gordoa, Teresa; Núñez-Valdovino, Barbara; Sánchez-Cánovas, Manuel; Matos, Ignacio; Alonso, Vicente; López, Carlos; Viudez, Antonio; Izquierdo, Marta; Calvo-Temprano, David; Grande, Enrique; Capdevila, Jaume; Jiménez-Fonseca, Paula (NATURE PUBLISHING GROUP, 2019-10-01)
    BACKGROUND: The purpose of our study was to analyse the usefulness of Choi criteria versus RECIST in patients with pancreatic neuroendocrine tumours (PanNETs) treated with sunitinib. METHOD: A multicentre, prospective study ...
  • Predicting long-term disease control in transplant-ineligible patients with multiple myeloma: impact of an MGUS-like signature 
    Rodríguez-Otero, Paula; Victoria-Mateos, María; Martínez-López, Joaquín; Hernández, Miguel-Teodoro; Ocio, Enrique-M; Rosinol, Laura; Martínez, Rafael; Teruel, Ana-Isabel; Gutiérrez, Norma-C; Bargay, Joan; Bengoechea, Enrique; González, Yolanda; Pérez-de-Oteyza, Jaime; Gironella, Mercedes; Núñez-Córdoba, Jorge-M; Encinas, Cristina; Martín, Jesús; Cabrera, Carmen; Palomera, Luis; de-Arriba, Felipe; Teresa-Cedena, María; Puig, Noemi; Oriol, Albert; Paiva, Bruno; Blade, Joan; Lahuerta, Juan-José; San-Miguel, Jesús-F (NATURE PUBLISHING GROUP, 2019-03-18)
    Disease control at 5 years would be a desirable endpoint for elderly multiple myeloma (MM) patients, but biomarkers predicting this are not defined. Therefore, to gain further insights in this endpoint, a population of 498 ...
  • Exome sequencing identifies germline variants in DIS3 in familial multiple myeloma 
    Pertesi, Maroulio; Vallee, Maxime; Wei, Xiaomu; Revuelta, María-V; Galia, Perrine; Demangel, Delphine; Oliver, Javier; Foll, Matthieu; Chen, Siwei; Perrial, Emeline; Garderet, Laurent; Corre, Jill; Leleu, Xavier; Boyle, Eileen-M; Decaux, Olivier; Rodon, Philippe; Kolb, Brigitte; Slama, Borhane; Mineur, Philippe; Voog, Eric; Le-Bris, Catherine; Fontan, Jean; Maigre, Michel; Beaumont, Marie; Azais, Isabelle; Sobol, Hagay; Vignon, Marguerite; Royer, Bruno; Perrot, Aurore; Fuzibet, Jean-Gabriel; Dorvaux, Veronique; Anglaret, Bruno; Cony-Makhoul, Pascale; Berthou, Christian; Desquesnes, Florence; Pegourie, Brigitte; Leyvraz, Serge; Mosser, Laurent; Frenkiel, Nicole; Augeul-Meunier, Karine; Leduc, Isabelle; Leyronnas, Cecile; Voillat, Laurent; Casassus, Philippe; Mathiot, Claire; Cheron, Nathalie; Paubelle, Etienne; Moreau, Philippe; Bignon, Yves-Jean; Joly, Bertrand; Bourquard, Pascal; Caillot, Denis; Naman, Herve; Rigaudeau, Sophie; Marit, Gerald; Macro, Margaret; Lambrecht, Isabelle; Cliquennois, Manuel; Vincent, Laure; Helias, Philippe; Avet-Loiseau, Herve; Moreno, Víctor; Reis, Rui-Manuel; Varkonyi, Judit; Kruszewski, Marcin; Vangsted, Annette-Juul; Jurczyszyn, Artur; Zaucha, Jan-Maciej; Sainz, Juan; Krawczyk-Kulis, Malgorzata; Watek, Marzena; Pelosini, Matteo; Iskierka-Jazdzewska, Elzbieta; Grzasko, Norbert; Martínez-López, Joaquín; Jerez-Cayuela, Andrés; Campa, Daniele; Buda, Gabriele; Lesueur, Fabienne; Dudzinski, Marek; García-Sanz, Ramón; Nagler, Arnon; Rymko, Marcin; Jamroziak, Krzysztof; Butrym, Aleksandra; Canzian, Federico; Obazee, Ofure; Nilsson, Bjorn; Klein, Robert-J; Lipkin, Steven-M; McKay, James-D; Dumontet, Charles (NATURE PUBLISHING GROUP, 2019-09)
  • Lytic cell death induced by melittin bypasses pyroptosis but induces NLRP3 inflammasome activation and IL-1ß release 
    Martín-Sánchez, Fatima; Martínez-García, Juan-José; Muñoz-García, María; Martínez-Villanueva, Miriam; Noguera-Velasco, José-Antonio; Andreu, David; Rivas, Luis; Pelegrín, Pablo (NATURE PUBLISHING GROUP, 2017-08)
    The nucleotide-binding domain and leucine-rich repeat-containing receptor with a pyrin domain 3 (NLRP3) inflammasome is a sensor for different types of infections and alterations of homeostatic parameters, including ...
  • Elosulfase alfa for mucopolysaccharidosis type IVA: Real-world experience in 7 patients from the Spanish Morquio-A early access program 
    Pintos-Morell, Guillem; Blasco-Alonso, Javier; Couce, María-L; Gutiérrez-Solana, Luis-G; Guillén-Navarro, Encarna; O'Callaghan, Mar; del-Toro, Mireia (ELSEVIER SCIENCE BV, 2018-06)
    There is a growing interest in evaluating the effectiveness of enzyme replacement therapy (ERT) with elosulfase alfa in patients with mucopolysaccharidosis type IVA (MPS-IVA) under real-world conditions. We present the ...
  • Are Environmental Factors for Atopic Eczema in ISAAC Phase Three due to Reverse Causation? 
    Rutter, Charlotte-E; Silverwood, Richard-J; Williams, Hywel-C; Ellwood, Philippa; Asher, Innes; García-Marcos, Luis; Strachan, David-P; Pearce, Neil; Langan, Sinead-M; Ait-Khaled, N; Anderson, H-R; Asher, MI; Beasley, R; Bjorksten, B; Brunekreef, B; Crane, J; Ellwood, P; Flohr, C; Foliaki, S; Forastiere, F; García-Marcos, Luis; Keil, U; Lai, C-K-W; Mallol, J; Mitchell, E-A; Montefort, S; Odhiambo, J; Pearce, N; Robertson, C-F; Stewart, A-W; Strachan, D; von-Mutius, E; Weiland, S-K; Weinmayr, G; Williams, H-C; Wong, G; Clayton, T-O; Ellwood, E; Baena-Cagnani, C-E; Gómez, M; Howitt, M-E; Weyler, J; Pinto-Vargas, R; da-Cunha, A-J; de-Freitas-Souza, L; Kuaban, C; Ferguson, A; Rennie, D; Standring, P; Aguilar, P; Amarales, L; Benavides, L-A; Contreras, A; Chen, Y-Z; Kunii, O; Pan, Q-Li; Zhong, N-S; Aristizabal, G; Cepeda, A-M; Ordóñez, G-A; Bustos, C; Riikjarv, M-A; Melaku, K; Sa'aga-Banuve, R; Pekkanen, J; Hypolite, I-E; Novak, Z; Zsigmond, G; Awasthi, S; Bhave, S; Hanumante, N-M; Jain, K-C; Joshi, M-K; Khatav, V-A; Mantri, S-N; Pherwani, AV; Rego, S; Sabir, M; Salvi, S; Setty, G; Sharma, S-K; Singh, V; Sukumaran, T; Babu, P-S-Suresh; Kartasasmita, C-B; Konthen, P; Suprihati, W; Masjedi, M-R; Steriu, A; Koffi, B-N; Odajima, H; al-Momen, J-A; Imanalieva, C; Kudzyte, J; Quah, B-S; Teh, K-H; Baeza-Bacab, M; Barragan-Meijueiro, M; del-Rio-Navarro, B-E; García-Almaraz, R; González-Díaz, S-N; Linares-Zapien, F-J; Merida-Palacio, JV; Ramírez-Chanona, N; Romero-Tapia, S; Romieu, I; Bouayad, Z; MacKay, R; Moyes, C; Pattemore, P; Onadeko, B-O; Cukier, G; Chiarella, P; Cua-Lim, F; Breborowicz, A; Sole, D; Sears, M; Aguirre, V; Barba, S; Shah, J; Baratawidjaja, K; Nishima, S; de-Bruyne, J; Tuuau-Potoi, N; Lai, C-K; Lee, B-W; El-Sony, A; Anderson, R (ELSEVIER SCIENCE INC, 2019-05)
    Some previously described environmental associations for atopic eczema may be due to reverse causation. We explored the role of reverse causation by comparing individual- and school-level results for multiple atopic eczema ...
  • Models of human psoriasis: Zebrafish the newly appointed player 
    Martínez-Navarro, Francisco-Juan; Martínez-Menchón, Teresa; Mulero, Victoriano; Galindo-Villegas, Jorge (ELSEVIER SCI LTD, 2019-08)
    Psoriasis is a human chronic, immune disease with severe cutaneous and systemic manifestations. Its prevalence, among the world population, highly varies with ethnicity and geography, but not sex from remarkable low levels ...
  • Fruit and vegetable intake and prostate cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) 
    Pérez-Cornago, Aurora; Travis, Ruth-C; Appleby, Paul-N; Tsilidis, Konstantinos-K; Tjonneland, Anne; Olsen, Anja; Overvad, Kim; Katzke, Verena; Kuehn, Tilman; Trichopoulou, Antonia; Peppa, Eleni; Kritikou, María; Sieri, Sabina; Palli, Domenico; Sacerdote, Carlotta; Tumino, Rosario; Bueno-de-Mesquita, Bas; Agudo, Antonio; Larrañaga, Nerea; Molina-Portillo, Elena; Ardanaz, Eva; Chirlaque-López, María-Dolores; Lasheras, Cristina; Stattin, Par; Wennberg, María; Drake, Isabel; Malm, Johan; Schmidt, Julie-A; Khaw, Kay-Tee; Gunter, Marc; Freisling, Heinz; Huybrechts, Inge; Aune, Dagfinn; Cross, Amanda-J; Riboli, Elio; Key, Timothy-J (WILEY, 2017-07-15)
    Several dietary factors have been studied in relation to prostate cancer; however, most studies have not reported on subtypes of fruit and vegetables or tumor characteristics, and results obtained so far are inconclusive. ...

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