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Envíos recientes

03. IMIB (Instituto Murciano de Investigación Biosanitaria Pascual Parrilla): Envíos recientes

  • Potential role of P2X7 receptor in neurodegenerative processes in a murine model of glaucoma 
    Pérez-de-Lara, María-J; Avilés-Trigueros, Marcelino; Guzman-Aranguez, Ana; Valiente-Soriano, Francisco-Javier; de-la-Villa, Pedro; Vidal-Sanz, Manuel; Pintor, Jesús (PERGAMON-ELSEVIER SCIENCE LTD, 2019-08)
    Glaucoma is a common cause of visual impairment and blindness, characterized by retinal ganglion cell (RGC) death. The mechanisms that trigger the development of glaucoma remain unknown and have gained significant relevance ...
  • A Systematic Review of Fitness Apps and Their Potential Clinical and Sports Utility for Objective and Remote Assessment of Cardiorespiratory Fitness 
    Muntaner-Mas, Adria; Martínez-Nicolás, Antonio; Lavie, Carl-J; Blair, Steven-N; Ross, Robert; Arena, Ross; Ortega, Francisco-B (ADIS INT LTD, 2019-04)
    BACKGROUND: Cardiorespiratory fitness (CRF) assessment provides key information regarding general health status that has high clinical utility. In addition, in the sports setting, CRF testing is needed to establish a ...
  • Effects of Social Attitude Change on Smoking Heritability 
    Mezquita, Laura; Sánchez-Romera, Juan-F; Ibáñez, Manuel-I; Morosoli, José-J; Colodro-Conde, Lucía; Ortet, Generos; Ordoñana, Juan-Ramón (SPRINGER, 2018-01)
    Societal attitudes and norms to female smoking changed in Spain in the mid-twentieth century from a restrictive to a tolerant, and an even pro-smoking, posture, while social attitudes remained stable for males. We explored ...
  • A nutrient-wide association study for risk of prostate cancer in the European Prospective Investigation into Cancer and Nutrition and the Netherlands Cohort Study 
    Papadimitriou, Nikos; Muller, David; van-den-Brandt, Piet-A; Geybels, Milan; Patel, Chirag-J; Gunter, Marc; López, David-S; Key, Timothy-J; Pérez-Cornago, Aurora; Ferrari, Pietro; Vineis, Paolo; Weiderpass, Elisabete; Boeing, Heiner; Agudo, Antonio; Sánchez, Maria-Jose; Overvad, Kim; Kuehn, Tilman; Fortner, Renee-T; Palli, Domenico; Drake, Isabel; Bjartell, Anders; Santiuste-de-Pablos, Carmen; Bueno-de-Mesquita, Bas; Krogh, Vittorio; Tjonneland, Anne; Lauritzen, Dorthe-Furstrand; Barricarte-Gurrea, Aurelio; Quirós, José-Ramón; Stattin, Par; Trichopoulou, Antonia; Martimianaki, Georgia; Karakatsani, Anna; Thysell, Elin; Johansson, Ingegerd; Ricceri, Fulvio; Tumino, Rosario; Larrañaga, Nerea; Khaw, Kay-Tee; Riboli, Elio; Tzoulaki, Ioanna; Tsilidis, Konstantinos-K (SPRINGER HEIDELBERG, 2020-10)
    PURPOSE: The evidence from the literature regarding the association of dietary factors and risk of prostate cancer is inconclusive. METHODS: A nutrient-wide association study was conducted to systematically and comprehensively ...
  • Interplay between genetic predisposition, macronutrient intake and type 2 diabetes incidence: analysis within EPIC-InterAct across eight European countries 
    Li, Sherly-X; Imamura, Fumiaki; Schulze, Matthias-B; Zheng, Jusheng; Ye, Zheng; Agudo, Antonio; Ardanaz, Eva; Aune, Dagfinn; Boeing, Heiner; Dorronsoro, Miren; Dow, Courtney; Fagherazzi, Guy; Grioni, Sara; Gunter, Marc; Huerta-Castaño, José-María; Ibsen, Daniel-B; Jakobsen, Marianne-Uhre; Kaaks, Rudolf; Key, Timothy-J; Khaw, Kay-Tee; Kyro, Cecilie; Mancini, Francesca-Romana; Molina-Portillo, Elena; Murphy, Neil; Nilsson, Peter-M; Onland-Moret, N-Charlotte; Palli, Domenico; Panico, Salvatore; Poveda, Alaitz; Quirós, J-Ramón; Ricceri, Fulvio; Sluijs, Ivonne; Spijkerman, Annemieke-M-W; Tjonneland, Anne; Tumino, Rosario; Winkvist, Anna; Langenberg, Claudia; Sharp, Stephen-J; Riboli, Elio; Scott, Robert-A; Forouhi, Nita-G; Wareham, Nicholas-J (SPRINGER, 2018-06)
    AIMS/HYPOTHESIS: Gene-macronutrient interactions may contribute to the development of type 2 diabetes but research evidence to date is inconclusive. We aimed to increase our understanding of the aetiology of type 2 diabetes ...
  • Prediagnostic circulating concentrations of plasma insulin-like growth factor-I and risk of lymphoma in the European Prospective Investigation into Cancer and Nutrition 
    Pérez-Cornago, Aurora; Appleby, Paul-N; Tipper, Sarah; Key, Timothy-J; Allen, Naomi-E; Nieters, Alexandra; Vermeulen, Roel; Roulland, Sandrine; Casabonne, Delphine; Kaaks, Rudolf; Fortner, Renee-T; Boeing, Heiner; Trichopoulou, Antonia; La-Vecchia, Carlo; Klinaki, Eleni; Hansen, Louise; Tjonneland, Anne; Bonnet, Fabrice; Fagherazzi, Guy; Boutron-Ruault, Marie-Christine; Pala, Valeria; Masala, Giovanna; Sacerdote, Carlotta; Peeters, Petra-H; Bueno-de-Mesquita, Bas; Weiderpass, Elisabete; Dorronsoro, Miren; Quirós, J-Ramón; Barricarte-Gurrea, Aurelio; Gavrila-Chervase, Diana; Agudo, Antonio; Borgquist, Signe; Rosendahl, Ann-H; Melin, Beatrice; Wareham, Nick; Khaw, Kay-Tee; Gunter, Marc; Riboli, Elio; Vineis, Paolo; Travis, Ruth-C (WILEY, 2017-03-01)
    Insulin-like growth factor (IGF)-I has cancer promoting activities. However, the hypothesis that circulating IGF-I concentration is related to risk of lymphoma overall or its subtypes has not been examined prospectively. ...
  • Saturation of acyl chains converts cardiolipin from an antagonist to an activator of Toll-like receptor-4 
    Pizzuto, Malvina; Lonez, Caroline; Baroja-Mazo, Alberto; Martínez-Banaclocha, Helios; Tourlomousis, Panagiotis; Gangloff, Monique; Pelegrín, Pablo; Ruysschaert, Jean-Marie; Gay, Nicholas-J; Bryant, Clare-E (SPRINGER BASEL AG, 2019-09)
    Cardiolipins (CLs) are tetra-acylated diphosphatidylglycerols found in bacteria, yeast, plants, and animals. In healthy mammals, CLs are unsaturated, whereas saturated CLs are found in blood cells from Barth syndrome ...
  • Pre-diagnostic circulating insulin-like growth factor-I and bladder cancer risk in the European Prospective Investigation into Cancer and Nutrition 
    Lin, Crystal; Travis, Ruth-C; Appleby, Paul-N; Tipper, Sarah; Weiderpass, Elisabete; Chang-Claude, Jenny; Gram, Inger-T; Kaaks, Rudolf; Kiemeney, Lambertus-A; Ljungberg, Borje; Tumino, Rosario; Tjonneland, Anne; Roswall, Nina; Overvad, Kim; Boutron-Ruault, Marie-Christine; Manciniveri, Francesca-Romana; Severi, Gianluca; Trichopoulou, Antonia; Masala, Giovanna; Sacerdote, Carlotta; Agnoli, Claudia; Panico, Salvatore; Bueno-de-Mesquita, Bas; Peeters, Petra-H; Salamanca-Fernández, Elena; Chirlaque-López, María-Dolores; Ardanaz, Eva; Dorronsoro, Miren; Menéndez, Virginia; Lujan-Barroso, Leila; Liedberg, Fredrik; Freisling, Heinz; Gunter, Marc; Aune, Dagfinn; Cross, Amanda-J; Riboli, Elio; Key, Timothy-J; Pérez-Cornago, Aurora (WILEY, 2018-11-15)
    Previous in vitro and case-control studies have found an association between the insulin-like growth factor (IGF)-axis and bladder cancer risk. Circulating concentrations of IGF-I have also been found to be associated with ...
  • Association Between Soft Drink Consumption and Mortality in 10 European Countries 
    Mullee, Amy; Romaguera, Dora; Pearson-Stuttard, Jonathan; Viallon, Vivian; Stepien, Magdalena; Freisling, Heinz; Fagherazzi, Guy; Mancini, Francesca-Romana; Boutron-Ruault, Marie-Christine; Kuehn, Tilman; Kaaks, Rudolf; Boeing, Heiner; Aleksandrova, Krasimira; Tjonneland, Anne; Halkjaer, Jytte; Overvad, Kim; Weiderpass, Elisabete; Skeie, Guri; Parr, Christine-L; Quirós, J-Ramón; Agudo, Antonio; Sánchez, Maria-Jose; Amiano, Pilar; Cirera-Suárez, LLuis; Ardanaz, Eva; Khaw, Kay-Tee; Tong, Tammy-Y-N; Schmidt, Julie-A; Trichopoulou, Antonia; Martimianaki, Georgia; Karakatsani, Anna; Palli, Domenico; Agnoli, Claudia; Tumino, Rosario; Sacerdote, Carlotta; Panico, Salvatore; Bueno-de-Mesquita, Bas; Verschuren, W-M-Monique; Boer, Jolanda-M-A; Vermeulen, Roel; Ramne, Stina; Sonestedt, Emily; van-Guelpen, Bethany; Holgersson, Pernilla-Lif; Tsilidis, Konstantinos-K; Heath, Alicia-K; Muller, David; Riboli, Elio; Gunter, Marc; Murphy, Neil (AMER MEDICAL ASSOC, 2019-11)
    IMPORTANCE: Soft drinks are frequently consumed, but whether this consumption is associated with mortality risk is unknown and has been understudied in European populations to date. OBJECTIVE: To examine the association ...
  • ZP4 confers structural properties to the zona pellucida essential for embryo development 
    Lamas-Toranzo, Ismael; Fonseca-Balvis, Noelia; Querejeta-Fernández, Ana; Izquierdo-Rico, María-José; González-Brusi, Leopoldo; Lorenzo, Pedro-L; García-Rebollar, Pilar; Avilés, Manuel; Bermejo-Álvarez, Pablo (ELIFE SCIENCES PUBLICATIONS LTD, 2019-10-22)
    Zona pellucida (ZP), the extracellular matrix sheltering mammalian oocytes and embryos, is composed by 3 to 4 proteins. The roles of the three proteins present in mice have been elucidated by KO models, but the function ...
  • DNA methylation and gene expression changes derived from assisted reproductive technologies can be decreased by reproductive fluids 
    Cánovas, Sebastián; Ivanova, Elena; Romar, Raquel; García-Martínez, Soledad; Soriano-Úbeda, Cristina; García-Vazquez, Francisco-A; Saadeh, Heba; Andrews, Simon; Kelsey, Gavin; Coy-Fuster, Pilar (ELIFE SCIENCES PUBLICATIONS LTD, 2017-02-01)
    The number of children born since the origin of Assisted Reproductive Technologies (ART) exceeds 5 million. The majority seem healthy, but a higher frequency of defects has been reported among ART-conceived infants, ...
  • L-Ferritin: One Gene, Five Diseases; from Hereditary Hyperferritinemia to Hypoferritinemia-Report of New Cases 
    Cadenas, Beatriz; Fita-Torro, Josep; Bermudez-Cortés, Mar; Hernández-Rodríguez, Inés; Fuster-Soler, José-Luis; Llinares, María-Esther; Galera-Miñarro, Ana-María; Romero, Julia-Lee; Pérez-Montero, Santiago; Tornador, Cristian; Sánchez, Mayka (MDPI, 2019-01-23)
    Ferritin is a multimeric protein composed of light (L-ferritin) and heavy (H-ferritin) subunits that binds and stores iron inside the cell. A variety of mutations have been reported in the L-ferritin subunit gene (FTL gene) ...
  • Vitamin D-Related Genes, Blood Vitamin D Levels and Colorectal Cancer Risk in Western European Populations 
    Fedirko, Veronika; Mandle, Hannah-B; Zhu, Wanzhe; Hughes, David-J; Siddiq, Afshan; Ferrari, Pietro; Romieu, Isabelle; Riboli, Elio; Bueno-de-Mesquita, Bas; van-Duijnhoven, Franzel-J-B; Siersema, Peter-D; Tjonneland, Anne; Olsen, Anja; Perduca, Vittorio; Carbonnel, Franck; Boutron-Ruault, Marie-Christine; Kuehn, Tilman; Johnson, Theron; Krasimira, Aleksandrova; Trichopoulou, Antonia; Makrythanasis, Periklis; Thanos, Dimitris; Panico, Salvatore; Krogh, Vittorio; Sacerdote, Carlotta; Skeie, Guri; Weiderpass, Elisabete; Colorado-Yohar, Sandra; Sala, Nuria; Barricarte-Gurrea, Aurelio; Sánchez, María-José; Quirós, José-Ramón; Amiano, Pilar; Gylling, Bjorn; Harlid, Sophia; Pérez-Cornago, Aurora; Heath, Alicia-K; Tsilidis, Konstantinos-K; Aune, Dagfinn; Freisling, Heinz; Murphy, Neil; Gunter, Marc-J; Jenab, Mazda (MDPI, 2019-08)
    Higher circulating 25-hydroxyvitamin D levels (25(OH)D) have been found to be associated with lower risk for colorectal cancer (CRC) in prospective studies. Whether this association is modified by genetic variation in genes ...
  • Association of Selenoprotein and Selenium Pathway Genotypes with Risk of Colorectal Cancer and Interaction with Selenium Status 
    Fedirko, Veronika; Jenab, Mazda; Meplan, Catherine; Jones, Jeb-S; Zhu, Wanzhe; Schomburg, Lutz; Siddiq, Afshan; Hybsier, Sandra; Overvad, Kim; Tjonneland, Anne; Omichessan, Hanane; Perduca, Vittorio; Boutron-Ruault, Marie-Christine; Kuehn, Tilman; Katzke, Verena; Aleksandrova, Krasimira; Trichopoulou, Antonia; Karakatsani, Anna; Kotanidou, Anastasia; Tumino, Rosario; Panico, Salvatore; Masala, Giovanna; Agnoli, Claudia; Naccarati, Alessio; Bueno-de-Mesquita, Bas; Vermeulen, Roel-C-H; Weiderpass, Elisabete; Skeie, Guri; Nost, Therese-Haugdahl; Lujan-Barroso, Leila; Quirós, José-Ramón; Huerta-Castaño, José-María; Rodríguez-Barranco, Miguel; Barricarte-Gurrea, Aurelio; Gylling, Bjoern; Harlid, Sophia; Bradbury, Kathryn-E; Wareham, Nick; Khaw, Kay-Tee; Gunter, Marc; Murphy, Neil; Freisling, Heinz; Tsilidis, Kostas; Aune, Dagfinn; Riboli, Elio; Hesketh, John-E; Hughes, David-J (MDPI, 2019-04)
    Selenoprotein genetic variations and suboptimal selenium (Se) levels may contribute to the risk of colorectal cancer (CRC) development. We examined the association between CRC risk and genotype for single nucleotide ...
  • Cognitive Training Therapy Improves the Effect of Hypocaloric Treatment on Subjects with Overweight/Obesity: A Randomised Clinical Trial 
    Galindo-Muñoz, Joaquín-S; Morillas-Ruiz, Juana-María; Gómez-Gallego, María; Díaz-Soler, Inmaculada; Barbera-Ortega, María-del-Carmen; Martínez, Carlos-M; Hernández-Morante, Juan-José (MDPI, 2019-04)
    Obesity has been associated with impaired cognitive performance. This study aimed to determine whether improvements in cognitive function may contribute to higher weight loss in patients with obesity. In this randomised, ...
  • Tomato Juice Supplementation Influences the Gene Expression Related to Steatosis in Rats 
    Elvira-Torales, Laura-Inés; Navarro-González, Inmaculada; González-Barrio, Rocío; Martín-Pozuelo, Gala; Domenech, Guillermo; Seva, Juan; García-Alonso, Javier; Periago-Caston, María-Jesús (MDPI, 2018-09)
    The objective of this work was to identify the effect of tomato juice on the expression of genes and levels of metabolites related to steatosis in rats. Male Sprague Dawley rats (8 weeks-old) were grouped (6 rats/group) ...
  • Beneficial Effects of Different Flavonoids on Vascular and Renal Function in L-NAME Hypertensive Rats 
    Paredes, María-Dolores; Romecin, Paola; Atucha, Noemi-M; O'Valle, Francisco; Castillo, Julian; Ortiz-Ruiz, M-Clara; García-Estañ, Joaquín (MDPI, 2018-04)
    BACKGROUND: we have evaluated the antihypertensive effect of several flavonoid extracts in a rat model of arterial hypertension caused by chronic administration (6 weeks) of the nitric oxide synthesis inhibitor, L-NAME. ...
  • Preclinical Studies of the Biosafety and Efficacy of Human Bone Marrow Mesenchymal Stem Cells Pre-Seeded into ß-TCP Scaffolds after Transplantation 
    Gonzalvez-García, Mar; Martínez, Carlos-M; Villanueva, Víctor; García-Hernández, Ana; Blanquer-Blanquer, Miguel; Meseguer-Olmo, Luis; Oñate-Sánchez, Ricardo-Elías; Moraleda-Jiménez, José-María; Rodríguez-Lozano, Francisco-Javier (MDPI, 2018-08)
    Background: Cell-Based Therapies (CBT) constitute a valid procedure for increasing the quantity and quality of bone in areas with an inadequate bone volume. However, safety and efficacy should be investigated prior to ...
  • A New Management Technique for Symptomatic Haematomas Following Therapeutic Vacuum-Assisted Biopsy 
    Guzmán-Aroca, Florentina; Berna-Serna, Juan-de-Dios; Azahara-García-Ortega, Ana; Hernández-Gómez, Dolores; Berna-Mestre, Juan-de-Dios (MDPI, 2019-09)
    The aim of this study was to investigate the efficacy of the vacuum-assisted biopsy (VAB) system in evacuating symptomatic haematomas after VAB excision of benign breast lesions. We retrospectively analysed the data of ...
  • The Combination of Different Ergonomic Supports during Dental Procedures Reduces the Muscle Activity of the Neck and Shoulder 
    García-Vidal, José-A; López-Nicolas, Manuel; Sánchez-Sobrado, Ana-C; Escolar-Reina, María-P; Medina-Mirapeix, Francesc; Bernabeu-Mora, Roberto (MDPI, 2019-08)
    Ergonomic supports have become popular for the prevention of musculoskeletal disorders. This study sought to evaluate the efficacy of different ergonomic supports and their combination to reduce muscle activity of the neck ...

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