Repositorio Dspace

Envíos recientes

03. IMIB (Instituto Murciano de Investigación Biosanitaria Pascual Parrilla): Envíos recientes

  • Melanopsin+RGCs Are fully Resistant to NMDA-Induced Excitotoxicity 
    Vidal-Villegas, Beatriz; Di-Pierdomenico, Johnny; Miralles-de-Imperial-Ollero, Juan-A; Ortin-Martínez, Arturo; Nadal-Nicolás, Francisco-M; Bernal-Garro, Jose-M; Cuenca-Navarro, Nicolas; Villegas-Pérez, María-Paz; Vidal-Sanz, Manuel (MDPI, 2019-06-02)
    We studied short- and long-term effects of intravitreal injection of N-methyl-d-aspartate (NMDA) on melanopsin-containing (m(+)) and non-melanopsin-containing (Brn3a(+)) retinal ganglion cells (RGCs). In adult SD-rats, the ...
  • Circulating Metabolites Associated with Alcohol Intake in the European Prospective Investigation into Cancer and Nutrition Cohort 
    van-Roekel, Eline-H; Trijsburg, Laura; Assi, Nada; Carayol, Marion; Achaintre, David; Murphy, Neil; Rinaldi, Sabina; Schmidt, Julie-A; Stepien, Magdalena; Kaaks, Rudolf; Kuehn, Tilman; Boeing, Heiner; Iqbal, Khalid; Palli, Domenico; Krogh, Vittorio; Tumino, Rosario; Ricceri, Fulvio; Panico, Salvatore; Peeters, Petra-H; Bueno-de-Mesquita, Bas; Ardanaz, Eva; Luján-Barroso, Leila; Quirós, J-Ramón; Huerta-Castaño, José-María; Molina-Portillo, Elena; Dorronsoro, Miren; Tsilidis, Konstantinos-K; Riboli, Elio; Rostgaard-Hansen, Agnetha-Linn; Tjonneland, Anne; Overvad, Kim; Weiderpass, Elisabete; Boutron-Ruault, Marie-Christine; Severi, Gianluca; Trichopoulou, Antonia; Karakatsani, Anna; Kotanidou, Anastasia; Hakansson, Anders; Malm, Johan; Weijenberg, Matty-P; Gunter, Marc-J; Jenab, Mazda; Johansson, Mattias; Travis, Ruth-C; Scalbert, Augustin; Ferrari, Pietro (MDPI, 2018-05)
    Identifying the metabolites associated with alcohol consumption may provide insights into the metabolic pathways through which alcohol may affect human health. We studied associations of alcohol consumption with circulating ...
  • On the Metal Cofactor in the Tyrosinase Family 
    Solano, Francisco (MDPI, 2018-02)
    The production of pigment in mammalian melanocytes requires the contribution of at least three melanogenic enzymes, tyrosinase and two other accessory enzymes called the tyrosinase-related proteins (Trp1 and Trp2), which ...
  • Melanin and Melanin-Related Polymers as Materials with Biomedical and Biotechnological Applications-Cuttlefish Ink and Mussel Foot Proteins as Inspired Biomolecules 
    Solano, Francisco (MDPI, 2017-07)
    The huge development of bioengineering during the last years has boosted the search for new bioinspired materials, with tunable chemical, mechanical, and optoelectronic properties for the design of semiconductors, batteries, ...
  • Tourniquet-ALPPS is a promising treatment for very large hepatocellular carcinoma and intrahepatic cholangiocarcinoma 
    López-López, Víctor; Robles-Campos, Ricardo; Brusadin, Roberto; López-Conesa, Asunción; Navarro, Álvaro; Arévalo-Pérez, Julio; Gil, Pedro-José; Parrilla-Paricio, Pascual (IMPACT JOURNALS LLC, 2018-06-15)
    When very large hepatocellular carcinomas (HCCs) and intrahepatic cholangiocarcinoma (IHCCs) with insufficient future liver remnants are treated using associating liver partition and portal vein ligation for staged hepatectomy ...
  • Recurrent mutations in a SERPINC1 hotspot associate with venous thrombosis without apparent antithrombin deficiency 
    Zeng, Wei; Hu, Bei; Tang, Liang; You, Yan-Yan; Toderici, Mara; de-la-Morena-Barrio, María-Eugenia; Corral, Javier; Hu, Yu (IMPACT JOURNALS LLC, 2017-10-13)
    Despite the essential anticoagulant function of antithrombin and the high risk of thrombosis associated with its deficiency, the prevalence of antithrombin deficiency among patients with venous thromboembolism (VTE) is ...
  • Glioblastoma progression is assisted by induction of immunosuppressive function of pericytes through interaction with tumor cells 
    Valdor, Rut; García-Bernal, David; Bueno, Carlos; Ródenas, Mónica; Moraleda-Jiménez, José-María; Macian, Fernando; Martínez, Salvador (IMPACT JOURNALS LLC, 2017-09-15)
    The establishment of immune tolerance during Glioblastoma Multiforme (GBM) progression, is characterized by high levels expression of anti-inflammatory cytokines, which suppress the function of tumor assocciated myeloid ...
  • Time for Radical Changes in Brain Stem Nomenclature-Applying the Lessons From Developmental Gene Patterns 
    Watson, Charles; Bartholomaeus, Caitlin; Puelles, Luis (FRONTIERS MEDIA SA, 2019-02-12)
    The traditional subdivision of the brain stem into midbrain, pons, and medulla oblongata is based purely on the external appearance of the human brain stem. There is an urgent need to update the names of brain stem structures ...
  • Identification of an Evolutionarily Conserved Ankyrin Domain Containing Protein, Caiap, Which Regulates Inflammasome-Dependent Resistance to Bacterial Infection 
    Tyrkalska, Sylwia-D; Candel, Sergio; Pérez-Oliva, Ana-Belén; Valera-Pérez, Ana; Alcaraz-Pérez, Francisca; García-Moreno, Diana; Cayuela-Fuentes, María-Luisa; Mulero, Víctoriano (FRONTIERS MEDIA SA, 2017-10-19)
    Many proteins contain tandemly repeated modules of several amino acids, which act as the building blocks that form the underlying architecture of a specific protein-binding interface. Among these motifs and one of the most ...
  • Habituation Training Improves Locomotor Performance in a Forced Running Wheel System in Rats 
    Toval, Ángel; Banos, Raul; de-la-Cruz, Ernesto; Morales-Delgado, Nicanor; Pallares, Jesús-G; Ayad, Abdelmalik; Tseng, Kuei-Y; Ferrán, José-Luis (FRONTIERS MEDIA SA, 2017-03-08)
  • Risk thresholds for alcohol consumption: combined analysis of individual-participant data for 599 912 current drinkers in 83 prospective studies 
    Wood, Ángela-M; Kaptoge, Stephen; Butterworth, Adam-S; Willeit, Peter; Warnakula, Samantha; Bolton, Thomas; Paige, Ellie; Paul, Dirk-S; Sweeting, Michael; Burgess, Stephen; Bell, Steven; Astle, William; Stevens, David; Koulman, Albert; Selmer, Randi-M; Verschuren, W-M-Monique; Sato, Shinichi; Njolstad, Inger; Woodward, Mark; Salomaa, Veikko; Nordestgaard, Borge-G; Yeap, Bu-B; Fletcher, Astrid; Melander, Olle; Kuller, Lewis-H; Balkau, Beverley; Marmot, Michael; Koenig, Wolfgang; Casiglia, Edoardo; Cooper, Cyrus; Arndt, Volker; Franco, Oscar-H; Wennberg, Patrik; Gallacher, John; Gómez-de-la-Cámara, Agustín; Volzke, Henry; Dahm, Christina-C; Dale, Caroline-E; Bergmann, Manuela-M; Crespo, Carlos-J; van-der-Schouw, Yvonne-T; Kaaks, Rudolf; Simons, Leon-A; Lagiou, Pagona; Schoufour, Josje-D; Boer, Jolanda-M-A; Key, Timothy-J; Rodríguez, Beatriz; Moreno-Iribas, Conchi; Davidson, Karina-W; Taylor, James-O; Sacerdote, Carlotta; Wallace, Robert-B; Quirós, J-Ramón; Tumino, Rosario; II; Linneberg, Allan; Daimon, Makoto; Panico, Salvatore; Howard, Barbara; Skeie, Guri; Strandberg, Timo; Weiderpass, Elisabete; Nietert, Paul-J; Psaty, Bruce-M; Kromhout, Daan; Salamanca-Fernández, Elena; Kiechl, Stefan; Krumholz, Harlan-M; Grioni, Sara; Palli, Domenico; Huerta-Castaño, José-María; Price, Jackie; Sundstrom, Johan; Arriola, Larraitz; Arima, Hisatomi; Travis, Ruth-C; Panagiotakos, Demosthenes-B; Karakatsani, Anna; Trichopoulou, Antonia; Kuhn, Tilman; Grobbee, Diederick-E; Barrett-Connor, Elizabeth; van-Schoor, Natasja; Boeing, Heiner; Overvad, Kim; Kauhanen, Jussi; Wareham, Nick; Langenberg, Claudia; Forouhi, Nita; Wennberg, María; Despres, Jean-Pierre; Cushman, Mary; Cooper, Jackie-A; Rodríguez, Carlos-J; Sakurai, Masaru; Shaw, Jonathan-E; Knuiman, Matthew; Voortman, Trudy; Meisinger, Christa; Tjonneland, Anne; Brenner, Hermann; Palmieri, Luigi; Dallongeville, Jean; Brunner, Eric-J; Assmann, Gerd; Trevisan, Maurizio; Gillum, Richard-F; Ford, Ian; Sattar, Naveed; Lazo, Mariana; Thompson, Simon-G; Ferrari, Pietro; León, David-A; Smith, George-Davey; Peto, Richard; Jackson, Rod; Banks, Emily; Di-Ángelantonio, Emanuele; Danesh, John (ELSEVIER SCIENCE INC, 2018-04-14)
    BACKGROUND: Low-risk limits recommended for alcohol consumption vary substantially across different national guidelines. To define thresholds associated with lowest risk for all-cause mortality and cardiovascular disease, ...
  • Genetic Etiology for Alcohol-Induced Cardiac Toxicity 
    Ware, James-S; Amor-Salamanca, Almudena; Tayal, Upasana; Govind, Risha; Serrano, Isabel; Salazar-Mendiguchia, Joel; García-Pinilla, José-Manuel; Pascual-Figal, Domingo-Andrés; Núñez, Julio; Guzzo-Merello, Gonzalo; González-Vioque, Emiliano; Bardaji, Alfredo; Manito, Nicolas; López-Garrido, Miguel; Padron-Barthe, Laura; Edwards, Elizabeth; Whiffin, Nicola; Walsh, Roddy; Buchan, Rachel-J; Midwinter, William; Wilk, Alicja; Prasad, Sanjay; Pantazis, Antonis; Baski, John; O'Regan, Declan-P; Alonso-Pulpon, Luis; Cook, Stuart-A; Lara-Pezzi, Enrique; Barton, Paul-J; García-Pavia, Pablo (ELSEVIER SCIENCE INC, 2018-05-22)
    BACKGROUND: Alcoholic cardiomyopathy (ACM) is defined by a dilated and impaired left ventricle due to chronic excess alcohol consumption. It is largely unknown which factors determine cardiac toxicity on exposure to alcohol. ...
  • Biallelic Mutations in KDSR Disrupt Ceramide Synthesis and Result in a Spectrum of Keratinization Disorders Associated with Thrombocytopenia 
    Takeichi, Takuya; Torrelo, Antonio; Lee, John-Y-W; Ohno, Yusuke; Lozano-Almela, María-Luisa; Kihara, Akio; Liu, Lu; Yasuda, Yuka; Ishikawa, Junko; Murase, Takatoshi; Belen-Rodrigo, Ana; Fernández-Crehuet, Pablo; Toi, Yoichiro; Mellerio, Jemima; Rivera, José; Vicente, Vicente; Kelsell, David-P; Nishimura, Yutaka; Okuno, Yusuke; Kojima, Daiei; Ogawa, Yasushi; Sugiura, Kazumitsu; Simpson, Michael-A; McLean, W-H-Irwin; Akiyama, Masashi; McGrath, John-A (ELSEVIER SCIENCE INC, 2017-11)
    Mutations in ceramide biosynthesis pathways have been implicated in a few Mendelian disorders of keratinization, although ceramides are known to have key roles in several biological processes in skin and other tissues. ...
  • Isolating the climate change impacts on air-pollution-related-pathologies over central and southern Europe - a modelling approach on cases and costs 
    Tarin-Carrasco, Patricia; Morales-Suárez-Varela, María; Im, Ulas; Brandt, Jorgen; Palacios-Pena, Laura; Jiménez-Guerrero, Pedro (COPERNICUS GESELLSCHAFT MBH, 2019-07-23)
  • Comparison of prognostic models to predict the occurrence of colorectal cancer in asymptomatic individuals: a systematic literature review and external validation in the EPIC and UK Biobank prospective cohort studies 
    Smith, Todd; Muller, David-C; Moons, Karel-G-M; Cross, Amanda-J; Johansson, Mattias; Ferrari, Pietro; Fagherazzi, Guy; Peeters, Petra-H-M; Severi, Gianluca; Huesing, Anika; Kaaks, Rudolf; Tjonneland, Anne; Olsen, Anja; Overvad, Kim; Bonet, Catalina; Rodríguez-Barranco, Miguel; Huerta-Castaño, José-María; Gurrea, Aurelio-Barricarte; Bradbury, Kathryn-E; Trichopoulou, Antonia; Bamia, Christina; Orfanos, Philippos; Palli, Domenico; Pala, Valeria; Vineis, Paolo; Bueno-de-Mesquita, Bas; Ohlsson, Bodil; Harlid, Sophia; Van-Guelpen, Bethany; Skeie, Guri; Weiderpass, Elisabete; Jenab, Mazda; Murphy, Neil; Riboli, Elio; Gunter, Marc-J; Aleksandrova, Krasimira-Jekova; Tzoulaki, Ioanna (BMJ PUBLISHING GROUP, 2019-04)
    OBJECTIVE: To systematically identify and validate published colorectal cancer risk prediction models that do not require invasive testing in two large population-based prospective cohorts. DESIGN: Models were identified ...
  • Mismatch between student and tutor evaluation of training needs: a study of traumatology rotations 
    Santonja-Medina, Fernando; García-Sanz, Mari-Paz; Santonja-Renedo, Sara; García-Estañ, Joaquín (BMC, 2018-11-21)
    OBJECTIVE: An e-portfolio was used to determine the optimal number of times students need to repeat a procedure before they are fully capable of performing it without supervision. The results were compared with the actual ...
  • Trends in incidence, mortality and survival in women with breast cancer from 1985 to 2012 in Granada, Spain: a population-based study 
    Baeyens-Fernández, José-Antonio; Molina-Portillo, Elena; Pollán, Marina; Rodríguez-Barranco, Miguel; Del-Moral, Rosario; Arribas-Mir, Lorenzo; Sánchez-Cantalejo-Ramírez, Emilio; Sánchez, María-José (BMC, 2018-08-02)
    BACKGROUND: The incidence of breast cancer has increased since the 1970s. Despite favorable trends in prognosis, the role of changes in clinical practice and the introduction of screening remain controversial. We examined ...
  • Association between plasma phospholipid saturated fatty acids and metabolic markers of lipid, hepatic, inflammation and glycaemic pathways in eight European countries: a cross-sectional analysis in the EPIC-InterAct study 
    Zheng, Ju-Sheng; Sharp, Stephen-J; Imamura, Fumiaki; Koulman, Albert; Schulze, Matthias-B; Ye, Zheng; Griffin, Jules; Guevara, Marcela; Huerta-Castaño, José-María; Kroeger, Janine; Sluijs, Ivonne; Agudo, Antonio; Barricarte, Aurelio; Boeing, Heiner; Colorado-Yohar, Sandra; Dow, Courtney; Dorronsoro, Miren; Dinesen, Pia-T; Fagherazzi, Guy; Franks, Paul-W; Feskens, Edith-J-M; Kuehn, Tilman; Katzke, Verena-Andrea; Key, Timothy-J; Khaw, Kay-Tee; de-Magistris, María-Santucci; Romana-Mancini, Francesca; Molina-Portillo, Elena; Nilsson, Peter-M; Olsen, Anja; Overvad, Kim; Palli, Domenico; Quirós, J-Ramón; Rolandsson, Olov; Ricceri, Fulvio; Spijkerman, Annemieke-M-W; Slimani, Nadia; Tagliabue, Giovanna; Tjonneland, Anne; Tumino, Rosario; van-der-Schouw, Yvonne-T; Langenberg, Claudia; Riboli, Elio; Forouhi, Nita-G; Wareham, Nicholas-J (BMC, 2017-11-17)
    BACKGROUND: Accumulating evidence suggests that individual circulating saturated fatty acids (SFAs) are heterogeneous in their associations with cardio-metabolic diseases, but evidence about associations of SFAs with ...
  • The cross-national epidemiology of social anxiety disorder: Data from the World Mental Health Survey Initiative 
    Stein, Dan-J; Lim, Carmen-C-W; Roest, Annelieke-M; de-Jonge, Peter; Aguilar-Gaxiola, Sergio; Al-Hamzawi, Ali; Alonso, Jordi; Benjet, Corina; Bromet, Evelyn-J; Bruffaerts, Ronny; de-Girolamo, Giovanni; Florescu, Silvia; Gureje, Oye; Haro, Josep-María; Harris, Meredith-G; He, Yanling; Hinkov, Hristo; Horiguchi, Itsuko; Hu, Chiyi; Karam, Aimee; Karam, Elie-G; Lee, Sing; Lepine, Jean-Pierre; Navarro-Mateu, Fernando; Pennell, Beth-Ellen; Piazza, Marina; Posada-Villa, Jose; ten-Have, Margreet; Torres, Yolanda; Viana, María-Carmen; Wojtyniak, Bogdan; Xavier, Miguel; Kessler, Ronald-C; Scott, Kate-M (BMC, 2017-07-31)
    BACKGROUND: There is evidence that social anxiety disorder (SAD) is a prevalent and disabling disorder. However, most of the available data on the epidemiology of this condition originate from high income countries in the ...
  • Manipulation of bicarbonate concentration in sperm capacitation media improvesin vitro fertilisation output in porcine species 
    Soriano-Úbeda, Cristina; Romero-Aguirregomezcorta, Jon; Matas-Parra, Carmen; Visconti, Pablo-E; García-Vázquez, Francisco-Alberto (BMC, 2019-03-11)
    BACKGROUND: The in vivo concentration of bicarbonate (HCO(3) (-)), one of the essential sperm capacitating effectors, varies greatly in the different environments sperm go through from cauda epididymis to the fertilisation ...

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