Repositorio Dspace

Envíos recientes

03.01. Investigación y comunicación científica: Envíos recientes

  • Internal connectivity of the mouse mesocortical ring and functional implications 
    Puelles, Luis; García-Calero, Elena (SPRINGER HEIDELBERG, 2026-05-08)
    The mammalian mesocortex (MCx) was redefined recently as a complete ring intercalated between the allo- and iso-cortex, attending to the consistent expression of 46 selective gene markers. The MCx exhibits various other ...
  • PARP2 deficiency impairs pancreatic cancer progression by promoting genomic instability and antitumor immunity 
    Martínez-Bosch, Neus; Manero-RuPérez, Noemi; Vázquez-Bellon, Nuria; Nickell-Hernández, Bennett; Ventura-Blanch, Cristina; Lutfi, Nura; Lechuga, Carmen-G; Martínez, Carlos; Moreno, Mireia; Ampurdanes, Coral; Abad, Etna; Iglesias, Mar; Muñoz-Escribano, María; Janic, Ana; Rovira, Meritxell; Guerra, Carmen; Rabinovich, Gabriel-A; Yelamos, José; Navarro, Pilar (AMER ASSOC ADVANCEMENT SCIENCE, 2026-05-08)
    Pancreatic cancer represents one of the most lethal tumors, characterized by an immunosuppressive microenvironment and a lack of cytotoxic immune cell infiltrates, which confer resistance to immunotherapy. Here, we demonstrate ...
  • The ERA Registry Annual Report 2023: epidemiology of kidney replacement therapy in Europe, with a focus on age comparisons 
    Hoekstra, Marin-W-F; Boenink, Rianne; Bonthuis, Marjolein; Boerstra, Brittany-A; Astley, Megan-E; Montez-de-Sousa, Iris-R; Gjorgjievski, Nikola; Resic, Halima; Mitsides, Nicos; Hommel, Kristine; Guidotti, Rebecca; Marín-Sánchez, Inmaculada; Slon-Roblero, María-F; Artamendi, Marta; Beckerman, Pazit; Buchwinkler, Lukas; Gellert, Ryszard; Kuzema, Viktorija; Oksa, Adrián; Comas, Jordi; Heylen, Line-M-T-J; Lassalle, Mathilde; Hernández-Ramírez, Sara; Santhakumaran, Shalini; Seyahi, Nurhan; Asberg, Anders; Weekers, Laurent-E; Muñoz-Terol, José-M; Trujillo-Alemán, Sara; Memeti-Smaili, Fatime; Ots-Rosenberg, Mai; Indridason, Olafur-S; Komissarov, Kirill-S; ten-Dam, Marc-A-G-J; Stendahl, María; Galvao, Ana-A; Ortiz, Alberto; Stel, Vianda-S; Kramer, Anneke (OXFORD UNIV PRESS, 2026-05-01)
    The European Renal Association (ERA) Registry collects data on patients with kidney failure receiving kidney replacement therapy (KRT). This paper presents a summary of the ERA Registry Annual Report 2023, and focuses ...
  • Postmortem genetic testing in sudden death: clinical and medico-legal implications 
    Sabater-Molina, María; Nicolás-Rocamora, Elisa; Munteanu, Serena; Fuentes-Bermejo, María-Dolores; Osuna-Carrillo-Albornoz, Eduardo; Pérez-Cárceles, María-Dolores; Pastor-Quirante, Francisco; Gimeno-Blanes, Juan-Ramón; Hernández-del-Rincón, Juan-Pedro (SPRINGER, 2026-05-08)
    BACKGROUND: Anatomopathological autopsy and postmortem genetic testing play a crucial role in forensic medicine, particularly in elucidating the causes of sudden death (SD) that remain unexplained by conventional methods. ...
  • Prevalence and risk factors of asthma, rhinoconjunctivitis and eczema in the very extreme environment of Naryn, Kyrgyzstan 
    Sulaimanov, Shaiirbek-A; Martínez-Torres, A-Elena; García-Marcos, Luis; Asheraliev, Mukhtar-E; Moidunov, Artur-A; Brimkulov, Nurlan-N; Muratova, Zhanara-K; Omusheva, Saltanat-E; Tynybekov, Kubanych-T; Narkoziev, Baktybek-E (ELSEVIER, 2026-05)
    BACKGROUND: There is not much information about the prevalence of allergic diseases in high altitudes in central Asia; and even less on their potential risk of protective factors. METHODS: A survey using the Global Asthma ...
  • Lessons of nature from trisomy-8 myeloid neoplasia: the riddle of oncogenic clonal drives. 
    Awada, Hussein; Durmaz, Arda; Guarnera, Luca; Brady, Zachary; Kubota, Yasuo; Unlu, Serhan; Gurnari, Carmelo; Bravo-Pérez, Carlos; Awada, Hassan; Haferlach, Torsten; Maciejewski, Jaroslaw-P; Visconte, Valeria (FERRATA STORTI FOUNDATION, 2026-05-07)
    Not available.
  • CVOT Summit Report 2025: advances along the cardiovascular-kidney-metabolic disease continuum 
    Schnell, Oliver; Agarwal, Arnav; Azizi, Michel; Ballwieser, Dennis; Barnard-Kelly, Katharine; Battelino, Tadej; Bluher, Matthias; Bugianesi, Elisabetta; Cebrián-Cuenca, Ana-María; Ceriello, Antonio; Choudhary, Pratik; Danne, Thomas; Dayan, Colin-M; del-Prato, Stefano; Eckel, Robert-H; Fioretto, Paola; Garvey, Timothy; Green, Jennifer-B; Heerspink, Hiddo-J-L; Holman, Rury-R; Itzhak, Baruch; Jacob, Stephan; Jhund, Pardeep-S; Ji, Linong; Judge, Parminder-K; Khunti, Kamlesh; Korenjak, Marko; Krentz, Andrew-J; Lambrinou, Ekaterini; Libby, Peter; Mader, Julia-K; Mann, Johannes-F-E; Marx, Nikolaus; Mathieu, Chantal; McMurray, John-J-V; Muller-Wieland, Dirk; Papanas, Nikolaos; Patel, Dipesh-C; Pfeiffer, Andreas-F-H; Reger-Tan, Susanne; Rodbard, Helena-W; Rosano, Giuseppe-M-C; Saboo, Banshi; Sato, Naoki; Solomon, Scott-D; Standl, Eberhard; Tacke, Frank; Topsever, Pinar; Wanner, Christoph; Wharton, Sean; Young, Veronika (SPRINGER, 2026-05-06)
    The 11th Cardiovascular Outcome Trial (CVOT) Summit: Congress on Cardiovascular, Kidney, and Metabolic Outcomes was held virtually on November 20-21, 2025. The Summit provided a multidisciplinary forum to review and discuss ...
  • Smoking, GAD65 autoimmunity, genetic susceptibility to type 1 diabetes and incident adult-onset diabetes in the EPIC-InterAct case-cohort study. 
    Keysendal, Emmy; Carlsson, Sofia; Lampousi, Anna-Maria; Hampe, Christiane-S; Huerta-Castaño, José-María; Kerrison, Nicola; Nilsson, Peter-M; Pala, Valeria; Schulze, Matthias-B; Sharp, Stephen-J; Rolandsson, Olov; Wareham, Nicholas-J (SPRINGERNATURE, 2026-04-16)
    AIMS/HYPOTHESIS: Smoking increases the risk of type 2 diabetes, but its role in autoimmune diabetes remains unclear. We investigated whether smoking is associated with being GAD65 autoantibody (GAD65Ab) positive or the ...
  • Redefining safety standards: a large-scale comparative analysis of bovine versus murine models for medical device embryotoxicity testing 
    Romar, Raquel; Romero-Aguirregomezcorta, Jon; Maroto, María; Gutiérrez-Adan, Alfonso; Coy-Fuster, Pilar (SPRINGER/PLENUM PUBLISHERS, 2026-06)
    PURPOSE: To overcome the limited sensitivity of the standard mouse embryo assay (MEA) for embryotoxicity screening of assisted reproduction devices and to assess the bovine embryo assay (BEA) as a suitable alternative. ...
  • Real-world characterization of PD-L1 expression in patients with advanced esophagogastric adenocarcinoma in Spain 
    Jiménez-Fonseca, Paula; Díez-García, Marc; Catoya-Villa, Juan-Luis; Pérez-Wert, Pablo; Visa, Laura; Carmona-Bayonas, Alberto; Limón, María-Luisa; Fernández-Montes, Ana; Reboredo, Margarita; Vidal-Tocino, Rosario; Gallego-Plazas, Javier; Mendoza, Guillermo-Eduardo; Landolfi, Stefania; Teijo, Ana; Guerra-Pastrian, Laura; Nieto, Andrés; Domínguez-Miranda, José-Luis; López-Vega, María-Luisa; Rodríguez-González, Marta; Illán-Gambín, Francisco-José; Martínez-de-Castro, Eva; Hierro, Cinta; Gil-Raga, Mireia; Robles-González, María; Moreno-Gutiérrez, María-Elena; Vilanova, David; Iglesias-Coma, Mar (SPRINGER INT PUBL AG, 2026-04-28)
    PURPOSE: Epidemiological data from Sapin are lacking, especially in a publication relating Spanish data and prevalence of programmed cell death ligand-1 (PD-L1) expression. This study aimed to evaluate the prevalence of ...
  • Real-World Effectiveness and Safety of Upadacitinib in Crohn's Disease: Insights From the Eneida Registry 
    Iborra, M; Botella, B; Martin-Arranz, M-D; Ceballos, D; Martínez-Pascual, C; Garrido, A; Varela, P; Moreta, M; Brunet-Mas, Eduard; González-Lama, Y; Rodríguez-González, E; Vicuna, M; Gisbert, J-P; Ordas, I; Arguelles-Arias, F; Tosca-Cuquerella, J; Vicente-Lidon, R; Sierra-Ausin, M; Rodríguez-Lago, I; Martin-Rodríguez, D; Paredes, JM; Sicilia, B; García-de-la-Filia, I; Jiménez, N; Barreiro-de-Acosta, M; Betore, E; Ferrer-Bradley, I; García-Alles, L; Huguet, JM; Castellet-Farrus, S; García, M-J; Gutiérrez-Casbas, A; Ponferrada-Díaz, A; Ramos, L; Calafat, M; Vera, I; Suárez-Ferrer, Consuelo; Fernández-Velado, E; Rodríguez-Sánchez, S; Mínguez, A; Mancebo, A; Barrio, J; Lario, S; de-La-Cruz, D-R; Hernández-Camba, Alejandro; Rodríguez-Gutiérrez, C; Chaparro, M; Ricart, E; Almenara-Michelena, L; Balaguer, A; Domenech, E; Nos, P (WILEY, 2026-05)
    BACKGROUND: Upadacitinib (UPA) is the first oral Janus kinase (JAK) inhibitor approved for the treatment of Crohn's disease (CD). Real-world data, particularly from large nationwide cohorts, remain limited. This study aimed ...
  • Functional, biochemical, and clinical characterization of natural mutations affecting arginine residues in the heparin-binding site of antithrombin 
    Cifuentes-Riquelme, Rosa; de-la-Morena-Barrio, María-Eugenia; Miñano, Antonia; Garrido-Rodríguez, Pedro; Velasco, Francisco; Rojo-Carrillo, Juan-José; López-Correas, Paloma; Zaragoza-Huesca, David; Padilla, José; Lozano-Almela, María-Luisa; Bravo-Pérez, Carlos; Corral, Javier (WILEY, 2026-04)
    Arginine residues in antithrombin are essential for heparin binding and for the activation of this key anticoagulant serpin. Mutations affecting these residues may cause antithrombin deficiency, specifically Type II ...
  • Machine learning-based prediction models for noninvasive respiratory support failure in acute respiratory failure: a systematic review and meta-analysis 
    Akgun, Kadir-Burak; Al-Otaibi, Hajed-M; Chiappa, Gaspar-R; Alqarni, Abdullah-A; Troxell, David; Przybylski, Franciszek; Esquinas-Rodríguez, Antonio (FRONTIERS MEDIA SA, 2026-04-10)
    BACKGROUND: Early identification of noninvasive respiratory support (NIRS) failure in acute respiratory failure (ARF) is clinically relevant, as delayed intubation is associated with worse outcomes. Machine learning-based ...
  • Diagnosis and therapeutic management of psoriatic arthritis: summary of 2024 update of the Spanish clinical practice guideline (ESPOGUIA) 
    Ramírez, Julio; López-Medina, Clementina; Montilla, Carlos; Moreno, Mireia; Moreno-Ramos, Manuel-José; Navarro, Victoria; Díaz, David; Fernández-Clotet, Agnes; Riera-Monroig, Josep; Díaz-del-Campo, Petra; Canete, Juan-D; Queiro, Rubén (SAGE PUBLICATIONS LTD, 2026-04)
    Psoriatic arthritis (PsA) is a heterogeneous chronic inflammatory disease affecting peripheral and axial joints, entheses, skin, and nails, requiring coordinated multidisciplinary management. Since the 2018 edition of ...
  • Predicting disease progression in multiple sclerosis with clinically accessible information and technology 
    Fuchs, Tom-A-N; Schoonheim, Menno-M; Strijbis, Eva-M-M; Jelgerhuis, Julia-R; Horakova, Dana; Havrdova, Eva-K; Uher, Tomas; Zivadinov, Robert; Ozakbas, Serkan; Girard, Marc; Alroughani, Raed; Grammond, Pierre; Lugaresi, Alessandra; Tomassini, Valentina; Kalincik, Tomas; Roos, Izanne; Gerlach, Oliver; van-der-Walt, Anneke; Khoury, Samia-J; van-Pesch, Vincent; Surcinelli, Andrea; Foschi, Matteo; Sa, María-José; D'amico, Emanuele; Kuhle, Jens; Cartechini, Elisabetta; Maimone, Davide; Karabudak, Rana; Soysal, Aysun; Spitaleri, Daniele; Laureys, Guy; Taylor, Bruce; D'hooghe, Marie; Ampapa, Radek; Castillo-Triviño, Tamara; Altintas, Ayse; Gray, Orla; Gouider, Riadh; Meca-Lallana, José-Eustasio; Kermode, Allan-G; Fabis-Pedrini, Marzena; Carroll, William-M; de-Gans, Koen; Sánchez-Menoyo, José-Luis; Etemadifar, Masoud; Al-Asmi, Abdullah; McCombe, Pamela; Simu, Mihaela; Yetkin, Mehmet-Fatih; Al-Harbi, Talal; Csepany, Tunde; Lalive, Patrice; Hardy, Todd-A; Ramanathan, Sudarshini; Willekens, Barbara; Pérez-Sempere, Ángel; Cárdenas-Robledo, Simón; Habek, Mario; Singhal, Bhim; Grigoriadis, Nikolaos; Simo, Magdolna; Shaygannejad, Vahid; Blanco, Yolanda; Agüera-Morales, Eduardo; Garber, Justin; Solaro, Claudio; Shuey, Neil; Khurana, Dheeraj; Decoo, Danny; Moghadasi, Abdorreza-Naser; Buzzard, Katherine; Skibina, Olga; John, Nevin; Petersen, Thor; Weinstock-Guttman, Bianca (SPRINGER HEIDELBERG, 2026-05)
    BACKGROUND: Predicting disease progression at the individual level is essential for personalized medicine. We previously developed machine-learning tools to estimate 5-year progression risk in people with multiple sclerosis ...
  • Gene editing of the GJB2 locus in porcine embryos using CRISPR/Cas9 and cytosine base editors: toward a model of congenital deafness 
    Pineiro-Silva, Celia; Bermejo-Álvarez, Pablo; García-Purrinos, Francisco-José; Gadea-Mateos, Joaquín (SPRINGERNATURE, 2026-04-18)
    Mutations in the GJB2 gene, which encodes Connexin 26 (Cx26), are responsible for the majority of cases of non-syndromic congenital hearing loss in humans. While murine GJB2 knockout models have provided mechanistic insight, ...
  • Reflections on the I-squared index for measuring inconsistency in meta-analysis 
    Higgins, Julian-P-T; López-López, José-Antonio (CAMBRIDGE UNIV PRESS, 2026-05)
    The I-squared index was proposed in 2002 as a measure to help understand the consistency of study results in a meta-analysis. It was developed to overcome some of the limitations of existing measures, principally the ...
  • Objective prediction of siesta based on machine learning and association with obesity 
    Rodríguez-Martin, María; Moreno-Caballero, Fernando; Dashti, Hassan-S; Saxena, Richa; Scheer, Frank-A-J-L; Fernández-Breis, Jesualdo-T; Garaulet, Marta (ELSEVIER, 2026-06)
    OBJECTIVES: To predict siesta behavior using machine learning models trained on self-reported and objective data-temperature (T), activity (A), position (P), and the integrated TAP variable-and to explore its associations ...
  • Quality of information about potentially malignant oral disorders on TikTok: a cross-sectional analysis in the context of social media 
    López-Jornet, Pía; Bennouna, Layla; Parra-Pérez, Francisco; Pons-Fuster, Eduardo (SPRINGER, 2026-05-18)
    OBJECTIVE: Potentially malignant oral disorders (PMODs) can progress to oral cancer, making the quality of available health information especially relevant. This research aimed to analyze TikTok content related to potentially ...
  • Latency following preterm prelabor rupture of membranes before 34 weeks of gestation and its association with perinatal outcomes: a retrospective cohort study 
    López-Martínez, Pilar; Sánchez-Romero, Javier; Muñoz-Porcel, Rosa; Mokachir-Mohsenin, Zoraya; Blanco-Carnero, José-Eliseo; Crespo-Bañón, Paz; Liandro, Romina-Sol; Hernández-Hernández, Laura; Dagklis, Themistoklis; Nieto-Díaz, Aníbal; de-Paco-Matallana, Catalina (SPRINGER HEIDELBERG, 2026-05-16)
    PURPOSE: To evaluate the association between latency duration and perinatal outcomes in pregnancies complicated by preterm prelabor rupture of membranes (PPROM) before 34 weeks of gestation, and to assess the role of ...

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