Repositorio Dspace

Envíos recientes

03. IMIB (Instituto Murciano de Investigación Biosanitaria Pascual Parrilla): Envíos recientes

  • Redefining safety standards: a large-scale comparative analysis of bovine versus murine models for medical device embryotoxicity testing 
    Romar, Raquel; Romero-Aguirregomezcorta, Jon; Maroto, María; Gutiérrez-Adan, Alfonso; Coy-Fuster, Pilar (SPRINGER/PLENUM PUBLISHERS, 2026-06)
    PURPOSE: To overcome the limited sensitivity of the standard mouse embryo assay (MEA) for embryotoxicity screening of assisted reproduction devices and to assess the bovine embryo assay (BEA) as a suitable alternative. ...
  • Real-world characterization of PD-L1 expression in patients with advanced esophagogastric adenocarcinoma in Spain 
    Jiménez-Fonseca, Paula; Díez-García, Marc; Catoya-Villa, Juan-Luis; Pérez-Wert, Pablo; Visa, Laura; Carmona-Bayonas, Alberto; Limón, María-Luisa; Fernández-Montes, Ana; Reboredo, Margarita; Vidal-Tocino, Rosario; Gallego-Plazas, Javier; Mendoza, Guillermo-Eduardo; Landolfi, Stefania; Teijo, Ana; Guerra-Pastrian, Laura; Nieto, Andrés; Domínguez-Miranda, José-Luis; López-Vega, María-Luisa; Rodríguez-González, Marta; Illán-Gambín, Francisco-José; Martínez-de-Castro, Eva; Hierro, Cinta; Gil-Raga, Mireia; Robles-González, María; Moreno-Gutiérrez, María-Elena; Vilanova, David; Iglesias-Coma, Mar (SPRINGER INT PUBL AG, 2026-04-28)
    PURPOSE: Epidemiological data from Sapin are lacking, especially in a publication relating Spanish data and prevalence of programmed cell death ligand-1 (PD-L1) expression. This study aimed to evaluate the prevalence of ...
  • Real-World Effectiveness and Safety of Upadacitinib in Crohn's Disease: Insights From the Eneida Registry 
    Iborra, M; Botella, B; Martin-Arranz, M-D; Ceballos, D; Martínez-Pascual, C; Garrido, A; Varela, P; Moreta, M; Brunet-Mas, Eduard; González-Lama, Y; Rodríguez-González, E; Vicuna, M; Gisbert, J-P; Ordas, I; Arguelles-Arias, F; Tosca-Cuquerella, J; Vicente-Lidon, R; Sierra-Ausin, M; Rodríguez-Lago, I; Martin-Rodríguez, D; Paredes, JM; Sicilia, B; García-de-la-Filia, I; Jiménez, N; Barreiro-de-Acosta, M; Betore, E; Ferrer-Bradley, I; García-Alles, L; Huguet, JM; Castellet-Farrus, S; García, M-J; Gutiérrez-Casbas, A; Ponferrada-Díaz, A; Ramos, L; Calafat, M; Vera, I; Suárez-Ferrer, Consuelo; Fernández-Velado, E; Rodríguez-Sánchez, S; Mínguez, A; Mancebo, A; Barrio, J; Lario, S; de-La-Cruz, D-R; Hernández-Camba, Alejandro; Rodríguez-Gutiérrez, C; Chaparro, M; Ricart, E; Almenara-Michelena, L; Balaguer, A; Domenech, E; Nos, P (WILEY, 2026-05)
    BACKGROUND: Upadacitinib (UPA) is the first oral Janus kinase (JAK) inhibitor approved for the treatment of Crohn's disease (CD). Real-world data, particularly from large nationwide cohorts, remain limited. This study aimed ...
  • Functional, biochemical, and clinical characterization of natural mutations affecting arginine residues in the heparin-binding site of antithrombin 
    Cifuentes-Riquelme, Rosa; de-la-Morena-Barrio, María-Eugenia; Miñano, Antonia; Garrido-Rodríguez, Pedro; Velasco, Francisco; Rojo-Carrillo, Juan-José; López-Correas, Paloma; Zaragoza-Huesca, David; Padilla, José; Lozano-Almela, María-Luisa; Bravo-Pérez, Carlos; Corral, Javier (WILEY, 2026-04)
    Arginine residues in antithrombin are essential for heparin binding and for the activation of this key anticoagulant serpin. Mutations affecting these residues may cause antithrombin deficiency, specifically Type II ...
  • Machine learning-based prediction models for noninvasive respiratory support failure in acute respiratory failure: a systematic review and meta-analysis 
    Akgun, Kadir-Burak; Al-Otaibi, Hajed-M; Chiappa, Gaspar-R; Alqarni, Abdullah-A; Troxell, David; Przybylski, Franciszek; Esquinas-Rodríguez, Antonio (FRONTIERS MEDIA SA, 2026-04-10)
    BACKGROUND: Early identification of noninvasive respiratory support (NIRS) failure in acute respiratory failure (ARF) is clinically relevant, as delayed intubation is associated with worse outcomes. Machine learning-based ...
  • Diagnosis and therapeutic management of psoriatic arthritis: summary of 2024 update of the Spanish clinical practice guideline (ESPOGUIA) 
    Ramírez, Julio; López-Medina, Clementina; Montilla, Carlos; Moreno, Mireia; Moreno-Ramos, Manuel-José; Navarro, Victoria; Díaz, David; Fernández-Clotet, Agnes; Riera-Monroig, Josep; Díaz-del-Campo, Petra; Canete, Juan-D; Queiro, Rubén (SAGE PUBLICATIONS LTD, 2026-04)
    Psoriatic arthritis (PsA) is a heterogeneous chronic inflammatory disease affecting peripheral and axial joints, entheses, skin, and nails, requiring coordinated multidisciplinary management. Since the 2018 edition of ...
  • Predicting disease progression in multiple sclerosis with clinically accessible information and technology 
    Fuchs, Tom-A-N; Schoonheim, Menno-M; Strijbis, Eva-M-M; Jelgerhuis, Julia-R; Horakova, Dana; Havrdova, Eva-K; Uher, Tomas; Zivadinov, Robert; Ozakbas, Serkan; Girard, Marc; Alroughani, Raed; Grammond, Pierre; Lugaresi, Alessandra; Tomassini, Valentina; Kalincik, Tomas; Roos, Izanne; Gerlach, Oliver; van-der-Walt, Anneke; Khoury, Samia-J; van-Pesch, Vincent; Surcinelli, Andrea; Foschi, Matteo; Sa, María-José; D'amico, Emanuele; Kuhle, Jens; Cartechini, Elisabetta; Maimone, Davide; Karabudak, Rana; Soysal, Aysun; Spitaleri, Daniele; Laureys, Guy; Taylor, Bruce; D'hooghe, Marie; Ampapa, Radek; Castillo-Triviño, Tamara; Altintas, Ayse; Gray, Orla; Gouider, Riadh; Meca-Lallana, José-Eustasio; Kermode, Allan-G; Fabis-Pedrini, Marzena; Carroll, William-M; de-Gans, Koen; Sánchez-Menoyo, José-Luis; Etemadifar, Masoud; Al-Asmi, Abdullah; McCombe, Pamela; Simu, Mihaela; Yetkin, Mehmet-Fatih; Al-Harbi, Talal; Csepany, Tunde; Lalive, Patrice; Hardy, Todd-A; Ramanathan, Sudarshini; Willekens, Barbara; Pérez-Sempere, Ángel; Cárdenas-Robledo, Simón; Habek, Mario; Singhal, Bhim; Grigoriadis, Nikolaos; Simo, Magdolna; Shaygannejad, Vahid; Blanco, Yolanda; Agüera-Morales, Eduardo; Garber, Justin; Solaro, Claudio; Shuey, Neil; Khurana, Dheeraj; Decoo, Danny; Moghadasi, Abdorreza-Naser; Buzzard, Katherine; Skibina, Olga; John, Nevin; Petersen, Thor; Weinstock-Guttman, Bianca (SPRINGER HEIDELBERG, 2026-05)
    BACKGROUND: Predicting disease progression at the individual level is essential for personalized medicine. We previously developed machine-learning tools to estimate 5-year progression risk in people with multiple sclerosis ...
  • Gene editing of the GJB2 locus in porcine embryos using CRISPR/Cas9 and cytosine base editors: toward a model of congenital deafness 
    Pineiro-Silva, Celia; Bermejo-Álvarez, Pablo; García-Purrinos, Francisco-José; Gadea-Mateos, Joaquín (SPRINGERNATURE, 2026-04-18)
    Mutations in the GJB2 gene, which encodes Connexin 26 (Cx26), are responsible for the majority of cases of non-syndromic congenital hearing loss in humans. While murine GJB2 knockout models have provided mechanistic insight, ...
  • Reflections on the I-squared index for measuring inconsistency in meta-analysis 
    Higgins, Julian-P-T; López-López, José-Antonio (CAMBRIDGE UNIV PRESS, 2026-05)
    The I-squared index was proposed in 2002 as a measure to help understand the consistency of study results in a meta-analysis. It was developed to overcome some of the limitations of existing measures, principally the ...
  • Objective prediction of siesta based on machine learning and association with obesity 
    Rodríguez-Martin, María; Moreno-Caballero, Fernando; Dashti, Hassan-S; Saxena, Richa; Scheer, Frank-A-J-L; Fernández-Breis, Jesualdo-T; Garaulet, Marta (ELSEVIER, 2026-06)
    OBJECTIVES: To predict siesta behavior using machine learning models trained on self-reported and objective data-temperature (T), activity (A), position (P), and the integrated TAP variable-and to explore its associations ...
  • Quality of information about potentially malignant oral disorders on TikTok: a cross-sectional analysis in the context of social media 
    López-Jornet, Pía; Bennouna, Layla; Parra-Pérez, Francisco; Pons-Fuster, Eduardo (SPRINGER, 2026-05-18)
    OBJECTIVE: Potentially malignant oral disorders (PMODs) can progress to oral cancer, making the quality of available health information especially relevant. This research aimed to analyze TikTok content related to potentially ...
  • Latency following preterm prelabor rupture of membranes before 34 weeks of gestation and its association with perinatal outcomes: a retrospective cohort study 
    López-Martínez, Pilar; Sánchez-Romero, Javier; Muñoz-Porcel, Rosa; Mokachir-Mohsenin, Zoraya; Blanco-Carnero, José-Eliseo; Crespo-Bañón, Paz; Liandro, Romina-Sol; Hernández-Hernández, Laura; Dagklis, Themistoklis; Nieto-Díaz, Aníbal; de-Paco-Matallana, Catalina (SPRINGER HEIDELBERG, 2026-05-16)
    PURPOSE: To evaluate the association between latency duration and perinatal outcomes in pregnancies complicated by preterm prelabor rupture of membranes (PPROM) before 34 weeks of gestation, and to assess the role of ...
  • Comparison of Three Devices Preventing Skin Damage During Facial Mask Ventilation in Acute Respiratory Failure: Multicenter Randomized Controlled Trial Protocol (3PROSNIVtrial) 
    Scala, Raffaele; Andolfi, Federica; Ottaviano, Giulia; Renda, Teresa; Ceparano, Elena; Caneschi, Manuela; Guidelli, Luca; Vega, María-Laura; Pisani, Lara; Bassi, Ilaria; Aprile, Alfredo; Bertini, Stefania; Bonanni, Daniela; Zoccali, Patrizia; Vitacca, Michele; Barbano, Luca; Torrano-Ferrandez, María; Rozua-López, Ana; Ruiz-Villa, Genoveva; Marchese, Santino-A; Lo-Grasso, Geraldine; Fiandra, Elisabetta; Scoscia, Elvio; Eslami, Amir; Albo, Emanuela; Baglioni, Stefano; Facciolongo, Nicola; Castagnetti, Claudia; Barbieri, Chiara; Boccafoglio, Fabio; Viola, Sonia; Esquinas-Rodríguez, Antonio (SPRINGERNATURE, 2026-06)
    BACKGROUND: In patients with acute respiratory failure (ARF) undergoing noninvasive ventilation (NIV), pressure-related skin injury is among the most frequent and clinically relevant complications. The reported prevalence ...
  • Rituximab and IVIG added to plasma exchange improves the outcome of severe CNS demyelinating attacks: a retrospective study 
    Chico-García, Juan-Luis; Morales-de-la-Prida, Moisés; Boix-Lago, Almudena; García-Domínguez, José-Manuel; Sepulveda, María; Martínez-Hernández, Eugenia; Guasp, Mar; Fonseca, Elianet; Calvi, Alberto; Alba-Isasi, María-Teresa; Alberti, Blanca; Cid, Joan; Lozano, Miquel; Charry, Paola; Rodríguez-Jorge, Fernando; Sainz-Amo, Raquel; Sainz-de-la-Maza, Susana; Monreal, Enric; Villar, Luisa-María; Masjuan, Jaime; Valero-López, Gabriel; Millán-Pascual, Jorge; Cuello, Juan-Pablo; Palacios, Michael; Gifreu-Fraixino, Ariadna; Martínez-Gins, María-Luisa; Álvarez-Bravo, Gary; Meca-Lallana, José-Eustasio; Costa-Frossard, Lucienne; Blanco, Yolanda; Cabrera-Maqueda, José-María; Saiz, Albert; Llufriu, Sara (SAGE PUBLICATIONS LTD, 2026-05)
    BACKGROUND: Plasma exchange (PE) is a therapeutic option for CNS demyelinating attacks unresponsive to corticosteroids, but the potential benefit of adding rituximab and IV immunoglobulins to PE (RTX-IVIG-PE), which has ...
  • Meta-regression with categorical moderators and dependent effect sizes: A simulation study 
    Fernández-Castilla, Belén; López-López, José-Antonio; Rubio-Aparicio, María (CAMBRIDGE UNIV PRESS, 2026-05-14)
    Categorical moderators are often found in meta-analysis and examined using meta-regression models. When multiple effect sizes are present within studies, several methods can be used for meta-regression: multivariate models, ...
  • Circulating fatty acid binding protein 4 (FABP-4) concentrations and mortality in individuals with colorectal cancer in the European Prospective Investigation into Cancer and Nutrition study 
    Pham, Thu-Thi; Nimptsch, Katharina; Aleksandrova, Krasimira; Jenab, Mazda; Fedirko, Veronika; Olsen, Anja; Tjonneland, Anne; Cadeau, Claire; Severi, Gianluca; Schulze, Matthias-B; Fortner, Renee-Turzanski; Katzke, Verena; Agnoli, Claudia; Sacerdote, Carlotta; Tumino, Rosario; Signoriello, Simona; Trobajo-Sanmartin, Camino; Gómez-Gómez, Jesús-Humberto; Chirlaque-López, María-Dolores; Sánchez, María-José; Crous-Bou, Marta; May, Anne; Heath, Alicia; Aune, Dagfinn; Weiderpass, Elisabete; Pischon, Tobias (WILEY, 2026-02)
    Human fatty acid binding protein-4 (FABP-4), a protein elevated in obesity that promotes colon cancer cell invasiveness and metastasis, may be associated with higher mortality in individuals with colorectal cancer (CRC) ...
  • Environmental risk factors for allergic rhinitis differ by income level: A Global Asthma Network survey 
    Masekela, Refiloe; Rutter, Charlotte-E; Mortimer, Kevin; Chiang, Chen-Yuan; García-Marcos, Luis; El-Sony, Asma; Bissell, Karen; Ellwood, Eamon; Pearce, Neil; Asher, Innes; Ellwood, Phillipa; Singh, Nishtha; Khumalo, Anele; Morales, Eva (WILEY, 2026-04)
    BACKGROUND: Estimating the prevalence and identifying risk factors for allergic rhinitis (AR) provides critical burden of disease data and offers opportunity to intervene in early-life preventing morbidity. METHODS: We ...
  • Rehabilitation interventions in bronchiectasis: expanding evidence, personalization, and clinical practice 
    Esquinas-Rodríguez, Antonio; Guimaraes, Fernando-Silva (FRONTIERS MEDIA SA, 2026-03-25)
    Bronchiectasis is a chronic and heterogeneous respiratory disease characterized by irreversible airway dilation, recurrent infection, persistent inflammation, and progressive functional impairment. Pulmonary rehabilitation ...
  • Vitamin D in the prevention of left ventricular remodelling after an acute myocardial infarction: a randomized clinical trial 
    Tunon, José; Rodríguez-López, Carlos; Balaguer, Jorge; Gómez-Talavera, Sandra; Rojas, Antonio; Salamanca, Jorge; López-García, Cecilia; Esteve-Pastor, María-Asunción; Laffond, Ana; Herrera, Cristian; Escudier-Villa, Juan-M; Orejas, Miguel; Tomas, Marta; López-Álvarez, María; Arcas-Tomeo, Mireia; Llanos-Jiménez, Lucía; González-Lorenzo, Óscar; Kallmeyer, Andrea; Ibáñez, Borja; González-Casaus, María-Luisa; Hernández, Gonzalo; Espadas, Cristina; Lorenzo, Óscar; Mahillo-Fernández, Ignacio; Egido, Jesús; Sánchez, Pedro-Luis; Marín, Francisco; Alfonso, Fernando (SPRINGERNATURE, 2026-04-06)
    No clinical trial has yet assessed the effect of vitamin D on patients experiencing ST-segment elevation myocardial infarction (STEMI). In this multicentre, randomised (2:1), double-blind, placebo-controlled trial, 93 ...
  • Durvalumab plus tremelimumab for the treatment of patients with progressive, refractory advanced thyroid carcinoma: the phase II GETNE-DUTHY trial 
    Capdevila, Jaume; Hernando, Jorge; Molina-Cerillo, Javier; Plana-Serrahima, María; Taberna-Sanz, Miren; Castelo, Beatriz; Álvarez-Escola, Cristina; Carmona-Bayonas, Alberto; Ballester-Navarro, Inmaculada; Iglesias, Lara; Bover, Mateo; García-Álvarez, Alejandro; Lavernia, Javier; Yaya-Tur, Ricardo; Ruiz, Sofía; Baste, Neus; Lorenzo-Lorenzo, Isabel; Sánchez-Hernández, Alfredo; Sanz-García, Enrique; Marquina, Gloria; Nuciforo, Paolo; Elguero, Belén; Grande, Enrique; Alonso-Gordoa, Teresa (SPRINGERNATURE, 2026-04-04)
    Single-agent PD-1 blockade demonstrated promising efficacy in advanced thyroid cancer. The phase II, single-arm, multi-cohort GETNE-DUTHY trial (clinicaltrials.gov NCT03753919, EudraCT 2018-001066-42) aimed to determine ...

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