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Repositorio Institucional en Ciencias de la Salud de la Región Murcia: Envíos recientes

  • Insights into type I photoreactivity of cyclometalated iridium(iii) and ruthenium(ii) photosensitizers 
    Vigueras, Gloria; Marchan, Vicente; Ruiz, José (ROYAL SOC CHEMISTRY, 2025)
    Photodynamic therapy (PDT) is a light-activated treatment that relies on the generation of cytotoxic reactive oxygen species (ROS). While most clinically approved photosensitizers (PSs) operate through a type II mechanism-based ...
  • Achieving red-light anticancer photodynamic therapy under hypoxia using Ir(iii)-COUPY conjugates 
    Ortega-Forte, Enrique; Rovira, Anna; Ashoo, Pezhman; Izquierdo-García, Eduardo; Hally, Cormac; Abad-Montero, Diego; Jorda-Redondo, Mireia; Vigueras, Gloria; Deya, Alba; Hernández, José-Luis; Galino, Jorge; Bosch, Manel; Alberto, Marta-E; Frances-Monerris, Antonio; Nonell, Santi; Ruiz, José; Marchan, Vicente (ROYAL SOC CHEMISTRY, 2025)
  • A novel benzothiazole-1,2,3-triazole-based arene osmium(ii) complex as an effective rhabdomyosarcoma cancer stem cell agent 
    Sharkawy, Sofia; Hernández-García, Alba; Kostrhunova, Hana; Bautista, Delia; Markova, Lenka; Santana-Lario, María-Dolores; Kasparkova, Jana; Brabec, Viktor; Ruiz, José (ROYAL SOC CHEMISTRY, 2025)
  • Effects of new lipid ingredients during pregnancy and lactation on rat offspring brain gene expression 
    Origüela-Carvajal, Valentina; Gázquez, Antonio; López-Andreo, María-José; Bueno-Vargas, Pilar; Vurma, Mustafa; López-Pedrosa, José-M; Leyshon, Brian-J; Kuchan, Matthew; Chan, Jia-Pei; Larque, Elvira (ROYAL SOC CHEMISTRY, 2025)
    Maternal dietary fat intake during pregnancy and lactation may influence the bioavailability of essential lipophilic nutrients, such as docosahexaenoic acid (DHA), that are important for both the mother and her child's ...
  • Portimine A toxin causes skin inflammation through ZAK?-dependent NLRP1 inflammasome activation 
    Gorse, Leana; Plessis, Loic; Wearne, Stephen; Paradis, Margaux; Pinilla-Marquínez, Miriam; Chua, Rae; Lim, Seong-Soo; Fernández-Pelluz, Elena; Toh, Gee-Ann; Mazars, Raoul; Bomfim, Caio; Herve, Fabienne; Lhaute, Korian; Reveillon, Damien; Suire, Bastien; Ravon-Katossky, Lea; Benoist, Thomas; Fromont, Lea; Pericat, David; Neil-Mertens, Kenneth; Derrien, Amelie; Terre-Terrillon, Aouregan; Chomerat, Nicolas; Bilien, Gwenael; Sechet, Veronique; Carpentier, Liliane; Fall, Mamadou; Sonko, Amidou; Hakim, Hadi; Sadio, Nfally; Bourdeaux, Jessie; Cougoule, Celine; Henras, Anthony-K; Pérez-Oliva, Ana-Belén; Brehmer, Patrice; Roca, Francisco-J; Zhong, Franklin-L; Common, John; Meunier, Etienne; Hess, Philipp (SPRINGERNATURE, 2025-02-13)
    In 2020-2021, a "mysterious illness" struck Senegalese fishermen, causing severe acute dermatitis in over one thousand individuals following exposure through drift-net fishing activity. Here, by performing deep analysis ...
  • Telomerase and alternative lengthening of telomeres coexist in the regenerating zebrafish caudal fins 
    Martínez-Balsalobre, Elena; Anchelin, Monique; Hernández-Silva, David; Mione, María-C; Mulero, Víctoriano; Alcaraz-Pérez, Francisca; García-Castillo, Jesús; Cayuela-Fuentes, María-Luisa (SPRINGERNATURE, 2025-10-21)
    Telomeres are essential for chromosome protection and genomic stability, and telomerase function is critical for organ homeostasis. Zebrafish is a useful vertebrate model for understanding cellular and molecular mechanisms ...
  • Cardiolipin inhibits the non-canonical inflammasome by preventing LPS binding to caspase-4/11 
    Pizzuto, Malvina; MonteLeóne, Mercedes; Burgener, Sabrina-Sofia; Began, Jakub; Kurera, Melan; Chia, Jing-Rong; Frampton, Emmanuelle; Crawford, Joanna; Oliveira, Monalisa; Kenney, Kirsten-M; Coombs, Jared-R; Yamamoto, Masahiro; Man, Si-Ming; Broz, Petr; Pelegrín, Pablo; Schroder, Kate (SPRINGERNATURE, 2025-07-16)
    Caspase-4 and caspase-11 (CASP4/11) sense bacterial lipopolysaccharide (LPS). Currently available inhibitors of CASP4/11 also block the activity of caspase-1 (CASP1), which restricts their usefulness in the study of CASP4/11 ...
  • DNA methylome biomarkers of rheumatoid arthritis-associated interstitial lung disease reflecting lung fibrosis pathways, an exploratory case-control study 
    Kaczmarczyk, Bartosz; de-la-Calle-Fabregat, Carlos; Conde, Adrián; Duarte, Ana-Catarina; Mena-Vázquez, Natalia; Fernández-Nebro, Antonio; Triguero-Martínez, Ana; Castañeda, Santos; Dos-Santos-Sobrin, Raquel; Mera-Varela, Antonio; López-Pedrera, Chary; Escudero-Contreras, Alejandro; Vela-Casasempere, Paloma; Molina, María; Narváez, Javier; Retuerto-Guerrero, Miriam; Pablos, José-L; Sarmiento-Monroy, Juan-C; Sanmarti, Raimon; Gómez-Carrera, Luis; Bonilla, Gema; Remuzgo-Martínez, Sara; González-Gay, Miguel-Ángel; Leiro-Fernández, Virginia; Pérez-Gómez, Nair; Vadillo-Font, Cristina; Abasolo, Lydia; Casafont-Sole, Ivette; Mateo-Soria, Lourdes; Castillo-González, Ana-Cristina; Marras-Fernández-Cid, Carlos; Pérez-Pampin, Eva; Ballestar, Esteban; González, Antonio (NATURE PORTFOLIO, 2025-04-29)
    Rheumatoid Arthritis-associated Interstitial Lung Disease (RA-ILD) significantly reduces life quality and survival, necessitating improvements in its understanding and clinical management. We addressed these goals using ...
  • Advanced analysis of retrotransposon variation in the human genome with nanopore sequencing using RetroInspector 
    Cuenca-Guardiola, Javier; de-la-Morena-Barrio, Belén; Corral, Javier; Fernández-Breis, Jesualdo-Tomás (NATURE PORTFOLIO, 2025-04-25)
    Transposable elements (TEs) make up 45% of the human genome, are a source of genetic variability difficult to detect, and involved in processes related to gene regulation and disease. Nanopore sequencing is recognized as ...
  • The cervical microbiome of ewe breeds with known divergent fertility following artificial insemination with frozen-thawed semen 
    Norstebo, Simen-Foyn; Rodríguez-Campos, Sabrina; Umu, Ozgun-C-O; Abril-Parreño, Laura; Dalland, Marianne; Gilfillan, Gregor-Duncan; Fair, Sean; Krogenaes, Anette (NATURE PORTFOLIO, 2025-04-26)
    The use of artificial insemination (AI) with frozen-thawed semen in sheep is limited internationally due to low pregnancy rates. An exception is Norway, where high success rates routinely occur following vaginal deposition ...
  • Discovery of Z1362873773: a novel fascin inhibitor from a large chemical library for colorectal cancer 
    Rodríguez-Martínez, Alejandro; Giraldo-Ruiz, Lucía; Ramos, María-C; Luque, Irene; Ribeiro, Diogo; Postigo-Corrales, Fátima; Alburquerque-González, Begoña; Montoro-García, Silvia; Arroyo-Rodríguez, Ana-Belén; Conesa-Zamora, Pablo; Hurtado-López, Ana-María; Luengo-Gil, Ginés; Pérez-Sánchez, Horacio (NATURE PORTFOLIO, 2025-04-28)
    Metastasis is one of the leading causes of cancer-related death worldwide. Fascin, a protein that bundles actin filaments to produce protrusions in cancer cells, plays a significant role in the enhancement of cell migration. ...
  • Identifying risk factors and predicting long COVID in a Spanish cohort 
    Guillén-Teruel, Antonio; Mellina-Andreu, José-L; Reina, Gabriel; González-Billalabeitia, Enrique; Rodríguez-Iborra, Ramón; Palma, José; Botia, Juan-A; Cisterna-García, Alejandro (NATURE PORTFOLIO, 2025-03-28)
    Many studies have investigated symptoms, comorbidities, demographic factors, and vaccine effects in relation to long COVID (LC-19) across global populations. However, a number of these studies have shortcomings, such as ...
  • The Sarcoplasmic/Endoplasmic reticulum Ca2+-ATPase (SERCA) is present in pig sperm and modulates their physiology over liquid preservation 
    Garriga, Ferran; Martínez-Hernández, Jesús; Parra-Balaguer, Ainhoa; Llavanera, Marc; Yeste, Marc (NATURE PORTFOLIO, 2025-02-04)
    Liquid storage is the primary preservation method in the swine breeding industry because of its advantages over cryopreservation. Calcium (Ca(2+)), a key regulator of cell physiology, plays a crucial role during liquid ...
  • Pilot clinical comparison of three occlusal splint fabrication techniques: A preliminary study 
    Torne-Duran, Sergi; Marco-Martínez, Laura; Serrano-Belmonte, Ildefonso (NATURE PORTFOLIO, 2025-12-19)
    To compare laboratory production time, clinical adjustment time, and patient-reported comfort of three occlusal splint fabrication techniques (heat-cured acrylic, vacuum-adapted acrylic, and CAD-CAM 3D-printed splints) in ...
  • Epigenetic regulation of electromechanical continuity might determine phenotypic heterogeneity in SCN5A mutation carriers in Brugada syndrome 
    Moscoso, Isabel; Serrano-Cruz, Valentina; Cebro-Marquez, María; Vilar-Sánchez, Marta-E; Vidal-Abeijon, Iria; Brion, María; Blanco-Verea, Alejandro; Martínez-Campelo, Laura; Feijoo-Bandin, Sandra; Jiménez-Ramos, Victor; Gimeno-Blanes, Juan-Ramón; Sabater-Molina, María; Jiménez-Jaimez, Juan; González-Juanatey, José-Ramón; Rodríguez-Manero, Moises; Lage, Ricardo (NATURE PORTFOLIO, 2025-10-22)
    Brugada syndrome (BrS) is an inherited cardiac disorder characterized by electrical disturbances. Pathogenic variants in the SCN5A gene are implicated in 25-30% of probands. Although loss-of-function mutations in SCN5A ...
  • Distinct roles of amniotic membrane epithelial (hAEC) and mesenchymal stromal cells (hAMSC) in amniotic membrane-driven wound healing 
    Alcaraz, M; Hernández-Mármol, Isabel; Puente-Cuadrado, José-María; Rodríguez-Valiente, Mónica; Silini, A-R; Parolini, O; Nicolás, Francisco-José (NATURE PORTFOLIO, 2025-10-21)
    Human skin wound healing is a complex process involving sequential cellular events to restore skin integrity. Chronic wounds fail to heal due to impaired keratinocyte activation and dysregulated cytokine signaling. The ...
  • A machine learning approach to identify patients at risk for long-term consequences after pulmonary embolism 
    Nopp, Stephan; Spielvogel, Clemens; Bikdeli, Behnood; Alberich-Conesa, Ana; Hernández-Blasco, Luis; Peris, Ma-Luisa; Otero, Remedios; Jiménez, David; Monreal, Manuel; Ay, Cihan; Agudo-de-Blas, P; Aibar, J; Alberich-Conesa, Ana; Alda-Lozano, A; Alfonso, J; Alonso-Carrillo, J; Álvarez-Vega, P; Amado, C; Angelina-García, M; Arcelus, J-I; Ballaz, A; Barba, R; Barbagelata, C; Barron, M; Barron-Andres, B; Bascuñana, J; Blanco-Molina, A; Bustos-Carpio, J; Casado, I; Chasco, L; Claver, G; De-Juana-Izquierdo, C; Del-Toro, J; Demelo-Rodríguez, P; Díaz-Brasero, A-M; Díaz-Pedroche, M-C; Díaz-Peromingo, J-A; Dubois-Silva, A; Escribano, J-C; Fernández-Capitan, C; Fernández-Jiménez, B; Fernández-Reyes, J-L; Fidalgo, M-A; Francisco, I; Gabara, C; Galeano-Valle, F; García-Bragado, F; García-González, C; García-Ortega, A; Gavin-Sebastian, O; Gil-de-Gómez, M-A; Gil-Díaz, A; Gómez-Cepeda, C; Gómez-Cuervo, C; González-Martínez, J; González-Munera, A; Gorostidi, J; Grau, E; Guirado-Torrecillas, Leticia; Gutiérrez-Guisado, J; Hernández-Blasco, L; Jara-Palomares, L; Jiménez, D; Jou, I; Joya, M-D; Lainez-Justo, S; Lecumberri, R; Lobo, J-L; López-Jiménez, L; López-Miguel, P; López-Núñez, J-J; López-Ruiz, Alfonso; López-Sáez, J-B; Lorenzo, A; Madridano, O; Maestre, A; Marchena, P-J; Marcos, M; Martín-del-Pozo, M; Martin-Martos, Francisco; Maza, J-M; Mercado, M-I; Molino, A; Monreal, M; Monzon, L; Navas, M-S; Nieto, J-A; Núñez-Fernández, M-J; Ordieres, L; Ortiz, O; Otalora-Valderrama, Sonia; Otero, R; Pacheco-Gómez, N; Pagan, J; Parra-Caballero, P; Pedrajas, J-M; Pérez-Amoros, J; Pérez-Cabezas, A; Pérez-Ductor, C; Pérez-Pinar, M; Peris, M-L; Pesce, M-L; Porras, J-A; Puchades, R; Puche, G; Rivas, A; Rivera-Civico, F; Rodríguez-Cobo, A; Romero-Bruguera, M; Salgueiro, G; Sánchez-Juez, A; Sancho, T; Sendin, V; Siguenza, P; Soler, S; Sota-Yoldi, L-A; Suárez-Fernández, S; Tirado, R; Torrents-Vilar, A; Torres, M-I; Trujillo-Santos, Javier; Uresandi, F; Valle, R; Varona, J-F; Vázquez, E; Villalobos, A; Villarejo, C; Villares, P; Ay, C; Nopp, S; Pabinger, I; Vanassche, T; Verhamme, P; Verstraete, A; Rocha, A-T; Yoo, H-H-B; Montenegro, A-C; Morales, S-N; Roa, J; Hirmerova, J; Maly, R; Acassat, S; Bertoletti, L; Brehon, M; Bura-Riviere, A; Catella, J; Chopard, R; Couturaud, F; Espitia, O; Le-Mao, R; Leclercq, B; Mahe, I; Moustafa, F; Plaisance, L; Poenou, G; Quere, I; Sarlon-Bartoli, G; Suchon, P; Versini, E; Schellong, S; Rashidi, F; Sadeghipour, P; Tahmasbi, F; Brenner, B; Kennet, G; Tzoran, I; Barillari, G; Basaglia, M; Bilora, F; Bissacco, D; Brandolin, B; Casana, R; Ciammaichella, M-M; Colaizzo, D; Di-Micco, P; Giorgi-Pierfranceschi, M; Grandone, E; Lambertenghi-Deliliers, D; Marcon, C; Poz, A; Prandoni, P; Simioni, P; Siniscalchi, C; Taflaj, B; Tufano, A; Visona, A; Zalunardo, B; Skride, A; Tazi-Mezalek, Z; Fonseca, S; Marques, R; Meireles, J; Pinto, S; Bosevski, M; Zdraveska, M; Barco, S; Bounameaux, H; Keller, S; Mazzolai, L; Porceddu, E; Aujayeb, A; Angiolillo, D-J; Bikdeli, B; Caprini, J-A; Khalil, A; Ortega-Paz, L; Tafur, J; Weinberg, I; Bui, H-M (NATURE PORTFOLIO, 2025-09-24)
    Pulmonary embolism (PE) can result in long-term sequelae, such as post-PE syndrome, including persistent dyspnea and chronic thromboembolic pulmonary hypertension (CTEPH). Existing prediction tools for severe post-PE ...
  • Impact of the initial administration of an antiretroviral drug with latency reversal properties on the HIV reservoir size 
    de-la-Torre-Tarazona, Erick; Moraga, Elisa; Vaquer, Raúl; Sánchez-Palomino, Sonsoles; de-Lazzari, Elisa; Luna, Laura; Vicens-Artes, Sonia; García-Fraile, Lucio-Jesús; Peraire, Joaquim; García-Gasalla, Mercedes; Balsalobre, Luz; Guillén-Martínez, Sergio; López-Cortés, Luis-Fernando; Jarrin, Inma; Serrano-Villar, Sergio; Alcami, José; Moreno, Santiago (NATURE PORTFOLIO, 2025-07-13)
    The elimination of the latent viral reservoir remains the main barrier in the quest for a cure for people with HIV (PWH). The administration of latency reversal agents (LRA) at antiretroviral treatment (ART) initiation ...
  • Post-mortem human Alzheimer<acute accent>s brain metallome depends on Braak stages and brain regions 
    Parra-Martínez, Cecilio; Callejon-Leblic, Belén; Rodrigo-Lara, Héctor; Fernández-Vega, Iván; Guerrero-Marquez, Carmen; Rabano, Alberto; García-Barrera, Tamara (NATURE PORTFOLIO, 2025-07-01)
    Limited studies have evaluated the influence of redox-related metals on Alzheimer´s brain. We determined 15 metals in 241 human brain samples obtained from five biobanks. We examined the levels of metals in the frontal ...
  • Clinical and immunopathological evaluation and its comparison with IHC consensus molecular subtypes of colorectal cancer 
    Feliciangeli-Moreno, Eduardo; Albaladejo-González, Ana; García-Rodríguez, José; Lázaro-Sánchez, Antonio-David; Borg, Rosanna; Pimentel-Cáceres, Paola; Soriano-Polo, Diego; Rodríguez-Braun, Edith; Balsalobre-Yago, José; Martínez-Ortiz, María-José; Wikstrom-Fernández, Sofía; Murillo-Herrera, Andrés; García-García, Teresa; García-Solano, José; Conesa-Zamora, Pablo; Luengo-Gil, Ginés (NATURE PORTFOLIO, 2025-07-01)
    This study examined the prognostic significance of immunoscore within consensus molecular subtypes (CMS), tumour budding (TB), and macrophage infiltration in colorectal cancer (CRC). A retrospective series was analysed ...