Repositorio Dspace

Envíos recientes

03. IMIB (Instituto Murciano de Investigación Biosanitaria Pascual Parrilla): Envíos recientes

  • Optimal nap timing and body mass index: beyond duration 
    Longo-Silva, Giovana; Rodríguez-Martin, María; Salmerón-Martínez, Diego; Scheer, Frank-A-J-L; Garaulet, Marta (SPRINGER, 2026-04-01)
    BACKGROUND: Overweight and obesity continue to rise globally, and sleep has emerged as an important behavioral determinant of body weight. While nighttime sleep has been widely studied, the role of daytime napping-especially ...
  • Quality of life, care needs and priorities in atrial fibrillation: the impact of number and patterns of comorbidities 
    Trevisan, Caterina; Ravelli, Adele; Rivera-Caravaca, José-Miguel; Zanforlini, Bruno-Micael; Sergi, Giuseppe; Dan, Gheorghe-Andrei; Dan, Anca-Rodica; Roldán-Schilling, Vanessa; Marín-Ortuño, Francisco; Johnsen, Soren-Paaske; Petrovic, Mirko; Vetrano, Davide-Liborio; Leo, Donato-Giuseppe; Lane, Deirdre-A (SPRINGER, 2026-05)
    PURPOSE: Atrial fibrillation (AF) often coexists with multiple chronic conditions, worsening health-related quality of life (HRQoL) and increasing the burden on patients and caregivers. While multimorbidity is known to ...
  • Comparative effectiveness of anti-CD20 therapies and S1P receptor modulators in late-onset multiple sclerosis: real-world evidence from the MSBase registry 
    Surcinelli, Andrea; Kalincik, Tomas; Roos, Izanne; D'amico, Emanuele; Lechner-Scott, Jeannette; Ozakbas, Serkan; Hradilek, Pavel; Horakova, Dana; Vachova, Marta; Panzera, Ivan; Ruzza, Stefano; Piscaglia, María-Grazia; Gerlach, Oliver; Meca-Lallana, José-Eustasio; Valero-López, Gabriel; Kermode, Allan-G; Fabis-Pedrini, Marzena-J; Prevost, Julie; Ampapa, Radek; Hodgkinson, Suzanne; Grand'maison, Francois; Khoury, Samia-J; John, Nevin-A; Peterka, Marek; Houskova, Jana; Recmanova, Eva; Rous, Zuzana; Shaygannejad, Vahid; Alroughani, Raed; Kuhle, Jens; Jakob, Gregor-Brecl; Grammond, Pierre; Patti, Francesco; Van-Der-Walt, Anneke; Butzkueven, Helmut; Foschi, Matteo (SAGE PUBLICATIONS LTD, 2026-03)
    BACKGROUND: Late-onset multiple sclerosis (LOMS), defined by symptom onset after age 50, is increasingly recognised as a distinct clinical entity. Evidence comparing disease-modifying therapies (DMTs) in this subgroup ...
  • Immune mechanisms driving clinical heterogeneity in oral lichen planus 
    Pons-Fuster, Eduardo; Conesa-Solano, Julia; Gimeno-Arias, Lourdes; Martí-de-Gea, Keren; Alguazas, Inmaculada; Ruiz-Lorente, Inmaculada; Minguela-Puras, Alfredo; López-Jornet, Pía (SPRINGERNATURE, 2026-03-31)
    Oral lichen planus (OLP) is a clinically localized mucosal disease that nonetheless exhibits systemic immune alterations contributing to its heterogeneous presentations. This study investigated systemic immunological ...
  • The Murcia Twin Registry: 20 Years of Study and Progress in Health and Behavioral Traits in Spain 
    Sánchez-Romera, Juan-F; Blanco-García, Federico-J; Carrillo-Verdejo, Eduvigis; Colodro-Conde, Lucía; González-Javier, Francisca; Madrid-Valero, Juan-José; Martínez-Selva, José-María; Monteagudo-Piqueras, Olga; Morosoli, José-J; Ordoñana, Juan-Ramón (CAMBRIDGE UNIV PRESS, 2026-03-31)
    The Murcia Twin Registry (MTR) has steadily expanded over two decades and has become a key resource for twin research in the Mediterranean region. The registry currently includes data from 3971 individual twins born between ...
  • Identification of a robust metabolic signature associated with hospital-acquired pneumonia and response to interferon-gamma treatment in critically ill patients 
    Petrier, Melanie; Sinha, Debajyoti; Martín, Florian-P; Poulain, Cecile; Duchaussoy, Delphine-Flattres; Ziogas, Athanasios; Novakovic, Boris; Hurtado-Navarro, Laura; Ferreira, Anaisa; Martens, Joost-H-A; Koulenti, Despoina; Fernández-Barat, Laia; Torres, Antoni; Montassier, Emmanuel; Netea, Mihai-G; Poschmann, Jeremie; Roquilly, Antoine (SPRINGER, 2026-03-12)
    AIM: Our objective was to increase our understanding of the effects of the time course of metabolic alterations on the risk of hospital-acquired pneumonia (HAP) and response to treatment in critically ill patients. METHODS: ...
  • Interventional strategies to address burnout in young medical oncologists: results from the Resilience-Spanish Society of Medical Oncology (SEOM) Study and a university hospital experience in Spain 
    Pacheco-Barcia, Vilma; Obispo, Berta; Tomas, Elia; Salva-de-Torres, Clara; Quintanar, Teresa; Paez, David; León-Mateos, Luis; Cancio, Hernan; Cortegoso, Alexandra; Anido, Urbano; Quilez, Alicia; Tarazona, Noelia; Jiménez-Labaig, Pablo; Sánchez-Martínez, Domingo-Antonio; Sesma-Goni, Andrea; Fernández-Montes, Ana; Felip, Enriqueta; Rodríguez, César; Elez, Elena (SPRINGER INT PUBL AG, 2025-12-23)
    PURPOSE: Burnout syndrome is an increasingly prevalent problem among young oncologists with a prevalence of up to 71% of physicians in Europe, with potential personal and professional consequences. Few studies have been ...
  • Dietary nitrosyl-heme from processed meats and its association with colorectal cancer risk: findings from the EPIC cohort study 
    Rizzolo-Brime, Lucía; Lujan-Barroso, Leila; Farran-Codina, Andreu; Bou, Ricard; Nicolas, Genevieve; Huybrechts, Inge; Lasheras, Cristina; Molina-Montes, Esther; Colorado-Yohar, Sandra; Gasque, Alba; Dahm, Christina-C; Bock, Niels; Olsen, Anja; Tjonneland, Anne; Katzke, Verena; Le-Cornet, Charlotte; Schulze, Matthias-B; Saieva, Calogero; Sieri, Sabina; de-Magistris, María-Santucci; Tumino, Rosario; Macciotta, Alessandra; Wareham, Nick; Weiderpass, Elisabete; Chatziioannou, Chrysovalantou; Vineis, Paolo; Jakszyn, Paula (SPRINGER, 2025-12-20)
    BACKGROUND: Processed meat (PM) consumption is an established risk factor for colorectal cancer (CRC). It has been hypothesized that nitrosyl-heme, formed by the addition of nitrites during meat processing, may enhance the ...
  • Regulation of glial markers expression in the rat basolateral amygdala and hippocampus during morphine aversive memory retrieval and its extinction 
    Franco-García, Aurelio; Gómez-Murcia, Victoria; Núñez, Cristina (SPRINGER, 2025-12-14)
    BACKGROUND: Opioid use disorder is driven by neurobehavioral adaptations where environmental cues trigger relapse. Consequently, extinction therapy (ET) aims to modify drug-associated memories but has limited long-term ...
  • Iptacopan for Immune Thrombocytopenia and Cold Agglutinin Disease: A Global Phase 2 Basket Clinical Trial 
    Roth, Alexander; Barcellini, Wilma; Ademokun, Christine; Jang, Junho; Lozano-Almela, María-Luisa; Valcárcel-Ferreiras, David; Pascual-izquierdo, Cristina; Chitnis, Shripad; Matviykiv, Sofiya; Vitaliti, Alessandra; Chen, Chi; Katsanou, Vasiliki; Chawla, Raghav; Al-samkari, Hanny (WILEY, 2026-02)
    Iptacopan is a first-in-class, oral, selective inhibitor of complement factor B that has demonstrated positive efficacy across several complement-driven diseases. Here we evaluate the efficacy and safety of iptacopan ...
  • External cephalic version outcomes with tocolysis and sedation: A 10-year retrospective cohort study 
    Sánchez-Romero, Javier; Gallego-Pozuelo, rosa-María; Blanco-Carnero, José-Eliseo; Herrera-Giménez, Javier; Araico-Rodríguez, Fernando; Guijarro-Campillo, Alberto-Rafael; Nieto-Díaz, Aníbal; de-Paco-Matallana, Catalina (WILEY, 2026-06)
    OBJECTIVE: To evaluate the effectiveness and safety of external cephalic version (ECV) performed with tocolysis and sedation or spinal anesthesia, and to identify predictors of ECV success, complications, and delivery ...
  • Relation of the stress hyperglycaemia ratio to residual risk in anticoagulated patients with atrial fibrillation: A report from the prospective Murcia AF Project III cohort 
    Soler-Espejo, Eva; Chen, Yang; Rivera-Caravaca, José-Miguel; Sánchez-Salas, José-Antonio; Esteve-Pastor, María-Asunción; Marín, Francisco; Roldán-Schilling, Vanessa; Lip, Gregory-Y-H (WILEY, 2026-02)
    INTRODUCTION: Atrial fibrillation (AF) carries residual thromboembolic and cardiovascular risk despite oral anticoagulation (OAC). The stress hyperglycaemia ratio (SHR), derived from admission glucose and glycated haemoglobin ...
  • Programmed cell death pathways coordinate neutrophil and macrophage clearance in zebrafish and are differentially exploited by Salmonella Typhimurium 
    Lozano-Gil, Juan-Manuel; Pedoto, Annamaria; Conesa-Hernández, Ana-María; Ocaña-Esparza, María; Mulero, Victoriano; Tyrkalska, Sylwia-D (SPRINGERNATURE, 2025-12-08)
    Programmed cell death (PCD) is essential for immune cell homeostasis and host defense, yet its role in neutrophil and macrophage elimination during bacterial infections remains poorly understood. Using the zebrafish model, ...
  • Pig Seminal Plasma Extracellular Vesicles Enhance Motility During Preservation of Epididymal Spermatozoa but Impair Capacitation and IVF Parameters 
    Moya-fernández, Ana; Toledo-guardiola, Santa-María; Silke, Peter; Navarro-Serna, Sergio; Matas-Parra, Carmen (WILEY, 2026-07)
    BACKGROUND: Extracellular vesicles (EVs) produced by accessory sex glands play a key role in sperm functionality, influencing motility, viability, acrosome integrity, metabolic activity, and capacitation. Most studies on ...
  • Teleost-specific ictacalcins exhibit similar structural organization, cation-dependent activation, and transcriptional regulation as human S100 proteins 
    Hernández, Liz; Paris, Theo; Demou, María; Birck, Catherine; Begon-pescia, Christina; Rodríguez-Vidal, Juan-Francisco; Tyrkalska, Sylwia-D; Bureau, Charlotte; González, Catherine; Gracia, Juliette; Lelievre, Etienne; Mulero, Victoriano; Nguyen-chi, Mai; Yatime, Laure (WILEY, 2026-04)
    S100 proteins are highly versatile calcium-binding proteins from vertebrates. Following extracellular release, they become essential in immune and antimicrobial defenses, initiating the inflammatory response through receptor ...
  • Response rate and long-term survival in patients with advanced melanoma: data from the prospective cohort study gem-1801 
    Espinosa, Enrique; Berciano-Guerrero, Miguel-Ángel; Muñoz-Couselo, Eva; Puertolas, Teresa; Manzano, José-Luis; Soria, Ainara; Ayala-de-Miguel, Pablo; Crespo, Guillermo; Gutiérrez-Sanz, Lourdes; Cerezuela-Fuentes, Pablo; Aguado-de-la-Rosa, Carlos; Majem, Margarita; García-Castaño, Almudena; Berrocal, Alfonso; García-Arroyo, Francisco-Ramon; Rodríguez-de-la-Borbolla, María; Bellido, Lorena; Medina-Martínez, Javier; Fernández, Luis-Antonio; Marín-Carnicero, Alfonso; López-Castro, Rafael; Bujosa-Rodríguez, Aida; Lecumberri, María-José; Villa-Guzmán, José-Carlos; Campos-Balea, Begoña; Rodríguez, Joaquin-Fra; Valdivia-Bautista, Javier; Navarro-Pérez, Víctor; Mujika, Karmele; Corral-Subias, Mónica; Hernández, Berta; Martín-Algarra, Salvador; Márquez-Rodas, Iván (SPRINGER INT PUBL AG, 2025-11-28)
    PURPOSE: Anti-PD-1-based immunotherapy and targeted therapies (TT) are the current standard of care for patients with advanced melanoma. However, some patients die in less than a year from diagnosis and others become ...
  • Does perioperative FLOT increase cure rates in resectable esophageal adenocarcinoma? A mixture cure model analysis 
    Mateos, Lucía; Jiménez-Fonseca, Paula; Gallego, Javier; Lecumberri, Arturo; Custodio, Ana; Martínez-de-Castro, Eva; Hernández-San-Gil, Raquel; Fernández-Montes, Ana; Limón, María-Luisa; Vidal-Tocino, Rosario; Cano, Juana-María; López-Robles, Javier; Gil, Mireia; Acosta-Eyzaguirre, Daniel; Marín-Zafra, Gema-Rocío; Merida-García, Antonio-José; Francisco-Fernández, Alejandro; Ribera-Fernández, Paula; Hierro, Cinta; Riesco, María-del-Carmen; García-Araque, Montse; Ruiz-Martin, Maribel; Pimentel-Cáceres, Paola; Visa, Laura; Cerdá, Paula; Granja, Mónica; RuPérez-Blanco, Ana-Belén; Gutiérrez, Lourdes; Carmona-Bayonas, Alberto (SPRINGERNATURE, 2026-02-08)
    BACKGROUND: Translating trial findings to real-world cure rates for resectable oesophageal and gastroesophageal junction (GEJ) adenocarcinoma is critical. Standard endpoints like disease-free survival (DFS) may not distinguish ...
  • Monolobated megakaryocytes and ring sideroblasts: A morphological prelude to multihit TP53 and complex karyotype 
    Marco-Ayala, Javier; Chen-Liang, Tzu-Hua; Ortuño, Francisco-José; Lozano-Almela, María-Luisa (WILEY, 2026-01)
  • New cases of ?-aminolevulinic acid dehydratase deficiency: Functional insights into gene variants using an innovative mouse liver model 
    Di-Pierro, Elena; Solares, Isabel; Jerico, Daniel; Castelbon, Francisco-J; Tomas-Solera, Javier; Riera-mestre, Antoni; Barreda-Sánchez, María; Poci, Carlo; Nicolli, AnnaMaría; Urigo, Francesco; Sampedro, Ana; Enríquez-de-Salamanca, Rafael; Marcacci, Matteo; Ávila, Matias-A; Harper, Pauline; Fanlo-maresma, Marta-G; Guillén-Navarro, Encarna; Graziadei, Giovanna; Wenzel, Andrea; Beck, Bodo-B; Ventura, Paolo; Morales-conejo, Montserrat; Fontanellas, Antonio (WILEY, 2026-01)
    BACKGROUND: Dysfunction of ?-aminolevulinic acid dehydratase (ALAD), the second enzyme involved in heme biosynthesis, leads to two pathologies: genetic and acquired. The genetic form is an ultrarare, severe childhood-onset ...
  • Cost-Utility Analysis of FreeStyle Libre Systems in People with Type 2 Diabetes Mellitus on Treatment with Basal Insulin and Poor Glycemic Control in Spain 
    Robles-Plaza, Mireya; Gómez-Peralta, Fernando; Bellido, Virginia; Ampudia-Blasco, Francisco-Javier; Carretero-Gómez, Juana; Cebrián-Cuenca, Ana-María; de-la-Cuadra-Grande, Alberto; Mezquita-Raya, Pedro (SPRINGER HEIDELBERG, 2026-01)
    INTRODUCTION: FreeStyle Libre (FSL) systems are effective and user-friendly glucose monitoring devices. This cost-effectiveness analysis compared FSL vs. self-blood glucose monitoring (SBGM) in patients with poorly controlled ...

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