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Envíos recientes

03. IMIB (Instituto Murciano de Investigación Biosanitaria Pascual Parrilla): Envíos recientes

  • The Zebrafish as an Emerging Model to Study DNA Damage in Aging, Cancer and Other Diseases 
    Cayuela-Fuentes, María-Luisa; Claes, Kathleen-B-M; Ferreira, Miguel-Godinho; Henriques, Catarina-Martins; van-Eeden, Fredericus; Varga, Mate; Vierstraete, Jeroen; Mione, María-Caterina (FRONTIERS MEDIA SA, 2019-01-10)
    Cancer is a disease of the elderly, and old age is its largest risk factor. With age, DNA damage accumulates continuously, increasing the chance of malignant transformation. The zebrafish has emerged as an important ...
  • Therapeutic management and one-year outcomes in elderly patients with acute coronary syndrome 
    Orenes-Piñero, Esteban; Ruiz-Nodar, Juan-M; Esteve-Pastor, María-Asunción; Quintana-Giner, Miriam; Rivera-Caravaca, José-Miguel; Veliz, Andrea; Valdés-Chavarri, Mariano; Macías, Manuel; Pernias-Escrig, Vicente; Vicente-Ibarra, Nuria; Carrillo, Luna; Sandin-Rollan, Miriam; Candela, Elena; Lozano, Teresa; Marín, Francisco (IMPACT JOURNALS LLC, 2017-10-06)
    BACKGROUND: Elderly represents a subgroup of high-risk ACS patients due to their advanced age and other comorbidities. Unfortunately, they are also often under-represented in many studies and clinical trials. Furthermore, ...
  • Patients with chronic lymphocytic leukemia and complex karyotype show an adverse outcome even in absence of TP53/ATM FISH deletions 
    Puiggros, Anna; Collado, Rosa; Calasanz, María-José; Ortega, Margarita; Ruiz-Xiville, Neus; Rivas-Delgado, Alfredo; Luno, Elisa; González, Teresa; Navarro, Blanca; García-Malo, María-Dolores; Valiente, Alberto; Hernández, José-Ángel; Teresa-Ardanaz, María; Pinan, Maria-Ángeles; Laura-Blanco, María; Hernández-Sánchez, María; Batlle-López, Ana; Salgado, Rocío; Salido, Marta; Ferrer, Ana; Abrisqueta, Pau; Gimeno, Eva; Abella, Eugenia; Ferra, Christelle; Terol, María-José; Ortuño, Francisco; Costa, Dolors; Moreno, Carol; Carbonell, Felix; Bosch, Francesc; Delgado, Julio; Espinet, Blanca (IMPACT JOURNALS LLC, 2017-08)
    Genomic complexity identified by chromosome banding analysis (CBA) predicts a worse clinical outcome in CLL patients treated either with standard or new treatments. Herein, we analyzed the clinical impact of complex ...
  • Quality indicators in gastroscopy. Gastroscopy procedure 
    Pérez-Romero, Shirley; Alberca-de-las-Parras, Fernando; Sánchez-del-Rio, Antonio; López-Picazo-Ferrer, Julio-J; Judea-Gutiérrez, Javier; León-Molina, Joaquín (ARAN EDICIONES, S A, 2019)
    Within the project "Quality indicators in digestive endoscopy", pioneered by the Spanish Society for Digestive Diseases (SEPD), the objective of this research is to suggest the structure, process, and results procedures ...
  • Is prophylactic gastrectomy indicated for healthy carriers of CDH1 gene mutations associated with hereditary diffuse gastric cancer? 
    Munitiz, Vicente; Jimeno, Pilar; Ruiz-de-Angulo, David; Ortiz, Ángeles; Martínez-de-Haro, Luisa-Fernanda; Marín, Miguel; Cascales, Pedro; Ruiz-García, Gema; Ortiz-Ruiz, Eduardo; Parrilla-Paricio, Pascual (ARAN EDICIONES, S A, 2019)
    INTRODUCTION: hereditary diffuse gastric cancer (HDGC) is a recently reported hereditary cancer syndrome. Patients with suspected HDGC must be under surveillance via endoscopy and multiple biopsies. As an alternative, some ...
  • Neurogenic appendicopathy. A report of 8 cases 
    Ruiz, José; Ríos-Zambudio, Antonio; Oviedo, María-Isabel; Rodríguez-González, José-Manuel; Parrilla-Paricio, Pascual (ARAN EDICIONES, S A, 2017)
    INTRODUCTION: Neurogenic appendicopathy is not a very well-known disease. OBJECTIVE: To analyze the experience in the management of neurogenic appendicopathy in a tertiary hospital, assessing its clinical presentation, ...
  • USP7 and USP47 deubiquitinases regulate NLRP3 inflammasome activation 
    Palazon-Riquelme, Pablo; Worboys, Jonathan-D; Green, Jack; Valera, Ana; Martín-Sánchez, Fatima; Pellegrini, Carolina; Brough, David; López-Castejón, Gloria (WILEY, 2018-10)
    The assembly and activation of the inflammasomes are tightly regulated by post-translational modifications, including ubiquitin. Deubiquitinases (DUBs) counteract the addition of ubiquitin and are essential regulators of ...
  • Polyamine biosynthesis in Xenopus laevis: the xlAZIN2/xlODC2 gene encodes a lysine/ornithine decarboxylase 
    Lambertos, Ana; Peñafiel, Rafael (PUBLIC LIBRARY SCIENCE, 2019-09-11)
    Ornithine decarboxylase (ODC) is a key enzyme in the biosynthesis of polyamines, organic cations that are implicated in many cellular processes. The enzyme is regulated at the post-translational level by an unusual system ...
  • New insights of polyamine metabolism in testicular physiology: A role of ornithine decarboxylase antizyme inhibitor 2 (AZIN2) in the modulation of testosterone levels and sperm motility 
    Lambertos, Ana; Ramos-Molina, Bruno; López-Contreras, Andrés-J; Cremades, Asunción; Peñafiel, Rafael (PUBLIC LIBRARY SCIENCE, 2018-12-19)
    The specific role of polyamines in the testis physiology is not fully understood. Antizymes (OAZs) and antizyme inhibitors (AZINs) are modulators of ornithine decarboxylase (ODC), a key enzyme in polyamine biosynthesis and ...
  • Angiogenic role of miR-20a in breast cancer 
    Luengo-Gil, Ginés; González-Billalabeitia, Enrique; Alejo-Pérez-Henarejos, Sergio; Navarro-Manzano, Esther; Chaves-Benito, Asunción; García-Martínez, Elena; García-Garre, Elisa; Vicente, Vicente; Ayala-de-la-Peña, Francisco (PUBLIC LIBRARY SCIENCE, 2018-04-04)
    BACKGROUND: Angiogenesis is a key process for tumor progression and a target for treatment. However, the regulation of breast cancer angiogenesis and its relevance for clinical resistance to antiangiogenic drugs is still ...
  • A new insight into the three-dimensional architecture of the Golgi complex: Characterization of unusual structures in epididymal principal cells 
    Martínez-Martínez, Narcisa; Martínez-Alonso, Emma; Tomas, Mónica; Neumueller, Josef; Pavelka, Margit; Martínez-Menárguez, José-Ángel (PUBLIC LIBRARY SCIENCE, 2017-09-28)
    Principal epididymal cells have one of the largest and more developed Golgi complex of mammalian cells. In the present study, we have used this cell as model for the study of the three-dimensional architecture of the Golgi ...
  • Facial thermal variations: A new marker of emotional arousal 
    Kosonogov, Vladimir; de-Zorzi, Lucas; Honore, Jacques; Martínez-Velazquez, Eduardo-S; Nandrino, Jean-Louis; Martínez-Selva, José-María; Sequeira, Henrique (PUBLIC LIBRARY SCIENCE, 2017-09-18)
    Functional infrared thermal imaging (fITI) is considered a promising method to measure emotional autonomic responses through facial cutaneous thermal variations. However, the facial thermal response to emotions still needs ...
  • Post-Traumatic Stress Disorder and other mental disorders in the general population after Lorca's earthquakes, 2011 (Murcia, Spain): A cross-sectional study 
    Navarro-Mateu, Fernando; Salmerón-Martínez, Diego; Vilagut, Gemma; Tormo, María-José; Ruiz-Merino, Guadaiupe; Escámez-Martínez, Teresa; Júdez, Javier; Martínez, Salvador; Koenen, Karestan-C; Navarro, Carmen; Alonso, Jordi; Kessler, Ronald-C (PUBLIC LIBRARY SCIENCE, 2017-07-19)
    AIMS: To describe the prevalence and severity of mental disorders and to examine differences in risk among those with and without a lifetime history prior to a moderate magnitude earthquake that took place in Lorca (Murcia, ...
  • Easy and non-invasive disease detection in pigs by adenosine deaminase activity determinations in saliva 
    Gutiérrez, Ana-María; de-la-Cruz-Sánchez, Ernesto; Montes, Ana; Sotillo, Juan; Gutiérrez-Panizo, Candido; Fuentes, Pablo; Tornel, Pedro-Luis; Cabezas-Herrera, Juan (PUBLIC LIBRARY SCIENCE, 2017-06-08)
    The quantification of adenosine deaminase (ADA) in porcine saliva samples has been analyzed for its use as a marker of disease. First, an analytical validation of the enzymatic assay used for ADA measurements was performed. ...
  • A new device for deep cervical artificial insemination in gilts reduces the number of sperm per dose without impairing final reproductive performance 
    Llamas-López, Pedro-J; López-Úbeda, Rebeca; López, Gustavo; Antinoja, Emily; García-Vázquez, Francisco-A (BMC, 2019-01-28)
    BACKGROUND: The aim of this study was to evaluate the reproductive performance of a new artificial insemination (AI) device specifically designed for gilts (Deep cervical AI, Dp-CAI) by means of which the sperm is deposited ...
  • The association of telomere length with substance use disorders: systematic review and meta-analysis protocol 
    Navarro-Mateu, Fernando; Rubio-Aparicio, María; Cayuela, Pedro; Álvarez, Francisco-Javier; Roca-Vega, Agustín; Chirlaque-López, María-Dolores; Cayuela-Fuentes, María-Luisa; Husky, Mathilde; Martínez, Salvador; Sánchez-Meca, Julio (BMC, 2019-12-01)
    BACKGROUND: The present protocol was designed for a systematic review and meta-analysis aimed at determining the association of telomere length with substance use disorders with the exclusion of nicotine addiction, and to ...
  • Silk fibroin scaffolds seeded with Wharton's jelly mesenchymal stem cells enhance re-epithelialization and reduce formation of scar tissue after cutaneous wound healing 
    Millan-Rivero, José-E; Martínez, Carlos-M; Romecin, Paola-A; Aznar-Cervantes, Salvador; Carpes-Ruiz, Marina; Cenis, José-L; Moraleda-Jiménez, José-María; Atucha, Noemi-M; García-Bernal, David (BMC, 2019-04-27)
    BACKGROUND: The treatment of extensive and/or chronic skin wounds is a widespread and costly public health problem. Mesenchymal stem cells (MSCs) have been proposed as a potential cell therapy for inducing wound healing ...
  • Risk prediction for estrogen receptor-specific breast cancers in two large prospective cohorts 
    Li, Kuanrong; Anderson, Garnet; Viallon, Vivian; Arveux, Patrick; Kvaskoff, Marina; Fournier, Agnes; Krogh, Vittorio; Tumino, Rosario; Sánchez, Maria-Jose; Ardanaz, Eva; Chirlaque-López, María-Dolores; Agudo, Antonio; Muller, David-C; Smith, Todd; Tzoulaki, Ioanna; Key, Timothy-J; Bueno-de-Mesquita, Bas; Trichopoulou, Antonia; Bamia, Christina; Orfanos, Philippos; Kaaks, Rudolf; Huesing, Anika; Fortner, Renee-T; Zeleniuch-Jacquotte, Anne; Sund, Malin; Dahm, Christina-C; Overvad, Kim; Aune, Dagfinn; Weiderpass, Elisabete; Romieu, Isabelle; Riboli, Elio; Gunter, Marc; Dossus, Laure; Prentice, Ross; Ferrari, Pietro (BMC, 2018-12-03)
    BACKGROUND: Few published breast cancer (BC) risk prediction models consider the heterogeneity of predictor variables between estrogen-receptor positive (ER+) and negative (ER-) tumors. Using data from two large cohorts, ...
  • Development and validation of circulating CA125 prediction models in postmenopausal women 
    Sasamoto, Naoko; Babic, Ana; Rosner, Bernard-A; Fortner, Renee-T; Vitonis, Allison-F; Yamamoto, Hidemi; Fichorova, Raina-N; Titus, Linda-J; Tjonneland, Anne; Hansen, Louise; Kvaskoff, Marina; Fournier, Agnes; Mancini, Francesca-Romana; Boeing, Heiner; Trichopoulou, Antonia; Peppa, Eleni; Karakatsani, Anna; Palli, Domenico; Grioni, Sara; Mattiello, Amalia; Tumino, Rosario; Fiano, Valentina; Onland-Moret, N-Charlotte; Weiderpass, Elisabete; Gram, Inger-T; Quirós, J-Ramón; Lujan-Barroso, Leila; Sánchez, Maria-Jose; Colorado-Yohar, Sandra; Barricarte-Gurrea, Aurelio; Amiano, Pilar; Idahl, Annika; Lundin, Eva; Sartor, Hanna; Khaw, Kay-Tee; Key, Timothy-J; Muller, David; Riboli, Elio; Gunter, Marc; Dossus, Laure; Trabert, Britton; Wentzensen, Nicolás; Kaaks, Rudolf; Cramer, Daniel-W; Tworoger, Shelley-S; Terry, Kathryn-L (BMC, 2019-11-26)
    BACKGROUND: Cancer Antigen 125 (CA125) is currently the best available ovarian cancer screening biomarker. However, CA125 has been limited by low sensitivity and specificity in part due to normal variation between individuals. ...
  • Microglial dynamics after axotomy-induced retinal ganglion cell death 
    Nadal-Nicolás, Francisco-M; Jiménez-López, Manuel; Salinas-Navarro, Manuel; Sobrado-Calvo, Paloma; Vidal-Sanz, Manuel; Agudo-Barriuso, Marta (BMC, 2017-11-09)
    BACKGROUND: Microglial cells (MCs) are the sentries of the central nervous system. In health, they are known as surveying MCs because they examine the tissue to maintain the homeostasis. In disease, they activate and, among ...

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