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Envíos recientes

02.02.01. Investigación y comunicación científica: Envíos recientes

  • Protocol for an open labelled observational study in children & adolescents with severe asthma with an eosinophilic phenotype treated with mepolizumab (CASAM) 
    Gupta, Atul; de-Mir-Messa, Inés; Valverde-Molina, José; Murray, Clare-S; Moral, Luis; Torres-Borrego, Javier; Pike, Katharine; Díaz-Izquierdo, Ana; Martínez-Cañavate, Ana; Nagakumar, Prasad; Cook, James; Gupta, Latika (PUBLIC LIBRARY SCIENCE, 2025-12-19)
    INTRODUCTION: Children with severe eosinophilic asthma are at an increased risk of severe exacerbations, medication side effects, impaired lung function, and significantly reduced quality of life. The advent of biologic ...
  • Impact of bictegravir/emtricitabine/tenofovir alafenamide on health-related quality of life and economic outcomes in HIV care: Substudy of the BIC-NOW clinical trial 
    Sequera-Arquelladas, Sergio; Vivancos, María-J; Vinuesa, David; Collado, Antonio; de-los-Santos, Ignacio; Sorni, Patricia; Cabello-Clotet, Noemi; Montero, Marta; Ramos-Font, Carlos; Terron, Alberto; Galindo, María-José; Martínez-Madrid, Onofre; Ryan, Pablo; Omar-Mohamed, Mohamed; Albendin-Iglesias, Helena; Javier, Rosario; Romero, Alberto; García-Vallecillos, Coral; Calleja, Miguel-Ángel; Hidalgo-Tenorio, Carmen (PUBLIC LIBRARY SCIENCE, 2025-09-22)
    BACKGROUND: The BICNOW clinical trial evaluated the effectiveness, safety, satisfaction, adherence to treatment, and retention in the system of a rapid initiation strategy with bictegravir/emtricitabine/tenofovir alafenamide ...
  • Development of a radio thin-layer chromatography scanner: Design and qualification 
    Chivato-Martín-Falquina, Tomás; Miñana-Olmo, Elena; Alonso-García, Ángela; Rosezky, Matthias (SPRINGERNATURE, 2025-12-19)
    BACKGROUND: Radiochemical Purity (RCP) assessment is a fundamental quality control parameter in radiopharmaceutical production. Thin-Layer Chromatography (TLC) using a radio-TLC scanner is the most common method employed ...
  • Hypomethylation of the MEG8:Int2-DMR in patients with pathogenic PLAG1 variants suggests new role of the chr14q32 imprinting cluster in Silver-Russell syndrome 
    D'angelo, Emilia; Pignata, Laura; Cecere, Francesco; Vimercati, Alessandro; Cubellis, María-Vittoria; Saadat, Abu; Giaccari, Carlo; Thibaud, Nathalie; Eggermann, Thomas; Fernández-Fructuoso, Jose-Ramón; Russo, Silvia; Netchine, Irene; Cerrato, Flavia; Riccio, Andrea; Brioude, Frederic (BMC, 2025-11-23)
    BACKGROUND: Silver-Russell syndrome (SRS) is a clinically and genetically heterogeneous imprinting disorder. The most common molecular defects are loss of methylation of the H19/IGF2:IG-DMR on chromosome 11p15.5, followed ...
  • Severe Paediatric Asthma Collaborative in Europe: real-world data on children on biologics 
    Liu, Norrice-M; Pijnenburg, Marielle-W; Deschildre, Antoine; de-Mir-Messa, Inés; Adalen, Sigve; Amat, Flore; Antonino, Luna; Bierme, Priscille; Bravo-López, Maynor; Carlsen, Karin-C-L; Carraro, Silvia; Cros, Pierrick; Delestrain, Celine; Díaz-García, Carolina; Epaud, Ralph; Fenu, Grazia; Ferraro, Valentina-A; Fleming, Louise; Hanssens, Laurence; Heine, Anouk; Labouret, Geraldine; Leóni, María-Chiara; Licari, Amelia; Lombardi, Enrico; López-Neyra, Alejandro; Marguet, Christophe; Mazenq, Julie; Pérez-Tarazona, Santiago; Ramos-Díaz, Juan-Carlos; Schweitzer, Cyril; Spada, Elena; Valverde-Molina, José; Verhulst, Stijn; Wanin, Stephanie; Rusconi, Franca (EUROPEAN RESPIRATORY SOC JOURNALS LTD, 2025-05)
    INTRODUCTION: Real-world data on children with severe asthma is scarce. We report characteristics of children with severe asthma already on biologics, enrolled in the Severe Paediatric Asthma Collaborative in Europe, a ...
  • Does Combining a Mobile Dose Calculation App with a Continuous Insulin Infusion System Improve Glycemic Control and Quality of Life Compared with a Hybrid System in Patients with Type 1 Diabetes? A Descriptive Open-Label Sequential Study 
    Pujante-Alarcón, Pedro; Álvarez, Elias-Delgado; Lambert-Goitia, Carmen; Moreira-Rodríguez, Manuela; Urbon, Lidia; Maldonado, Alfonso; García, Susana; Bau-Serrallonga, Nuria; Ruiz-Avino, Lidia; Ruiz-Palomar, Juan-M; González-López, Javier; Navarro-Hoyas, Clara-Isabel; Corcoy, Rosa; Martínez-Raimond, Teresa; Lainez-López, María; Soldevilla-Madorell, Berta; Hernández, Marta; Kyriakos, Georgios; Cotovad-Bellas, Laura; Girbes-Borras, Juan; Simo-Servant, Olga; Megía-Colet, Ana; Serrano-García, Cristina; Contreras, Cristina; Rebollo-Roman, Ángel; Diez, May; Veladesojo, Amaya; Andujar, Paula; Diez, Alberto; Abellán-Galiana, Pablo; Pla-Peris, Begoña; Fernández, Elsa; Ferrer, Marta; Gómez-Alfonso, Francisco-Javier; Menéndez-Torre, Edelmiro-Luis (MARY ANN LIEBERT, INC, 2025-10)
    Introduction: Achieving optimal glycemic control in patients with type 1 diabetes mellitus (PwT1DM) is essential to prevent complications. Continuous subcutaneous insulin infusion (CSII) systems combined with continuous ...
  • Real-World Impact of Calcipotriol/Betamethasone Dipropionate Aerosol Foam on Quality of Life in Patients With Plaque Psoriasis: A Prospective Observational Study 
    Torres, Tiago; Martorell, Antonio; Leal-Filipe, Paulo; Soria, Caridad; Mota, Fernando; Pardo, José; Ribera, Miquel; Ruiz-Villaverde, Ricardo (WILEY, 2025-01)
  • Fatigue, Physical Symptoms, Psychological Distress, and Use of Integrative Medicine in Patients With Advanced Cancer 
    Calderón, Caterina; Muñoz-Sánchez, M-Mar; Peña-López, Jesús; López-Ceballos, M-Helena; Fernández-Montes, Ana; Asensio-Martínez, Elena; Carrillo-Vicente, Raul; Gustems, Marina; Jiménez-Fonseca, Paula (WILEY, 2025-01)
  • Hydroxychloroquine in patients with systemic lupus erythematosus: how much is enough? 
    Ruiz-Irastorza, Guillermo; Paredes-Ruiz, Diana; Arizpe, Fernando; Campos-Rodríguez, Valerio; Moreno-Torres, Victor; Amo, Laura; Ruiz-Arruza, Ioana; Martín-Iglesias, Daniel (BMJ PUBLISHING GROUP, 2025-02)
    OBJECTIVE: To assess the daily and weight-adjusted dosages of hydroxychloroquine (HCQ) and the effects on long-term remission in the Lupus-Cruces cohort. METHODS: Observational study of routine clinical care data. We ...
  • Segmentation Techniques Applied to CNNs for Cervical Cancer Classification 
    Ortiz-González, Ana; Martínez-Espana, Raquel; Morales-García, Juan; Imbernon, Baldomero; Martínez-Mas, José; Álvarez, Mauricio-A; Romero, Óscar-David; Martínez-Cendán, Juan-Pedro; Bueno-Crespo, Andrés (IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC, 2025)
  • Characterization of thrombosis risk in ambulatory patients with cancer: results of the observational, prospective, multicenter CARTAGO study 
    Trujillo-Santos, Javier; García-Escobar, Ignacio; Salgado, Mercedes; Araujo, Antonio; Martínez-de-Castro, Eva; Molina, Raquel; Castellón-Rubio, Victoria-Eugenia; Domenech, Pere; Gallardo, Enrique; Colome, Esteve; Torres, Ferran; Benítez-Montanez, José-Carlos; Porta, Rut; Lobo-de-Mena, Miriam; Malheiro, Mariana; Font, Carme; Brozos-Vázquez, Elena; Garicano, Fernando; Sapena, Victor; Costa, Ana-Lucía; Albuquerque, Ana-Cristina; Cerezuela-Fuentes, Pablo; CARTAGO-Study-Grp, Sara (OXFORD UNIV PRESS, 2025-08-04)
    BACKGROUND: Venous thromboembolism (VTE) is one of the leading causes of death in patients with cancer. Currently, there is a need to develop an easily applicable risk model that can identify patients who will benefit from ...
  • Arrhythmic genotypes in dilated cardiomyopathy and risk of advanced heart failure 
    Mora-Ayestaran, Nerea; Ochoa, Juan-Pablo; Gómez-González, Cristina; Navarro-Peñalver, Marina; Gallego-Delgado, María; Larrañaga-Moreira, José-M; Robles-Mezcua, Ainhoa; Basurte-Elorz, María-Teresa; Rodríguez-Palomares, José-Fernando; Climent-Paya, Vicente; Jiménez-Jaimez, Juan; Mogollon-Jiménez, María-Victoria; García-Granja, Pablo-Elpidio; García-Álvarez, Ana; Peña-Peña, María-Luisa; Álvarez-Barredo, María; Ripoll-Vera, Tomas; Palomino-Doza, Julián; Bayes-Genis, Antoni; Tiron, Coloma; Fernández, Ana-Isabel; Sabater-Molina, María; Toranzo, Inés; Crespo-Leiro, María-G; Doncel-Abad, Victoria; Lacuey-Lecumberri, Gemma; Limeres-Freire, Javier; I; Cabrera-Borrego, Eva; Kounka-Ait-El-Maalem, Zineb; Vilches, Silvia; González-López, Esther; Villacorta, Eduardo; García-Pinilla, José-M; Barriales-Villa, Roberto; Gimeno-Blanes, Juan-Ramón; García-Pavia, Pablo; Domínguez, Fernando (OXFORD UNIV PRESS, 2025-12-22)
    BACKGROUND AND AIMS: Certain genetic forms of dilated cardiomyopathy (DCM) entail a higher arrhythmic risk. It is unknown whether DCM patients with high-risk arrhythmic genotypes also develop more advanced heart failure ...
  • Discovery of Z1362873773: a novel fascin inhibitor from a large chemical library for colorectal cancer 
    Rodríguez-Martínez, Alejandro; Giraldo-Ruiz, Lucía; Ramos, María-C; Luque, Irene; Ribeiro, Diogo; Postigo-Corrales, Fátima; Alburquerque-González, Begoña; Montoro-García, Silvia; Arroyo-Rodríguez, Ana-Belén; Conesa-Zamora, Pablo; Hurtado-López, Ana-María; Luengo-Gil, Ginés; Pérez-Sánchez, Horacio (NATURE PORTFOLIO, 2025-04-28)
    Metastasis is one of the leading causes of cancer-related death worldwide. Fascin, a protein that bundles actin filaments to produce protrusions in cancer cells, plays a significant role in the enhancement of cell migration. ...
  • A machine learning approach to identify patients at risk for long-term consequences after pulmonary embolism 
    Nopp, Stephan; Spielvogel, Clemens; Bikdeli, Behnood; Alberich-Conesa, Ana; Hernández-Blasco, Luis; Peris, Ma-Luisa; Otero, Remedios; Jiménez, David; Monreal, Manuel; Ay, Cihan; Agudo-de-Blas, P; Aibar, J; Alberich-Conesa, Ana; Alda-Lozano, A; Alfonso, J; Alonso-Carrillo, J; Álvarez-Vega, P; Amado, C; Angelina-García, M; Arcelus, J-I; Ballaz, A; Barba, R; Barbagelata, C; Barron, M; Barron-Andres, B; Bascuñana, J; Blanco-Molina, A; Bustos-Carpio, J; Casado, I; Chasco, L; Claver, G; De-Juana-Izquierdo, C; Del-Toro, J; Demelo-Rodríguez, P; Díaz-Brasero, A-M; Díaz-Pedroche, M-C; Díaz-Peromingo, J-A; Dubois-Silva, A; Escribano, J-C; Fernández-Capitan, C; Fernández-Jiménez, B; Fernández-Reyes, J-L; Fidalgo, M-A; Francisco, I; Gabara, C; Galeano-Valle, F; García-Bragado, F; García-González, C; García-Ortega, A; Gavin-Sebastian, O; Gil-de-Gómez, M-A; Gil-Díaz, A; Gómez-Cepeda, C; Gómez-Cuervo, C; González-Martínez, J; González-Munera, A; Gorostidi, J; Grau, E; Guirado-Torrecillas, Leticia; Gutiérrez-Guisado, J; Hernández-Blasco, L; Jara-Palomares, L; Jiménez, D; Jou, I; Joya, M-D; Lainez-Justo, S; Lecumberri, R; Lobo, J-L; López-Jiménez, L; López-Miguel, P; López-Núñez, J-J; López-Ruiz, Alfonso; López-Sáez, J-B; Lorenzo, A; Madridano, O; Maestre, A; Marchena, P-J; Marcos, M; Martín-del-Pozo, M; Martin-Martos, Francisco; Maza, J-M; Mercado, M-I; Molino, A; Monreal, M; Monzon, L; Navas, M-S; Nieto, J-A; Núñez-Fernández, M-J; Ordieres, L; Ortiz, O; Otalora-Valderrama, Sonia; Otero, R; Pacheco-Gómez, N; Pagan, J; Parra-Caballero, P; Pedrajas, J-M; Pérez-Amoros, J; Pérez-Cabezas, A; Pérez-Ductor, C; Pérez-Pinar, M; Peris, M-L; Pesce, M-L; Porras, J-A; Puchades, R; Puche, G; Rivas, A; Rivera-Civico, F; Rodríguez-Cobo, A; Romero-Bruguera, M; Salgueiro, G; Sánchez-Juez, A; Sancho, T; Sendin, V; Siguenza, P; Soler, S; Sota-Yoldi, L-A; Suárez-Fernández, S; Tirado, R; Torrents-Vilar, A; Torres, M-I; Trujillo-Santos, Javier; Uresandi, F; Valle, R; Varona, J-F; Vázquez, E; Villalobos, A; Villarejo, C; Villares, P; Ay, C; Nopp, S; Pabinger, I; Vanassche, T; Verhamme, P; Verstraete, A; Rocha, A-T; Yoo, H-H-B; Montenegro, A-C; Morales, S-N; Roa, J; Hirmerova, J; Maly, R; Acassat, S; Bertoletti, L; Brehon, M; Bura-Riviere, A; Catella, J; Chopard, R; Couturaud, F; Espitia, O; Le-Mao, R; Leclercq, B; Mahe, I; Moustafa, F; Plaisance, L; Poenou, G; Quere, I; Sarlon-Bartoli, G; Suchon, P; Versini, E; Schellong, S; Rashidi, F; Sadeghipour, P; Tahmasbi, F; Brenner, B; Kennet, G; Tzoran, I; Barillari, G; Basaglia, M; Bilora, F; Bissacco, D; Brandolin, B; Casana, R; Ciammaichella, M-M; Colaizzo, D; Di-Micco, P; Giorgi-Pierfranceschi, M; Grandone, E; Lambertenghi-Deliliers, D; Marcon, C; Poz, A; Prandoni, P; Simioni, P; Siniscalchi, C; Taflaj, B; Tufano, A; Visona, A; Zalunardo, B; Skride, A; Tazi-Mezalek, Z; Fonseca, S; Marques, R; Meireles, J; Pinto, S; Bosevski, M; Zdraveska, M; Barco, S; Bounameaux, H; Keller, S; Mazzolai, L; Porceddu, E; Aujayeb, A; Angiolillo, D-J; Bikdeli, B; Caprini, J-A; Khalil, A; Ortega-Paz, L; Tafur, J; Weinberg, I; Bui, H-M (NATURE PORTFOLIO, 2025-09-24)
    Pulmonary embolism (PE) can result in long-term sequelae, such as post-PE syndrome, including persistent dyspnea and chronic thromboembolic pulmonary hypertension (CTEPH). Existing prediction tools for severe post-PE ...
  • Impact of the initial administration of an antiretroviral drug with latency reversal properties on the HIV reservoir size 
    de-la-Torre-Tarazona, Erick; Moraga, Elisa; Vaquer, Raúl; Sánchez-Palomino, Sonsoles; de-Lazzari, Elisa; Luna, Laura; Vicens-Artes, Sonia; García-Fraile, Lucio-Jesús; Peraire, Joaquim; García-Gasalla, Mercedes; Balsalobre, Luz; Guillén-Martínez, Sergio; López-Cortés, Luis-Fernando; Jarrin, Inma; Serrano-Villar, Sergio; Alcami, José; Moreno, Santiago (NATURE PORTFOLIO, 2025-07-13)
    The elimination of the latent viral reservoir remains the main barrier in the quest for a cure for people with HIV (PWH). The administration of latency reversal agents (LRA) at antiretroviral treatment (ART) initiation ...
  • Clinical and immunopathological evaluation and its comparison with IHC consensus molecular subtypes of colorectal cancer 
    Feliciangeli-Moreno, Eduardo; Albaladejo-González, Ana; García-Rodríguez, José; Lázaro-Sánchez, Antonio-David; Borg, Rosanna; Pimentel-Cáceres, Paola; Soriano-Polo, Diego; Rodríguez-Braun, Edith; Balsalobre-Yago, José; Martínez-Ortiz, María-José; Wikstrom-Fernández, Sofía; Murillo-Herrera, Andrés; García-García, Teresa; García-Solano, José; Conesa-Zamora, Pablo; Luengo-Gil, Ginés (NATURE PORTFOLIO, 2025-07-01)
    This study examined the prognostic significance of immunoscore within consensus molecular subtypes (CMS), tumour budding (TB), and macrophage infiltration in colorectal cancer (CRC). A retrospective series was analysed ...
  • L.Fermentum CECT5716 and B.Breve CECT7263 on premature infants morbidities: a randomized clinical trial 
    Hurtado-Suazo, José-Antonio; Alonso-Ojembarrena, Almudena; Sánchez-Tamayo, Tomas; Martín-Álvarez, Estefanía; Sáez, María-Eugenia; Martínez-Pardo, Luz; Diez-Delgado-Rubio, Javier; Granero-Asencio, Mercedes; Serrano-López, Laura; Maldonado-Lobon, José-Antonio; Mora-Navarro, David; De-Benito-Guerra, María-Teresa; Torres-Begara, Eva; Ruiz-Moreno, Juan-Antonio; Macias-Díaz, Carmen; Lloreda-García, José-María; Peña-Caballero, Manuela; Olivares, Mónica; Blanco-Rojo, Ruth (SPRINGERNATURE, 2025-11-27)
    BACKGROUND: This study examined the effects of two doses of probiotics isolated from human milk on the incidences of necrotizing enterocolitis (NEC) and mortality in preterm infants. METHODS: This multicenter, randomized, ...
  • Rebuilding the atrophied brain: 6-month nasal esketamine therapy expands key frontal and hippocampal regions and reduces serum neurofilament levels in patients with major depressive disorder. A proof-of-concept study of the depTesk (DEPression treatment with ESKetamine) study 
    Rodríguez-Lorente, Ana; Campos-Navarro, María-Pilar; Gil-Montoya, Ángela; Marín-Pérez, Celia; Masó-Navarro, María-Luisa; Orgaz-Morales, Manuel-Tomás; López-Ramírez, Nuria; García-Carmona, Juan-Antonio (CAMBRIDGE UNIV PRESS, 2025)
    OBJECTIVES: This proof-of-concept study aimed to assess the impact of intranasal esketamine (ESK-IN) in brain volume and neurofilament light chain (sNfL) over 6-months in patients with treatment resistant depression (TDR). ...
  • 250 cases of "type 2 Gaucher disease": A novel system of clinical categorisation and evidence of genotype: Phenotype correlation 
    Donald, A; Brothwell, S; Cabello, B-M; Ehrstedt, C; Fernández-Fructuoso, Jose-Ramón; Fernández-Marin, E; González-Lamuno, D; Lloreda-García, José-María; Lykopoulou, L; Mignot, C; Nurse, J; O'Sullivan, S; Persson, A-N; Raiman, J; Rajan, D-S; Uberos, J; Jones, S-A; Church, H-J (ACADEMIC PRESS INC ELSEVIER SCIENCE, 2025-06)
    'Type 2' Gaucher disease, also referred to as 'acute neuronopathic' or 'infantile' Gaucher disease is an aggressive subtype of Gaucher disease, resulting from pathogenic variants in GBA1. The spectrum of phenotype ranges ...
  • Consensus document for Severe Asthma. 2025 Update. 
    Álvarez-Gutierrez, Francisco-Javier; Blanco-Aparicio, Marina; Casas-Maldonado, Francisco; Plaza, Vicente; Soto-Campos, Gregorio; González-Barcala, Francisco-Javier; Almonacid, Carlos; Arismendi, Ebymar; Cabrera, Carlos; Cabestre-García, Roberto; Carretero, José-Ángel; Castilla-Martínez, Manuel; Castillo-Vizuete, José-Antonio; Cisneros-Serrano, Carolina; Gimeno-Díaz-de-Atauri, Álvaro; Díaz-Pérez, David; Domingo-Ribas, Christian; García-Rivero, Juan-Luis; López-Neyra, Alejandro; Martínez-Moragon, Eva; de-Mir-Messa, Inés; Muñoz-Gall, Xavier; Padilla-Galo, Alicia; Perpina-Tordera, Miguel; Pérez-de-Llano, Luis; Sánchez-Toril, Fernando; Sanz-Santiago, Veronica; Valverde-Molina, José (ELSEVIER, 2025-10)
    Severe asthma is a heterogeneous syndrome with several clinical variants and often represents a complex disease requiring a specialized and multidisciplinary approach, as well as the use of multiple drugs. The prevalence ...

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