Repositorio Dspace

Envíos recientes

03. IMIB (Instituto Murciano de Investigación Biosanitaria Pascual Parrilla): Envíos recientes

  • Concentration-dependent biphasic toxicity and steroidogenic stimulation by aminocarb in murine Leydig cells 
    Moreira, Silvia; Martins, Ana-D; Bernardino, Raquel-L; Pinho, Marisa; Guerra, Inés-M-S; Alves, Marco-G; Pastor, Luis-Miguel; Seco-Rovira, Vicente; Pereira, María-de-Lourdes; Oliveira, Pedro-F; Domingues, M-Rosario (ELSEVIER, 2025-09)
    Exposure to environmental chemicals, like pesticides, can impair male reproductive health by affecting Leydig cell (LC) function. This study investigated aminocarb, a widely used carbamate pesticide, and its impact on ...
  • Impact of a community-based educational intervention on the burden and health-related quality of life of informal caregivers 
    Martínez-Melero, Inmaculada; Ruiz-García, María-Jesús; Ruiz-Merino, Guadalupe; García-Rubio, Ana (MOSBY-ELSEVIER, 2025-09)
    BACKGROUND: Caregiving for immobilized patients presents significant challenges that can profoundly impact the mental and physical health of informal caregivers. This study evaluates the impact of a community-based educational ...
  • MET pathway inhibition increases chemo-immunotherapy efficacy in small cell lung cancer 
    del Rey-Vergara, Raul; Galindo-Campos, Miguel Alejandro; Rocha, Pedro; Carpes, Marina; Martinez, Carlos; Masfarre, Laura; Menendez, Silvia; Quimis, Fabricio; Rossell, Adria; Inanez, Albert; Perez-Buira, Sandra; Rojo, Federico; Gimeno, Ramon; Isla, Dolores; Zugazagoitia, Jon; Blanco, Cristina Marti; Garcia-Campelo, Rosario; Moreno-Vega, Alberto; Leon-Mateos, Luis; Mellen, Angel Callejo; Park, Kwon-Sik; Heeke, Simon; Heymach, John V.; Taus, Alvaro; Paz-Ares, Luis; Rovira, Ana; Arriola, Edurne (CELL PRESS, 2025-07)
    The introduction of immunotherapy as a first-line treatment for advanced small cell lung cancer (SCLC) represents significant progress, yet there remains an opportunity to further improve patient outcomes. Hepatocyte growth ...
  • Annotation of biological samples data to standard ontologies with support from large language models 
    Riquelme-García, Andrea; Mulero-Hernández, Juan; Fernández-Breis, Jesualdo-Tomás (ELSEVIER, 2025)
    The semantic integration of biological data is hindered by the vast heterogeneity of data sources and their limited semantic formalization. A crucial step in this process is mapping data elements to ontological concepts, ...
  • Quality of anticoagulation with vitamin K antagonists in Spain: A systematic review with meta-analysis of national registries 
    Rivera-Caravaca, José-Miguel; Menichelli, Danilo; Pastori, Daniele; Soler-Espejo, Eva; Esteve-Pastor, María-Asunción; Vivas, David; Roldan, Inmaculada; Anguita, Manuel; Ferreiro, José-Luis; Roldán-Schilling, Vanessa; Marín, Francisco (ELSEVIER ESPAÑA, 2025-09)
    BACKGROUND: Vitamin K antagonists (VKAs) depend on appropriate time in therapeutic range (TTR). We reviewed studies in Spain providing data on the quality of oral anticoagulation with VKA in atrial fibrillation (AF) patients, ...
  • Isolation and characterization of extracellular vesicle subsets in donkey seminal plasma 
    Catalán, Jaime; Martínez-Díaz, Pablo; Parra, Ana; Bonet, Sergi; Yeste, Marc; Roca, Jordi; Barranco-Boada, María-Isabel; Miró, Jordi (ELSEVIER SCIENCE INC, 2025-09)
    Seminal plasma (SP), a fluid composed of secretions from the male genital tract, is rich in seminal extracellular vesicles (sEVs), nano-sized particles surrounded by a lipid bilayer membrane and loaded with functionally ...
  • Economic impact of RSV infections in young children attending primary care: a prospective cohort study in five European countries, 2021 to 2023 
    Sankatsing, Valerie-D-V; Hak, Sarah-F; Wildenbeest, Joanne-G; Venekamp, Roderick-P; Pistello, Mauro; Rizzo, Caterina; Alfayate-Miguelez, Santiago; Van-Brusselen, Daan; Carballal-Marino, Marta; Hoang, Uy; Kramer, Rolf; de-Lusignan, Simon; Martyn, Oliver; Raes, Marc; Meijer, Adam; van-Summeren, Jojanneke (EUR CENTRE DIS PREVENTION & CONTROL, 2025-05-22)
    BackgroundData on economic costs of respiratory syncytial virus (RSV) infections among children in primary care are scarce, although most RSV-infections are managed in this setting.AimTo estimate outpatient costs for ...
  • Nutritional profile of the diet according to circadian clock genes in the European Prospective Investigation into Cancer and Nutrition (EPIC) chronodiet study 
    Molina-Montes, Esther; Rodríguez-Barranco, Miguel; Alcalá-Santiago, Ángela; Galvez-Navas, José-María; Huerta-Castaño, José-María; Amiano, Pilar; Lasheras, Cristina; Moreno-Iribas, Conchi; Jiménez-Zabala, Ana; Chirlaque-López, María-Dolores; Gasque, Alba; Luján-Barroso, Leila; Agudo, Antonio; Jakszyn, Paula; Quiros, José-Ramón; Sánchez, María-José (CHURCHILL LIVINGSTONE, 2025-06)
    BACKGROUND & AIMS: Circadian rhythms seem to impact both dietary intake and metabolism, depending on the individual's chronotype. We aimed to explore whether the nutritional composition of meals throughout the day is ...
  • Derivation and validation of the Caravaggio score for the risk stratification for recurrence in patients with cancer-associated venous thromboembolism 
    Vedovati, María-Cristina; Muñoz-Martín, Andrés-Jesús; Giustozzi, Michela; Jiménez-Fonseca, Paula; Becattini, Cecilia; Martínez-del-Prado, María-Purificación; Dentali, Francesco; V; Cohen, Alexander-T; Bauersachs, Rupert; Carmona-Bayonas, Alberto; Agnelli, Giancarlo (ELSEVIER, 2025-07)
    BACKGROUND: In patients with cancer associated venous thromboembolism (CAT), risk factor-based scores for recurrence could drive clinical management. The aim of this study in patients with CAT was to develop and validate ...
  • Spanish consensus on the diagnosis and management of adrenocortical carcinoma 
    Araujo-Castro, Marta; Álvarez-Escola, Cristina; Casteras, Ana; Carmona-Bayonas, Alberto; Chiara, María-Dolores; Hanzu, Felicia-A; Hernando, Jorge; Vercher-Conejero, José-L; Rodríguez-Fraile, Macarena; Gómez-Dos-Santos, Victoria; Jiménez-Fonseca, Paula; Giraldo, Alexandra; Valdés, Nuria; Vidal, Oscar; del-Olmo-García, Maribel; Capdevila, Jaume (BIOSCIENTIFICA LTD, 2025-04-11)
    Adrenocortical carcinoma (ACC) is a rare endocrine malignancy with an estimated incidence of 0.7-2 cases per million/year. The rarity of this disease, coupled with limited preclinical models and clinical trials, has hindered ...
  • Biocompatibility and osteogenic potential of novel tricalcium silicate-based materials in human dental pulp stem cells: Advancing vital pulp therapies 
    Mora, Alejandro; García-Bernal, David; Rodríguez-Lozano, Francisco-Javier; Ghilotti, James; Lozano, Adrián; López-García, Sergio (ELSEVIER SCI LTD, 2025-06)
    OBJECTIVES: To evaluate the cytocompatibility, bioactivity, and mineralization potential of new tricalcium silicate-based Material (Biodentine XP) on human dental pulp stem cells (hDPSCs) compared to other calcium ...
  • Patient physical condition and functional sequelae following hospitalization with COVID-19: A cross-sectional observational study 
    García, Daniel-Á+F2854ngel; Calvo-Muñoz, Inmaculada; Martínez-Nicolás, Ismaes; Salmeri, Bianca (LIPPINCOTT WILLIAMS & WILKINS, 2025-03-28)
    After hospitalization caused by COVID-19, a high prevalence of physical deterioration has been observed, hence the importance of having tests to evaluate the functional status of patients and to be able to perform a partition ...
  • HLA-A*03 may confer protection against long COVID through an enhanced immune response 
    Pons-Fuster, Eduardo; Martínez-Rodríguez, Rodrigo; Gimeno-Arias, Lourdes; Alcaraz, M-J; Moreno, Marta; Gómez, José-M; Peláez-Ballesta, Ana-Isabel; García, Elisa; Tomas, Cristina; Muñoz, Ángeles; V; Ruiz-Lorente, Inmaculada; Ceballos, Diana; Minguela-Puras, Alfredo; Bernal-Morell, Enrique (ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER, 2025-06)
    BACKGROUND: The COVID-19 pandemic has led to widespread infection, with a significant subset of patients developing persistent symptoms known as Long COVID. Understanding the genetic factors influencing Long COVID ...
  • The action of 7,8-dihydroxyflavone preserves retinal ganglion cell survival and visual function via the TrkB pathway in NMDA-induced retinal excitotoxicity. 
    Gallego-Ortega, Alejandro; Galindo-Romero, Caridad; Vidal-Villegas, Beatriz; Bernal-Garro, José-Manuel; de-la-Villa, Pedro; Avilés-Trigueros, Marcelino; Vidal-Sanz, Manuel (ELSEVIER, 2025-04)
    PURPOSE: To analyze the response of different retinal ganglion cell (RGC) populations to NMDA-induced retinal excitotoxicity and the effect of an intraperitoneal treatment with 7,8-Dihydroxyflavone (DHF), a potent selective ...
  • Step-by-step combination of 99mTc and ICG with endoscopic near infrared cameras in SLN mapping early-stage vulvar cancer 
    Guijarro-Campillo, Alberto-Rafael; Padilla-Iserte, Pablo; Lago, Victor; Quintana-Berto, Raquel; Arnaez-de-la-Cruz, Marta; Nieto-Díaz, Anibal; Del-Pozo, Santiago-Domingo (ELSEVIER SCIENCE INC, 2025-02)
    Vulvar cancer guidelines recommend inguinal sentinel lymph node (SLN) biopsy as the standard of care for patients with unifocal squamous cell carcinoma tumors less than 4 cm and clinically non-suspicious nodes in the groin ...
  • Profile and Usefulness of Serum Cytokines to Predict Prognosis in Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease 
    Villacieros-Álvarez, Javier; Espejo, Carmen; Arrambide, Georgina; Dinoto, Alessandro; Mulero, Patricia; Rubio-Flores, Laura; Nieto, Pablo; Alcalá, Carmen; Meca-Lallana, José-Eustasio; Millán-Pascual, Jorge; Martínez-García, Pedro; Bernard-Valnet, Raphael; González-Suarez, Inés; Orviz, Aida; Tellez, Raquel; Navarro-Canto, Laura; Presas-Rodríguez, Silvia; Martínez-Yelamos, Sergio; Cuello, Juan-Pablo; Alonso, Ana; Pinar-Morales, Raquel; Álvarez-Bravo, Gary; Benyahya, Lakhdar; Trouillet-Assant, Sophie; Dyon-Tafan, Virginie; Froment-Tilikete, Caroline; Ruet, Aurelie; Bourre, Bertrand; Deschamps, Romain; Papeix, Caroline; Maillart, Elisabeth; Kerschen, Philippe; Ayrignac, Xavier; Rovira, Alex; Auger, Cristina; Audoin, Bertrand; Montalban, Xavier; Tintore, Mar; Mariotto, Sara; Cobo-Calvo, Álvaro; Marignier, Romain (LIPPINCOTT WILLIAMS & WILKINS, 2025-03)
    OBJECTIVES: To characterize the serum cytokine profile in myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) at onset and during follow-up and assess their utility for predicting relapses and disability. ...
  • Novel insights into antithrombin deficiency enabled by mass spectrometry-based precision diagnostics 
    Kruijt, Mirjam; de-la-Morena-Barrio, María-Eugenia; Corral, Javier; Cobbaert, Christa-M; Ruhaak, L-Renee (ELSEVIER SCIENCE INC, 2025-01)
    BACKGROUND: Although P5 (preventive, personalized, predictive, participatory, psychocognitive) medicine and patient-focused healthcare are gaining ground in various healthcare areas, the diagnosis of antithrombin deficiency ...
  • Oviductin sets the species-specificity of the mammalian zona pellucida 
    de-la-Fuente, Daniel; Maroto, María; Cajas, Yulia-N; Canon-Beltran, Karina; Fernández-González, Raúl; Muñoz-Maceda, Ana; Sánchez-Puig, Juana-M; Blasco, Rafael; Cots-Rodríguez, Paula; Avilés, Manuel; Rizos, Dimitrios; Gutiérrez-Adan, Alfonso (eLIFE SCIENCES PUBL LTD, 2025-06-09)
    The zona pellucida (ZP) is vital for species-specific fertilization as this barrier mediates sperm-oocyte binding. Here, we determined whether sperm from distant mammalian orders (Carnivora, Primates, and Rodentia) could ...
  • Evaluation of a "Simuloteca" as a self-directed learning environment in clinical simulation and validation ofa a student perception questionnaire 
    Adánez-Martínez, Gracia; Pérez-Cánovas, Carlos; de-Gea-García, José-Higinio; Cantero-Sandoval, Antonia; Reyes-Domínguez, Susana-Beatriz; Febrero, Beatriz (UNIV POLITECNICA VALENCIA, EDITORIAL UPV, 2025-12-31)
  • IMU-Based Assessment of Arm Movement in Breast Cancer Survivors: An Exploratory Study 
    Navarro-Martínez, Carlos; Hernán-Villarejo-García, Diego; Carvajal-Espinosa, Rafael; Cánovas-Ambit, Germán; Becerra-Patino, Boryi-A; Pino-Ortega, José (MDPI, 2025-11-06)

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