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Envíos recientes

03. IMIB (Instituto Murciano de Investigación Biosanitaria Pascual Parrilla): Envíos recientes

  • Metal-coumarin derivatives as promising photosensitizers: unlocking their cancer phototherapy potential 
    Vigueras, Gloria; Izquierdo-García, Eduardo; de-la-Torre-Rubio, Elena; Abad-Montero, Diego; Santana-Lario, María-Dolores; Marchan, Vicente; Ruiz, José (ROYAL SOC CHEMISTRY, 2025)
  • Insights into type I photoreactivity of cyclometalated iridium(iii) and ruthenium(ii) photosensitizers 
    Vigueras, Gloria; Marchan, Vicente; Ruiz, José (ROYAL SOC CHEMISTRY, 2025)
    Photodynamic therapy (PDT) is a light-activated treatment that relies on the generation of cytotoxic reactive oxygen species (ROS). While most clinically approved photosensitizers (PSs) operate through a type II mechanism-based ...
  • Achieving red-light anticancer photodynamic therapy under hypoxia using Ir(iii)-COUPY conjugates 
    Ortega-Forte, Enrique; Rovira, Anna; Ashoo, Pezhman; Izquierdo-García, Eduardo; Hally, Cormac; Abad-Montero, Diego; Jorda-Redondo, Mireia; Vigueras, Gloria; Deya, Alba; Hernández, José-Luis; Galino, Jorge; Bosch, Manel; Alberto, Marta-E; Frances-Monerris, Antonio; Nonell, Santi; Ruiz, José; Marchan, Vicente (ROYAL SOC CHEMISTRY, 2025)
  • A novel benzothiazole-1,2,3-triazole-based arene osmium(ii) complex as an effective rhabdomyosarcoma cancer stem cell agent 
    Sharkawy, Sofia; Hernández-García, Alba; Kostrhunova, Hana; Bautista, Delia; Markova, Lenka; Santana-Lario, María-Dolores; Kasparkova, Jana; Brabec, Viktor; Ruiz, José (ROYAL SOC CHEMISTRY, 2025)
  • Effects of new lipid ingredients during pregnancy and lactation on rat offspring brain gene expression 
    Origüela-Carvajal, Valentina; Gázquez, Antonio; López-Andreo, María-José; Bueno-Vargas, Pilar; Vurma, Mustafa; López-Pedrosa, José-M; Leyshon, Brian-J; Kuchan, Matthew; Chan, Jia-Pei; Larque, Elvira (ROYAL SOC CHEMISTRY, 2025)
    Maternal dietary fat intake during pregnancy and lactation may influence the bioavailability of essential lipophilic nutrients, such as docosahexaenoic acid (DHA), that are important for both the mother and her child's ...
  • Portimine A toxin causes skin inflammation through ZAK?-dependent NLRP1 inflammasome activation 
    Gorse, Leana; Plessis, Loic; Wearne, Stephen; Paradis, Margaux; Pinilla-Marquínez, Miriam; Chua, Rae; Lim, Seong-Soo; Fernández-Pelluz, Elena; Toh, Gee-Ann; Mazars, Raoul; Bomfim, Caio; Herve, Fabienne; Lhaute, Korian; Reveillon, Damien; Suire, Bastien; Ravon-Katossky, Lea; Benoist, Thomas; Fromont, Lea; Pericat, David; Neil-Mertens, Kenneth; Derrien, Amelie; Terre-Terrillon, Aouregan; Chomerat, Nicolas; Bilien, Gwenael; Sechet, Veronique; Carpentier, Liliane; Fall, Mamadou; Sonko, Amidou; Hakim, Hadi; Sadio, Nfally; Bourdeaux, Jessie; Cougoule, Celine; Henras, Anthony-K; Pérez-Oliva, Ana-Belén; Brehmer, Patrice; Roca, Francisco-J; Zhong, Franklin-L; Common, John; Meunier, Etienne; Hess, Philipp (SPRINGERNATURE, 2025-02-13)
    In 2020-2021, a "mysterious illness" struck Senegalese fishermen, causing severe acute dermatitis in over one thousand individuals following exposure through drift-net fishing activity. Here, by performing deep analysis ...
  • Telomerase and alternative lengthening of telomeres coexist in the regenerating zebrafish caudal fins 
    Martínez-Balsalobre, Elena; Anchelin, Monique; Hernández-Silva, David; Mione, María-C; Mulero, Víctoriano; Alcaraz-Pérez, Francisca; García-Castillo, Jesús; Cayuela-Fuentes, María-Luisa (SPRINGERNATURE, 2025-10-21)
    Telomeres are essential for chromosome protection and genomic stability, and telomerase function is critical for organ homeostasis. Zebrafish is a useful vertebrate model for understanding cellular and molecular mechanisms ...
  • Cardiolipin inhibits the non-canonical inflammasome by preventing LPS binding to caspase-4/11 
    Pizzuto, Malvina; MonteLeóne, Mercedes; Burgener, Sabrina-Sofia; Began, Jakub; Kurera, Melan; Chia, Jing-Rong; Frampton, Emmanuelle; Crawford, Joanna; Oliveira, Monalisa; Kenney, Kirsten-M; Coombs, Jared-R; Yamamoto, Masahiro; Man, Si-Ming; Broz, Petr; Pelegrín, Pablo; Schroder, Kate (SPRINGERNATURE, 2025-07-16)
    Caspase-4 and caspase-11 (CASP4/11) sense bacterial lipopolysaccharide (LPS). Currently available inhibitors of CASP4/11 also block the activity of caspase-1 (CASP1), which restricts their usefulness in the study of CASP4/11 ...
  • Advanced analysis of retrotransposon variation in the human genome with nanopore sequencing using RetroInspector 
    Cuenca-Guardiola, Javier; de-la-Morena-Barrio, Belén; Corral, Javier; Fernández-Breis, Jesualdo-Tomás (NATURE PORTFOLIO, 2025-04-25)
    Transposable elements (TEs) make up 45% of the human genome, are a source of genetic variability difficult to detect, and involved in processes related to gene regulation and disease. Nanopore sequencing is recognized as ...
  • The cervical microbiome of ewe breeds with known divergent fertility following artificial insemination with frozen-thawed semen 
    Norstebo, Simen-Foyn; Rodríguez-Campos, Sabrina; Umu, Ozgun-C-O; Abril-Parreño, Laura; Dalland, Marianne; Gilfillan, Gregor-Duncan; Fair, Sean; Krogenaes, Anette (NATURE PORTFOLIO, 2025-04-26)
    The use of artificial insemination (AI) with frozen-thawed semen in sheep is limited internationally due to low pregnancy rates. An exception is Norway, where high success rates routinely occur following vaginal deposition ...
  • Discovery of Z1362873773: a novel fascin inhibitor from a large chemical library for colorectal cancer 
    Rodríguez-Martínez, Alejandro; Giraldo-Ruiz, Lucía; Ramos, María-C; Luque, Irene; Ribeiro, Diogo; Postigo-Corrales, Fátima; Alburquerque-González, Begoña; Montoro-García, Silvia; Arroyo-Rodríguez, Ana-Belén; Conesa-Zamora, Pablo; Hurtado-López, Ana-María; Luengo-Gil, Ginés; Pérez-Sánchez, Horacio (NATURE PORTFOLIO, 2025-04-28)
    Metastasis is one of the leading causes of cancer-related death worldwide. Fascin, a protein that bundles actin filaments to produce protrusions in cancer cells, plays a significant role in the enhancement of cell migration. ...
  • The Sarcoplasmic/Endoplasmic reticulum Ca2+-ATPase (SERCA) is present in pig sperm and modulates their physiology over liquid preservation 
    Garriga, Ferran; Martínez-Hernández, Jesús; Parra-Balaguer, Ainhoa; Llavanera, Marc; Yeste, Marc (NATURE PORTFOLIO, 2025-02-04)
    Liquid storage is the primary preservation method in the swine breeding industry because of its advantages over cryopreservation. Calcium (Ca(2+)), a key regulator of cell physiology, plays a crucial role during liquid ...
  • Epigenetic regulation of electromechanical continuity might determine phenotypic heterogeneity in SCN5A mutation carriers in Brugada syndrome 
    Moscoso, Isabel; Serrano-Cruz, Valentina; Cebro-Marquez, María; Vilar-Sánchez, Marta-E; Vidal-Abeijon, Iria; Brion, María; Blanco-Verea, Alejandro; Martínez-Campelo, Laura; Feijoo-Bandin, Sandra; Jiménez-Ramos, Victor; Gimeno-Blanes, Juan-Ramón; Sabater-Molina, María; Jiménez-Jaimez, Juan; González-Juanatey, José-Ramón; Rodríguez-Manero, Moises; Lage, Ricardo (NATURE PORTFOLIO, 2025-10-22)
    Brugada syndrome (BrS) is an inherited cardiac disorder characterized by electrical disturbances. Pathogenic variants in the SCN5A gene are implicated in 25-30% of probands. Although loss-of-function mutations in SCN5A ...
  • Distinct roles of amniotic membrane epithelial (hAEC) and mesenchymal stromal cells (hAMSC) in amniotic membrane-driven wound healing 
    Alcaraz, M; Hernández-Mármol, Isabel; Puente-Cuadrado, José-María; Rodríguez-Valiente, Mónica; Silini, A-R; Parolini, O; Nicolás, Francisco-José (NATURE PORTFOLIO, 2025-10-21)
    Human skin wound healing is a complex process involving sequential cellular events to restore skin integrity. Chronic wounds fail to heal due to impaired keratinocyte activation and dysregulated cytokine signaling. The ...
  • Clinical and immunopathological evaluation and its comparison with IHC consensus molecular subtypes of colorectal cancer 
    Feliciangeli-Moreno, Eduardo; Albaladejo-González, Ana; García-Rodríguez, José; Lázaro-Sánchez, Antonio-David; Borg, Rosanna; Pimentel-Cáceres, Paola; Soriano-Polo, Diego; Rodríguez-Braun, Edith; Balsalobre-Yago, José; Martínez-Ortiz, María-José; Wikstrom-Fernández, Sofía; Murillo-Herrera, Andrés; García-García, Teresa; García-Solano, José; Conesa-Zamora, Pablo; Luengo-Gil, Ginés (NATURE PORTFOLIO, 2025-07-01)
    This study examined the prognostic significance of immunoscore within consensus molecular subtypes (CMS), tumour budding (TB), and macrophage infiltration in colorectal cancer (CRC). A retrospective series was analysed ...
  • Restorative potential of ciliary body cells in a retinal ganglion cell degeneration model 
    Lucas-Ruiz, Fernando; Fernández-Nogales, Marta; Valiente-Soriano, Francisco-Javier; Herrera, Macarena; Nadal-Nicolás, Francisco-M; Agudo-Barriuso, Marta; Herrera, Eloisa (NATURE PORTFOLIO, 2025-05-03)
    The ciliary body (CB) has been proposed as a niche of neural stem cells because, in vitro, cells from this area are able to form neurospheres, proliferate and differentiate. Here, we explore the potential of CB cells to ...
  • Genetics of monozygotic twins reveals the impact of environmental sensitivity on psychiatric and neurodevelopmental phenotypes 
    Assary, Elham; Coleman, Jonathan-R-I; Hemani, Gibran; van-de-Weijer, Margot-P; Howe, Laurence-J; Palviainen, Teemu; Grasby, Katrina-L; Ahlskog, Rafael; Nygaard, Marianne; Cheesman, Rosa; Lim, Kai; Reynolds, Chandra-A; Ordoñana, Juan-Ramón; Colodro-Conde, Lucía; Gordon, Scott; Madrid-Valero, Juan-José; Thalamuthu, Anbupalam; Hottenga, Jouke-Jan; Mengel-From, Jonas; Armstrong, Nicola-J; Sachdev, Perminder-S; Lee, Teresa; Brodaty, Henry; Trollor, Julian-N; Wright, Margaret; Ames, David; Catts, Vibeke-S; Latvala, Antti; Vuoksimaa, Eero; Mallard, Travis; Harden, K-Paige; Tucker-Drob, Elliot-M; Oskarsson, Sven; Hammond, Christopher-J; Christensen, Kaare; Taylor, Mark; Lundstrom, Sebastian; Larsson, Henrik; Karlsson, Robert; Pedersen, Nancy-L; Mather, Karen-A; Medland, Sarah-E; Boomsma, Dorret-I; Martin, Nicholas-G; Plomin, Robert; Bartels, Meike; Lichtenstein, Paul; Kaprio, Jaakko; Eley, Thalia-C; Davies, Neil-M; Munroe, Patricia-B; Keers, Robert (NATURE PORTFOLIO, 2025-06-10)
    Individual sensitivity to environmental exposures may be genetically influenced. This genotype-by-environment interplay implies differences in phenotypic variance across genotypes, but these variants have proven challenging ...
  • Maternal plasma cell-free RNA as a predictor of early and late-onset preeclampsia throughout pregnancy 
    Castillo-Marco, Nerea; Cordero, Teresa; Igual, Marina; Muñoz-Blat, Irene; Gómez-Álvarez, Carla; Bernat-González, Neus; Gaspar-Domenech, Ángela; Ortiz-Domingo, Erika; Vives, Alba; Ortega-Sanchis, Sheila; Monfort-Ortiz, Rogelio; Volkov, Petr; Delgado-Marín, Juan-Luis; Hernández-Hernández, Laura; Cánovas, Esther; Gil, María-del-Mar; Santacruz, Belén; González-González, Nieves-Luisa; Plasencia, Walter; Perales-Marin, Alfredo; Marcos-Puig, Beatriz; Palacios-Marqués, Ana-María; Melchor, Inigo; Martín-Martínez, Alicia; Benítez-Delgado, Taysa; Simon, Carlos; Garrido-Gómez, Tamara (NATURE PORTFOLIO, 2025-10-20)
    Early- and late-onset preeclampsia (EOPE and LOPE) pose serious maternal-fetal risks, yet non-invasive early prediction remains challenging. In a prospective cohort of 9,586 pregnancies, we analyze trimester-specific plasma ...
  • Programmed cell death pathways coordinate neutrophil and macrophage clearance in zebrafish and are differentially exploited by Salmonella Typhimurium 
    Lozano-Gil, Juan-Manuel; Pedoto, Annamaria; Conesa-Hernández, Ana-María; Ocaña-Esparza, María; Mulero, Víctoriano; Tyrkalska, Sylwia-D (SPRINGER NATURE, 2025-12-08)
    Programmed cell death (PCD) is essential for immune cell homeostasis and host defense, yet its role in neutrophil and macrophage elimination during bacterial infections remains poorly understood. Using the zebrafish model, ...
  • Does perioperative FLOT increase cure rates in resectable esophageal adenocarcinoma? A mixture cure model analysis 
    Mateos, Lucía; Jiménez-Fonseca, Paula; Gallego, Javier; Lecumberri, Arturo; Custodio, Ana; Martínez-de-Castro, Eva; Hernández-San-Gil, Raquel; Fernández-Montes, Ana; Limon, María-Luisa; Vidal-Tocino, Rosario; Cano, Juana-María; López-Robles, Javier; Gil, Mireia; Acosta-Eyzaguirre, Daniel; Marín-Zafra, Gema-Rocío; Merida-García, Antonio-José; Francisco-Fernández, Alejandro; Ribera-Fernández, Paula; Hierro, Cinta; Riesco, María-Carmen; García-Araque, Montse; Ruiz-Martin, Maribel; Pimentel-Cáceres, Paola; Visa, Laura; Cerdá, Paula; Granja, Mónica; Ruperez-Blanco, Ana-Belén; Gutiérrez, Lourdes; Carmona-Bayonas, Alberto (SPRINGERNATURE, 2026-02-08)
    BACKGROUND: Translating trial findings to real-world cure rates for resectable oesophageal and gastroesophageal junction (GEJ) adenocarcinoma is critical. Standard endpoints like disease-free survival (DFS) may not distinguish ...

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