Repositorio Dspace

Envíos recientes

Repositorio Institucional en Ciencias de la Salud de la Región Murcia: Envíos recientes

  • Restorative potential of ciliary body cells in a retinal ganglion cell degeneration model 
    Lucas-Ruiz, Fernando; Fernández-Nogales, Marta; Valiente-Soriano, Francisco-Javier; Herrera, Macarena; Nadal-Nicolás, Francisco-M; Agudo-Barriuso, Marta; Herrera, Eloisa (NATURE PORTFOLIO, 2025-05-03)
    The ciliary body (CB) has been proposed as a niche of neural stem cells because, in vitro, cells from this area are able to form neurospheres, proliferate and differentiate. Here, we explore the potential of CB cells to ...
  • Genetics of monozygotic twins reveals the impact of environmental sensitivity on psychiatric and neurodevelopmental phenotypes 
    Assary, Elham; Coleman, Jonathan-R-I; Hemani, Gibran; van-de-Weijer, Margot-P; Howe, Laurence-J; Palviainen, Teemu; Grasby, Katrina-L; Ahlskog, Rafael; Nygaard, Marianne; Cheesman, Rosa; Lim, Kai; Reynolds, Chandra-A; Ordoñana, Juan-Ramón; Colodro-Conde, Lucía; Gordon, Scott; Madrid-Valero, Juan-José; Thalamuthu, Anbupalam; Hottenga, Jouke-Jan; Mengel-From, Jonas; Armstrong, Nicola-J; Sachdev, Perminder-S; Lee, Teresa; Brodaty, Henry; Trollor, Julian-N; Wright, Margaret; Ames, David; Catts, Vibeke-S; Latvala, Antti; Vuoksimaa, Eero; Mallard, Travis; Harden, K-Paige; Tucker-Drob, Elliot-M; Oskarsson, Sven; Hammond, Christopher-J; Christensen, Kaare; Taylor, Mark; Lundstrom, Sebastian; Larsson, Henrik; Karlsson, Robert; Pedersen, Nancy-L; Mather, Karen-A; Medland, Sarah-E; Boomsma, Dorret-I; Martin, Nicholas-G; Plomin, Robert; Bartels, Meike; Lichtenstein, Paul; Kaprio, Jaakko; Eley, Thalia-C; Davies, Neil-M; Munroe, Patricia-B; Keers, Robert (NATURE PORTFOLIO, 2025-06-10)
    Individual sensitivity to environmental exposures may be genetically influenced. This genotype-by-environment interplay implies differences in phenotypic variance across genotypes, but these variants have proven challenging ...
  • Maternal plasma cell-free RNA as a predictor of early and late-onset preeclampsia throughout pregnancy 
    Castillo-Marco, Nerea; Cordero, Teresa; Igual, Marina; Muñoz-Blat, Irene; Gómez-Álvarez, Carla; Bernat-González, Neus; Gaspar-Domenech, Ángela; Ortiz-Domingo, Erika; Vives, Alba; Ortega-Sanchis, Sheila; Monfort-Ortiz, Rogelio; Volkov, Petr; Delgado-Marín, Juan-Luis; Hernández-Hernández, Laura; Cánovas, Esther; Gil, María-del-Mar; Santacruz, Belén; González-González, Nieves-Luisa; Plasencia, Walter; Perales-Marin, Alfredo; Marcos-Puig, Beatriz; Palacios-Marqués, Ana-María; Melchor, Inigo; Martín-Martínez, Alicia; Benítez-Delgado, Taysa; Simon, Carlos; Garrido-Gómez, Tamara (NATURE PORTFOLIO, 2025-10-20)
    Early- and late-onset preeclampsia (EOPE and LOPE) pose serious maternal-fetal risks, yet non-invasive early prediction remains challenging. In a prospective cohort of 9,586 pregnancies, we analyze trimester-specific plasma ...
  • SETBP1 variants outside the degron disrupt DNA-binding, transcription and neuronal differentiation capacity to cause a heterogeneous neurodevelopmental disorder 
    Wong, Maggie-M-K; Kampen, Rosalie-A; Braden, Ruth-O; Alagoz, Gokberk; Hildebrand, Michael-S; Dingemans, Alexander-J-M; Corbally, Jean; den-Hoed, Joery; Mendoza, Ezequiel; Claassen, Willemijn-J-J; Barnett, Christopher; Barnett, Meghan; Brusco, Alfredo; Carli, Diana; de-Vries, Bert-B-A; Elmslie, Frances; Ferrero, Giovanni-Battista; Jansen, Nadieh-A; van-de-Laar, Ingrid-M-B-H; Moroni, Alice; Mowat, David; Murray, Lucinda; Novara, Francesca; Peron, Ángela; Scheffer, Ingrid-E; Sirchia, Fabio; Turner, Samantha-J; Vignoli, Aglaia; Vino, Arianna; Weber, Sacha; Chung, Wendy-K; Gerard, Marion; López-González, Vanesa; Palmer, Elizabeth; Morgan, Angela-T; van-Bon, Bregje-W; Fisher, Simon-E (NATURE PORTFOLIO, 2025-10-10)
    Different types of germline de novo SETBP1 variants cause clinically distinct and heterogeneous neurodevelopmental disorders: Schinzel-Giedion syndrome (SGS, via missense variants at a critical degron region) and ...
  • Programmed cell death pathways coordinate neutrophil and macrophage clearance in zebrafish and are differentially exploited by Salmonella Typhimurium 
    Lozano-Gil, Juan-Manuel; Pedoto, Annamaria; Conesa-Hernández, Ana-María; Ocañaa-Esparza, María; Mulero, Víctoriano; Tyrkalska, Sylwia-D (SPRINGERNATURE, 2025-12-08)
    Programmed cell death (PCD) is essential for immune cell homeostasis and host defense, yet its role in neutrophil and macrophage elimination during bacterial infections remains poorly understood. Using the zebrafish model, ...
  • Does perioperative FLOT increase cure rates in resectable esophageal adenocarcinoma? A mixture cure model analysis 
    Mateos, Lucía; Jiménez-Fonseca, Paula; Gallego, Javier; Lecumberri, Arturo; Custodio, Ana; Martínez-de-Castro, Eva; Hernández-San-Gil, Raquel; Fernández-Montes, Ana; Limon, María-Luisa; Vidal-Tocino, Rosario; Cano, Juana-María; López-Robles, Javier; Gil, Mireia; Acosta-Eyzaguirre, Daniel; Marín-Zafra, Gema-Rocío; Merida-García, Antonio-José; Francisco-Fernández, Alejandro; Ribera-Fernández, Paula; Hierro, Cinta; Riesco, María-Carmen; García-Araque, Montse; Ruiz-Martin, Maribel; Pimentel-Cáceres, Paola; Visa, Laura; Cerdá, Paula; Granja, Mónica; Ruperez-Blanco, Ana-Belén; Gutiérrez, Lourdes; Carmona-Bayonas, Alberto (SPRINGERNATURE, 2026-02-08)
    BACKGROUND: Translating trial findings to real-world cure rates for resectable oesophageal and gastroesophageal junction (GEJ) adenocarcinoma is critical. Standard endpoints like disease-free survival (DFS) may not distinguish ...
  • Real world outcomes of momelotinib in myelofibrosis patients with anemia: results from the MOMGEMFIN study 
    Pérez-Lamas, Lucía; Segura-Díaz, Adrián; García-Delgado, Regina; Álvarez-Larran, Alberto; Senin, María-Alicia; Mora, Elvira; Fox, María-Laura; Pastor-Galan, Irene; Azaceta, Gemma; Garrido-Paniagua, Sara; Pérez-López, Raúl; Trejos-Carvajal, Diana-Margarita; Angona, Anna; Albo-López, Carmen; Lorente-Alegre, Pablo; Vara, Miriam; Vera-Goni, Juan-Antonio; De-Miguel-Llorente, Dunia; Fernández-Rodríguez, Ángeles; Marín-Sánchez, Alberto; Hernando-Megido, Adriana; Gómez-Casares, María-Teresa; Stuckey, Ruth; Carreno-Tarragona, Gonzalo; De-Las-Heras-Rodríguez, Natalia; Xicoy, Blanca; Pérez-Encinas, Manuel; Mata-Serna, Raquel; Núñez-Martín-Buitrago, Lucía; Ferrer-Marín, Francisca; Amer-Salas, Neus; Guillén-Rienda, Carolina; Velez, Patricia; Lamarca-Eraso, Laura; Martin, Sandra; Luts-Khoroz, Iryna; De-Cabo-López, Erik; Gil, Ángela; Martín-Consuegra-Ramos, Sofia; Marco-de-Lucas, Fernando; Otero-Martínez-Fornes, María-José; Martín-Mateos, María-Luisa; Arquero, Teresa; Cabezudo-Pérez, Elena; López-Gómez, Luis-Antonio; Martínez-Hellin, Ángela; Tejedor-Gutiérrez, Aurelia; Herrera-de-Pablo, Esther; Mata-Vázquez, María-Isabel; Castillo-Valero, Inmaculada; Fernández, María-José; Aguilar, Carlos; Santaliestra, Marta; García-Menchon, Antonio; Navas-Elorza, Begoña; Durán, María-Antonia; Pérez-Sala, María; Hernández-Santamaria, Teresa; Muñoz-Jarreno, María-Ángeles; Dávila-Valls, Julio; Torres-Jiménez, Williana; Gonzalvez-Fernández, Joan-Alfons; Torres-Mantilla, Hugo-Alexander; Cobo-Rodríguez, Teresa; Abuin-Blanco, Aitor; Pérez, Francisco; Osorio-Prendes, Santiago; Beneit-Villena, Paola; Peralta, Raisa; Herrera, Federico; Canamero-Giro, Eloi; Jiménez-Barcenas, Reyes; Gasior-Kabat, Mercedes; González-de-Villambrosia, Sonia; Tercero-Mora-Rodríguez, Mariana-Teresa; Menéndez-Cuevas, Marina; Cuevas-Ruiz, Beatriz; Fonseca-Santos, Marta; Garces-Piquer, Sonia; de-la-Puerta, Rosalía; Lorenzo-Vizcaya, Álvaro; Hernández-Boluda, Juan-Carlos; García-Gutiérrez, Valentín (SPRINGERNATURE, 2025-04-17)
  • Allo-HCT refined ELN 2022 risk classification: validation of the Adverse-Plus risk group in AML patients undergoing allogeneic hematopoietic cell transplantation within the Spanish Group for Hematopoietic Cell Transplantation (GETH-TC) 
    Jiménez-Vicente, Carlos; Esteve, Jordi; Baile-González, Mónica; Pérez-López, Estefanía; Martín-Calvo, Carmen; Aparicio, Clara; Oiartzabal-Ormategi, Itziar; Esquirol, Albert; Peña-Muñoz, Felipe; Fernández-Luis, Sara; Heras-Fernando, Inmaculada; González-Rodríguez, Ana-Pilar; López-García, Alberto; López-Lorenzo, José-Luis; Torrado, Tamara; Sáez-Marin, Adolfo-Jesús; Acosta-Fleytas, Cynthia; García, Lucía; Villar, Sara; Filaferro, Silvia; Balsalobre, Pascual; Pascual-Cascon, María-Jesús; Queralt-Salas, María (SPRINGERNATURE, 2025-03-21)
    This multicenter retrospective study by GETH-TC validates the prognostic value of the Allo-HCT Refined ELN 2022 risk classification in allografted AML patients. The new classification refines the ELN 2022 risk classification, ...
  • CALRins5-mediated clonal hematopoiesis causes severe hemolytic anemia in a female PGK1Ser320Asn carrier 
    Morales, M-L; Cano, H; de-la-Morena-Barrio, Belén; Vives-Corrons, J-L; Cuenca-Zamora, E-J; Garrido-Rodríguez, P; Bento, C; Pereira, J; Martínez-Nieto, J; Chen-Liang, Tzu-Hua; Fuster-Soler, José-Luis; Caracena, S; Lozano-Almela, María-Luisa; Teruel-Montoya, Raúl; Corral, Javier; Ferrer-Marín, Francisca (SPRINGERNATURE, 2025-02-01)
  • L.Fermentum CECT5716 and B.Breve CECT7263 on premature infants morbidities: a randomized clinical trial 
    Hurtado-Suazo, José-Antonio; Alonso-Ojembarrena, Almudena; Sánchez-Tamayo, Tomas; Martín-Álvarez, Estefanía; Sáez, María-Eugenia; Martínez-Pardo, Luz; Diez-Delgado-Rubio, Javier; Granero-Asencio, Mercedes; Serrano-López, Laura; Maldonado-Lobon, José-Antonio; Mora-Navarro, David; De-Benito-Guerra, María-Teresa; Torres-Begara, Eva; Ruiz-Moreno, Juan-Antonio; Macias-Díaz, Carmen; Lloreda-García, José-María; Peña-Caballero, Manuela; Olivares, Mónica; Blanco-Rojo, Ruth (SPRINGERNATURE, 2025-11-27)
    BACKGROUND: This study examined the effects of two doses of probiotics isolated from human milk on the incidences of necrotizing enterocolitis (NEC) and mortality in preterm infants. METHODS: This multicenter, randomized, ...
  • Long-term benefits of autologous stem cell transplantation versus intensive chemotherapy consolidation for acute myeloid leukemia patients: A propensity score matching analysis from the PETHEMA AML registry 
    Alfonso-Pierola, Ana; Martínez-Cuadrón, David; Rodríguez-Veiga, Rebeca; Gil, Cristina; Martínez-Sánchez, Pilar; Bernal, Teresa; Benavente, Celina; Romero-Riquelme, Mónica-A; Serrano-López, Josefina; Bergua, Juan-M; García-Boyero, Raimundo; Tormo, Mar; Herrera, Pilar; Sossa-Melo, Claudia-L; Pérez-Simon, José-A; Rodríguez-Medina, Carlos; Bass-Maturana, María-F; López-Lorenzo, José-L; Algarra-Algarra, Lorenzo; Vidriales-Vicente, Belén; Pérez-Encinas, Manuel; Barrios-García, Manuel; Vives, Susana; Sayas-Lloris, María-J; Capurro, Marisa; Hidalgo, Sebastian; Olave, Mayte; Cuervo-Lozada, Diana; Lavilla-Rubira, Esperanza; Casado, Felipe; Mena-Duran, Armando; Valero-Núñez, Marta; Casado-Calderón, Soledad; Balerdi, Amaia; Torres, Vivianne; Fernández, Rosa; Noriega, Victor; Stevenazzi, Mariana; Labrador, Jorge; León-Maldonado, Pilar; de-Rueda-Ciller, Beatriz; Arce-Fernández, Olga; Amigo, María-Luz; Raposo-Puglia, José-Ángel; Sole, María; Boluda, Blanca; Ayala, Rosa; Barragán, Eva; Montesinos, Pau (SPRINGERNATURE, 2025-11)
    While allogeneic stem cell transplantation (allo-SCT) is the preferred consolidation for high and most intermediate-risk acute myeloid leukemia (AML) patients in first remission, the role of autologous SCT (auto-SCT) vs. ...
  • A novel chimeric antigen receptor T-cell therapy targeting CD84 for the treatment of acute myeloid and T-cell lymphoblastic leukemias 
    Pérez-Amill, Lorena; Armand-Ugon, Mercedes; Val-Casals, María; Martín-Herreros, Beatriz; Álamo, José-R; Peña, Sergio; Frigola, Gerard; Altuna, Ane; Santos, Claudio; Guijarro, Francesca; Minguela-Puras, Alfredo; Bataller, Alex; Casanovas-Alberti, Berta; Uribe-Herranz, Mireia; Navarro, Irene; Guerreiro, Manuel; Sánchez-Martínez, Diego; Tirado, Nestor; Velasco-Hernández, Talia; Menéndez, Pablo; Martínez, Antonio; Rovira, Montse; Colomer, Dolors; González-Navarro, Europa-Azucena; Esteve, Jordi; Urbano-Ispizua, Álvaro; Montesinos, Pau; Delgado, Julio; Juan, Manel; Klein-González, Nela (SPRINGERNATURE, 2025-10)
    Despite the remarkable clinical successes of chimeric antigen receptor (CAR) T-cell therapies in treating B-cell malignancies and multiple myeloma, similar outcomes have not been achieved in other indications. For patients ...
  • Non canonical c-CBL mutations define a specific phenotype of myeloid neoplasia 
    Guarnera, Luca; Gurnari, Carmelo; Bravo-Pérez, Carlos; Durmaz, Arda; Williams, Nakisha-D; Awada, Hussein; Kawashima, Naomi; Ahmed, Arooj; Unlu, Serhan; Ogbue, Olisaemeka-D; Haddad, Christopher; Mandala, Aashray; Kubota, Yasuo; Bodo, Juraj; Crane, Genevieve-M; Rogers, Heesun-J; Maciejewski, Jaroslaw-P; Visconte, Valeria (SPRINGERNATURE, 2025-03)
  • Photoactivatable Cyclometalated Ir(III) Compound Penetrates the Blood-Brain Barrier in 3D Spheroidal and Advanced 3D Organoid Models of Inherently Resistant and Aggressive Brain Tumors 
    Novohradsky, Vojtech; Marco, Alicia; Svitelova, Marie; Cutillas-Aulló, Natalia; Ruiz, José; Brabec, Viktor (AMER CHEMICAL SOC, 2025-07-11)
    The blood-brain barrier represents a significant challenge in delivering anticancer drugs for glioblastoma treatment. The study investigates the potential of a series of octahedral photoactivatable cyclometalated iridium ...
  • Novel Insights into the Human Gut Microbially Conjugated Bile Acids: The New Diversity of the Amino Acid-Conjugated Derivatives 
    García, Carlos-J; García-Villalba, Rocío; Frutos-Lison, María-D; Beltran, David; Martínez-Sánchez, María-Antonia; Núñez-Sánchez, María-Ángeles; Ramos-Molina, Bruno; Tomas-Barberan, Francisco-A (AMER CHEMICAL SOC, 2025-08-06)
    Bile acids (BAs) are biomolecules involved in lipids and glucose metabolism, and recently discovered microbially conjugated BAs (MCBAs) play an important role. Although the production of MCBAs amidated with amino acids ...
  • Lifetime Swimming Pool Attendance and Cancer Risk: Findings from the Multicase-Control Study in Spain (MCC-Spain) 
    Donat-Vargas, Carolina; Vallbona-Vistos, Miquel; Castaño-Vinyals, Gemma; Moreno, Victor; Aragonés, Nuria; Boldo, Elena; Molina-de-la-Torre, Antonio-José; Gómez-Acebo, Inés; Guevara, Marcela; Jiménez-Zabala, Ana; Amiano, Pilar; Molina-Barceló, Ana; Fernández-Tardon, Guillermo; Chirlaque-López, María-Dolores; Pollan, Marina; Kogevinas, Manolis; Villanueva, Cristina-M (AMER CHEMICAL SOC, 2025-11-18)
    Swimming in pools involves inhalation and skin absorption of potential carcinogenic disinfection byproducts (DBPs) as well as physical activity, which is protective for some cancer sites. We evaluated the association between ...
  • Mapping of care pathways in pediatric and adult palliative care in Spain: A case study 
    Ruiz-Gil, Tania; Rodenas-Rigla, Francisco; Valero-Ramon, Zoe; Rodríguez-Rabadan, María-Dolores (CAMBRIDGE UNIV PRESS, 2025)
    OBJECTIVES: This study aimed to map the actual care pathways for pediatric and adult palliative care (PC) patients at a hospital in the Region of Murcia (Spain) utilizing Process Mining (PM) techniques. The goal was to ...
  • Barriers and competencies in nursing care for diabetic foot management: a mixed-methods observational study 
    Rodríguez-Valiente, Mónica; Martínez-Alcaraz, Roberto-Carlos; Sánchez-Galvez, Javier; Mateo-Ramírez, Francisco; Baño-Egea, Juan-Jesús; Solé-Agustí, Maria-Cristina; Pereda-Mas, Arturo; Beteta-Fernández, María-Dolores (CAMBRIDGE UNIV PRESS, 2026)
    AIM: To explore nurses' perceptions regarding their knowledge, degree of autonomy, and the difficulties encountered in managing diabetic foot in Primary Care. BACKGROUND: Diabetes mellitus is a chronic condition with a ...
  • Rebuilding the atrophied brain: 6-month nasal esketamine therapy expands key frontal and hippocampal regions and reduces serum neurofilament levels in patients with major depressive disorder. A proof-of-concept study of the depTesk (DEPression treatment with ESKetamine) study 
    Rodríguez-Lorente, Ana; Campos-Navarro, María-Pilar; Gil-Montoya, Ángela; Marín-Pérez, Celia; Masó-Navarro, María-Luisa; Orgaz-Morales, Manuel-Tomás; López-Ramírez, Nuria; García-Carmona, Juan-Antonio (CAMBRIDGE UNIV PRESS, 2025)
    OBJECTIVES: This proof-of-concept study aimed to assess the impact of intranasal esketamine (ESK-IN) in brain volume and neurofilament light chain (sNfL) over 6-months in patients with treatment resistant depression (TDR). ...
  • Monitoring effectiveness of nirsevimab immunization against RSV hospitalization using surveillance data: a test-negative case-control study, Spain, October 2024-March 2025 
    Campos-Mena, Sandra; Pérez-Gimeno, Gloria; Lorusso, Nicola; Álvarez-Rio, Virginia; Basile, Luca; Batalla-Rebollo, Noa; García-Comas, Luis; Andreu-Ivorra, Blanca; Pérez-Panades, Jordi; Ramos-Marin, Violeta; Castrillejo, Daniel; Fernández-Ibáñez, Ana; Rafael-de-la-Cruz-López, María-Ángeles; Núñez, Olivier; Monge, Susana (CAMBRIDGE UNIV PRESS, 2026)
    Effectiveness of nirsevimab against respiratory syncytial virus (RSV) hospitalization during the 2024/2025 season in Spain was estimated using a test-negative design (TND) and hospital-based respiratory infections surveillance ...