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Envíos recientes

03. IMIB (Instituto Murciano de Investigación Biosanitaria Pascual Parrilla): Envíos recientes

  • Assessing Chronotypes by Ambulatory Circadian Monitoring 
    Martínez-Nicolás, Antonio; Martínez-Madrid, María-José; Francisco-Almaida-Pagan, Pedro; Bonmati-Carrión, Maria-Ángeles; Madrid, Juan-Antonio; Rol, María-Ángeles (FRONTIERS MEDIA SA, 2019-11-20)
    In order to develop objective indexes for chronotype identification by means of direct measurement of circadian rhythms, 159 undergraduate students were recruited as volunteers and instructed to wear ambulatory circadian ...
  • Bile Acids Do Not Contribute to the Altered Calcium Homeostasis of Platelets from Rats with Biliary Cirrhosis 
    Romecin, Paola; Navarro, Esther-G; Clara-Ortiz, M; Iyu, David; García-Estañ, Joaquín; Atucha, Noemi-M (FRONTIERS MEDIA SA, 2017-06-07)
    Previously, we have found that intracellular calcium homeostasis is altered in platelets from an experimental model of liver cirrhosis, the bile-duct ligated (BDL) rat; these alterations are compatible with the existence ...
  • Genetics and Gene-Environment Interactions in Childhood and Adult Onset Asthma 
    Morales, Eva; Duffy, David (FRONTIERS MEDIA SA, 2019-12-11)
    Asthma is a heterogeneous disease that results from the complex interaction between genetic factors and environmental exposures that occur at critical periods throughout life. It seems plausible to regard childhood-onset ...
  • Regulatory T Cells in Allergy and Asthma 
    Martín-Orozco, Elena; Norte-Muñoz, María; Martínez-García, Javier (FRONTIERS MEDIA SA, 2017-05-23)
    The immune system's correct functioning requires a sophisticated balance between responses to continuous microbial challenges and tolerance to harmless antigens, such as self-antigens, food antigens, commensal microbes, ...
  • Dietary and Gut Microbiota Polyamines in Obesity- and Age-Related Diseases 
    Ramos-Molina, Bruno; Queipo-Ortuño, María-Isabel; Lambertos, Ana; Tinahones, Francisco-J; Peñafiel, Rafael (FRONTIERS MEDIA SA, 2019-03-14)
    The polyamines putrescine, spermidine, and spermine are widely distributed polycationic compounds essential for cellular functions. Intracellular polyamine pools are tightly regulated by a complex regulatory mechanism ...
  • Application of Machine Learning Methods to Ambulatory Circadian Monitoring (ACM) for Discriminating Sleep and Circadian Disorders 
    Rodríguez-Morilla, Beatriz; Estivill, Eduard; Estivill-Domenech, Carla; Albares, Javier; Segarra, Francisco; Correa, Ángel; Campos, Manuel; Rol, María-Ángeles; Madrid, Juan-Antonio (FRONTIERS MEDIA SA, 2019-12-10)
    The present study proposes a classification model for the differential diagnosis of primary insomnia (PI) and delayed sleep phase disorder (DSPD), applying machine learning methods to circadian parameters obtained from ...
  • Systemic and Intravitreal Antagonism of the TNFR1 Signaling Pathway Delays Axotomy-Induced Retinal Ganglion Cell Loss 
    Lucas-Ruiz, Fernando; Galindo-Romero, Caridad; Salinas-Navarro, Manuel; González-Riquelme, María-Josefa; Vidal-Sanz, Manuel; Agudo-Barriuso, Marta (FRONTIERS MEDIA SA, 2019-10-15)
    Here, we have blocked the signaling pathway of tumor necrosis factor ? (TNF?) in a mouse model of traumatic neuropathy using a small cell permeable molecule (R7050) that inhibits TNF?/TNF receptor 1 (TNFR1) complex ...
  • Validation of a Device for the Ambulatory Monitoring of Sleep Patterns: A Pilot Study on Parkinson's Disease 
    Madrid-Navarro, Carlos-Javier; Puertas-Cuesta, Francisco-Javier; Escamilla-Sevilla, Francisco; Campos, Manuel; Ruiz-Abellán, Fernando; Rol, María-Ángeles; Madrid, Juan-Antonio (FRONTIERS MEDIA SA, 2019-04-11)
    The development of wearable devices has increase interest in the use of ambulatory methods to detect sleep disorders more objectively than those permitted by subjective scales evaluating sleep quality, while subjects ...
  • Multidimensional circadian Monitoring by Wearable Biosensors in Parkinson's Disease 
    Madrid-Navarro, Carlos-J; Escamilla-Sevilla, Francisco; Mínguez-Castellanos, Adolfo; Campos, Manuel; Ruiz-Abellán, Fernando; Madrid, Juan-A; Rol, M-A (FRONTIERS MEDIA SA, 2018-03-26)
    Parkinson's disease (PD) is associated with several non-motor symptoms that may precede the diagnosis and constitute a major source of frailty in this population. The digital era in health care has open up new prospects ...
  • Unexpected Exacerbation of Neuroinflammatory Response After a Combined Therapy in Old Parkinsonian Mice 
    Gil-Martínez, Ana-Luisa; Cuenca, Lorena; Estrada, Cristina; Sánchez-Rodrigo, Consuelo; Fernández-Villalba, Emiliano; Herrero, María-Trinidad (FRONTIERS MEDIA SA, 2018-11-30)
    The design of therapeutic strategies that focus on the repositioning of anti-inflammatory and antioxidant drugs are a great bet to slow down the progression of neurodegenerative disorders. Despite the fact that Parkinson's ...
  • Time Course of the Neural Activity Related to Behavioral Decision-Making as Revealed by Event-Related Potentials 
    Martínez-Selva, José-María; Muñoz, Miguel-A; Sánchez-Navarro, Juan-P; Walteros, Cesar; Montoya, Pedro (FRONTIERS MEDIA SA, 2019-09-03)
    Objective: To study the time course of the electrocortical activity evoked by gains and losses in the Iowa Gambling Task (IGT), the brain sources of this electrical activity, and its association with behavioral parameters ...
  • Time-of-Day and Age Impact on Memory in Elevated Plus-Maze Test in Rats 
    Morales-Delgado, Nicanor; Popovic, Natalija; de-la-Cruz-Sánchez, Ernesto; Caballero-Bleda, María; Popovic, Miroljub (FRONTIERS MEDIA SA, 2018-12-06)
    The purpose of the present study was to establish the effect of daytime and aging on memory in rats in the Elevated Plus-Maze (EPM) test. Young (2-months) and aged (18-months) male Wistar rats were exposed to the EPM test, ...
  • Patterned Vascularization of Embryonic Mouse Forebrain, and Neuromeric Topology of Major Human Subarachnoidal Arterial Branches: A Prosomeric Mapping 
    Puelles, Luis; Martínez-Marín, Rafael; Melgarejo-Otalora, Pedro; Ayad, Abdelmalik; Valavanis, Antonios; Ferran, José-Luis (FRONTIERS MEDIA SA, 2019-06-19)
    The prosomeric brain model contemplates progressive regionalization of the central nervous system (CNS) from a molecular and morphological ontogenetic perspective. It defines the forebrain axis relative to the notochord, ...
  • Survey of Midbrain, Diencephalon, and Hypothalamus Neuroanatomic Terms Whose Prosomeric Definition Conflicts With Columnar Tradition 
    Puelles, Luis (FRONTIERS MEDIA SA, 2019-02-27)
    Recent neuroanatomic concepts and terms referring to the non-telencephalic forebrain are presented and discussed, in context with the present scenario in which the old columnar paradigm is being substituted by the prosomeric ...
  • The MAPT H1 Haplotype Is a Risk Factor for Alzheimer's Disease in APOE e4 Non-carriers 
    Sánchez-Juan, Pascual; Moreno, Sonia; de-Rojaso, Itziar; Hernández, Isabel; Valero, Sergi; Alegret, Montse; Montrreal, Laura; García-González, Pablo; Lage, Carmen; López-García, Sara; Rodriiguez-Rodríguez, Eloy; Orellana, Adelina; Tarraga, Lluis; Boada, Merce; Ruiz, Agustín; Abdelnour, C; Aguilera, N; Alarcón, E; Alegret, M; Boada, M; Buendía, M; Canabate, P; de-Rojas, I; Diego, S; Espinosa, A; Gailhajenet, A; García-González, P; Gil, S; Guitart, M; Hernández, I; Ibarria, M; Lafuente, A; Martín, E; Mauleon, A; Monte-Rubio, G; Montrreal, L; Moreno-Grau, S; Moreno, M; Orellana, A; Ortega, G; Pancho, A; Peleja, E; Pérez-Cordon, A; Preckler, S; Rodríguez-Gómez, O; Rosende-Roca, M; Ruiz, A; Ruiz, S; Sanabria, A; Santos-Santos, M-A; Sotolongo-Grau, O; Tarraga, L; Valero, S; Vargas, L; Quintela, I; Real, L-M; Carracedo, A; Maronas, O; Corbaton, A; Martínez, M-T; Serrano-Rios, M; González-Pérez, A; Saez, M-E; Macías, J; Pineda, J-A; Adarmes-Gómez, A-D; Buiza-Rueda, D; Carrillo, F; Carrión-Claro, M; Gómez-Garre, P; Jesús, S; Labrador-Espinosa, M-A; Macías, D; Mir, P; Perinan-Tocino, T; Blesa, R; Bullido, M-J; Calero, M; Clarimon, J; Fortea, J; Frank-García, A; Lage, C; Lleo, A; López-García, S; Martín-Montes, A; Medina, M; Pérez-Tur, J; Pinol-Ripoll, G; Rabano, A; Rodríguez-Rodríguez, E; Sánchez-Juan, P; Sastre, I; Alarcón-Martín, E; Marquie, M; Cruz-Gamero, J-M; Royo, J-L; Álvarez, I; Díez-Fairen, M; Pastor, P; Álvarez, V; Martínez, C; Menéndez-González, M; Amer-Ferrer, G; Antequera, M; Antunez, C; Legaz, A; Manzanares, S; Marin-Muñoz, J; Martínez, B; Martínez, V; Vicente, M-P; Vivancos, L; Baquero, M; Burguera, J-A; Bernal, M; Franco, E; Marín, M; Rodrigo, S; del-Ser, T; Pastor, A-B; García-Madrona, S; García-Ribas, G; Casajeros, M-J; de-Pancorbo, M-M; García-Alberca, J-M; Hevilla, S; Marín, T; López-de-Munain, A; Martínez-Lage-Álvarez, P; Mendioroz-Iriarte, M; Molinuevo, J-L; Real-de-Asua, D; sánchez-del-Valle-Díaz, R (FRONTIERS MEDIA SA, 2019-12-04)
    An ancestral inversion of 900 kb on chromosome 17q21, which includes the microtubule-associated protein tau (MAPT) gene, defines two haplotype clades in Caucasians (H1 and H2). The H1 haplotype has been linked inconsistently ...
  • WNT Signaling in Tumors: The Way to Evade Drugs and Immunity 
    Martín-Orozco, Elena; Sánchez-Fernández, Ana; Ortiz-Parra, Irene; Ayala-San-Nicolás, María (FRONTIERS MEDIA SA, 2019-12-20)
    WNT/?-catenin signaling is involved in many physiological processes. Its implication in embryonic development, cell migration, and polarization has been shown. Nevertheless, alterations in this signaling have also been ...
  • Late-Onset Cryopyrin-Associated Periodic Syndromes Caused by Somatic NLRP3 Mosaicism - UK Single Center Experience 
    Rowczenio, Dorota-M; Gomes, Sonia-Melo; Arostegui, Juan-I; Mensa-Vilaro, Anna; Omoyinmi, Ebun; Trojer, Hadija; Baginska, Anna; Baroja-Mazo, Alberto; Pelegrín, Pablo; Savic, Sinisa; Lane, Thirusha; Williams, Rene; Brogan, Paul; Lachmann, Helen-J; Hawkins, Philip-N (FRONTIERS MEDIA SA, 2017-10-31)
    Cryopyrin-associated periodic syndrome (CAPS) is caused by gain-of-function NLRP3 mutations. Recently, somatic NLRP3 mosaicism has been reported in some CAPS patients who were previously classified as "mutation-negative." ...
  • Estrogens Promote the Production of Natural Neutralizing Antibodies in Fish through G Protein-Coupled Estrogen Receptor 1 
    Rodenas, María-C; Cabas, Isabel; Gómez-González, Nuria-Esther; Arizcun, Marta; Meseguer, José; Mulero, Víctoriano; García-Ayala, Alfonsa (FRONTIERS MEDIA SA, 2017-06-29)
    Natural antibodies play crucial roles in pathogen elimination, B-cell survival and homeostasis, and inflammatory and autoimmune diseases. Although estrogens are able to regulate both innate and adaptive immune responses, ...
  • Saharan Dust Modeling Over the Mediterranean Basin and Central Europe: Does the Resolution Matter? 
    Palacios-Pena, Laura; Lorente-Plazas, Raquel; Montavez, Juan-Pedro; Jiménez-Guerrero, Pedro (FRONTIERS MEDIA SA, 2019-11-08)
  • Transient Sperm Starvation Improves the Outcome of Assisted Reproductive Technologies 
    Navarrete, Felipe-A; Aguila, Luis; Martín-Hidalgo, David; Tourzani, Darya-A; Luque, Guillermina-M; Ardestani, Goli; García-Vázquez, Francisco-A; Levin, Lonny-R; Buck, Jochen; Darszon, Alberto; Buffone, Mariano-G; Mager, Jesse; Fissore, Rafael-A; Salicioni, Ana-M; Gervasi, María-G; Visconti, Pablo-E (FRONTIERS MEDIA SA, 2019-11-05)
    To become fertile, mammalian sperm must undergo a series of biochemical and physiological changes known as capacitation. These changes involve crosstalk between metabolic and signaling pathways and can be recapitulated in ...

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