Repositorio Dspace

Envíos recientes

03. IMIB (Instituto Murciano de Investigación Biosanitaria Pascual Parrilla): Envíos recientes

  • Elucidating the neuromeric organization of the Mongolian gerbil brain 
    Lucero-Arteaga, F; Labegorra, S; Abrego-Álvarez, A; Heck, V; Portu, A-I; Boeris, M-A; Alonso, A; Ribeiro-Do-Couto, B; García-Cabezas, M-A; Tseng, K-Y; Ferrán, José-Luis (SPRINGER, 2025-11-04)
    The Mongolian Gerbil (Meriones unguiculatus) diverged from rats/mice around 45 million years ago and developed adaptations to extreme temperatures and water scarcity. Another feature of the Mongolian Gerbils is their social ...
  • Postmortem study of adrenomedullin and cortisol in femoral serum and pericardial fluid related to acute pulmonary edema 
    Martínez-Jiménez, Daniel; Hernández-del-Rincón, Juan-Pedro; Sabater-Molina, María; Pérez-Martínez, Cristina; Torres, Carmen; Pérez-Cárceles, María-Dolores; Luna-Maldonado, Aurelio (SPRINGER, 2025-01)
    Currently, various tools aid in determining the cause of death and the circumstances surrounding it. Thanatochemistry is one such method that provides insights into the physiopathological mechanisms of death and the behavior ...
  • Enasidenib as treatment for AML with IDH2 mutation: multicenter real-life study of the early-access program in Spain 
    Jiménez-Vicente, Carlos; Beneit, Paola; Cano-Ferri, Isabel; Merchan, Brayan; Arnan, Montserrat; García-Guinon, Antoni; Martínez-Bilbao, Cristina; Alfonso, Ana; Martínez-Sánchez, Pilar; Alonso-Domínguez, Juan-Manuel; López-Godino, Oriana; Castaño-Diez, Sandra; Zugasti, Inés; Esteve, Jordi; Díaz-Beya, Marina; de-la-Fuente, Adolfo (SPRINGER, 2025-09)
    Enasidenib is an oral IDH2 inhibitor that reduces the production of the oncometabolite 2-hydroxyglutarate, differentiating IDH2 mutated leukemic cells with initial promising results for acute myeloid leukemia (AML) and ...
  • Validation of pharmacokinetic model for quizartinib quantified by UPLC-MS/MS in patients with FLT3-ITD negative newly diagnosed acute myeloid leukemia 
    Solana-Altabella, Antonio; Iniesta-Navalón, Carles; Chovi-Trull, María; Rodríguez-Veiga, Rebeca; López-Nogueroles, Marina; Martínez-Cuadrón, David; Gil-Candel, Mayte; Torres-Miñana, Laura; Acuna-Cruz, Evelyn; Cano-Ferri, Isabel; Boluda, Blanca; Navarro-Vicente, Irene; Lloret-Madrid, Pilar; Barragán, Eva; Gil, José-Vicente; Rodenas-Rovira, Mario; Megias-Vericat, Juan-Eduardo; Labrador, Jorge; Peris-Ribera, José-Esteban; Poveda-Andres, José-Luis; Montesinos, Pau (SPRINGER, 2025-11)
    PURPOSE: Quizartinib pharmacokinetics in FLT3-ITD negative acute myeloid leukemia (AML) remain largely unexplored. This study aims to validate a population pharmacokinetics model (popPK) for quizartinib in plasma samples ...
  • 4-octyl itaconate reduces human NLRP3 inflammasome constitutive activation with the cryopyrin-associated periodic syndrome p.R262W, p.D305N and p.T350M variants 
    Molina-López, Cristina; Hurtado-Navarro, Laura; O'Neill, Luke-A-J; Pelegrín, Pablo (SPRINGER BASEL AG, 2025-05-23)
    Cryopyrin-associated periodic syndrome (CAPS) is a condition characterized by dominant genetic variants in the NLRP3 gene, which lead to the formation of constitutively active inflammasomes. These inflammasomes play a ...
  • Biparietal diameter for first-trimester pregnancy dating: multicenter cohort study 
    de-Paco-Matallana, Catalina; Rolle, Valeria; Fidalgo, A-M; Sánchez-Romero, J; Jani, J-C; Chaveeva, P; Delgado-Marín, Juan-Luis; Santacruz, B; Nicolaides, K-H; Gil, M-M (WILEY, 2025-05)
    OBJECTIVE: To evaluate the accuracy of fetal biparietal diameter (BPD) measurement in comparison with crown-rump length (CRL) measurement for pregnancy dating at 11-13 weeks' gestation. METHODS: This was a retrospective ...
  • Early meal timing attenuates high polygenic risk of obesity 
    de-la-Pena-Armada, R; Rodríguez-Martin, María; Dashti, Hassan-S; Cascales, Ana-Isabel; Scheer, Frank-A-J-L; Saxena, Richa; Garaulet, Marta (WILEY, 2025-08)
    OBJECTIVE: We examined whether meal timing is associated with long-term weight-loss maintenance and whether meal timing interacts with a genome-wide polygenic score (PRS-BMI) on body weight-related outcomes. We then examined ...
  • Siesta behavior and genetics interact to influence obesity risk 
    Rodríguez-Martin, María; Salmerón-Martínez, Diego; Dashti, Hassan-S; Isabel-Cascales, Ana; Aragón-Alonso, Aurora; Scheer, Frank-A-J-L; Saxena, Richa; Garaulet, Marta (WILEY, 2025-01)
    OBJECTIVE: In this cross-sectional study, we aim to investigate the interactions between obesity, siesta behavior, and the genetic propensity for siesta in a Mediterranean population, in whom siesta is deeply rooted. ...
  • Burnout and Physical Symptoms in Healthcare Professionals: A Cross-Sectional Study 
    Puigtio-rebollo, Nuria; Serda-ferrer, Bernat-Carles; Sitjar-Suner, Miquel; Gacto-Sánchez, Mariano (WILEY, 2025-11)
    AIM: The Burnout syndrome (BOS) generates sustained stress and an inability to cope with demands. The aims of this cross-sectional study were (1) to describe the prevalence of BOS; (2) to explore the relation of the BOS ...
  • External cephalic version outcomes with tocolysis and sedation: A 10-year retrospective cohort study 
    Sánchez-Romero, Javier; Gallego-Pozuelo, rosa-María; Blanco-Carnero, José-Eliseo; Herrera-Giménez, Javier; Araico-Rodríguez, Fernando; Guijarro-Campillo, Alberto-Rafael; Nieto-Díaz, Anibal; de-Paco-Matallana, Catalina (WILEY, 2025-12-13)
    OBJECTIVE: To evaluate the effectiveness and safety of external cephalic version (ECV) performed with tocolysis and sedation or spinal anesthesia, and to identify predictors of ECV success, complications, and delivery ...
  • Circulating fatty acid binding protein 4 (FABP-4) concentrations and mortality in individuals with colorectal cancer in the European Prospective Investigation into Cancer and Nutrition study 
    Pham, Thu-Thi; Nimptsch, Katharina; Aleksandrova, Krasimira; Jenab, Mazda; Fedirko, Veronika; Olsen, Anja; Tjonneland, Anne; Cadeau, Claire; Severi, Gianluca; Schulze, Matthias-B; Fortner, Renee-Turzanski; Katzke, Verena; Agnoli, Claudia; Sacerdote, Carlotta; Tumino, Rosario; Signoriello, Simona; Trobajo-Sanmartin, Camino; Gómez-Gómez, Jesús-Humberto; Chirlaque-López, María-Dolores; Sánchez, María-José; Crous-Bou, Marta; May, Anne; Heath, Alicia; Aune, Dagfinn; Weiderpass, Elisabete; Pischon, Tobias (WILEY, 2026-02)
    Human fatty acid binding protein-4 (FABP-4), a protein elevated in obesity that promotes colon cancer cell invasiveness and metastasis, may be associated with higher mortality in individuals with colorectal cancer (CRC) ...
  • Perturbations in the blood metabolome up to a decade before prostate cancer diagnosis in 4387 matched case-control sets from the European Prospective Investigation into Cancer and Nutrition 
    Grenville, Zoe-S; Noor, Urwah; Rinaldi, Sabina; Gunter, Marc-J; Ferrari, Pietro; Agnoli, Claudia; Amiano, Pilar; Catalano, Alberto; Chirlaque-López, María-Dolores; Christakoudi, Sofia; Guevara, Marcela; Johansson, Matthias; Kaaks, Rudolf; Katzke, Verena; Masala, Giovanna; Olsen, Anja; Papier, Keren; Sánchez, María-José; Schulze, Matthias-B; Tjonneland, Anne; Tong, Tammy-Y-N; Tumino, Rosario; Weiderpass, Elisabete; Zamora-Ros, Raúl; Key, Timothy-J; Smith-Byrne, Karl; Schmidt, Julie-A; Travis, Ruth-C (WILEY, 2025-03)
    Measuring pre-diagnostic blood metabolites may help identify novel risk factors for prostate cancer. Using data from 4387 matched case-control pairs from the European Prospective Investigation into Cancer and Nutrition ...
  • Sex- and site-specific associations of circulating lipocalin 2 and incident colorectal cancer: Results from the EPIC cohort 
    Reichmann, Robin; Nimptsch, Katharina; Pischon, Tobias; Gunter, Marc-J; Jenab, Mazda; Eriksen, Anne-Kirstine; Tjonneland, Anne; Janke, Juergen; Katzke, Verena; Kaaks, Rudolf; Schulze, Matthias-B; Eichelmann, Fabian; Masala, Giovanna; Sieri, Sabina; Pasanisi, Fabrizio; Tumino, Rosario; Giraudo, María-Teresa; Rothwell, Joseph; Severi, Gianluca; Jakszyn, Paula; Sánchez-Pérez, María-José; Amiano, Pilar; Colorado-Yohar, Sandra; Guevara, Marcela; van-Guelpen, Bethany; Aglago, Elom-K; Heath, Alicia-K; Smith-Byrne, Karl; Weiderpass, Elisabete; Aleksandrova, Krasimira (WILEY, 2025-03)
    Experimental research has uncovered lipocalin 2 (LCN2) as a novel biomarker implicated in the modulation of intestinal inflammation, metabolic homeostasis, and colon carcinogenesis. However, evidence from human research ...
  • Spironolactone inhibits the NLRP1 inflammasome and alleviates defective erythropoiesis in Diamond-Blackfan anemia 
    Rodríguez-Ruiz, Lola; Lozano-Gil, Juan-Manuel; Ocañaa-Esparza, María; Conesa-Hernández, Ana-María; Pérez-Oliva, Ana-Belén; Fuster-Soler, José-Luis; Jerez-Cayuela, Andrés; Murillo-Sanjuan, Laura; Díaz-de-Heredia, Cristina; López-de-Hontanar, Guzman; Sevilla, Julián; García-Moreno, Diana; Cayuela-Fuentes, María-Luisa; Martínez-López, Alicia; Tyrkalska, Sylwia-D; Mulero, Víctoriano (WILEY, 2025-04)
  • High-risk features of early relapse in newly-diagnosed multiple myeloma: The impact of cytogenetics and response to initial therapy 
    Manubens, Andrea; Paiva, Bruno; Gutiérrez, Norma-C; Fernández, Manuela; Calasanz, María-José; Rosinol, Laura; Oriol, Albert; Blanchard, Ma-Jesús; Carrillo, Estrella; Benavente, Celina; Martínez-López, Joaquín; Bargay, Joan; Hernández, Miguel-Teodoro; de-la-Rubia, Javier; González, Yolanda; Paricio, Miguel; de-Arriba-de-la-Fuente, Felipe; Ocio, Enrique-M; Teruel, Ana-Isabel; López-de-la-Guía, Ana; Sirvent, Maialen; Gironella, Mercedes; Sampol, Antonia; Arguiñano, José-María; Cabrera, Carmen; Alegre, Adrián; Granell, Miquel; Cabanas-Perianes, Valentín; Núñez-Córdoba, Jorge-M; Mateos, María-Victoria; Lahuerta, Juan-José; San-Miguel, Jesús-F; Blade, Joan; Rodríguez-Otero, Paula (WILEY, 2025-04)
    Patients with newly-diagnosed multiple myeloma (MM) who experience early relapse (ER) have dismal overall survival (OS). Their prospective identification, either before or soon after treatment initiation, is paramount to ...
  • Evaluation of the Presence of Native Valvular Disease in Patients With Atrial Fibrillation Using the EHRA (Evaluated Heartvalves, Rheumatic, or Artificial) Classification 
    Escolar-Conesa, Antonio; Esteve-Pastor, María-Asunción; Roldán-Schilling, Vanessa; Soler-Espejo, Eva; Rivera-Caravaca, José-Miguel; Gil-Pérez, Pablo; González-Lozano, Eduardo; Arribas-Leal, José-María; Cánovas-López, Sergio; Saura-Espín, Daniel; Oliva-Sandoval, María-José; Pinar-Bermúdez, Eduardo; García-de-Lara, Juan; Lip, Gregory-Y-H; Marín, Francisco (WILEY, 2025-08)
    BACKGROUND: Atrial fibrillation (AF) in association with native valvular heart disease (VHD) is very common and both entities perpetuate each other due to volume and pressure overload. In 2017, the new EHRA classification ...
  • The Neutrophil-to-Lymphocyte Ratio Is an Independent Inflammatory Biomarker for Adverse Events in Patients With Atrial Fibrillation: Insights From the Murcia AF Project II (MAFP-II) Cohort Study 
    Soler-Espejo, Eva; Marín, Francisco; López-Gálvez, Raquel; Ramos-Bratos, María-Pilar; Sánchez-Villalobos, María; Esteve-Pastor, María-Asunción; Lip, Gregory-Y-H; Rivera-Caravaca, José-Miguel; Roldán-Schilling, Vanessa (WILEY, 2025-02)
    BACKGROUND: Systemic inflammation plays a central role in atrial fibrillation (AF). The neutrophil-to-lymphocyte ratio (NLR) is a simple hematological index that has been shown to be associated with prognosis in different ...
  • Iptacopan for Immune Thrombocytopenia and Cold Agglutinin Disease: A Global Phase 2 Basket Clinical Trial 
    Roth, Alexander; Barcellini, Wilma; Ademokun, Christine; Jang, Junho; Lozano-Almela, María-Luisa; Valcárcel-Ferreiras, David; Pascual-Izquierdo, Cristina; Chitnis, Shripad; Matviykiv, Sofiya; Vitaliti, Alessandra; Chen, Chi; Katsanou, Vasiliki; Chawla, Raghav; Al-samkari, Hanny (WILEY, 2026-02)
    Iptacopan is a first-in-class, oral, selective inhibitor of complement factor B that has demonstrated positive efficacy across several complement-driven diseases. Here we evaluate the efficacy and safety of iptacopan ...
  • Pregnancy-Related Disease Outcomes in Women With Moderate to Severe Multiple Sclerosis Disability 
    Shipley, Jessica; Beadnall, Heidi-N; Sanfilippo, Paul-G; Yeh, Wei-Zhen; Horakova, Dana; Kubala-Havrdova, Eva; Hradilek, Pavel; Kalincik, Tomas; Roos, Izanne; Prat, Alexandre; Girard, Marc; Rous, Zuzana; Pavelek, Zbysek; Gerlach, Oliver-H-H; Lechner-Scott, Jeannette; Alroughani, Raed; Ozakbas, Serkan; Peterka, Marek; Buzzard, Katherine; Skibina, Olga-G; Maimone, Davide; Foschi, Matteo; Surcinelli, Andrea; Karabudak, Rana; Spitaleri, Daniele-L-A; Lugaresi, Alessandra; Tomassini, Valentina; Gouider, Riadh; Mrabet, Saloua; Romero-Ferrando, Beatriz; Hodgkinson, Suzanne; Stourac, Pavel; Guimaraes, Joana; John, Nevin-A; Macdonell, Richard-A-L; Meca-Lallana, José-Eustasio; Butzkueven, Helmut; van-der-Walt, Anneke; Jokubaitis, Vilija-G (AMER MEDICAL ASSOC, 2025-09-15)
    IMPORTANCE: Understanding the association between pregnancy and clinical outcomes in women with moderate to severe multiple sclerosis (MS) disability is crucial for guiding family planning and management strategies. ...
  • Diagnosis and follow-up of patients with Hunter syndrome in Spain A Delphi consensus 
    González-Gutiérrez-Solana, Luis; Guillén-Navarro, Encarna; del-Toro, Mireia; Dalmau, Jaime; González-Meneses, Antonio; Couce, María-L (LIPPINCOTT WILLIAMS & WILKINS, 2018-07)
    Hunter syndrome or mucopolysaccharidosis type II (MPSII) is a progressive multisystem X-linked lysosomal storage disease caused by mutations in the IDS gene that shows a wide spectrum of clinical symptoms and severity. ...

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