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Envíos recientes

03. IMIB (Instituto Murciano de Investigación Biosanitaria Pascual Parrilla): Envíos recientes

  • Physical activity domains and risk of gastric adenocarcinoma in the MCC-Spain case-control study 
    Huerta-Castaño, José-María; Chirlaque-López, María-Dolores; Molina, Antonio-J; Amiano, Pilar; Martín, Vicente; Fernández-Villa, Tania; Pérez-Gómez, Beatriz; Moreno, Víctor; Burgui, Rosana; Gómez-Acebo, Inés; Ramos-Lora, Manuel; Fernández-Tardon, Guillermo; Peiro, Rosana; Olmedo-Requena, Rocío; Pollan, Marina; Kogevinas, Manolis; Castaño-Vinyals, Gemma; Aragonés, Nuria; Navarro, (PUBLIC LIBRARY SCIENCE, 2017-07-06)
    BACKGROUND: Evidence for a protective role of physical activity against development of stomach cancer is yet inconclusive. We studied the association of domain-specific physical activity and the risk of gastric adenocarcinoma ...
  • Characterization and mutational analysis of a nicotinamide mononucleotide deamidase from Agrobacterium tumefaciens showing high thermal stability and catalytic efficiency 
    Martínez-Moñino, Ana-Belén; Zapata-Pérez, Rubén; García-Saura, Antonio-Ginés; Gil-Ortiz, Fernando; Pérez-Gilabert, Manuela; Sánchez-Ferrer, Álvaro (PUBLIC LIBRARY SCIENCE, 2017-04-07)
    NAD+ has emerged as a crucial element in both bioenergetic and signaling pathways since it acts as a key regulator of cellular and organismal homeostasis. Among the enzymes involved in its recycling, nicotinamide mononucleotide ...
  • Mapping the association between back pain and type 2 diabetes: A cross-sectional and longitudinal study of adult Spanish twins 
    Dario, Amabile; Ferreiraz, Manuela; Refshauge, Kathryn; Harmer, Alison; Sánchez-Romera, Juan-F; Pérez-Riquelme, Francisco; Cisneros, Ligia; Ordoñana, Juan-Ramón; Ferreira, Paulo (PUBLIC LIBRARY SCIENCE, 2017-04-03)
    BACKGROUND: Back pain and type 2 diabetes often co-occur, resulting in greater impact on people's health and complexity in their care. Plausible causal mechanisms for this association have been proposed, yet the nature of ...
  • Nutritional quality of food as represented by the FSAm-NPS nutrient profiling system underlying the Nutri-Score label and cancer risk in Europe: Results from the EPIC prospective cohort study 
    Deschasaux, Melanie; Huybrechts, Inge; Murphy, Neil; Julia, Chantal; Hercberg, Serge; Srour, Bernard; Kesse-Guyot, Emmanuelle; Latino-Martel, Paule; Biessy, Carine; Casagrande, Corinne; Jenab, Mazda; Ward, Heather; Weiderpass, Elisabete; Dahm, Christina-C; Overvad, Kim; Kyro, Cecilie; Olsen, Anja; Affret, Aurelie; Boutron-Ruault, Marie-Christine; Mahamat-Saleh, Yahya; Kaaks, Rudolf; Kuehn, Tilman; Boeing, Heiner; Schwingshackl, Lukas; Bamia, Christina; Peppa, Eleni; Trichopoulou, Antonia; Masala, Giovanna; Krogh, Vittorio; Panico, Salvatore; Tumino, Rosario; Sacerdote, Carlotta; Bueno-de-Mesquita, Bas; Peeters, Petra-H; Hjartaker, Anette; Rylander, Charlotta; Skeie, Guri; Quirós, José-Ramón; Jakszyn, Paula; Salamanca-Fernández, Elena; Huerta-Castaño, José-María; Ardanaz, Eva; Amiano, Pilar; Ericson, Ulrika; Sonestedt, Emily; Huseinovic, Ena; Johansson, Ingegerd; Khaw, Kay-Tee; Wareham, Nick; Bradbury, Kathryn-E; Pérez-Cornago, Aurora; Tsilidis, Konstantinos-K; Ferrari, Pietro; Riboli, Elio; Gunter, Marc-J; Touvier, Mathilde (PUBLIC LIBRARY SCIENCE, 2018-09)
    BACKGROUND: Helping consumers make healthier food choices is a key issue for the prevention of cancer and other diseases. In many countries, political authorities are considering the implementation of a simplified labelling ...
  • Effect of Porcine circovirus 2 (PCV-2) maternally derived antibodies on performance and PCV-2 viremia in vaccinated piglets under field conditions 
    Figueras-Gourgues, S; Fraile, L; Segales, J; Hernández-Caravaca, I; López-Ubeda, R; García-Vazquez, F-A; Gómez-Duran, O; Grosse-Liesner, B (BMC, 2019-09-05)
    BACKGROUND: Nowadays, the most common presentation of PCV-2 is the subclinical infection in piglets after weaning. The success of PCV-2 vaccination is associated with the control of the clinical disease as well as the ...
  • Analysis and visualization of disease courses in a semantically-enabled cancer registry 
    Esteban-Gil, Ángel; Fernández-Breis, Jesualdo-Tomás; Boeker, Martin (BMC, 2017-09-29)
    BACKGROUND: Regional and epidemiological cancer registries are important for cancer research and the quality management of cancer treatment. Many technological solutions are available to collect and analyse data for cancer ...
  • Does the sex of one's co-twin affect height and BMI in adulthood? A study of dizygotic adult twins from 31 cohorts 
    Bogl, Leonie-H; Jelenkovic, Aline; Vuoksimaa, Eero; Ahrenfeldt, Linda; Pietilainen, Kirsi-H; Stazi, María-A; Fagnani, Corrado; D'Ippolito, Cristina; Hur, Yoon-Mi; Jeong, Hoe-Uk; Silberg, Judy-L; Eaves, Lindon-J; Maes, Hermine-H; Bayasgalan, Gombojav; Narandalai, Danshiitsoodol; Cutler, Tessa-L; Kandler, Christian; Jang, Kerry-L; Christensen, Kaare; Skytthe, Axel; Kyvik, Kirsten-O; Cozen, Wendy; Hwang, Amie-E; Mack, Thomas-M; Derom, Catherine-A; Vlietinck, Robert-F; Nelson, Tracy-L; Whitfield, Keith-E; Corley, Robin-P; Huibregtse, Brooke-M; McAdams, Tom-A; Eley, Thalia-C; Gregory, Alice-M; Krueger, Robert-F; Mcgue, Matt; Pahlen, Shandell; Willemsen, Gonneke; Bartels, Meike; van-Beijsterveldt, Toos-C-E-M; Pang, Zengchang; Tan, Qihua; Zhang, Dongfeng; Martin, Nicholas-G; Medland, Sarah-E; Montgomery, Grant-W; Hjelmborg, Jacob-van-B; Rebato, Esther; Swan, Gary-E; Krasnow, Ruth; Busjahn, Andreas; Lichtenstein, Paul; Oncel, Sevgi-Y; Aliev, Fazil; Baker, Laura-A; Tuvblad, Catherine; Siribaddana, Sisira-H; Hotopf, Matthew; Sumathipala, Athula; Rijsdijk, Fruhling; Magnusson, Patrik-K-E; Pedersen, Nancy-L; Aslan, Anna-K-Dahl; Ordoñana, Juan-Ramón; Sánchez-Romera, Juan-F; Colodro-Conde, Lucía; Duncan, Glen-E; Buchwald, Dedra; Tarnoki, Adam-D; Tarnoki, David-L; Yokoyama, Yoshie; Hopper, John-L; Loos, Ruth-J-F; Boomsma, Dorret-I; Sorensen, Thorkild-I-A; Silventoinen, Karri; Kaprio, Jaakko (BMC, 2017-04-27)
    BACKGROUND: The comparison of traits in twins from opposite-sex (OS) and same-sex (SS) dizygotic twin pairs is considered a proxy measure of prenatal hormone exposure. To examine possible prenatal hormonal influences on ...
  • Two histologically colorectal carcinomas subsets from the serrated pathway show different methylome signatures and diagnostic biomarkers 
    García-Solano, José; Turpin, María-C; Torres-Moreno, Daniel; Huertas-López, Francisco; Tuomisto, Anne; Makinen, Markus-J; Conesa, Ana; Conesa-Zamora, Pablo (BMC, 2018-11-09)
    BACKGROUND: Altered methylation patterns are driving forces in colorectal carcinogenesis. The serrated adenocarcinoma (SAC) and sporadic colorectal carcinoma showing histological and molecular features of microsatellite ...
  • Mitochondrial DNA copy number variation, leukocyte telomere length, and breast cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) study 
    Campa, Daniele; Barrdahl, Myrto; Santoro, Aurelia; Severi, Gianluca; Baglietto, Laura; Omichessan, Hanane; Tumino, Rosario; Bueno-de-Mesquita, Bas; Peeters, Petra-H; Weiderpass, Elisabete; Chirlaque-López, María-Dolores; Rodríguez-Barranco, Miguel; Agudo, Antonio; Gunter, Marc; Dossus, Laure; Krogh, Vittorio; Matullo, Giuseppe; Trichopoulou, Antonia; Travis, Ruth-C; Canzian, Federico; Kaaks, Rudolf (BIOMED CENTRAL LTD, 2018-04-17)
    BACKGROUND: Leukocyte telomere length (LTL) and mitochondrial genome (mtDNA) copy number and deletions have been proposed as risk markers for various cancer types, including breast cancer (BC). METHODS: To gain a more ...
  • Correlates of circulating ovarian cancer early detection markers and their contribution to discrimination of early detection models: results from the EPIC cohort 
    Fortner, Renee-T; Vitonis, Allison-F; Schock, Helena; Huesing, Anika; Johnson, Theron; Fichorova, Raina-N; Fashemi, Titilayo; Yamamoto, Hidemi-S; Tjonneland, Anne; Hansen, Louise; Overvad, Kim; Boutron-Ruault, Marie-Christine; Kvaskoff, Marina; Severi, Gianluca; Boeing, Heiner; Trichopoulou, Antonia; Benetou, Vassiliki; La-Vecchia, Carlo; Palli, Domenico; Sieri, Sabina; Tumino, Rosario; Matullo, Giuseppe; Mattiello, Amalia; Onland-Moret, N-Charlotte; Peeters, Petra-H; Weiderpass, Elisabete; Gram, Inger-Torhild; Jareid, Mie; Quirós, José-Ramón; Duell, Eric-J; Sánchez, María-José; Chirlaque-López, María-Dolores; Ardanaz, Eva; Larrañaga, Nerea; Nodin, Bjorn; Brandstedt, Jenny; Idahl, Annika; Khaw, Kay-Tee; Allen, Naomi; Gunter, Marc; Johansson, Mattias; Dossus, Laure; Merritt, Melissa-A; Riboli, Elio; Cramer, Daniel-W; Kaaks, Rudolf; Terry, Kathryn-L (BMC, 2017-03-20)
    BACKGROUND: Ovarian cancer early detection markers CA125, CA15.3, HE4, and CA72.4 vary between healthy women, limiting their utility for screening. METHODS: We evaluated cross-sectional relationships between lifestyle and ...
  • Zebrafish modeling reveals that SPINT1 regulates the aggressiveness of skin cutaneous melanoma and its crosstalk with tumor immune microenvironment 
    Gómez-Abenza, Elena; Ibañez-Molero, Sofia; García-Morenou, Diana; Fuentes, Inmaculada; Zon, Leonard; Mione, María-C; Cayuela-Fuentes, María-Luisa; Gabellini, Chiara; Mulero, Victoriano (BMC, 2019-09-13)
    BACKGROUND: Skin cutaneous melanoma (SKCM) is the most lethal form of skin cancer and while incidence rates are declining for most cancers, they have been steadily rising for SKCM. Serine protease inhibitor, kunitz-type, ...
  • High penetrance of acute intermittent porphyria in a Spanish founder mutation population and CYP2D6 genotype as a susceptibility factor 
    Barreda-Sánchez, María; Buendía-Martínez, Juan; Glover-López, Guillermo; Carazo-Díaz, Carmen; Ballesta-Martínez, María-Juliana; López-González, Vanesa; Sánchez-Soler, María-José; Rodríguez-Pena, Lidya; Serrano-Anton, Ana-Teresa; Gil-Ferrer, Remedios; Martínez-Romero, María-del-Carmen; Carbonell-Meseguer, Pablo; Guillén-Navarro, Encarna (BMC, 2019-02-26)
    BACKGROUND: Acute intermittent porphyria (AIP) is a low-penetrant genetic metabolic disease caused by a deficiency of hydroxymethylbilane synthase (HMBS) in the haem biosynthesis. Manifest AIP (MAIP) is considered when ...
  • Effect of NAC treatment and physical activity on neuroinflammation in subchronic Parkinsonism; is physical activity essential? 
    Gil-Martínez, Ana-Luisa; Cuenca, Lorena; Sánchez, Consuelo; Estrada, Cristina; Fernández-Villalba, Emiliano; Herrero, María-Trinidad (BMC, 2018-11-26)
    BACKGROUND: Neuroprotective strategies are becoming relevant to slow down dopaminergic cell death and inflammatory processes related to the progressive neurodegeneration in Parkinson's disease (PD). Interestingly, among ...
  • In search of an evidence-based strategy for quality assessment of human tissue samples: report of the tissue Biospecimen Research Working Group of the Spanish Biobank Network 
    Esteva-Socias, Margalida; Artiga, María-Jesús; Bahamonde, Olga; Belar, Oihana; Bermudo, Raquel; Castro, Erika; Escámez, Teresa; Fraga, Maximo; Jauregui-Mosquera, Laura; Novoa, Isabel; Peiro-Chova, Lorena; Rejon, Juan-David; Ruiz-Miro, María; Vieiro-Balo, Paula; Villar-Campo, Virginia; Zazo, Sandra; Rabano, Alberto; Villena, Cristina (BMC, 2019-11-12)
    The purpose of the present work is to underline the importance of obtaining a standardized procedure to ensure and evaluate both clinical and research usability of human tissue samples. The study, which was carried out by ...
  • Prospective analysis of circulating metabolites and breast cancer in EPIC 
    His, Mathilde; Viallon, Vivian; Dossus, Laure; Gicquiau, Audrey; Achaintre, David; Scalbert, Augustin; Ferrari, Pietro; Romieu, Isabelle; Onland-Moret, N-Charlotte; Weiderpass, Elisabete; Dahm, Christina-C; Overvad, Kim; Olsen, Anja; Tjonneland, Anne; Fournier, Agnes; Rothwell, Joseph-A; Severi, Gianluca; Kuehn, Tilman; Fortner, Renee-T; Boeing, Heiner; Trichopoulou, Antonia; Karakatsani, Anna; Martimianaki, Georgia; Masala, Giovanna; Sieri, Sabina; Tumino, Rosario; Vineis, Paolo; Panico, Salvatore; van-Gils, Carla-H; Nost, Therese-H; Sandanger, Torkjel-M; Skeie, Guri; Quirós, José-Ramón; Agudo, Antonio; Sánchez, María-José; Amiano, Pilar; Huerta-Castaño, José-María; Ardanaz, Eva; Schmidt, Julie-A; Travis, Ruth-C; Riboli, Elio; Tsilidis, Konstantinos-K; Christakoudi, Sofia; Gunter, Marc-J; Rinaldi, Sabina (BMC, 2019-09-24)
    BACKGROUND: Metabolomics is a promising molecular tool to identify novel etiologic pathways leading to cancer. Using a targeted approach, we prospectively investigated the associations between metabolite concentrations in ...
  • Childhood generalized specific phobia as an early marker of internalizing psychopathology across the lifespan: results from the World Mental Health Surveys 
    de-Vries, Ymkje-Anna; Al-Hamzawi, Ali; Alonso, Jordi; Borges, Guilherme; Bruffaerts, Ronny; Bunting, Brendan; Caldas-de-Almeida, José-Miguel; Cia, Alfredo-H; De-Girolamo, Giovanni; Dinolova, Rumyana; Esan, Oluyomi; Florescu, Silvia; Gureje, Oye; Haro, Josep-María; Hu, Chiyi; Karam, Elie-G; Karam, Aimee; Kawakami, Norito; Kiejna, Andrzej; Kovess-Masfety, Viviane; Lee, Sing; Mneimneh, Zeina; Navarro-Mateu, Fernando; Piazza, Marina; Scott, Kate; ten-Have, Margreet; Torres, Yolanda; Viana, María-Carmen; Kessler, Ronald-C; de-Jonge, Peter; Aguilar-Gaxiola, Sergio; Al-Kaisy, Mohammed-Salih; Andrade, Laura-Helena; Benjet, Corina; Bromet, Evelyn-J; Caldas-de-Almeida, José-Miguel; Cardoso, Graca; Chatterji, Somnath; Degenhardt, Louisa; Demyttenaere, Koen; de-Girolamo, Giovanni; Hinkov, Hristo; Hu, Chi-yi; Karam, Aimee-Nasser; Lepine, Jean-Pierre; Levinson, Daphna; McGrath, John; Medina-Mora, María-Elena; Moskalewicz, Jacek; Pennell, Beth-Ellen; Posada-Villa, José; Scott, Kate-M; Slade, Tim; Stagnaro, Juan-Carlos; Stein, Dan-J; Whiteford, Harvey; Williams, David-R; Wojtyniak, Bogdan (BMC, 2019-05-24)
    BACKGROUND: Specific phobia (SP) is a relatively common disorder associated with high levels of psychiatric comorbidity. Because of its early onset, SP may be a useful early marker of internalizing psychopathology, especially ...
  • Exposure to bacterial products lipopolysaccharide and flagellin and hepatocellular carcinoma: a nested case-control study 
    Fedirko, Veronika; Hao-Quang-Tran,; Gewirtz, Andrew-T; Stepien, Magdalena; Trichopoulou, Antonia; Aleksandrova, Krasimira; Olsen, Anja; Tjonneland, Anne; Overvad, Kim; Carbonnel, Franck; Boutron-Ruault, Marie-Christine; Severi, Gianluca; Kuhn, Tilman; Kaaks, Rudolf; Boeing, Heiner; Bamia, Christina; Lagiou, Pagona; Grioni, Sara; Panico, Salvatore; Palli, Domenico; Tumino, Rosario; Naccarati, Alessio; Peeters, Petra-H; Bueno-de-Mesquita, Bas; Weiderpass, Elisabete; Huerta-Castaño, José-María; Barricarte-Gurrea, Aurelio; Sánchez, María-José; Dorronsoro, Miren; Quirós, José-Ramón; Agudo, Antonio; Sjoberg, Klas; Ohlsson, Bodil; Hemmingsson, Oskar; Werner, Marten; Bradbury, Kathryn-E; Khaw, Kay-Tee; Wareham, Nick; Tsilidis, Konstantinos-K; Aune, Dagfinn; Scalbert, Augustin; Romieu, Isabelle; Riboli, Elio; Jenab, Mazda (BMC, 2017-04-04)
    BACKGROUND: Leakage of bacterial products across the gut barrier may play a role in liver diseases which often precede the development of liver cancer. However, human studies, particularly from prospective settings, are ...
  • Osteoprotegerin and breast cancer risk by hormone receptor subtype: a nested case-control study in the EPIC cohort 
    Fortner, Renee-T; Sarink, Danja; Schock, Helena; Johnson, Theron; Tjonneland, Anne; Olsen, Anja; Overvad, Kim; Affret, Aurelie; His, Mathilde; Boutron-Ruault, Marie-Christine; Boeing, Heiner; Trichopoulou, Antonia; Naska, Androniki; Orfanos, Philippos; Palli, Domenico; Sieri, Sabina; Mattiello, Amalia; Tumino, Rosario; Ricceri, Fulvio; Bueno-de-Mesquita, Bas; Peeters, Petra-H-M; Van-Gils, Carla-H; Weiderpass, Elisabete; Lund, Eiliv; Quirós, José-Ramón; Agudo, Antonio; Sánchez, María-José; Chirlaque-López, María-Dolores; Ardanaz, Eva; Dorronsoro, Miren; Key, Tim; Khaw, Kay-Tee; Rinaldi, Sabina; Dossus, Laure; Gunter, Marc; Merritt, Melissa-A; Riboli, Elio; Kaaks, Rudolf (BMC, 2017-02-08)
    BACKGROUND: Circulating osteoprotegerin (OPG), a member of the receptor activator of nuclear factor kappa-B (RANK) axis, may influence breast cancer risk via its role as the decoy receptor for both the RANK ligand (RANKL) ...
  • Clinical pilot study to evaluate the neovaginal PACIENA prosthesis® for vaginoplasty without skin grafts in women with vaginal agenesis 
    Acien, Pedro; Nohales-Alfonso, Francisco-J; Sánchez-Ferrer, María-Luisa; Sánchez-Lozano, Miguel; Navarro-Lillo, Victoria; Acien, Maribel (BMC, 2019-11-26)
    BACKGROUND: To evaluate the feasibility and clinical outcomes of vaginoplasties using a neovaginal polylactic acid prosthesis made with 3-dimensional (3D) printing technology as an intraneovaginal mould. METHODS: This was ...
  • Epidemiology of non-steroidal anti-inflammatory drugs consumption in Spain. The MCC-Spain study 
    Gómez-Acebo, Inés; Dierssen-Sotos, Trinidad; de-Pedro, María; Pérez-Gómez, Beatriz; Castaño-Vinyals, Gemma; Fernández-Villa, Tania; Palazuelos-Calderon, Camilo; Amiano, Pilar; Etxeberria, Jaione; Benavente, Yolanda; Fernández-Tardon, Guillermo; Salcedo-Bellido, Inmaculada; Capelo, Rocío; Peiro, Rosana; Marcos-Gragera, Rafael; Huerta-Castaño, José-María; Tardon, Adonina; Barricarte-Gurrea, Aurelio; Altzibar, Jone-Miren; Alonso-Molero, Jessica; Davila-Batista, Verónica; Aragonés, Nuria; Pollan, Marina; Kogevinas, Manolis; Llorca, Javier (BMC, 2018-09-21)
    BACKGROUND: Non-steroidal anti-inflammatory drugs (NSAIDs) are widely used despite their risk of gastrointestinal bleeding or cardiovascular events. We report the profile of people taking NSAIDs in Spain, and we include ...

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