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Envíos recientes

03. IMIB (Instituto Murciano de Investigación Biosanitaria Pascual Parrilla): Envíos recientes

  • AEOL-induced NRF2 activation and DWORF overexpression mitigate myocardial I/R injury 
    Asensio-López, María-del-Carmen; Ruiz-Ballester, Miriam; Pascual-Oliver, Silvia; Bastida-Nicolás, Francisco-José; Sassi, Yassine; Fuster, José-Javier; Pascual-Figal, Domingo-Andrés; Soler, Fernando; Lax, Antonio (SPRINGER, 2025-05-15)
    BACKGROUND: The causal relationship between the activation of nuclear factor erythroid 2-related factor 2 (NRF2) and the preservation of SERCA2a function in mitigating myocardial ischemia-reperfusion (mI/R) injury, along ...
  • Impact of environmental exposures on exhaled breath and lung function: NELA Birth Cohort 
    Sola-Martínez, Rosa-Alba; Jiménez-Guerrero, Pedro; Sánchez-Solís, Manuel; Lozano-Terol, Gema; Gallego-Jara, Julia; Martínez-Vivancos, Adrián; Morales, Eva; García-Marcos, Luis; de-Diego-Puente, Teresa (EUROPEAN RESPIRATORY SOC JOURNALS LTD, 2025-01)
    INTRODUCTION: Exposure to environmental factors (i.e. air pollution and second-hand tobacco smoke) have been associated with impaired lung function. However, the impact of environmental factors on lung health is usually ...
  • Clinical impact of [18F]FDG-PET/CT in ARI0002h treatment, a CAR-T against BCMA for relapsed/refractory multiple myeloma 
    Zugas, Inés; Tormo-Ratera, Marta; Oliver-Caldes, Aina; Soler-Perromat, Juan-Carlos; González-Calle, Veronica; Moreno, David-F; Cabanas-Perianes, Valentín; López-Muñoz, Nieves; Bartolome-Solanas, Álvaro; Español-Rego, Marta; Reguera-Ortega, Juan-Luis; Rosinol, Laura; López-Corral, Lucía; Tovar, Natalia; Rodríguez-Lobato, Luis-Gerardo; Álvarez-Pérez, Rosa-María; Varea, Sara; Olesti, Eulalia; Gómez-Grande, Adolfo; Frutos-Esteban, Laura; Tamayo, Pilar; Juan, Manel; Moraleda-Jiménez, José-María; Urbano-Ispizua, Álvaro; González-Navarro, Europa-Azucena; Martínez-López, Joaquín; Mateos, María-Victoria; Tomas, Xavier; Setoain, Xavier; Fernández-de-Larrea, Carlos (ELSEVIER, 2025-02-11)
    Multiple myeloma (MM) remains incurable, with poor outcomes in heavily pretreated patients. Chimeric antigen receptor (CAR) T-cell therapy has emerged as a promising treatment; however, outcomes after such therapy in ...
  • Cost Analysis of the FreeStyle Libre Systems in People with Type 2 Diabetes Mellitus on Basal Insulin with Poor Glycemic Control: A Spanish Perspective 
    Ampudia-Blasco, Francisco-Javier; de-la-Cuadra-Grande, Alberto; Bellido, Virginia; Cebrián-Cuenca, Ana-María; Mezquita-Raya, Pedro; Carretero-Gómez, Juana; Hernández-Martínez, Antonio-Miguel; Oyaguez, Itziar; Gómez-Peralta, Fernando (MARY ANN LIEBERT, INC, 2026-01)
    Background and Aims: FreeStyle Libre® systems are effective and convenient glucose flash monitoring (FM) devices. This cost analysis compared FM versus self-monitoring of blood glucose (SMBG) in poorly controlled (glycated ...
  • Four years on: Pregnancy and birth outcomes reported in the MSBase pregnancy, neonatal outcomes, and Women's Health Registry (2020-2024) 
    Jokubaitis, Vilija-G; Alroughani, Raed; Altintas, Ayse; Eichau, Sara; Hughes, Stella; Willekens, Barbara; Horakova, Dana; Kubala-Havrdova, Eva; Ozakbas, Serkan; Boz, Cavit; Habek, Mario; Kalincik, Tomas; Roos, Izanne; Etemadifar, Masoud; Peterka, Marek; Lechner-Scott, Jeannette; Meca-Lallana, José-Eustasio; Rous, Zuzana; Houskova, Jana; Prat, Alexandre; Girard, Marc; Ampapa, Radek; Buzzard, Katherine; Skibina, Olga; John, Nevin-A; Kermode, Allan-G; Fabis-Pedrini, Marzena-J; Foschi, Matteo; Surcinelli, Andrea; Blanco, Yolanda; Baghbanian, Seyed-Mohammad; Gerlach, Oliver; Macdonell, Richard; Pavelek, Zbysek; Stourac, Pavel; McCombe, Pamela; Laureys, Guy; Butzkueven, Helmut; van-der-Walt, Anneke; Gray, Orla (SAGE PUBLICATIONS LTD, 2025-08)
    BACKGROUND: Family planning is an important aspect of multiple sclerosis (MS), and neuromyelitis optica spectrum disorder (NMOSD) management. Knowledge gaps remain, including optimal perinatal management strategies, and ...
  • Inborn errors of immunity underlie clonal T cell expansions in large granular lymphocyte leukemia 
    Bravo-Pérez, Carlos; Gurnari, Carmelo; Huuhtanen, Jani; Kawashima, Naomi; Guarnera, Luca; Mandala, Aashray; Williams, Nakisha-D; Haddad, Christopher; Witt, Michaela; Unlu, Serhan; Brady, Zachary; Ogbue, Olisaemeka; Orland, Mark; Ahmed, Arooj; Kubota, Yasuo; Pagliuca, Simona; Durmaz, Arda; Mustjoki, Satu; Visconte, Valeria; Maciejewski, Jaroslaw-P (AMER SOC CLINICAL INVESTIGATION INC, 2025-05-01)
    BACKGROUNDT cell large granular lymphocyte leukemia (T-LGLL) is a lymphoproliferative disorder of cytotoxic T lymphocytes (CTLs), often with gain-of-function STAT3 mutations. T-LGLL represents a unique model for the study ...
  • Advancing Chrononutrition for Cardiometabolic Health: A 2023 National Heart, Lung, and Blood Institute Workshop Report 
    Dashti, Hassan-S; Jansen, Erica-C; Zuraikat, Faris-M; Dixit, Shilpy; Brown, Marishka; Laposky, Aaron; Broussard, Josiane-L; Butler, Matthew-P; Creasy, Seth-A; Crispim, Cibele-A; Depner, Christopher-M; Esser, Karyn-A; Garaulet, Marta; Hanlon, Erin-C; Makarem, Nour; Manoogian, Emily-N-C; Peterson, Courtney-M; Scheer, Frank-A-J-L; Wright-Jr, Kenneth-P; Goff, David-C; Pratt, Charlotte-A; Gamble, Karen-L; St-Onge, Marie-Pierre (WILEY, 2025-05-06)
    The circadian system maintains optimal biological functions at the appropriate time of day, and the disruption of this organization can contribute to the pathogenesis of cardiometabolic disorders. The timing of eating is ...
  • Optimal Medical Therapy for Heart Failure and Integrated Care in Patients With Atrial Fibrillation: A Report From the ESC-EHRA EORP Atrial Fibrillation Long-Term General Registry 
    Bonini, Niccolo; Proietti, Marco; Romiti, Giulio-Francesco; Vitolo, Marco; Fawzy, Ameenathul-Mazaya; Ding, Wern-Yew; Imberti, Jacopo-Francesco; Fauchier, Laurent; Marín, Francisco; Nabauer, Michael; Dan, Gheorghe-Andrei; Potpara, Tatjana-S; Boriani, Giuseppe; Lip, Gregory-Y-H; ESC-EHRA-EORP-AF-Gen-Long-Term-Registry-Investigators (WILEY, 2025-01-07)
    BACKGROUND: Heart failure (HF) often occurs in patients with atrial fibrillation (AF), with a major impact on prognosis. Few data are available on the effect of integrated treatment strategies to improve prognosis in ...
  • Cabozantinib plus Atezolizumab in Advanced, Progressive Endocrine Malignancies: A Multicohort, Basket, Phase II Trial (CABATEN/GETNE-T1914) 
    Capdevila, Jaume; Hernando, Jorge; Molina-Cerrillo, Javier; Benavent-Vinuales, Marta; García-Carbonero, Rocío; Teule, Alex; Custodio, Ana; Jiménez-Fonseca, Paula; López, Carlos; Hierro, Cinta; Carmona-Bayonas, Alberto; Alonso, Vicente; Llanos, Marta; Sevilla, Isabel; García-Álvarez, Alejandro; Alonso-Gordoa, Teresa; Gallego-Jiménez, Inmaculada; Antón-Pascual, Beatriz; Modrego-Sánchez, Andrea; Grande, Enrique (AMER ASSOC CANCER RESEARCH, 2025-11-14)
    PURPOSE: Multikinase inhibitors have shown efficacy in endocrine neoplasms, and synergism with immune checkpoint inhibitors has been noted in other tumors. PATIENTS AND METHODS: This is a prospective, multicenter, open-label, ...
  • Evaluation of the 4Kscore Test in Relation to Subsequent Risk of Aggressive Prostate Cancer in the European Prospective Investigation into Cancer and Nutrition 
    Smith-Byrne, Karl; Fensom, Georgina-K; Noor, Urwah; Watts, Eleanor-L; Allen, Naomi-E; Amiano, Pilar; Chirlaque-López, María-Dolores; Crous-Bou, Marta; Guevara-Eslava, Marcela; Palli, Domenico; Katzke, Verena-A; Sacerdote, Carlotta; Sánchez, María-José; Schulze, Matthias-B; Sieri, Sabina; Tumino, Rosario; Tsilidis, Konstantinos-K; Kaaks, Rudolf; Gunter, Marc-J; Riboli, Elio; Key, Timothy-J; Travis, Ruth-C (AMER ASSOC CANCER RESEARCH, 2025-11-03)
    BACKGROUND: PSA is central to referrals for prostate biopsy but has low specificity for aggressive prostate cancer. This study evaluates the 4Kscore (OPKO Diagnostics) versus total PSA in predicting short- and long-term ...
  • Impact of physical activity on presentation and prognosis of Brugada syndrome 
    Fernández-Gil, María-Jesús; Carrillo-Mora, Lidia-María; Fernández-Vázquez, David; Melgarejo-Meseguer, Francisco-Manuel; Santos-Mateo, Juan-José; Muñoz-Esparza, Carmen; Rodríguez-Serrano, Ana-Isabel; Navarro-Peñalver, Marina; Sánchez-Muñoz, Juan-José; Gimeno-Blanes, Juan-Ramón; Sabater-Molina, María; Gimeno-Blanes, Juan-Ramón (BMJ PUBLISHING GROUP, 2025-07)
    INTRODUCTION AND OBJECTIVES: Brugada syndrome (BS) is a channelopathy associated with an increased risk of sudden cardiac death (SCD). Intense physical activity is a recognised trigger of life-threatening arrhythmias in ...
  • Does lifestyle explain the relationship between socioeconomic position and multimorbidity of cancer and cardiometabolic diseases? A mediation analysis applied to the European Prospective Investigation into Cancer and Nutrition 
    Manfredi, Luca; Buscema, Federica; Giraudo, María-Teresa; Sodano, Barbara; Padroni, Lisa; Destefanis, Cinzia; Freisling, Heinz; Ferrari, Pietro; Cesaroni, Giulia; Uzzau, Sergio; Schulze, Matthias-B; Saieva, Calogero; Tumino, Rosario; Weiderpass, Elisabete; Matta, Komodo; Vaccarella, Salvatore; Guevara, Marcela; Halkjaer, Jytte; Tjonneland, Anne; Crous-Bou, Marta; Katzke, Verena; Pour, Toktam; Panico, Salvatore; Pala, Valeria; Tzoulaki, Ioanna; Tin-Tin, Sandar; Dahm, Christina-C; Chirlaque-López, María-Dolores; Sacerdote, Carlotta; Ricceri, Fulvio (BMJ PUBLISHING GROUP, 2026-01)
    BACKGROUND: Multimorbidity is socially patterned, with lower socioeconomic position (SEP) linked to higher risk. We examined whether a Healthy Lifestyle Index (HLI) mediates the SEP-multimorbidity association and whether ...
  • Intrahepatic donor microbiota-based metataxonomic signature detected in organ preservation solution enables prediction of short-term liver transplant outcomes 
    Lucas-Ruiz, Fernando; Vidal-Correoso, Daniel; V; de-la-Torre-Álamo, María-Magdalena; Jover-Aguilar, Marta; Alconchel-Gago, Felipe; Martínez-Alarcón, Laura; López-López, Víctor; Ríos-Zambudio, Antonio; Cascales-Campos, Pedro-Antonio; Pelegrín, Pablo; Pons-Miñano, José-Antonio; Ramírez, Pablo; Baroja-Mazo, Alberto (BMJ PUBLISHING GROUP, 2025-12)
    BACKGROUND: Liver transplantation (LT) remains hampered by post-transplant complications. While gut microbiota dysbiosis has been linked to transplant outcomes, the role of the intrahepatic graft's native microbiota remains ...
  • Death risk in nursing homes between the prepandemic period and the COVID-19 era: a retrospective cohort study in Murcia Region, Spain 
    Gómez-Gómez, Jesús-Humberto; Sánchez-Rodríguez, Inés; Soriano-López, Jesús; García-Pina, Rocío; Cabrera-Castro, Natalia-Alejandra; Moreno-Diaz, Marían-Inmaculada; Conesa-Hernández, Ana-María; Sola-Roca, Antonio; Molina-de-los-Cobos, Enrique; Sánchez-Montesinos, María-Carmen; Palomar-Rodríguez, Joaquín; Chirlaque-López, María-Dolores (BMJ PUBLISHING GROUP, 2025-07)
    BACKGROUND: With the end of COVID-19 status as a public health emergency of international concern, evaluating its effects on vulnerable groups like nursing home residents is crucial. We aimed to examine the mortality risk ...
  • Differential pathological dynamics triggered by distinct Parkinson patient-derived ?-synuclein extracts in nonhuman primates 
    Kinet, R; Bourdenx, M; Dovero, S; Darricau, M; Arotcarena, M-l; Camus, S; Porras, G; Thiolat, M-l; Trigo-Damas, I; Bohic, S; Morari, M; Doudnikoff, E; Goikoetxea, M; Claverol, S; Tokarski, C; Kruse, N; Mollenhauer, B; Estrada, C; García-Carrillo, Nuria; Herrero, María-Trinidad; Vila, M; Obeso, J-A; Bezard, E; Dehay, B (AMER ASSOC ADVANCEMENT SCIENCE, 2025-06-20)
    The presence of ?-synuclein (?-syn) aggregates, such as Lewy bodies in patients with Parkinson's disease (PD), contributes to dopaminergic cell death. Injection of PD patient-derived ?-syn in nonhuman primates has illustrated ...
  • New cases of ?-aminolevulinic acid dehydratase deficiency: Functional insights into gene variants using an innovative mouse liver model 
    Di-Pierro, Elena; Solares, Isabel; Jerico, Daniel; Castelbon, Francisco-J; Tomás-Solera, Javier; Riera-mestre, Antoni; Barreda-Sánchez, María; Poci, Carlo; Nicolli, Annamaria; Urigo, Francesco; Sampedro, Ana; Enríquez-de-Salamanca, Rafael; Marcacci, Matteo; Ávila, Matias-A; Harper, Pauline; Fanlo-maresma, Marta-G; Guillén-Navarro, Encarna; Graziadei, Giovanna; Wenzel, Andrea; Beck, Bodo-B; Ventura, Paolo; Morales-conejo, Montserrat; Fontanellas, Antonio (WILEY, 2026-01)
    BACKGROUND: Dysfunction of ?-aminolevulinic acid dehydratase (ALAD), the second enzyme involved in heme biosynthesis, leads to two pathologies: genetic and acquired. The genetic form is an ultrarare, severe childhood-onset ...
  • Cultivating Compassion in Students for End-Of-Life Processes: A Mixed-Methods Participatory Research Protocol 
    Abad-Corpa, Eva; Espinosa-Sánchez, Miriam; Barnestein-Fonseca, Pilar; Camacho-Bejarano, Rafaela; Delgado-Hito, Pilar; Miró-Bonet, Rosa (WILEY, 2025-10-11)
    AIMS: To analyse the impact of a participatory process of awareness and reflection on compassion, in the face of end-of-life processes, in students aged 12-23 years in six Spanish regions, and to understand how the ...
  • COVID-19 Vaccine Effectiveness Against Medically Attended Symptomatic SARS-CoV-2 Infection Among Target Groups in Europe, October 2024-January 2025, VEBIS Primary Care Network 
    Delaunay, Charlotte-Laniece; Verdasca, Nuno; Monge, Susana; Domegan, Lisa; Seve, Noemie; Buda, Silke; Meijer, Adam; Lucaccioni, Heloise; López-Torrijos, Miriam; Mckenna, Adele; Enouf, Vincent; Duerrwald, Ralf; In't-Velt, Eline; de-Valcárcel-Laiglesia, Ma-Angel; Bennett, Charlene; Masse, Shirley; Erdwiens, Annika; Hooiveld, Mariette; Mlinaric, Ivan; Turi, Gergo; Rodrigues, Ana-Paula; Martínez-Baz, Iván; Lazar, Mihaela; Latorre-Margalef, Neus; Borges, Vitor; Kaczmarek, Marlena; Bacci, Sabrina; Kissling, Esther; European-Primary-Care-VE-Group (WILEY, 2025-05)
    We estimated the effectiveness of 2024/25 COVID-19 vaccination against medically attended SARS-CoV-2 infection in Europe, among target groups. We included 3204 patients (8/139 cases vaccinated: 6%; 517/3065 controls ...
  • Teleost-specific ictacalcins exhibit similar structural organization, cation-dependent activation, and transcriptional regulation as human S100 proteins 
    Hernández, Liz; Paris, Theo; Demou, María; Birck, Catherine; Begon-pescia, Christina; Rodríguez-Vidal, Juan-Francisco; Tyrkalska, Sylwia-D; Bureau, Charlotte; González, Catherine; Gracia, Juliette; Lelievre, Etienne; Mulero, Víctoriano; Nguyen-chi, Mai; Yatime, Laure (WILEY, 2025-11-28)
    S100 proteins are highly versatile calcium-binding proteins from vertebrates. Following extracellular release, they become essential in immune and antimicrobial defenses, initiating the inflammatory response through receptor ...
  • Dopamine D3 receptor blockade accelerates the extinction of opioid withdrawal-induced drug-seeking behaviours and alters microglia in dopaminoceptive nuclei 
    Franco-García, Aurelio; Gómez-Murcia, Victoria; Milanés, María-Victoria; Nuñez, Cristina (WILEY, 2025-09)
    BACKGROUND AND PURPOSE: Among all drugs of abuse, opioids cause most of the deaths and treatment seeking. Despite abundant research in multifaceted therapeutic strategies, a high rate of relapse still characterises this ...

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