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Envíos recientes

02.06. Área de Salud VI Vega Media: Envíos recientes

  • Targeting of Non-Classical Human Leukocyte Antigens as Novel Therapeutic Strategies in Cancer 
    Benítez-Fuentes, Javier-David; Arcilla, Jorge-Bartolomé; Mohamed-Mohamed, Kauzar; López-de-Sa, Alfonso; de-Luna-Aguilar, Alicia; Guevara-Hoyer, Kissy; Ballestin-Martínez, Pablo; Lázaro-Sánchez, Antonio-David; Carosella, Edgardo-D; Ocana, Alberto; Sánchez-Ramon, Silvia (MDPI, 2024-12)
    Human leukocyte antigens (HLAs) are essential regulators of immune responses against cancer, with classical HLAs well-documented for their role in tumor recognition and immune surveillance. In recent years, non-classical ...
  • Prognostic Implications of Blood Immune-Cell Composition in Metastatic Castration-Resistant Prostate Cancer 
    Pérez-Navarro, Enrique; Conteduca, Vincenza; Funes, Juan-M; Domínguez, José-I; Martín-Serrano, Miguel; Cremaschi, Paolo; Fernández-Pérez, María-Piedad; Alonso-Gordoa, Teresa; Font, Albert; Vázquez-Estevez, Sergio; González-del-Alba, Aranzazu; Wetterskog, Daniel; Mellado, Begoña; Fernández-Calvo, Ovidio; Méndez-Vidal, María-José; Climent, Miguel-Ángel; Durán, Ignacio; Gallardo, Enrique; Rodríguez-Sánchez, Ángel; Santander, Carmen; Isabel-Saez, María; Puente, Javier; Tudela, Julián; Marinas, Cecilia; López-Andreo, María-José; Castellano, Daniel; Attard, Gerhardt; Grande, Enrique; Rosino, Antonio; Botia, Juan-A; Palma-Méndez, José; de-Giorgi, Ugo; González-Billalabeitia, Enrique (MDPI, 2024-07)
    The prognosis for patients with metastatic castration-resistant prostate cancer (mCRPC) varies, being influenced by blood-related factors such as transcriptional profiling and immune cell ratios. We aimed to address the ...
  • Immunotherapy in Neuroendocrine Neoplasms: A Diamond to Cut 
    García-Torralba, Esmeralda; García-Lorenzo, Esther; Doger, Bernard; Spada, Francesca; Lamarca, Ángela (MDPI, 2024-07)
    A raise in the incidence of NENs is expected. Therefore, the identification of new therapeutic strategies, such as immunotherapy, remains crucial. To date, immune checkpoint inhibitors as monotherapy have shown modest ...
  • Belantamab Mafodotin in Patients with Relapsed/Refractory Multiple Myeloma: Results of the Compassionate Use or the Expanded Access Program in Spain 
    de-la-Rubia, Javier; Alonso, Rafael; Clavero, María-Esther; Askari, Elham; García, Alfonso; Antón, Cristina; Fernández, Margarita; Escalante, Fernando; García, Ana; Ríos-Tamayo, Rafael; Conesa, Venancio; Bermúdez, María-Arancha; Merchan, Beatriz; Velasco, Alberto-E; Blanchard, María-Jesús; Sampol, Antonia; Gainza, Eukene; Hernández, Prisma-Montserrat; Alegre, Adrián (MDPI, 2023-05)
    Belantamab-mafodotin (belamaf) is a novel antibody-drug conjugate targeting B-cell maturation antigen that showed anti-myeloma activity in patients with relapsed and refractory multiple myeloma (RRMM). We performed an ...
  • Clinical Meaning of Stromal Tumor Infiltrating Lymphocytes (sTIL) in Early Luminal B Breast Cancer 
    García-Torralba, Esmeralda; Pérez-Ramos, Miguel; Ivars-Rubio, Alejandra; Navarro-Manzano, Esther; Blaya-Boluda, Noel; de-la-Morena-Barrio, Pilar; García-Garre, Elisa; Martínez-Díaz, Francisco; Chaves-Benito, Asunción; García-Martínez, Elena; Ayala-de-la-Peña, Francisco (MDPI, 2023-05)
    Luminal breast cancer (BC) is associated with less immune activation, and the significance of stromal lymphocytic infiltration (sTIL) is more uncertain than in other BC subtypes. The aim of this study was to investigate ...
  • Impact of the COVID-19 Pandemic on Cancer Diagnosis in Madrid (Spain) Based on the RTMAD Tumor Registry (2019-2021) 
    Garrido-Cantero, Gregorio; Longo-Muñoz, Federico; Hernández-González, Javier; Pueyo, Ángel; Fernández-Aparicio, Tomás; Dorado, Juan-C; Angulo, Javier-C (MDPI, 2023-03)
    The coronavirus disease 2019 (COVID-19) pandemic has caused a significant disruption to cancer diagnosis, treatment and prevention worldwide that could have serious consequences in the near future. We intend to evaluate ...
  • Deepening Our Understanding of the Factors Affecting Landscape of Myeloproliferative Neoplasms: What Do We Know about Them? 
    Morales, María-Luz; Ferrer-Marín, Francisca (MDPI, 2023-02)
    Myeloproliferative neoplasms (MPNs) arise from the uncontrolled proliferation of hematopoietic stem and progenitor cells in bone marrow. As with all tumors, the development of MPNs is a consequence of alterations in malignant ...
  • Molecular Landscape and Validation of New Genomic Classification in 2668 Adult AML Patients: Real Life Data from the PETHEMA Registry 
    Sargas, Claudia; Ayala, Rosa; Larrayoz, María-José; Chillón, María-del-Carmen; Carrillo-Cruz, Estrella; Bilbao-Sieyro, Cristina; Prados-de-la-Torre, Esther; Martínez-Cuadrón, David; Rodríguez-Veiga, Rebeca; Boluda, Blanca; Gil, Cristina; Bernal, Teresa; Bergua-Burgues, Juan-Miguel; Algarra, Lorenzo; Tormo, Mar; Martínez-Sánchez, Pilar; Soria, Elena; Serrano, Josefina; Alonso-Domínguez, Juan-Manuel; García-Boyero, Raimundo; Amigo, María-Luz; Herrera-Puente, Pilar; Sayas, María-José; Lavilla-Rubira, Esperanza; Martínez-López, Joaquín; Calasanz, María-José; García-Sanz, Ramón; Pérez-Simón, José-Antonio; Gómez-Casares, María-Teresa; Sánchez-García, Joaquín; Barragán, Eva; Montesinos, Pau (MDPI, 2023-01)
    Next-Generation Sequencing (NGS) implementation to perform accurate diagnosis in acute myeloid leukemia (AML) represents a major challenge for molecular laboratories in terms of specialization, standardization, costs and ...
  • How to Manage Patients with Lenalidomide-Refractory Multiple Myeloma 
    de-Arriba-de-la-Fuente, Felipe; Montes-Gaisan, Carmen; de-la-Rubia, Javier (MDPI, 2023-01)
    Although lenalidomide-based combinations, such as lenalidomide plus a proteasome inhibitor or an anti-CD38 monoclonal antibody, improve the overall response rate, progression-free survival, and overall survival of patients ...
  • Evolution of RAS Mutations in Cell-Free DNA of Patients with Tissue RAS Wild-Type Metastatic Colorectal Cancer Receiving First-Line Treatment: The PERSEIDA Study 
    Valladares-Ayerbes, Manuel; García-Alfonso, Pilar; Muñoz-Luengo, Jorge; Pimentel-Cáceres, Paola-Patricia; Trujillo, Óscar-Alfredo; Vidal-Tocino, Rosario; Llanos, Marta; Llorente-Ayala, Beatriz; Limón-Mirón, María-Luisa; Salud-Salvia, Antonieta; Cirera-Nogueras, Lluis; García-Carbonero, Rocío; Safont-Aguilera, María-José; Falcó-Ferrer, Esther; Aparicio, Jorge; Vicente-Conesa, María-Ángeles; Guillén-Ponce, Carmen; García-Teijido, Paula; Medina-Magán, María-Begoña; Busquier, Isabel; Salgado-Fernández, Mercedes; Vila, Ariadna-Lloansi (MDPI, 2022-12)
    The serial analysis of cell-free DNA (cfDNA) enables minimally invasive monitoring of tumor evolution, providing continuous genetic information. PERSEIDA was an observational, prospective study assessing the cfDNA RAS ...
  • Impact of FLT3-ITD Mutation Status and Its Ratio in a Cohort of 2901 Patients Undergoing Upfront Intensive Chemotherapy: A PETHEMA Registry Study 
    Ayala, Rosa; Carreño-Tarragona, Gonzalo; Barragán, Eva; Boluda, Blanca; Larrayoz, María-José; Chillón, María-del-Carmen; Carrillo-Cruz, Estrella; Bilbao, Cristina; Sánchez-García, Joaquín; Bernal, Teresa; Martínez-Cuadrón, David; Gil, Cristina; Serrano, Josefina; Rodríguez-Medina, Carlos; Bergua, Juan; Pérez-Simón, José-Antonio; Calbacho, María; Alonso-Domínguez, Juan-Manuel; Labrador, Jorge; Tormo, Mar; Amigo, María-Luz; Herrera-Puente, Pilar; Rapado, Inmaculada; Sargas, Claudia; Vázquez, Iria; Calasanz, María-José; Gómez-Casares, María-Teresa; García-Sanz, Ramón; Sanz, Miguel-Ángel; Martínez-López, Joaquín; Montesinos, Pau (MDPI, 2022-12)
    FLT3?ITD results in a poor prognosis in terms of overall survival (OS) and relapse-free survival (RFS) in acute myeloid leukemia (AML). However, the prognostic usefulness of the allelic ratio (AR) to select post-remission ...
  • Allogeneic Hematopoietic Stem Cell Transplantation in Transformed Follicular Lymphoma (tFL): Results of a Retrospective Multicenter Study from GELTAMO/GETH-TC Spanish Groups 
    Rey-Bua, Beatriz; Cabrero, Mónica; Bento, Leyre; Montoro, Juan; Bastos-Oreiro, Mariana; Parody, Rocío; Yañez, Lucrecia; López-Godino, Oriana; Zanabili, Joud; Herrera, Pilar; Gutiérrez, Gonzalo; Pérez, Ariadna; Piñana, José-Luis; Novelli, Silvana; Cortés, María; Sureda, Anna; Caballero, Dolores; Martín-García-Sancho, Alejandro (MDPI, 2022-11)
    BACKGROUND: Transformation of follicular lymphoma into an aggressive lymphoma (tFL) worsens the prognosis and the standard treatment is not completely defined. Allogeneic hematopoietic stem cell transplantation (alloSCT) ...
  • Recurrence of Oral Leukoplakia after CO2 Laser Resection: A Prospective Longitudinal Study 
    Rodríguez-Luján, Adela; López-Jornet, Pía; Pons-Fuster, Eduardo (MDPI, 2022-11)
    AIM: The aim of this study is to assess the efficacy of CO(2) laser treatment in oral leukoplakia and to analyse the recurrence rate of oral leukoplakia lesions at 18-month follow-up. MATERIALS AND METHODS: A prospective ...
  • Transcriptional Profile Associated with Clinical Outcomes in Metastatic Hormone-Sensitive Prostate Cancer Treated with Androgen Deprivation and Docetaxel 
    Jiménez, Natalia; Reig, Óscar; Marín-Aguilera, Mercedes; Aversa, Caterina; Ferrer-Mileo, Laura; Font, Albert; Rodríguez-Vida, Alejo; Climent, Miguel-Ángel; Cros, Sara; Chirivella, Isabel; Domenech, Montserrat; Figols, Mariona; González-Billalabeitia, Enrique; Jiménez-Peralta, Daniel; Rodríguez-Carunchio, Leonardo; García-Esteve, Samuel; García-de-Herreros, Marta; Ribal, María-J; Prat, Aleix; Mellado, Begoña (MDPI, 2022-10)
    (1) Background: Androgen deprivation therapy (ADT) and docetaxel (DX) combination is a standard therapy for metastatic hormone-sensitive prostate cancer (mHSPC) patients. (2) Methods: We investigate if tumor transcriptomic ...
  • Optical Genome Mapping: A Promising New Tool to Assess Genomic Complexity in Chronic Lymphocytic Leukemia (CLL) 
    Puiggros, Anna; Ramos-Campoy, Silvia; Kamaso, Joanna; de-la-Rosa, Mireia; Salido, Marta; Melero, Carme; Rodríguez-Rivera, María; Bougeon, Sandrine; Collado, Rosa; Gimeno, Eva; García-Serra, Rocío; Alonso, Sara; Moro-García, Marco-Antonio; García-Malo, María-Dolores; Calvo, Xavier; Arenillas, Leonor; Ferrer, Ana; Mantere, Tuomo; Hoischen, Alexander; Schoumans, Jacqueline; Espinet, Blanca (MDPI, 2022-07)
    Novel treatments in chronic lymphocytic leukemia (CLL) have generated interest regarding the clinical impact of genomic complexity, currently assessed by chromosome banding analysis (CBA) and chromosomal microarray analysis ...
  • Characteristics and Outcomes of Adult Patients in the PETHEMA Registry with Relapsed or Refractory FLT3-ITD Mutation-Positive Acute Myeloid Leukemia 
    Martínez-Cuadrón, David; Serrano, Josefina; Mariz, José; Gil, Cristina; Tormo, Mar; Martínez-Sánchez, Pilar; Rodríguez-Arboli, Eduardo; García-Boyero, Raimundo; Rodríguez-Medina, Carlos; Martínez-Chamorro, Carmen; Polo, Marta; Bergua, Juan; Aguiar, Eliana; Amigo, María-Luz; Herrera, Pilar; Alonso-Domínguez, Juan-Manuel; Bernal, Teresa; Espadana, Ana; Sayas, María-José; Algarra, Lorenzo; Vidriales, María-B; Vasconcelos, Graca; Vives, Susana; Pérez-Encinas, Manuel-Mateo; López, Aurelio; Noriega, Víctor; García-Fortes, María; Chillón, María-del-Carmen; Rodríguez-Gutiérrez, Juan; Calasanz, María-José; Labrador, Jorge; López, Juan-A; Boluda, Blanca; Rodríguez-Veiga, Rebeca; Martínez-López, Joaquín; Barragán, Eva; Sanz, Miguel-Ángel; Montesinos, Pau (MDPI, 2022-06)
    This retrospective study investigated outcomes of 404 patients with relapsed/refractory (R/R) FMS-like tyrosine kinase 3 (FLT3)-internal tandem duplication (ITD) acute myeloid leukemia (AML) enrolled in the PETHEMA registry, ...
  • Allogeneic Stem Cell Transplantation in Mantle Cell Lymphoma; Insights into Its Potential Role in the Era of New Immunotherapeutic and Targeted Therapies: The GETH/GELTAMO Experience 
    Gutiérrez, Antonio; Bento, Leyre; Novelli, Silvana; Martín, Alejandro; Gutiérrez, Gonzalo; Queralt-Salas, María; Bastos-Oreiro, Mariana; Pérez, Ariadna; Hernani, Rafael; Viguria, María-Cruz; López-Godino, Oriana; Montoro, Juan; Piñana, José-Luis; Ferra, Christelle; Parody, Rocío; Martín, Carmen; Español-Morales, Ignacio; Yañez, Lucrecia; Rodríguez, Guillermo; Zanabili, Joud; Herrera, Pilar; Varela, María; Sampol, Antonia; Solano, Carlos; Caballero, Dolores (MDPI, 2022-06)
    Allo-SCT is a curative option for selected patients with relapsed/refractory (R/R) MCL, but with significant NRM. We present the long-term results of patients receiving allo-SCT in Spain from March 1995 to February 2020. ...
  • Prognostic and Predictive Effects of Tumor and Plasma miR-200c-3p in Locally Advanced and Metastatic Breast Cancer 
    Navarro-Manzano, Esther; Luengo-Gil, Ginés; González-Conejero, Rocío; García-Garre, Elisa; García-Martínez, Elena; García-Torralba, Esmeralda; Chaves-Benito, Asunción; Vicente, Vicente; Ayala-de-la-Peña, Francisco (MDPI, 2022-05)
    While the role of miR-200c in cancer progression has been established, its expression and prognostic role in breast cancer is not completely understood. The predictive role of miR-200c in response to chemotherapy has also ...
  • Persistent Large Granular Lymphocyte Clonal Expansions: "The Root of Many Evils"-And of Some Goodness 
    Bravo-Pérez, Carlos; Carrillo-Tornel, Salvador; García-Torralba, Esmeralda; Jerez-Cayuela, Andrés (MDPI, 2022-03)
    Large granular lymphocyte leukemia (LGLL) is a chronic disease of either mature phenotype cytotoxic CD3+ T lymphocytes or CD3- NK cells. LGLL diagnosis is hampered by the fact that reactive persistent clonal LGL expansions ...
  • Impact of Individual Comorbidities on Survival of Patients with Myelofibrosis 
    García-Fortes, María; Hernández-Boluda, Juan-Carlos; Álvarez-Larrán, Alberto; Raya, José-María; Angona, Anna; Estrada, Natalia; Fox, María-Laura; Cuevas, Beatriz; García-Hernández, María-C; Gómez-Casares, María-Teresa; Ferrer-Marín, Francisca; Saavedra, Silvana; Cervantes, Francisco; García-Delgado, Regina (MDPI, 2022-05)
    The comorbidity burden is an important risk factor for overall survival (OS) in several hematological malignancies. This observational prospective study was conducted to evaluate the impact of individual comorbidities on ...

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