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Envíos recientes

02.02.01. Investigación y comunicación científica: Envíos recientes

  • New Potential Pharmacological Options for Endometriosis Associated Pain 
    García-Izquierdo, Laura; Marín-Sánchez, Pilar; García-Penarrubia, Pilar; Martínez-Esparza, María (MDPI, 2024-07)
    Endometriosis is a chronic inflammatory disorder characterized by the abnormal growth of endometrial-like tissue outside the uterine cavity, affecting 10-15% of women of reproductive age. Pain is the most common symptom. ...
  • The Mediating Role of Exercise in Depression and Fatigue in Patients with Advanced Cancer 
    Calderón, Caterina; Gustems, Marina; Obispo, Berta; García-García, Teresa; Hernández, Raquel; Fernández-Montes, Ana; Jiménez-Fonseca, Paula (MDPI, 2024-06)
    This study explored the interconnections between sociodemographic elements, depression, fatigue, and exercise in patients suffering from incurable neoplasm, particularly emphasizing the mediating influence of exercise on ...
  • Upregulation of Heat-Shock Protein (hsp)-27 in a Patient with Heterozygous SPG11 c.1951C>T and SYNJ1 c.2614G>T Mutations Causing Clinical Spastic Paraplegia 
    García-Carmona, Juan-Antonio; Amores-Iniesta, Joaquín; Soler-Usero, José; Cerdan-Sánchez, María; Navarro-Zaragoza, Javier; López-López, María; Soria-Torrecillas, Juan-José; Ballesteros-Arenas, Ainhoa; Pérez-Vicente, José-Antonio; Almela-Rojo, Pilar (MDPI, 2023-07)
    We report a 49-year-old patient suffering from spastic paraplegia with a novel heterozygous mutation and analyzed the levels of heat shock proteins (hsp)-27, dopamine (DA), and its metabolites in their cerebrospinal fluid ...
  • Whole Sequencing and Detailed Analysis of SARS-CoV-2 Genomes in Southeast Spain: Identification of Recurrent Mutations in the 20E (EU1) Variant with Some Clinical Implications 
    López-Andreo, María-José; Vicente-Romero, María-Rosario; Bernal-Morell, Enrique; Navarro-González, Inmaculada; Salazar-Martínez, Francisco; Cánovas-Cánovas, Vanesa; Gil-Ortuño, Cristina; Riquelme-Rocamora, María-Gema; Solano, Francisco; Ibáñez-López, Francisco-Javier; Tomás, Cristina; Candel-Pérez, Carmen; Pérez-Parra, Santiago; Flores-Flores, César (MDPI, 2023-06)
    During the COVID-19 pandemic caused by SARS-CoV-2, new waves have been associated with new variants and have the potential to escape vaccinations. Therefore, it is useful to conduct retrospective genomic surveillance ...
  • Mineral Metabolism in Children: Interrelation between Vitamin D and FGF23 
    Pons-Belda, Óscar-D; Alonso-Álvarez, M-Agustina; González-Rodríguez, Juan-David; Mantecón-Fernández, Laura; Santos-Rodríguez, Fernando (MDPI, 2023-04)
    Fibroblast growth factor 23 (FGF23) was identified at the turn of the century as the long-sought circulating phosphatonin in human pathology. Since then, several clinical and experimental studies have investigated the ...
  • Fatigue, Emotional Distress, and Illness Uncertainty in Patients with Metastatic Cancer: Results from the Prospective NEOETIC_SEOM Study 
    Rodríguez-González, Adán; Velasco-Durántez, Verónica; Martín-Abreu, Carla; Cruz-Castellanos, Patricia; Hernández, Raquel; Gil-Raga, Mireia; García-Torralba, Esmeralda; García-García, Teresa; Jiménez-Fonseca, Paula; Calderón, Caterina (MDPI, 2022-12)
    A cancer diagnosis can have a substantial impact on a patient's mental health and quality of life. The aim of this study was to investigate the prevalence of fatigue, emotional distress, and uncertainty and examine the ...
  • Thermography as a Non-Ionizing Quantitative Tool for Diagnosing Burning Mouth Syndrome: Case-Control Study 
    Nicolás-Rodríguez, Elena; García-Martínez, Ana; Molino-Pagan, Diana; Marín-Martínez, Luis; Pons-Fuster, Eduardo; López-Jornet, Pía (MDPI, 2022-08)
    OBJECTIVES: Thermography is an imaging technique based on the acquisition and analysis of thermal data. The present study evaluates the use of tongue infrared thermography (IRT) as a tool for the diagnosis of burning mouth ...
  • Integrative Genomic and Transcriptomic Profiling Reveals a Differential Molecular Signature in Uterine Leiomyoma versus Leiomyosarcoma 
    Machado-López, Alba; Alonso, Roberto; Lago, Víctor; Jiménez-Almazán, Jorge; García, Marta; Monleon, Javier; López, Susana; Barceló, Francisco; Torroba, Amparo; Ortiz-Reina, Sebastián; Domingo, Santiago; Simón, Carlos; Mas, Aymara (MDPI, 2022-02)
    The absence of standardized molecular profiling to differentiate uterine leiomyosarcomas versus leiomyomas represents a current diagnostic challenge. In this study, we aimed to search for a differential molecular signature ...
  • The Role of Regulation and Emotional Eating Behaviour in the Early Development of Obesity 
    Valero-García, Ana-V; Olmos-Soria, Marina; Madrid-Garrido, Julia; Martínez-Hernández, Irene; Haycraft, Emma (MDPI, 2021-11)
    The purpose of our research was to explore the role of both parents' use of behavioural regulation with food and children's emotional self-regulation in young children with and without overweight/obesity. For this purpose, ...
  • Post-COVID-19 Syndrome and the Potential Benefits of Exercise 
    Jimeno-Almazán, Amaya; Pallarés, Jesús-G; Buendía-Romero, Ángel; Martínez-Cava, Alejandro; Franco-López, Francisco; Sánchez-Alcaraz-Martínez, Bernardino-J; Bernal-Morell, Enrique; Courel-Ibáñez, Javier (MDPI, 2021-05)
    The coronavirus disease (COVID-19), caused by severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) infection, is leading to unknown and unusual health conditions that are challenging to manage. Post-COVID-19 syndrome ...
  • Qualitative and Quantitative Comparison of Plasma Exosomes from Neonates and Adults 
    Penas-Martínez, Julia; Barrachina, María-N; Cuenca-Zamora, Ernesto-José; Luengo-Gil, Ginés; Bravo, Susana-Belén; Caparrós-Pérez, Eva; Teruel-Montoya, Raúl; Eliseo-Blanco, José; Vicente, Vicente; García, Ángel; Martínez-Martínez, Irene; Ferrer-Marin, Francisca (MDPI, 2021-02)
    Exosomes are extracellular vesicles that contain nucleic acids, lipids and metabolites, and play a critical role in health and disease as mediators of intercellular communication. The majority of extracellular vesicles in ...
  • Blood Lead Level in a Paediatric Population of South-Eastern Spain and Associated Risk Factors 
    Ruiz-Tudela, Lucía; Vázquez-López, María-Ángeles; García-Escobar, Iciar; Cabrera-Sevilla, José-Eugenio; Gómez-Bueno, Sara; Martín-González, Manuel; Muñoz-Vico, Francisco-Javier (MDPI, 2021-02)
    OBJECTIVE: To determine blood lead levels (BLL) in a healthy paediatric population and to analyse related sociodemographic, dietary and haematological factors. METHODS: A cross-sectional study was made of 1427 healthy ...
  • Involvement and Autonomy of Minors in Medical Settings: Perceptions of Children Undergoing Surgery and Parents 
    Rodríguez-Domínguez, Francisco-J; Osuna-García, Teresa; Guillén, Alberto; Pérez-Carceles, María-D; Osuna, Eduardo (MDPI, 2023-12)
    Informed consent presupposes competence and represents a formal decision by an informed person who has the legal capacity to accept medical action or participate in research. Our aim was to analyze the perceptions of minors ...
  • Exploring the Immunoresponse in Bladder Cancer Immunotherapy 
    Ruiz-Lorente, Inmaculada; Gimeno, Lourdes; López-Abad, Alicia; López-Cubillana, Pedro; Fernández, Aparicio; Asensio-Egea, Lucas-Jesús; Moreno-Avilés, Juan; Donate-Iñíguez, Gloria; Guzmán-Martínez-Valls, Pablo-Luis; Server-Gómez, Gerardo; Escudero-Bregante, José-Félix; Ferri, Belén; Campillo, José-Antonio; Pons-Fuster, Eduardo; Martínez-Hernández, María-Dolores; Martínez-Sánchez, María-Victoria; Ceballos, Diana; Minguela-Puras, Alfredo (MDPI, 2024-12)
    Bladder cancer (BC) represents a wide spectrum of diseases, ranging from recurrent non-invasive tumors to advanced stages that require intensive treatments. BC accounts for an estimated 500,000 new cases and 200,000 deaths ...
  • Targeting of Non-Classical Human Leukocyte Antigens as Novel Therapeutic Strategies in Cancer 
    Benítez-Fuentes, Javier-David; Arcilla, Jorge-Bartolomé; Mohamed-Mohamed, Kauzar; López-de-Sa, Alfonso; de-Luna-Aguilar, Alicia; Guevara-Hoyer, Kissy; Ballestin-Martínez, Pablo; Lázaro-Sánchez, Antonio-David; Carosella, Edgardo-D; Ocana, Alberto; Sánchez-Ramon, Silvia (MDPI, 2024-12)
    Human leukocyte antigens (HLAs) are essential regulators of immune responses against cancer, with classical HLAs well-documented for their role in tumor recognition and immune surveillance. In recent years, non-classical ...
  • Evolution of RAS Mutations in Cell-Free DNA of Patients with Tissue RAS Wild-Type Metastatic Colorectal Cancer Receiving First-Line Treatment: The PERSEIDA Study 
    Valladares-Ayerbes, Manuel; García-Alfonso, Pilar; Luengo, Jorge-Muñoz; Pimentel-Cáceres, Paola-Patricia; Trujillo, Óscar-Alfredo; Vidal-Tocino, Rosario; Llanos, Marta; Llorente-Ayala, Beatriz; Limón-Mirón, María-Luisa; Salud-Salvia, Antonieta; Cirera-Nogueras, Luis; García-Carbonero, Rocío; Safont, María-José; Falcó-Ferrer, Esther; Aparicio, Jorge; Vicente-Conesa, María-Ángeles; Guillén-Ponce, Carmen; García-Teijido, Paula; Medina-Magán, María-Begoña-Medina; Busquier, Isabel; Salgado-Fernández, Mercedes; Vila, Ariadna-Lloansi (MDPI, 2022-12)
    The serial analysis of cell-free DNA (cfDNA) enables minimally invasive monitoring of tumor evolution, providing continuous genetic information. PERSEIDA was an observational, prospective study assessing the cfDNA RAS ...
  • Antitumoral Effects of Tricyclic Antidepressants: Beyond Neuropathic Pain Treatment 
    Asensi-Canto, Antonio; López-Abellán, María-Dolores; Castillo-Guardiola, Veronica; Hurtado, Ana-María; Martínez-Penella, Mónica; Luengo-Gil, Ginés; Conesa-Zamora, Pablo (MDPI, 2022-07)
    Growing evidence shows that nerves play an active role in cancer development and progression by altering crucial molecular pathways and cell functions. Conversely, the use of neurotropic drugs, such as tricyclic antidepressants ...
  • Is Laterality Prognostic in Resected KRAS-Mutated Colorectal Liver Metastases? A Systematic Review and Meta-Analysis 
    Belias, Michail; Sasaki, Kazunari; Wang, Jane; Andreatos, Nikolaos; Kamphues, Carsten; Kyriakos, Georgios; Seeliger, Hendrik; Beyer, Katharina; Kreis, Martín-E; Margonis, Georgios-Antonios (MDPI, 2022-02)
    It is debated whether primary tumor laterality (PTL) is prognostic in all patients with colorectal liver metastases (CRLM) or only those with KRAS wild-type or KRAS-mutated tumors; Methods: We systematically reviewed PubMed ...
  • Global Methylome Scores Correlate with Histological Subtypes of Colorectal Carcinoma and Show Different Associations with Common Clinical and Molecular Features 
    Turpin-Sevilla, María-del-Carmen; Pérez-Sanz, Fernando; García-Solano, José; Sebastian-Leon, Patricia; Trujillo-Santos, Javier; Carbonell, Pablo; Estrada, Eduardo; Tuomisto, Anne; Herruzo, Irene; Fennell, Lochlan-J; Makinen, Markus-J; Rodríguez-Braun, Edith; Whitehall, Vicki-LJ; Conesa, Ana; Conesa-Zamora, Pablo (MDPI, 2021-10)
    BACKGROUND: The typical methylation patterns associated with cancer are hypermethylation at gene promoters and global genome hypomethylation. Aberrant CpG island hypermethylation at promoter regions and global genome ...
  • The FDA-Approved Antiviral Raltegravir Inhibits Fascin1-Dependent Invasion of Colorectal Tumor Cells In Vitro and In Vivo 
    Alburquerque-González, Begoña; Bernabé-García, Ángel; Bernabé-García, Manuel; Ruiz-Sanz, Javier; López-Calderón, Fernando-Feliciano; Gonnelli, Leonardo; Banci, Lucía; Peña-García, Jorge; Luque, Irene; Nicolás, Francisco-José; Cayuela-Fuentes, María-Luisa; Luchinat, Enrico; Pérez-Sánchez, Horacio; Montoro-García, Silvia; Conesa-Zamora, Pablo (MDPI, 2021-02)
    BACKGROUND: Fascin1 is the key actin-bundling protein involved in cancer invasion and metastasis whose expression is associated with bad prognosis in tumor from different origins. METHODS: In the present study, virtual ...

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