Repositorio Dspace
Clonal chromosomal mosaicism and loss of chromosome Y in elderly men increase vulnerability for SARS-CoV-2
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| dc.contributor.author | Pérez-Jurado, Luis-A | |
| dc.contributor.author | Caceres, Alejandro | |
| dc.contributor.author | Balague-Dobon, Laura | |
| dc.contributor.author | Esko, Tonu | |
| dc.contributor.author | de-Heredia, Miguel-López | |
| dc.contributor.author | Quintela, Ines | |
| dc.contributor.author | Cruz, Raquel | |
| dc.contributor.author | Lapunzina, Pablo | |
| dc.contributor.author | Carracedo, Angel | |
| dc.contributor.author | Abellan, Javier | |
| dc.contributor.author | Acosta-Isaac, Rene | |
| dc.contributor.author | María-Aguado, José | |
| dc.contributor.author | Aguilar, Carlos | |
| dc.contributor.author | Aguilera-Albesa, Sergio | |
| dc.contributor.author | Ahmadi-Sabbagh, Abdolah | |
| dc.contributor.author | Alba, Jorge | |
| dc.contributor.author | Albu, Sergiu | |
| dc.contributor.author | Alcala-Gallardo, Karla-AM | |
| dc.contributor.author | Alcoba-Florez, Julia | |
| dc.contributor.author | Alcolea-Batres, Sergio | |
| dc.contributor.author | Rafael-Algarin-Lara, Holmes | |
| dc.contributor.author | Almadana, Virginia | |
| dc.contributor.author | Medeiros, Kelliane-A | |
| dc.contributor.author | Almeida, Julia | |
| dc.contributor.author | Almoguera, Berta | |
| dc.contributor.author | Alonso, María-R | |
| dc.contributor.author | Alvarez, Nuria | |
| dc.contributor.author | Alvarez-Sala-Walther, Rodolfo | |
| dc.contributor.author | Alvarez-Benitez, Yady | |
| dc.contributor.author | Alvarez-Navia, Felipe | |
| dc.contributor.author | dos-Santos, Katiusse-A | |
| dc.contributor.author | Andreu-Bernabeu, Alvaro | |
| dc.contributor.author | Rosa-Antonijoan, María | |
| dc.contributor.author | Martínez-Aquino, Eleno | |
| dc.contributor.author | Arana-Arri, Eunate | |
| dc.contributor.author | Aranda, Carlos | |
| dc.contributor.author | Arango, Celso | |
| dc.contributor.author | Araque, Carolina | |
| dc.contributor.author | Araujo, Nathalia-K | |
| dc.contributor.author | Arcanjo, Ana-C | |
| dc.contributor.author | Arnaiz, Ana | |
| dc.contributor.author | Arnalich-Fernández, Francisco | |
| dc.contributor.author | Arranz, María-J | |
| dc.contributor.author | Arribas-Leal, José-M | |
| dc.contributor.author | Artiga, María-Jesus | |
| dc.contributor.author | Avello-Malaver, Yubelly | |
| dc.contributor.author | Ayuso, Carmen | |
| dc.contributor.author | Ballina-Martín, Belen | |
| dc.contributor.author | Baptista-Rosas, Raul-C | |
| dc.contributor.author | María-Baldion, Ana | |
| dc.contributor.author | Barranco-Diaz, Andrea | |
| dc.contributor.author | Barreda-Sánchez, María | |
| dc.contributor.author | Barrera-Penagos, Viviana | |
| dc.contributor.author | Belhassen-García, Moncef | |
| dc.contributor.author | Bernal-Bello, David | |
| dc.contributor.author | Bernal-Morell, Enrique | |
| dc.contributor.author | Bezerra, Joao-F | |
| dc.contributor.author | Bezerra, Marcos-AC | |
| dc.contributor.author | Blanca-López, Natalia | |
| dc.contributor.author | Blancas, Rafael | |
| dc.contributor.author | Boix-Palop, Lucia | |
| dc.contributor.author | Borobia, Alberto | |
| dc.contributor.author | Bravo, Elsa | |
| dc.contributor.author | Brion, María | |
| dc.contributor.author | Brochado-Kith, Oscar | |
| dc.contributor.author | Brugada, Ramon | |
| dc.contributor.author | Bustos, Matilde | |
| dc.contributor.author | Cabello, Alfonso | |
| dc.contributor.author | Caceres, Alejandro | |
| dc.contributor.author | Caceres-Agra, Juan-J | |
| dc.contributor.author | Calbo, Esther | |
| dc.contributor.author | Calderon, Enrique-J | |
| dc.contributor.author | Camacho, Shirley | |
| dc.contributor.author | Ceballos, Francisco-C | |
| dc.contributor.author | Canadas, Yolanda | |
| dc.contributor.author | Carbonell, Cristina | |
| dc.contributor.author | Cardona-Huerta, Servando | |
| dc.contributor.author | Sánchez-Carpintero-Abad, María | |
| dc.contributor.author | Carpio-Segura, Carlos | |
| dc.contributor.author | Antonio-Carrillo-Avila, José | |
| dc.contributor.author | Campos, Marcela-C | |
| dc.contributor.author | Casasnovas, Carlos | |
| dc.contributor.author | Castano, Luis | |
| dc.contributor.author | Castano, Carlos-F | |
| dc.contributor.author | Castelao, José-E | |
| dc.contributor.author | Castellano-Candalija, Aranzazu | |
| dc.contributor.author | Castillo, María-A | |
| dc.contributor.author | Chaves-Santiago, Walter-G | |
| dc.contributor.author | Chiquillo-Gómez, Sylena | |
| dc.contributor.author | Cid-López, Marco-A | |
| dc.contributor.author | Cienfuegos-Jiménez, Oscar | |
| dc.contributor.author | Conde-Vicente, Rosa | |
| dc.contributor.author | Cunha, Gabriela-CR | |
| dc.contributor.author | Lourdes-Cordero-Lorenzana, M | |
| dc.contributor.author | Corella, Dolores | |
| dc.contributor.author | Corrales, Almudena | |
| dc.contributor.author | Cortes-Sánchez, José-L | |
| dc.contributor.author | Corton, Marta | |
| dc.contributor.author | Souza, Karla-SC | |
| dc.contributor.author | Silva, Fabiola-TC | |
| dc.contributor.author | Cruz, Raquel | |
| dc.contributor.author | Cuesta, Luisa | |
| dc.contributor.author | Tavares, Nathali-AC | |
| dc.contributor.author | Carvalho, María-CC | |
| dc.contributor.author | Dalmau, David | |
| dc.contributor.author | Dantas-Komatsu, Raquel-CS | |
| dc.contributor.author | Teresa-Darnaude, M | |
| dc.contributor.author | de-Andres, Raimundo | |
| dc.contributor.author | de-Juan, Carmen | |
| dc.contributor.author | de-la-Cruz-Troca, Juan-J | |
| dc.contributor.author | de-la-Horra, Carmen | |
| dc.contributor.author | de-la-Hoz, Ana-B | |
| dc.contributor.author | De-Martíno-Rodríguez, Alba | |
| dc.contributor.author | Cruz, Marina-S | |
| dc.contributor.author | de-Sousa-Alves-Neri, Juliánna-Lys | |
| dc.contributor.author | del-Campo-Pérez, Victor | |
| dc.contributor.author | Delgado-Cuesta, Juan | |
| dc.contributor.author | Diaz-de-Bustamante, Aranzazu | |
| dc.contributor.author | Diaz-Pérez, Anderson | |
| dc.contributor.author | Dietl, Beatriz | |
| dc.contributor.author | Diz-de-Almeida, Silvia | |
| dc.contributor.author | Alves, Manoella-do-Monte | |
| dc.contributor.author | Domínguez-Garrido, Elena | |
| dc.contributor.author | Rosa, Lidia-S | |
| dc.contributor.author | Luchessi, Andre-D | |
| dc.contributor.author | Echave-Sustaeta, José | |
| dc.contributor.author | Eiros, Rocio | |
| dc.contributor.author | Enciso-Olivera, Cesar-O | |
| dc.contributor.author | Escudero, Gabriela | |
| dc.contributor.author | Pablo-Espana, Pedro | |
| dc.contributor.author | Estigarribia-Sanabria, Gladys | |
| dc.contributor.author | Carmen-Farinas, María | |
| dc.contributor.author | Fernández, Ramon | |
| dc.contributor.author | Fernández-Caballero, Lidia | |
| dc.contributor.author | Fernández-Cruz, Ana | |
| dc.contributor.author | Fernández-Ferrero, Silvia | |
| dc.contributor.author | Fernández-Martínez, Yolanda | |
| dc.contributor.author | Fernández-Nestosa, María-J | |
| dc.contributor.author | Fernández-Robelo, Uxia | |
| dc.contributor.author | Fernández-Rodríguez, Amanda | |
| dc.contributor.author | Fernández-Sampedro, Marta | |
| dc.contributor.author | Fernández, Ruth | |
| dc.contributor.author | Fernández-Villa, Tania | |
| dc.contributor.author | Fernández-Capitan, Carmen | |
| dc.contributor.author | Carioca, Antonio-Augusto-F | |
| dc.contributor.author | Flores-Pérez, Patricia | |
| dc.contributor.author | Fuenmayor-Hernández, Lacides | |
| dc.contributor.author | Fuertes-Nunez, Marta | |
| dc.contributor.author | Fumado, Victoria | |
| dc.contributor.author | Gadea, Ignacio | |
| dc.contributor.author | Gagliardi, Lidia | |
| dc.contributor.author | Gago-Domínguez, Manuela | |
| dc.contributor.author | Gallego, Natalia | |
| dc.contributor.author | Galoppo, Cristina | |
| dc.contributor.author | García-Soidan, Ana | |
| dc.contributor.author | García-Cerrada, Carlos | |
| dc.contributor.author | García-de-Vicuna, Aitor | |
| dc.contributor.author | García-García, Josefina | |
| dc.contributor.author | García-García, Irene | |
| dc.contributor.author | García-Ibarbia, Carmen | |
| dc.contributor.author | García-Montero, Andres-C | |
| dc.contributor.author | García, Leticia | |
| dc.contributor.author | García, Mercedes | |
| dc.contributor.author | García-Torrejon, María-Carmen | |
| dc.contributor.author | García, Ines | |
| dc.contributor.author | García-Vazquez, Elisa | |
| dc.contributor.author | Garza-Frias, Emiliano | |
| dc.contributor.author | Gentile, Angela | |
| dc.contributor.author | Gil-Fournier, Belen | |
| dc.contributor.author | de-Araujo, Jessica-NG | |
| dc.contributor.author | Gómez-Duque, Mario | |
| dc.contributor.author | Gómez-Arrue, Javier | |
| dc.contributor.author | Gómez-Carrera, Luis | |
| dc.contributor.author | Gómez-García, María | |
| dc.contributor.author | Gómez-Sacristan, Angela | |
| dc.contributor.author | González, Juan-R | |
| dc.contributor.author | González-Neira, Anna | |
| dc.contributor.author | González-Alvarez, Beatriz | |
| dc.contributor.author | Bernaldo-de-Quiros, Fernan-González | |
| dc.contributor.author | González-Montelongo, Rafaela | |
| dc.contributor.author | González-Penas, Javier | |
| dc.contributor.author | González-Sagrado, Manuel | |
| dc.contributor.author | Gonzalo-Benito, Hugo | |
| dc.contributor.author | Gorgojo-Galindo, Oscar | |
| dc.contributor.author | Gorgolas, Miguel | |
| dc.contributor.author | Guaragna, Florencia | |
| dc.contributor.author | Chaux, Jessica-G | |
| dc.contributor.author | Guillén-Navarro, Encarna | |
| dc.contributor.author | Guillen-Guio, Beatriz | |
| dc.contributor.author | Guisado-Vasco, Pablo | |
| dc.contributor.author | Gutierrez-Castaneda, Luz-D | |
| dc.contributor.author | Gutierrez-Bautista, Juan-F | |
| dc.contributor.author | Heili-Frades, Sara | |
| dc.contributor.author | Jacomo, Rafael-H | |
| dc.contributor.author | Hernández, Estefania | |
| dc.contributor.author | Hernández-Moro, Cristina | |
| dc.contributor.author | Hernández-Ortega, Luis-D | |
| dc.contributor.author | Hernández-Pérez, Guillermo | |
| dc.contributor.author | Hernández-Vaquero, Rebeca | |
| dc.contributor.author | Herraez, Belen | |
| dc.contributor.author | Teresa-Herranz, M | |
| dc.contributor.author | Herrera, María | |
| dc.contributor.author | José-Herrero, María | |
| dc.contributor.author | Herrero-González, Antonio | |
| dc.contributor.author | Horcajada, Juan-P | |
| dc.contributor.author | Imaz-Ayo, Natale | |
| dc.contributor.author | Intxausti-Urrutibeaskoa, Maider | |
| dc.contributor.author | Inigo-Campos, Antonio | |
| dc.contributor.author | Iniguez, María | |
| dc.contributor.author | Jara, Ruben | |
| dc.contributor.author | Jiménez, Angel | |
| dc.contributor.author | Jiménez-Alfaro, Ignacio | |
| dc.contributor.author | Jiménez, Pilar | |
| dc.contributor.author | Jiménez-Sousa, María-A | |
| dc.contributor.author | Jordan, Iolanda | |
| dc.contributor.author | Laguna-Goya, Rocio | |
| dc.contributor.author | Laorden, Daniel | |
| dc.contributor.author | Lasa-Lazaro, María | |
| dc.contributor.author | Claudia-Lattig, María | |
| dc.contributor.author | Lauriente, Ailen | |
| dc.contributor.author | Liger-Borja, Anabel | |
| dc.contributor.author | Llanos, Lucia | |
| dc.contributor.author | López-Bernus, Amparo | |
| dc.contributor.author | López-de-Heredia, Miguel | |
| dc.contributor.author | López-García, Esther | |
| dc.contributor.author | López-Granados, Eduardo | |
| dc.contributor.author | López-Rodríguez, Rosario | |
| dc.contributor.author | López-Ruz, Miguel-A | |
| dc.contributor.author | Lorente, Leonardo | |
| dc.contributor.author | Lorenzo-Salazar, Josem | |
| dc.contributor.author | Lozano, José-E | |
| dc.contributor.author | Lozano-Espinosa, María | |
| dc.contributor.author | Mahillo, Ignacio | |
| dc.contributor.author | Mancebo, Esther | |
| dc.contributor.author | Mar, Carmen | |
| dc.contributor.author | Marcelo-Calvo, Cristina | |
| dc.contributor.author | Marcos-Delgado, Alba | |
| dc.contributor.author | Marcos, Miguel | |
| dc.contributor.author | Marin-Candon, Alicia | |
| dc.contributor.author | Mariscal-Aguilar, Pablo | |
| dc.contributor.author | Martín-Pedraza, Laura | |
| dc.contributor.author | Martín-Fernández, Marta | |
| dc.contributor.author | Martín-López, Caridad | |
| dc.contributor.author | Martín-Oterino, José-Angel | |
| dc.contributor.author | Dolores-Martín, María | |
| dc.contributor.author | Martín, Vicente | |
| dc.contributor.author | Martín, María-M | |
| dc.contributor.author | Martín-Vicente, María | |
| dc.contributor.author | Martínez, Amalia | |
| dc.contributor.author | Martínez-González, Oscar | |
| dc.contributor.author | Martínez, Ricardo | |
| dc.contributor.author | Martínez-Paz, Pedro | |
| dc.contributor.author | Diaz-Caneja, Covadonga-M | |
| dc.contributor.author | Martínez-Nieto, Oscar | |
| dc.contributor.author | Martínez-López, Iciar | |
| dc.contributor.author | Martínez-Resendez, Michel-F | |
| dc.contributor.author | Martínez, Silvia | |
| dc.contributor.author | José-Martínez, Juan | |
| dc.contributor.author | Martínez-Pérez, Angel | |
| dc.contributor.author | Martínez-Ramas, Andrea | |
| dc.contributor.author | Martínez-Robles, Violeta | |
| dc.contributor.author | Marzal, Laura | |
| dc.contributor.author | Mazzeu, Juliána-F | |
| dc.contributor.author | Medrano, Francisco-J | |
| dc.contributor.author | Meijome, Xose-M | |
| dc.contributor.author | Mejuto-Montero, Natalia | |
| dc.contributor.author | Mendes, Ingrid | |
| dc.contributor.author | Duarte, Alice-L | |
| dc.contributor.author | Mendez-Echevarria, Ana | |
| dc.contributor.author | Mendoza-Charris, Humberto | |
| dc.contributor.author | Merayo-Macias, Eleuterio | |
| dc.contributor.author | Mercadillo, Fatima | |
| dc.contributor.author | Mercado-Sesma, Arieh-R | |
| dc.contributor.author | Minguez, Pablo | |
| dc.contributor.author | Molina-Roldan, Elena | |
| dc.contributor.author | Molina, AntonioJJ | |
| dc.contributor.author | José-Montoya, Juan | |
| dc.contributor.author | Pinho, Susana-MT | |
| dc.contributor.author | Moreira-Escriche, Patricia | |
| dc.contributor.author | Morelos-Arnedo, Xenia | |
| dc.contributor.author | Moreno, Rocio | |
| dc.contributor.author | Moreno-Cuerda, Victor | |
| dc.contributor.author | Moreno-Docon, Antonio | |
| dc.contributor.author | Moreno-Escalante, Junior | |
| dc.contributor.author | Moreno-Fernández, Alberto | |
| dc.contributor.author | Munoz-García, Patricia | |
| dc.contributor.author | Neira, Pablo | |
| dc.contributor.author | Nevado, Julián | |
| dc.contributor.author | Nieto-Ganan, Israel | |
| dc.contributor.author | Silbiger, Vivian-N | |
| dc.contributor.author | Nunez-Torres, Rocio | |
| dc.contributor.author | Obrador-Hevia, Antonia | |
| dc.contributor.author | Gonzalo-Ocejo-Vinyals, J | |
| dc.contributor.author | Olivar, Virginia | |
| dc.contributor.author | Oliveira, Silviene-F | |
| dc.contributor.author | Ondo, Lorena | |
| dc.contributor.author | Orfao, Alberto | |
| dc.contributor.author | Ortega-Paino, Eva | |
| dc.contributor.author | Ortega, Luis | |
| dc.contributor.author | Ortiz-López, Rocio | |
| dc.contributor.author | Ortiz-Flores, Fernando | |
| dc.contributor.author | Oteo, José-A | |
| dc.contributor.author | Pacheco, Manuel | |
| dc.contributor.author | Javier-Pacheco-Miranda, Fredy | |
| dc.contributor.author | Padilla-Conejo, Irene | |
| dc.contributor.author | Panadero-Fajardo, Sonia | |
| dc.contributor.author | Parellada, Mara | |
| dc.contributor.author | Pariente-Rodríguez, Roberto | |
| dc.contributor.author | Friaza, Vicente | |
| dc.contributor.author | Paz-Artal, Estela | |
| dc.contributor.author | Peces-Barba, German | |
| dc.contributor.author | Pedromingo-Kus, Miguel-S | |
| dc.contributor.author | Perales, Celia | |
| dc.contributor.author | Santos, Ney-PC | |
| dc.contributor.author | Guegel, Genilson-P | |
| dc.contributor.author | Jazmin-Pérez, María | |
| dc.contributor.author | Pérez, Alexandra | |
| dc.contributor.author | Pérez-Matute, Patricia | |
| dc.contributor.author | Pérez, Cesar | |
| dc.contributor.author | Pérez-de-Nanclares, Gustavo | |
| dc.contributor.author | Pérez-García, Felipe | |
| dc.contributor.author | Pérez, Patricia | |
| dc.contributor.author | Pérez-Jurado, Luis-A | |
| dc.contributor.author | Elena-Pérez-Tomás, M | |
| dc.contributor.author | Perucho, Teresa | |
| dc.contributor.author | Pichardo, Lisbeth-A | |
| dc.contributor.author | Ribeiro, Adriana-P | |
| dc.contributor.author | Pinsach-Abuin, Mel-lina | |
| dc.contributor.author | Adriana-Pinzon, Luz | |
| dc.contributor.author | Medeiros, Jeane-FP | |
| dc.contributor.author | Pita, Guillermo | |
| dc.contributor.author | Pla-Junca, Francesc | |
| dc.contributor.author | Planas-Serra, Laura | |
| dc.contributor.author | Pompa-Mera, Ericka-N | |
| dc.contributor.author | Porras-Hurtado, Gloria-L | |
| dc.contributor.author | Pujol, Aurora | |
| dc.contributor.author | Eugenia-Quevedo-Chavez, María | |
| dc.contributor.author | Angeles-Quijada, María | |
| dc.contributor.author | Quintela, Ines | |
| dc.contributor.author | Ramiro-Leon, Soraya | |
| dc.contributor.author | Rascado-Sedes, Pedro | |
| dc.contributor.author | Nunes, Joana-FR | |
| dc.contributor.author | Recalde, Delia | |
| dc.contributor.author | Recio-Fernández, Emma | |
| dc.contributor.author | Resino, Salvador | |
| dc.contributor.author | Sousa, Renata-R | |
| dc.contributor.author | Rivadeneira-Chamorro, Carlos-S | |
| dc.contributor.author | Roa-Agudelo, Diana | |
| dc.contributor.author | Robelo-Pardo, Montserrat | |
| dc.contributor.author | Fernandes, Maríanne-R | |
| dc.contributor.author | Rodríguez-Hernández, María-A | |
| dc.contributor.author | Rodríguez-Palmero, Agusti | |
| dc.contributor.author | Rodríguez-Ruiz, Emilio | |
| dc.contributor.author | Johanna-Rodríguez, Marilyn | |
| dc.contributor.author | Rodríguez-Artalejo, Fernando | |
| dc.contributor.author | Rodríguez-Ferrer, Marena | |
| dc.contributor.author | Rodríguez-Gallego, Carlos | |
| dc.contributor.author | Rodríguez-García, José-A | |
| dc.contributor.author | Rodríguez-Maya, Belen | |
| dc.contributor.author | Rodríguez-Nicolas, Antonio | |
| dc.contributor.author | Ezequiel-Rodríguez-Novoa, German | |
| dc.contributor.author | Rodríguez-Urrego, Paula-A | |
| dc.contributor.author | Rojo, Federico | |
| dc.contributor.author | Romero-Coronado, Andrea | |
| dc.contributor.author | Morilla, Ruben | |
| dc.contributor.author | Rondon-García, Filomeno | |
| dc.contributor.author | Rosales-Castillo, Antonio | |
| dc.contributor.author | Rubio, Cladelis | |
| dc.contributor.author | Rubio-Olivera, María | |
| dc.contributor.author | Ruiz-Cabello, Francisco | |
| dc.contributor.author | Ruiz-Casares, Eva | |
| dc.contributor.author | Ruiz-Cubillan, Juan-J | |
| dc.contributor.author | Ruiz-Hornillos, Javier | |
| dc.contributor.author | Ruiz, Montserrat | |
| dc.contributor.author | Ryan, Pablo | |
| dc.contributor.author | Salamanca, Hector-D | |
| dc.contributor.author | Salazar-García, Lorena | |
| dc.contributor.author | Gabriela-Salgueiro-Origlia, Giorgina | |
| dc.contributor.author | Sangil, Anna | |
| dc.contributor.author | Sánchez-Pernaute, Olga | |
| dc.contributor.author | Sánchez, Pedro-Luis | |
| dc.contributor.author | Sánchez-López, Antonio-J | |
| dc.contributor.author | Sánchez-Pablo, Clara | |
| dc.contributor.author | Concepcion-Sánchez-Prados, María | |
| dc.contributor.author | Sánchez-Real, Javier | |
| dc.contributor.author | Sánchez-Redondo, Jorge | |
| dc.contributor.author | Sancho-Sainz, Cristina | |
| dc.contributor.author | Sande, Esther | |
| dc.contributor.author | Santos, Arnoldo | |
| dc.contributor.author | Schluter, Agatha | |
| dc.contributor.author | Segovia, Sonia | |
| dc.contributor.author | Serra-Llovich, Alex | |
| dc.contributor.author | Sevil-Puras, Fernando | |
| dc.contributor.author | Sevilla-Porras, Marta | |
| dc.contributor.author | Sicolo, Miguel-A | |
| dc.contributor.author | Silvan-Fuentes, Cristina | |
| dc.contributor.author | Moraes, Vitor-MS | |
| dc.contributor.author | Souza, Vanessa-S | |
| dc.contributor.author | Sole-Violan, Jordi | |
| dc.contributor.author | Manuel-Soria, José | |
| dc.contributor.author | Sorli, José-V | |
| dc.contributor.author | Silva, Nayara-S | |
| dc.contributor.author | Carlos-Souto, Juan | |
| dc.contributor.author | Sprockel, John-J | |
| dc.contributor.author | Javier-Suárez-Rama, José | |
| dc.contributor.author | Suárez-Zamora, David-A | |
| dc.contributor.author | Taboada-Fraga, Xiana | |
| dc.contributor.author | Tamayo, Eduardo | |
| dc.contributor.author | Tamayo-Velasco, Alvaro | |
| dc.contributor.author | Carlos-Taracido-Fernández, Juan | |
| dc.contributor.author | Vasconcelos, Romero-HT | |
| dc.contributor.author | Telleria, Carlos | |
| dc.contributor.author | Carratto, Thassia-MT | |
| dc.contributor.author | Antonio-Tenorio-Castano, Jair | |
| dc.contributor.author | Teper, Alejandro | |
| dc.contributor.author | Araujo, Izabel-MT | |
| dc.contributor.author | Torres-Macho, Juan | |
| dc.contributor.author | Torres-Tobar, Lilian | |
| dc.contributor.author | Torres-Gutierrez, Ronald-P | |
| dc.contributor.author | Troya, Jesus | |
| dc.contributor.author | Urioste, Miguel | |
| dc.contributor.author | Valencia-Ramos, Juan | |
| dc.contributor.author | Valido, Agustin | |
| dc.contributor.author | Pablo-Vargas-Gallo, Juan | |
| dc.contributor.author | Varon, Belen | |
| dc.contributor.author | Vega, Tomás | |
| dc.contributor.author | Velasco-Quirce, Santiago | |
| dc.contributor.author | Velez-Santamaria, Valentina | |
| dc.contributor.author | Victor, Virginia | |
| dc.contributor.author | Vidan-Estevez, Julia | |
| dc.contributor.author | Silva, Gabriela-V | |
| dc.contributor.author | Vieitez-Santiago, Miriam | |
| dc.contributor.author | Vilches, Carlos | |
| dc.contributor.author | Villalobos, Lavinia | |
| dc.contributor.author | Villar, Felipe | |
| dc.contributor.author | Villar-García, Judit | |
| dc.contributor.author | Villaverde, Cristina | |
| dc.contributor.author | Villoslada-Blanco, Pablo | |
| dc.contributor.author | Virseda-Berdices, Ana | |
| dc.contributor.author | Costa, Tatiana-X | |
| dc.contributor.author | Yanez, Zuleima | |
| dc.contributor.author | Zapatero-Gaviria, Antonio | |
| dc.contributor.author | Zarate, Ruth | |
| dc.contributor.author | Zazo, Sandra | |
| dc.contributor.author | Flores, Carlos | |
| dc.contributor.author | Riancho, José-A | |
| dc.contributor.author | Rojas-Martínez, Augusto | |
| dc.contributor.author | Lapunzina, Pablo | |
| dc.contributor.author | Carracedo, Angel | |
| dc.contributor.author | González, Juan-R | |
| dc.date.accessioned | 2025-11-19T15:39:23Z | |
| dc.date.available | 2025-11-19T15:39:23Z | |
| dc.date.issued | 2024-02 | |
| dc.identifier.citation | Pérez-Jurado LA, Cáceres A, Balagué-Dobón L, Esko T, López De Heredia M, Quintela I, et al. Clonal chromosomal mosaicism and loss of chromosome Y in elderly men increase vulnerability for SARS-CoV-2. Commun Biol. 19 de febrero de 2024;7(1):202. | |
| dc.identifier.uri | https://sms.carm.es/ricsmur/handle/123456789/21377 | |
| dc.description.abstract | The pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, COVID-19) had an estimated overall case fatality ratio of 1.38% (pre-vaccination), being 53% higher in males and increasing exponentially with age. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, we found 133 cases (1.42%) with detectable clonal mosaicism for chromosome alterations (mCA) and 226 males (5.08%) with acquired loss of chromosome Y (LOY). Individuals with clonal mosaic events (mCA and/or LOY) showed a 54% increase in the risk of COVID-19 lethality. LOY is associated with transcriptomic biomarkers of immune dysfunction, pro-coagulation activity and cardiovascular risk. Interferon-induced genes involved in the initial immune response to SARS-CoV-2 are also down-regulated in LOY. Thus, mCA and LOY underlie at least part of the sex-biased severity and mortality of COVID-19 in aging patients. Given its potential therapeutic and prognostic relevance, evaluation of clonal mosaicism should be implemented as biomarker of COVID-19 severity in elderly people. | |
| dc.language.iso | eng | |
| dc.publisher | NATURE PORTFOLIO | |
| dc.rights | Atribución-NoComercial-SinDerivadas 3.0 España | |
| dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/es | * |
| dc.subject.mesh | Male | |
| dc.subject.mesh | Humans | |
| dc.subject.mesh | Aged | |
| dc.subject.mesh | SARS-CoV-2/genetics | |
| dc.subject.mesh | Mosaicism | |
| dc.subject.mesh | COVID-19/genetics | |
| dc.subject.mesh | Chromosomes, Human, Y | |
| dc.subject.mesh | Aging | |
| dc.title | Clonal chromosomal mosaicism and loss of chromosome Y in elderly men increase vulnerability for SARS-CoV-2 | |
| dc.type | info:eu-repo/semantics/article | |
| dc.identifier.pmid | 38374351 | |
| dc.relation.publisherversion | https://www.nature.com/articles/s42003-024-05805-6 | |
| dc.identifier.doi | 10.1038/s42003-024-05805-6 | |
| dc.journal.title | Communications Biology | |
| dc.identifier.essn | 2399-3642 |
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