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Envíos recientes

02.01.01. Investigación y comunicación científica: Envíos recientes

  • Diagnosis and treatment of malignant middle cerebral artery infarction and cerebellar infarction with mass effect. Recommendations of the Spanish Society of Neurology's Stroke Study Group 
    Moniche, F; Ponz, A; López-Cancio-Martínez, E; Rubiera, M; de-Lecinana, MA; Ayo, O; Castellanos, M; López-Fernández, J-C; Marta-Moreno, J; Morales-Ortiz, Ana-María; Ramírez-Moreno, JM; Tur, S; Ximénez-Carrillo, A; Freijo-Guerrero, M (ELSEVIER, 2026-07)
    AIMS: To update the recommendations of the Spanish Society of Neurology's Stroke Study Group on the diagnosis and treatment of malignant middle cerebral artery (MCA) infarction and malignant cerebellar infarction, including ...
  • Accuracy and variability of locoregional staging in T1 rectal cancer: nationwide multicentre cohort study 
    Daca-Álvarez, María; Manzotti, Cristina; Zaffalon, Diana; Portillo, Isabel; Bujanda, Luis; Gil-Lasa, Inés; Ibáñez-Sanz, Gemma; Sanjuan, Xavier; Herreros-de-Tejada, Alberto; Salces, Inmaculada; Aguilera, Lara; Ponce, Marta; Pizarro, Ángeles; Barquero, David; Puig, Ignasi; Díez-Redondo, Pilar; Martínez-de-Juan, Fernando; Morales, Victor-Jair; Alburquerque, Marco; Machlab, Salvador; Ferrandez, Ángel; Penas, Beatriz; Díaz-González, Álvaro; Sargatal, Lluisa; Jover, Rodrigo; Hernández, Luis; Pérez-Pedrosa, Alberto; Musulen, Eva; Hernández, Goretti; Trelles, Marita; Ono-Ono, Akiko; López-Vicente, Jorge; Bravo, Raquel; Ayuso, Juan-R; Gines, Angels; Saez-de-Gordoa, Karmele; Cuatrecasas, Miriam; Pellise, María (OXFORD UNIV PRESS, 2026-03-05)
    BACKGROUND: Accurate locoregional staging is critical in the management of T1 rectal cancer and guides organ-preserving strategies. Despite guideline recommendations, the real-world performance of magnetic resonance imaging ...
  • Delphy study on epidemiology, clinical management, disease burden, and treatment in paediatric patients with Duchenne muscular dystrophy in Spain 
    Pitarch-Castellano, I; Ortez-González, C-I; Nascimento-Osorio, A; Aguilera-López, P; Barca, M-O-Blanco; Camacho-Salas, A; García-Campos, O; García-Jiménez, M-C; García-Romero, M; Gómez-Andres, D; Grimalt-Calatayud, MA; Hernández-Fabián, Aranzazu; Malaga-Dieguez, I; Madruga-Garrido, M; Martí-Carrera, I; Martin-Viota, L; Martínez-García, M-J; Ramos-Fernández, JM; Sánchez-Carpintero-Abad, R; Vázquez-Martin, S; Giro-Perafita, A (ELSEVIER, 2026-07)
    INTRODUCTION: Duchenne muscular dystrophy (DMD) is a rare hereditary disease caused by mutations in the DMD gene, leading to progressive muscle weakness and degeneration. METHODS: Twenty paediatric neurologists with expertise ...
  • Elexacaftor/tezacaftor/ivacaftor for cystic fibrosis and rare CFTR variants: in vitro translation to a phase 3, double-blind, randomized, placebo-controlled trial, and real-world study 
    Castellani, Carlo; Mondéjar-López, Pedro; Van-Goor, Fredrick; Quon, Bradley-S; Alghisi, Federico; Fabrizzi, Benedetta; Ramsey, Bonnie; Taylor-Cousar, Jennifer-L; McKone, Edward-F; Tullis, Elizabeth; Weinstock, Tanya-G; Tan, Vincent; Ahluwalia, Neil; Mahic, Milada; Liu, Lingyun; Saayman, Sheena; Altshuler, David; Waltz, David; Mall, Marcus-A; Fajac, Isabelle (OXFORD UNIV PRESS, 2026-02-01)
    RATIONALE: Elexacaftor/tezacaftor/ivacaftor, a CF transmembrane conductance regulator (CFTR) modulator, stabilizes and restores F508del-CFTR function, which is the most common CFTR variant. In multiple clinical and real-world ...
  • Childhood-onset RASopathy-associated hypertrophic cardiomyopathy, diastolic dysfunction, and arrhythmias 
    Boleti, Olga-Dimitra; Roussos, Sotirios; Monda, Emanuele; Norrish, Gabrielle; Field, Ella; Cervi, Elena; Bakalakos, Athanasios; Fernandes, Precylia; Mcleod, Karen; Ilina, María; Khodaghalian, Bernadette; Jones, Caroline; Escudero-Cárceles, Fuensanta; Castro, Fransisco; Ali, Mohamed-Najih-Liaqath; Bharucha, Tara; Nepali, Gauri; Bhole, Vinay; Delle-Donne, Grazia; Brown, Elspeth; Gimeno-Blanes, Juan-Ramón; Elliott, Perry-Mark; Wolf, Cordula; Limongelli, Giuseppe; Kaski, Juan-Pablo (OXFORD UNIV PRESS, 2026-05-18)
  • Impact of dapagliflozin on key pathophysiological pathways underlying chronic heart failure progression: the DAPA-MODA biomarker study 
    Martínez-Pina, Veronica; Bayes-Genis, Antoni; Núñez, Julio; Riquelme-Pérez, Alejandro; Cebreiros-López, Iria; Morillas, Herminio; Cobo-Marcos, Marta; García-Pinilla, José-M; Rodríguez-Palomares, Juan-F; Dobarro, David; Restrepo-Cordoba, María-A; González-Juanatey, José-R; Zamorano, José-L; Noguera-Velasco, José-Antonio; Pascual-Figal, Domingo-Andrés (ELSEVIER, 2026-05)
    INTRODUCTION AND OBJECTIVES: Dapagliflozin improves clinical outcomes in patients with chronic heart failure (HF), irrespective of left ventricular ejection fraction. However, its effects on circulating biomarkers that ...
  • Genomic Surveillance and Antigenic Characterization of Respiratory Syncytial Virus (RSV) in Spain During the 2023-2024 Season of Nirsevimab Administration 
    Iglesias-Caballero, María; Mas, Vicente; Campoy, Albert; Calvo, Cristina; García, María-Luz; Alcolea, Sonia; Moreno-Parrado, Laura; Reina, Jordi; Navascues, Ana; Anton, Andrés; Davina-Núñez, Carlos; Pérez-Castro, Sonia; Costa, José; Fernández-González, Ana; Lepe, José-Antonio; Gaona, Cristina; Pérez, Zulema; García-Martínez-de-Artola, Diego; Vázquez-Moron, Sonia; Camarero, Sara; Cano, Olga; Pozo, Francisco; Casas, Inmaculada (OXFORD UNIV PRESS, 2026-02-18)
    Respiratory Syncytial Virus (RSV) is a leading cause of respiratory infections in infants and older adults. In Spain, surveillance is supported by the SiVIRA system and the RELECOV genomic sequencing network. The 2023-2024 ...
  • Knowledge, perception and predisposition to implement the MAPEX strategy in hospital pharmacy residents in Spain. FIRMAPEX project 
    Alfonsín-Lara, María; Areas-del-Aguila, Vera; Contreras-Macias, Enrique; Mancebo-González, Almudena; Martínez-Castro, Beatriz; Pérez-Menéndez-Conde, Covadonga; Sanmartin-Fenollera, Patricia; Morillo-Verdugo, Ramón (ELSEVIER, 2026-01)
  • Co-mutation signatures are age-dependent and impact the prognosis in NPM1-mutated acute myeloid leukemia: a PETHEMA multicenter study. 
    Gil, José-Vicente; Sargas, Claudia; Ayala, Rosa; Gutiérrez, Norma-Carmen; Pérez-Simon, José-Antonio; Gómez-Casares, María-Teresa; Larrayoz, María-José; Prados-de-la-Torre, Esther; Cano-Ferri, Isabel; Navarro, Irene; Gil, Cristina; Bernal, Teresa; Rodríguez-Arboli, Eduardo; Pérez-Santaolalla, Esther; Colmenares, Rafael; Tormo, Mar; Bergua, Juan; Amigo, María-Luz; Rodríguez-Medina, Carlos; Serrano, Josefina; Oliva, Ana-Yurena; Alonso-Domínguez, Juan-Manuel; Noriega, Víctor; Algarra, Lorenzo; Olave, María-Teresa; García-Pérez, María-José; Couto, Carmen; Almela, Agata; García-Fortes, María; Madrigal, María-Dolores; Hermosin, María-Lourdes; Colorado, Mercedes; García-Boyero, Raimundo; Ibáñez, Francisco; Sole, María; Martínez-Chamorro, Carmen; Mateos, María-Del-Carmen; García-Garay, María-Del-Carmen; Solana-Altabella, Antonio; Martin-Herreros, Beatriz; Martínez-López, Joaquín; Chillón, María-Del-Carmen; Soria, Elena; Bilbao, Cristina; Calasanz, María-José; Sánchez-García, Joaquín; Barragán, Eva; Montesinos, Pau (FERRATA STORTI FOUNDATION, 2026-07-16)
    NPM1-mutated acute myeloid leukemia is genetically heterogeneous, and risk assessment remains focused exclusively on FLT3-ITD despite the potential role of other co-mutations. We retrospectively analyzed 1,360 adults from ...
  • Mutational profile and cardiovascular risk factors impact prognosis in triple-negative essential thrombocythemia 
    Carreño-Tarragona, Gonzalo; Gil-Manso, Rodrigo; Hernández-Boluda, Juan-Carlos; Martínez-Ávila, José-Carlos; Bellosillo, Beatriz; Pérez-López, Raúl; Segura, Adrián; Ferrer-Marín, Francisca; Arellano-Rodrigo, Eduardo; Angona, Anna; García-Gutiérrez, Valentín; Noya, María-Soledad; Blanco, Ángela; Zamora, Lurdes; Navarro, Miguel; Senin, Alicia; Magro, Elena; Pastor-Galan, Irene; Mata-Vázquez, María-Isabel; Morales, María-Luz; Cuevas, Beatriz; Velez, Patricia; Mora, Elvira; Martínez-Bilbao, Cristina; Colmenares, Rafael; Alonso, Juan-Manuel; Pérez-Encinas, Manuel; Caballero-Navarro, Gonzalo; Cortes, Miguel-Ángel; Santaliestra, Marta; Raya, José-María; Blanco-Sánchez, Alberto; Hernández-Rivas, Jesus-María; Martínez-López, Joaquín; Ayala, Rosa; Álvarez-Larran, Alberto (SPRINGERNATURE, 2026-07-13)
    Triple-negative essential thrombocythemia (TN-ET) represents a diagnostic and therapeutic challenge. The aim of the present study was to identify prognostic factors useful for tailoring treatment. 241 TN-ET patients with ...
  • Automatic Evaluation of Small Bowel Cleanliness in Capsule Endoscopy: A Comparative Study of Four Preparations using Artificial Intelligence 
    Nevarez, Andrea; Noorda, Reinier; Alonso-Lazaro, Noelia; Carretero, Cristina; Prieto-de-Frias, César; González-Suárez, Begoña; Giordano, Antonio; Jiménez-García, Victoria-Alejandra; Lorenzo-González, Laura; Caunedo-Álvarez, Ángel; Valle-Muñoz, Julio; García-Vela, Almudena; Lujan-Sanchis, Marisol; Ruiz-Sánchez, Lucía; Sánchez-Ceballos, Francisco; Mendoza-Hernández, Juan-Luis; García-Lledo, Javier; Nogales-Rincon, Óscar; Egea-Valenzuela, Juan; Mesa-López, María-José; Merino-Zubizarreta, Ainara; Estevez-Boullosa, Pamela; Martínez-Turnes, Alfonso; Bustamante-Balen, Marco; Naranjo, Valery; Pons-Beltrán, Vicente (GEORG THIEME VERLAG KG, 2026-07-03)
    Background Diagnostic yield (DY) of small bowel capsule endoscopy (SBCE) is limited by the presence of intestinal content. An objective assessment of the cleanliness grade of the small bowel (SB) is currently lacking. We ...
  • First national study on the ethical dimension of neonatal nursing 
    Jiménez-Flores, Javier; Casado-Rodríguez, Aroa; Fernández-Tunas, María-del-Carmen; Laiz-Rodríguez, Marta-Eva; Salcedo-Madridejos, Ángel; Sánchez-Suárez, Patricia; Lambea-Rueda, Leticia; Torres-López, Lorena; Molina-Ruiz, Cristina; Jiménez-Herrera, María-F; Bazo-Hernández, Leticia (SAGE PUBLICATIONS LTD, 2026-07-08)
    BackgroundNeonatal nursing care requires ethical competence alongside technical expertise. Despite progress in Spain, disparities persist in ethical training and professional autonomy in neonatal units.ObjectiveTo examine ...
  • Landscape of copy number variants in Spanish people with dementia. 
    de-Rojas, Itziar; García-González, Pablo; Olive, Claudia; Puerta, Raquel; Montrreal, Laura; Alegret, Montserrat; Sotolongo-Grau, Óscar; Cano, Amanda; Marquie, Marta; Valero, Sergi; Calero, Miguel; Rabano, Alberto; Pastor, Ana-Belén; del-Ser, Teodoro; Quintela, Inés; Macias, Juan; Corma-Gómez, Anais; Pineda, Juan-A; Franco-Macias, Emilio; Buiza-Rueda, Dolores; Bernal-Sánchez-Arjona, Maria; Royo, José-Luis; Mendoza, Silvia; Lage, Carmen; Antúnez-Almagro, Carmen; Corbaton-Anchuelo, Arturo; Martínez-Larrad, María-Teresa; Díez-Fairen, Mónica; Álvarez, Ignacio; Huerto-Vilas, Raquel; Arias-Pastor, Alfonso; Menendez-González, Manuel; Martínez-Rodríguez, Carmen; Rosas-Allende, Irene; García-Madrona, Sebastián; Frank-García, Ana; Martin-Montes, Ángel; Baquero, Miquel; Pérez-Tur, Jordi; Bullido, María-J; García-Ribas, Guillermo; Álvarez, Victoria; Pinol-Ripoll, Gerard; Pastor, Pau; Rodríguez-Rodríguez, Eloy; García-Alberca, José-María; Mir, Pablo; Real, Luis-M; Medina, Miguel; Saez, María-Eugenia; Carracedo, Ángel; Heneka, Michael-T; Tarraga, Lluis; Boada, Merce; Sánchez-Juan, Pascual; Fernández, M-Victoria; van-der-Lee, Sven-J; Ruiz, Agustin (SPRINGERNATURE, 2026-06-30)
    Recent studies suggest that copy number variants (CNVs) may contribute to the missing heritability of complex diseases such as Alzheimer's disease (AD) and related dementias (ADRD). We performed a CNV analysis using ...
  • ELECLA trial: final results of perioperative chemotherapy with fluoropyrimidine and oxaliplatin in mismatch repair proficient locally advanced colon cancer 
    Arredondo, J; Aliseda, D; Castañón, C; Pastor, E; Tejedor, P; Muinelo, M; Pastor, C; García-Flórez, L; Vigorita, V; Gallarin, I; Montoya, M; Tasende, M; García, F; Rodríguez, P; Ruiz-de-la-Hermosa, A; Simo, V; Álvarez, C; Rodríguez, C; Núñez-Cordoba, JM; Rodríguez, J (ELSEVIER, 2026-07)
    BACKGROUND: The current standard of care for resectable locally advanced colon cancer (LACC) is based on upfront surgery followed by adjuvant chemotherapy (AC). This study aimed to evaluate the safety and efficacy of ...
  • Polyphenols increase circulating lipids but improve LDL particle quality and reduce LDL oxidation in postmenopausal women: metabotype- and age-dependent effects in a randomised, placebo-controlled crossover trial 
    García-Nicolas, María; Jarrin-Orozco, María-Paula; Romo-Vaquero, María; Carrascosa, Concepcion; Avilés-Plaza, Francisco; Martínez-Villanueva, Miriam; Noguera, José-Antonio; Ávila-Gálvez, María-Ángeles; Espin, Juan-Carlos (SPRINGER HEIDELBERG, 2026-08)
    PURPOSE: Menopause increases cardiometabolic risk via dyslipidaemia, oxidative stress, and low-grade inflammation. Polyphenols may modulate these processes, but human evidence is inconsistent. We investigated the effects ...
  • Tracing the pathogenic PLN p.(Arg14del) variant across the globe; more than just a local curiosity 
    van-Drie, Esmee; van-Lint, Freyja-H-M; Zwart, Rob; Wang, Jie; Chen, Yucheng; Postma, Alex-V; Elferink, Martin-G; van-Steenbrugge, Joris-J-M; van-der-Zwaag, Paul-A; Jongbloed, Jan-D-H; Dooijes, Dennis; van-der-Heide, Myrthe-Y-C; Houweling, Arjan-C; Haugaa, Kristina-H; Leren, Ida-Skrinde; Kostareva, Anna; Milting, Hendrik; Nguyen, Thuy-Vy; Huynh, Thuy-Duong-Ho; Chevalier, Philippe; Deliniere, Antoine; Gimeno-Blanes, Juan-Ramón; Sabater-Molina, María; Barriales-Villa, Roberto; Mazzanti, Andrea; Memmi, Mirella; Kuramoto, Yuki; Tabata, Tomoka; Wilde, Arthur-A-M; van-Spaendonck-Zwarts, Karin-Y; van-Tintelen, J-Peter (SPRINGER, 2026-12)
    Studying the global distribution of the pathogenic variant c.40_42delAGA;p.(Arg14del) in the phospholamban (PLN) gene is highly important for raising awareness among healthcare providers and may help uncover factors ...
  • Advances in pig embryo production for cryopreservation, transfer and genome editing 
    Cuello, Cristina; García-Cánovas, Manuela; Torregrosa-fuentes, Marcos; López-jara, Adelina; Parrilla, Inmaculada; Gil, M-Antonia; Martínez, Emilio-A (SOCIETY REPRODUCTION & DEVELOPMENT-SRD, )
    Pig embryo production has emerged as a cornerstone for advancing both agricultural efficiency and biomedical innovation. In vivo-derived embryos remain the gold standard for cryopreservation and embryo transfer due to their ...
  • Intertwin birth weight discordance, mode of delivery, and fetal and neonatal outcomes in twin pregnancies 
    Martínez-Zarco, Ana; Sánchez-Romero, Javier; Blanco-Carnero, José-Eliseo; Crespo-Bañón, Paz; Liandro, Romina-Sol; Pertegal-Ruiz, Miriam; Plasencia-Acevedo, Walter; Nieto-Díaz, Aníbal; de-Paco-Matallana, Catalina (WILEY, 2026-06-13)
    OBJECTIVE: The aim of the present study was to evaluate the association between intertwin birth weight discordance and fetal and neonatal outcomes in twin pregnancies, and to assess its relationship with mode of delivery. ...
  • Zebrafish dspb-/- mutant as a model for non-dilated left ventricular cardiomyopathy: exploring cardiac dysfunction and exercise modulation 
    Munteanu, Serena; Wagih-Gómez, Jesus; Júdez-Serrano, Ángel; Saura-Espín, Daniel; Santos-Mateo, Juan-José; Nicolas-Rocamora, María-Elisa; Gil-Ortuno, Cristina; Bernabé-García, Ángel; Gimeno-Blanes, Juan-Ramón; Cayuela-Fuentes, María-Luisa; Sabater-Molina, María (SPRINGERNATURE, 2026-06-15)
    Truncating variants in the DSP gene are associated with non-dilated left ventricular cardiomyopathy (ND-LVC), characterized by impaired ventricular function without dilation. The influence of physical activity in disease ...
  • Real-world pegcetacoplan treatment of paroxysmal nocturnal hemoglobinuria patients with an unsatisfactory response to prior therapies 
    Vallejo, Carlos; González, Carmen; Gaya, Anna; de-la-Iglesia, Silvia; Tormo, Mar; Benet, Carmen; Lavilla, Esperanza; Fernández, Ana; Beneitez, David; Bonanad, Santiago; Carnicero, Fernando; Díaz, Bianca; González, Fernando-Ataulfo; González-Rodríguez, Ana-Pilar; Hernández, Inés; Martí, Jaime; Melero, Virginia; Morado, Marta; Salido-Fiérrez, Eduardo-José; Sánchez, Piva; Torres, Williana; Vara, Miriam; Vidan, Julia (TAYLOR & FRANCIS LTD, 2026-12-31)
    OBJECTIVES: Terminal complement inhibitors can control intravascular hemolysis in Paroxysmal Nocturnal Hemoglobinuria (PNH) patients, although the hematological response achieved may not persist, and it may become ...

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