Repositorio Dspace

Envíos recientes

02.06. Área de Salud VI Vega Media: Envíos recientes

  • Signature of Circulating Biomarkers in Recurrent Non-Infectious Anterior Uveitis. Immunomodulatory Effects of DHA-Triglyceride. A Pilot Study 
    Pinazo-Durán, María-Dolores-; García-Medina, José-Javier; Sanz-González, Silvia-M; O'Connor, José-E; Casaroli-Marano, Ricardo-P; Valero-Vello, Mar; López-Gálvez, Maribel; Peris-Martínez, Cristina; Zanón-Moreno, Vicente; Diaz-Llopis, Manuel (MDPI, 2021-04)
    The purpose of this study was to identify circulating biomarkers of recurrent non-infectious anterior uveitis (NIAU), and to address the anti-inflammatory effects of triglyceride containing docosahexaenoic acid (DHA-TG). ...
  • Role of Thrombopoietin Receptor Agonists in Inherited Thrombocytopenia 
    Bastida, José-María; González-Porras, José-Ramón; Rivera, José; Lozano-Almela, María-Luisa (MDPI, 2021-05)
    In the last decade, improvements in genetic testing have revolutionized the molecular diagnosis of inherited thrombocytopenias (ITs), increasing the spectrum of knowledge of these rare, complex and heterogeneous disorders. ...
  • The PI3Kd Inhibitor Idelalisib Diminishes Platelet Function and Shows Antithrombotic Potential 
    Barrachina, María-N; Izquierdo, Irene; Hermida-Nogueira, Lidia; Morán, Luis-A; Pérez, Amparo; Arroyo, Ana-B; García-Barbera, Nuria; González-Conejero, Rocío; Troitino, Sara; Eble, Johannes-A; Rivera, José; Martínez, Constantino; Loza, María-I; Domínguez, Eduardo; García, Ángel (MDPI, 2021-04)
    BACKGROUND: Clinical management of ischemic events and prevention of vascular disease is based on antiplatelet drugs. Given the relevance of phosphatidylinositol-4,5-bisphosphate 3-kinase (PI3K) as a candidate target in ...
  • MicroRNAs as New Regulators of Neutrophil Extracellular Trap Formation 
    Águila, Sonia; de-los-Reyes-García, Ascensión-María; Fernández-Pérez, María-Piedad; Reguilón-Gallego, Laura; Zapata-Martínez, Laura; Ruiz-Lorente, Inmaculada; Vicente, Vicente; González-Conejero, Rocío; Martínez, Constantino (MDPI, 2021-02)
    Neutrophil extracellular traps (NETs) are formed after neutrophils expelled their chromatin content in order to primarily capture and eliminate pathogens. However, given their characteristics due in part to DNA and different ...
  • Qualitative and Quantitative Comparison of Plasma Exosomes from Neonates and Adults 
    Peñas-Martínez, Julia; Barrachina, María-N; Cuenca-Zamora, Ernesto-José; Luengo-Gil, Ginés; Bravo, Susana-Belén; Caparrós-Pérez, Eva; Teruel-Montoya, Raúl; Blanco-Carnero, José-Eliseo; Vicente, Vicente; García, Ángel; Martínez-Martínez, Irene; Ferrer-Marín, Francisca (MDPI, 2021-02)
    Exosomes are extracellular vesicles that contain nucleic acids, lipids and metabolites, and play a critical role in health and disease as mediators of intercellular communication. The majority of extracellular vesicles in ...
  • Bleeding Complications in Anticoagulated and/or Antiplatelet-Treated Patients at the Dental Office: A Retrospective Study 
    Martínez-Moreno, Esther; Martínez-López, Federico; Rodríguez-Lozano, Francisco-Javier; Oñate-Sánchez, Ricardo-Elías (MDPI, 2021-02)
    BACKGROUND: Bleeding complications in patients undergoing antiplatelet and/or anticoagulant therapy have been one of the main concerns in dental practice. Upon the introduction of new antiplatelet and anticoagulant drugs, ...
  • Emerging Role of Neutrophils in the Thrombosis of Chronic Myeloproliferative Neoplasms 
    Ferrer-Marín, Francisca; Cuenca-Zamora, Ernesto-José; Guijarro-Carrillo, Pedro-Jesús; Teruel-Montoya, Raúl (MDPI, 2021-02)
    Thrombosis is a major cause of morbimortality in patients with chronic Philadelphia chromosome-negative myeloproliferative neoplasms (MPN). In the last decade, multiple lines of evidence support the role of leukocytes in ...
  • N-Glycosylation as a Tool to Study Antithrombin Secretion, Conformation, and Function 
    Águila, Sonia; Noto, Rosina; Luengo-Gil, Ginés; Espin, Salvador; Bohdan, Nataliya; de-la-Morena-barrio, María-Eugenia; Peñas-Martínez, Julia; Ródenas, María-del-Carmen; Vicente, Vicente; Corral, Javier; Manno, Mauro; Martínez-Martínez, Irene (MDPI, 2021-01)
    N-linked glycosylation is a crucial post-translational modification involved in protein folding, function, and clearance. N-linked glycosylation is also used therapeutically to enhance the half-lives of many proteins. ...
  • Exploring the Immunoresponse in Bladder Cancer Immunotherapy 
    Ruiz-Lorente, Inmaculada; Gimeno, Lourdes; López-Abad, Alicia; López-Cubillana, Pedro; Fernández, Aparicio; Asensio-Egea, Lucas-Jesús; Moreno-Avilés, Juan; Donate-Iñíguez, Gloria; Guzmán-Martínez-Valls, Pablo-Luis; Server-Gómez, Gerardo; Escudero-Bregante, José-Félix; Ferri, Belén; Campillo, José-Antonio; Pons-Fuster-López, Eduardo; Martínez-Hernández, María-Dolores; Martínez-Sánchez, María-Victoria; Ceballos, Diana; Minguela-Puras, Alfredo (MDPI, 2024-12)
    Bladder cancer (BC) represents a wide spectrum of diseases, ranging from recurrent non-invasive tumors to advanced stages that require intensive treatments. BC accounts for an estimated 500,000 new cases and 200,000 deaths ...
  • Targeting of Non-Classical Human Leukocyte Antigens as Novel Therapeutic Strategies in Cancer 
    Benítez-Fuentes, Javier-David; Arcilla, Jorge-Bartolomé; Mohamed-Mohamed, Kauzar; López-de-Sa, Alfonso; de-Luna-Aguilar, Alicia; Guevara-Hoyer, Kissy; Ballestin-Martínez, Pablo; Lázaro-Sánchez, Antonio-David; Carosella, Edgardo-D; Ocana, Alberto; Sánchez-Ramon, Silvia (MDPI, 2024-12)
    Human leukocyte antigens (HLAs) are essential regulators of immune responses against cancer, with classical HLAs well-documented for their role in tumor recognition and immune surveillance. In recent years, non-classical ...
  • The Value of Bone Marrow Assessment by FDG PET/CT, Biopsy and Aspirate in the Upfront Evaluation of Mantle Cell Lymphoma: A Nationwide Cohort Study 
    Ródenas-Quiñonero, Isabel; Marco-Ayala, Javier; Chen-Liang, Tzu-Hua; de-la-Cruz-vicente, Fatima; Baumann, Tycho; Navarro, José-Tomás; Martín-García-Sancho, Alejandro; Martín-Santos, Taida; López-Jiménez, Javier; Andreu, Rafael; Parra, Ester; Usas, Andrea; Alonso, David; Fernández-González, Marta; Rumschisky, Pablo-Palomo; Frutos, Laura; Navarro, José-Luis; Álvarez-Pérez, Rosa-María; Sarandeses, Pilar; Cortés, Montserrat; Tamayo, Pilar; Una, Jon; Martínez-Lorca, Alberto; Ruiz, Cristina; Lozano-Almela, María-Luisa; Ortuño, Francisco-José (MDPI, 2024-12)
    BACKGROUND: Assessment of bone marrow infiltration (BMI) is part of the initial staging of mantle cell lymphoma (MCL), although BMI evaluated by biopsy (BMB) is not considered significant in the MIPI scales, and standardized ...
  • Prognostic Implications of Blood Immune-Cell Composition in Metastatic Castration-Resistant Prostate Cancer 
    Pérez-Navarro, Enrique; Conteduca, Vincenza; Funes, Juan-M; Domínguez, José-I; Martín-Serrano, Miguel; Cremaschi, Paolo; Fernández-Pérez, María-Piedad; Alonso-Gordoa, Teresa; Font, Albert; Vázquez-Estevez, Sergio; González-del-Alba, Aranzazu; Wetterskog, Daniel; Mellado, Begoña; Fernández-Calvo, Ovidio; Mendez-Vidal, María-José; Ángel-Climent, Miguel; Duran, Ignacio; Gallardo, Enrique; Rodríguez-Sánchez, Ángel; Santander, Carmen; Isabel-Saez, María; Puente, Javier; Tudela, Julián; Marinas, Cecilia; López-Andreo, María-José; Castellano, Daniel; Attard, Gerhardt; Grande, Enrique; Rosino, Antonio; Botia, Juan-A; Palma-Mendez, José; de-Giorgi, Ugo; González-Billalabeitia, Enrique (MDPI, 2024-07)
    The prognosis for patients with metastatic castration-resistant prostate cancer (mCRPC) varies, being influenced by blood-related factors such as transcriptional profiling and immune cell ratios. We aimed to address the ...
  • Immunotherapy in Neuroendocrine Neoplasms: A Diamond to Cut 
    García-Torralba, Esmeralda; García-Lorenzo, Esther; Doger, Bernard; Spada, Francesca; Lamarca, Ángela (MDPI, 2024-07)
    A raise in the incidence of NENs is expected. Therefore, the identification of new therapeutic strategies, such as immunotherapy, remains crucial. To date, immune checkpoint inhibitors as monotherapy have shown modest ...
  • Belantamab Mafodotin in Patients with Relapsed/Refractory Multiple Myeloma: Results of the Compassionate Use or the Expanded Access Program in Spain 
    de-la-Rubia, Javier; Alonso, Rafael; Clavero, María-Esther; Askari, Elham; García, Alfonso; Antón, Cristina; Fernández, Margarita; Escalante, Fernando; García, Ana; Ríos-Tamayo, Rafael; Conesa, Venancio; Bermudez, María-Arancha; Merchan, Beatriz; Velasco, Alberto-E; Blanchard, María-Jesús; Sampol, Antonia; Gainza, Eukene; Hernández, Prisma-Montserrat; Alegre, Adrián (MDPI, 2023-05)
    Belantamab-mafodotin (belamaf) is a novel antibody-drug conjugate targeting B-cell maturation antigen that showed anti-myeloma activity in patients with relapsed and refractory multiple myeloma (RRMM). We performed an ...
  • Clinical Meaning of Stromal Tumor Infiltrating Lymphocytes (sTIL) in Early Luminal B Breast Cancer 
    García-Torralba, Esmeralda; Pérez-Ramos, Miguel; Ivars-Rubio, Alejandra; Navarro-Manzano, Esther; Blaya-Boluda, Noel; de-la-Morena-Barrio, Pilar; García-Garre, Elisa; Martínez-Diaz, Francisco; Chaves-Benito, Asunción; García-Martínez, Elena; Ayala-de-la-Peña, Francisco (MDPI, 2023-05)
    Luminal breast cancer (BC) is associated with less immune activation, and the significance of stromal lymphocytic infiltration (sTIL) is more uncertain than in other BC subtypes. The aim of this study was to investigate ...
  • Impact of the COVID-19 Pandemic on Cancer Diagnosis in Madrid (Spain) Based on the RTMAD Tumor Registry (2019-2021) 
    Garrido-Cantero, Gregorio; Longo-Muñoz, Federico; Hernández-González, Javier; Pueyo, Ángel; Fernández-Aparicio, Tomás; Dorado, Juan-C; Angulo, Javier-C (MDPI, 2023-03)
    The coronavirus disease 2019 (COVID-19) pandemic has caused a significant disruption to cancer diagnosis, treatment and prevention worldwide that could have serious consequences in the near future. We intend to evaluate ...
  • Deepening Our Understanding of the Factors Affecting Landscape of Myeloproliferative Neoplasms: What Do We Know about Them? 
    Morales, María-Luz; Ferrer-Marín, Francisca (MDPI, 2023-02)
    Myeloproliferative neoplasms (MPNs) arise from the uncontrolled proliferation of hematopoietic stem and progenitor cells in bone marrow. As with all tumors, the development of MPNs is a consequence of alterations in malignant ...
  • Molecular Landscape and Validation of New Genomic Classification in 2668 Adult AML Patients: Real Life Data from the PETHEMA Registry 
    Sargas, Claudia; Ayala, Rosa; Larrayoz, María-José; Chillón, María-del-Carmen; Carrillo-Cruz, Estrella; Bilbao-Sieyro, Cristina; Prados-de-la-Torre, Esther; Martínez-Cuadrón, David; Rodríguez-Veiga, Rebeca; Boluda, Blanca; Gil, Cristina; Bernal, Teresa; Bergua-Burgues, Juan-Miguel; Algarra, Lorenzo; Tormo, Mar; Martínez-Sánchez, Pilar; Soria, Elena; Serrano, Josefina; Alonso-Dominguez, Juan-Manuel; García-Boyero, Raimundo; Amigo, María-Luz; Herrera-Puente, Pilar; Sayas, María-José; Lavilla-Rubira, Esperanza; Martínez-López, Joaquín; Calasanz, María-José; García-Sanz, Ramón; Antonio-Pérez-Simon, José; Teresa-Gómez-Casares, María-Teresa; Sánchez-García, Joaquín; Barragan, Eva; Montesinos, Pau (MDPI, 2023-01)
    Next-Generation Sequencing (NGS) implementation to perform accurate diagnosis in acute myeloid leukemia (AML) represents a major challenge for molecular laboratories in terms of specialization, standardization, costs and ...
  • How to Manage Patients with Lenalidomide-Refractory Multiple Myeloma 
    de-Arriba-de-la-Fuente, Felipe; Montes-Gaisan, Carmen; de-la-Rubia-Comos, Javier (MDPI, 2023-01)
    Although lenalidomide-based combinations, such as lenalidomide plus a proteasome inhibitor or an anti-CD38 monoclonal antibody, improve the overall response rate, progression-free survival, and overall survival of patients ...
  • Evolution of RAS Mutations in Cell-Free DNA of Patients with Tissue RAS Wild-Type Metastatic Colorectal Cancer Receiving First-Line Treatment: The PERSEIDA Study 
    Valladares-Ayerbes, Manuel; García-Alfonso, Pilar; Muñoz-Luengo, Jorge; Pimentel-Cáceres, Paola-Patricia; Trujillo, Óscar-Alfredo; Vidal-Tocino, Rosario; Llanos, Marta; Llorente-Ayala, Beatriz; Limón-Mirón, María-Luisa; Salud-Salvia, Antonieta; Cirera-Nogueras, Lluis; García-Carbonero, Rocío; Safont-Aguilera, María-José; Falcó-Ferrer, Esther; Aparicio, Jorge; Vicente-Conesa, María-Ángeles; Guillén-Ponce, Carmen; García-Teijido, Paula; Medina-Magán, María-Begoña; Busquier, Isabel; Salgado-Fernández, Mercedes; Vila, Ariadna-Lloansi (MDPI, 2022-12)
    The serial analysis of cell-free DNA (cfDNA) enables minimally invasive monitoring of tumor evolution, providing continuous genetic information. PERSEIDA was an observational, prospective study assessing the cfDNA RAS ...

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