Repositorio Dspace

Envíos recientes

03. IMIB (Instituto Murciano de Investigación Biosanitaria Pascual Parrilla): Envíos recientes

  • The peripheral immune landscape of human breast cancer 
    García-Torralba, Esmeralda; Buque, Aitziber; Galluzzi, Lorenzo (TAYLOR & FRANCIS INC, 2026-12-31)
    The clinical management of patients with breast cancer is largely dictated by tumor stage, disease subtype and (at least in some settings) specific molecular features thereof (e.g., BRCA1 mutations, PD-L1 positivity). ...
  • Moderate NEFA reprogram early follicular development and oocyte competence: evidence for a targetable redox mechanism 
    Rojo-Fleming, Camila; Di-Berardino, Chiara; Peserico, Alessia; Canciello, Angelo; Rapini, Chiara-Camerano-Spelta; Sacchetti, Gianna; Capacchietti, Giulia; D'Antonio, Veronica; Angelino, Donato; Serafini, Mauro; Cánovas-Bernabé, Sebastián; Barboni, Barbara (FRONTIERS MEDIA SA, 2026-06-17)
    INTRODUCTION: Elevated circulating non-esterified fatty acids (NEFA), a hallmark of metabolic stress and negative energy balance, are increasingly associated with reduced female fertility. While most studies focus on late ...
  • Associations of proteomic age clocks with lifestyle risk factors, incident chronic diseases and mortality in two European cohorts 
    Robinson, Oliver; Xiao, Han; Homann, Jan; Viallon, Vivian; Ferrari, Pietro; Frank, Philipp; Huerta-Castaño, José-María; Jiménez-Zabala, Ana; Kaaks, Rudolf; Katzke, Verena; Kivimaki, Mika; Langenberg, Claudia; Lau, Chung-Ho-E; Middleton, Lefkos; Onland-Moret, N-Charlotte; Panico, Salvatore; Prizment, Anna; Ricceri, Fulvio; Sánchez, María-José; Smith-Byrne, Karl; Verschuren, W-M-Monique; Vermeulen, Roel; Vineis, Paolo; Wang, Shuo; Wareham, Nick; Lill, Christina-M; Riboli, Elio; Gunter, Marc-J (SPRINGERNATURE, 2026-06-29)
    Assessment of biological aging using proteomic clocks may enhance risk prediction and elucidate the molecular links between aging and chronic diseases. Here, among 17,473 participants of the European Prospective Investigation ...
  • Platelet proteome links metabolism to reactivity in Essential Thrombocythemia. 
    Guerrero-Carreno, Xiomara; Smits, Sanne; Esteban-Lasso, Alfonso; Samiotaki, Martina; Navarro, Virtu-Calabuig; Iborra, Francisco-Jose; Rantanen, Frida; Álvarez-Larran, Alberto; Angona-Figueras, Anna; Bellosillo, Beatriz; Saen-Marin, Adolfo-J; García-Gutiérrez, Valentín; Dekkers, Dick; Demmers, Jeroen; Ferrer-Marín, Francisca; Hernández-Boluda, Juan-Carlos; Matsakas, Antonios; Benavente-Cuesta, Celina; Vandenberghe, Peter; Papadopoulos, Petros (ELSEVIER, 2026-06)
    Essential thrombocythemia (ET) is a myeloproliferative neoplasm in which JAK2, CALR, and MPL mutations are associated with distinct clinical phenotypes. Here, we analyzed the platelet proteome of ET patients by MS, combined ...
  • Polyphenols increase circulating lipids but improve LDL particle quality and reduce LDL oxidation in postmenopausal women: metabotype- and age-dependent effects in a randomised, placebo-controlled crossover trial 
    García-Nicolas, María; Jarrin-Orozco, María-Paula; Romo-Vaquero, María; Carrascosa, Concepcion; Avilés-Plaza, Francisco; Martínez-Villanueva, Miriam; Noguera, José-Antonio; Ávila-Gálvez, María-Ángeles; Espin, Juan-Carlos (SPRINGER HEIDELBERG, 2026-08)
    PURPOSE: Menopause increases cardiometabolic risk via dyslipidaemia, oxidative stress, and low-grade inflammation. Polyphenols may modulate these processes, but human evidence is inconsistent. We investigated the effects ...
  • Common and rare variants in complement genes as biomarkers of COVID-19 infection and severity. A lesson to learn for emerging pathogens 
    de-la-Morena-Barrio, María-Eugenia; van-den-Rym, Ana; Escorial-Sanz, Olga; Corvillo, Fernando; García-Sánchez, Rosario; González-Sánchez, Laura; Muñoz-Barrera, Adrián; González-Montelongo, Rafaela; Lorenzo-Salazar, José-Miguel; Flores, Carlos; de-Andres-Martin, Ana; Rodríguez-Gallego, Carlos; Allende, Luis; Alsina, Laia; Sánchez-Ramon, Silvia; López-Collazo, Eduardo; López-Trascasa, Margarita; Sánchez-Corral, Pilar; Pérez-de-Diego, Rebeca; Corral, Javier; López-Lera, Alberto (FRONTIERS MEDIA SA, 2026-06-11)
    INTRODUCTION: The first wave of Coronavirus disease 2019 (COVID-19), driven by the global emergence of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), severely affected Spain with high infection and mortality ...
  • Exploring mechanisms of scar-free skin wound healing in adult zebrafish in comparison to mouse 
    Kucukaylak, Ismail; Halwas, Kai; Martínez-Morcillo, Francisco-Javier; Reiche, Nils; Metzger, Manuel; Comelli, Petra; Voigt, Birgit; Brinckmann, Jurgen; Eming, Sabine; Hammerschmidt, Matthias (PUBLIC LIBRARY SCIENCE, 2026-06-24)
    Adult zebrafish have the ability to perfectly regenerate their skin after injury without leaving a scar behind. Yet, they intermediately form a collagen-rich granulation tissue that later fully regresses. In contrast, adult ...
  • Immune Markers and Risk of Pancreatic Cancer in the European EPIC Cohort 
    Katzke, Verena; Chen, Yue; Dutta, Srimanti; Canzian, Federico; Andersen, Julie-Louise-Munk; Rostgaard-Hansen, Agnetha-Linn; Bouteille, Lea; Rebours, Vinciane; Truong, Therese; Schulze, Matthias-B; Bendinelli, Benedetta; Pala, Valeria; Simeon, Vittorio; Tumino, Rosario; Sacerdote, Carlotta; Vermeulen, Roel; Kolijn, P-Martijn; Elias, Sjoerd-G; Crous-Bou, Marta; Sánchez, María-José; Jiménez-Zabala, Ana; Huerta-Castaño, José-María; Guevara, Marcela; Wareham, Nick; Breeur, Marie; Johansson, Mattias; Yarmolinsky, James; Campa, Daniele; Kaaks, Rudolf (WILEY, 2026-06-23)
    The immune system is a major driver in pancreatic cancer development. Several prospective cohort studies have found associations for single immune system-derived proteins such as IL6 or CRP, but results are inconclusive, ...
  • History of sexually transmitted infections among mpox cases in the 2022 outbreak in Spain 
    March-Yague, Aina; Toledo, Diana; Díaz, Asunción; Godoy, Pere; Pérez-Martínez, Olaia; Pericas, Carles; Sánchez-Migallon, Alonso; Chirlaque-López, María-Dolores; Ospina, Jesús; Grau, María; Roig, Francisco; Domínguez, Ángela (WILEY, 2026-06-19)
    OBJECTIVE: The aim was to describe the history of sexually transmitted infections (STIs) among adult mpox men cases and to analyse sociodemographic and epidemiological characteristics according to the presence or absence ...
  • Advances in pig embryo production for cryopreservation, transfer and genome editing 
    Cuello, Cristina; García-Cánovas, Manuela; Torregrosa-fuentes, Marcos; López-jara, Adelina; Parrilla, Inmaculada; Gil, M-Antonia; Martínez, Emilio-A (SOCIETY REPRODUCTION & DEVELOPMENT-SRD, )
    Pig embryo production has emerged as a cornerstone for advancing both agricultural efficiency and biomedical innovation. In vivo-derived embryos remain the gold standard for cryopreservation and embryo transfer due to their ...
  • Intertwin birth weight discordance, mode of delivery, and fetal and neonatal outcomes in twin pregnancies 
    Martínez-Zarco, Ana; Sánchez-Romero, Javier; Blanco-Carnero, José-Eliseo; Crespo-Bañón, Paz; Liandro, Romina-Sol; Pertegal-Ruiz, Miriam; Plasencia-Acevedo, Walter; Nieto-Díaz, Aníbal; de-Paco-Matallana, Catalina (WILEY, 2026-06-13)
    OBJECTIVE: The aim of the present study was to evaluate the association between intertwin birth weight discordance and fetal and neonatal outcomes in twin pregnancies, and to assess its relationship with mode of delivery. ...
  • Zebrafish dspb-/- mutant as a model for non-dilated left ventricular cardiomyopathy: exploring cardiac dysfunction and exercise modulation 
    Munteanu, Serena; Wagih-Gómez, Jesus; Júdez-Serrano, Ángel; Saura-Espín, Daniel; Santos-Mateo, Juan-José; Nicolas-Rocamora, María-Elisa; Gil-Ortuno, Cristina; Bernabé-García, Ángel; Gimeno-Blanes, Juan-Ramón; Cayuela-Fuentes, María-Luisa; Sabater-Molina, María (SPRINGERNATURE, 2026-06-15)
    Truncating variants in the DSP gene are associated with non-dilated left ventricular cardiomyopathy (ND-LVC), characterized by impaired ventricular function without dilation. The influence of physical activity in disease ...
  • Genetic and environmental influences on educational disparities in adult weight change: an individual-based pooled analysis of 11 twin cohorts 
    Obeso, Álvaro; Drouard, Gabin; Jelenkovic, Aline; Medda, Emanuela; Fagnani, Corrado; Toccaceli, Virgilia; Latvala, Antti; Aaltonen, Sari; Medland, Sarah-E; Gordon, Scott-D; Lee, Jooyeon; Lee, Soo-Ji; Sung, Joohon; Pyun, Hyojin; Duncan, Glen-E; Buchwald, Dedra; Ordoñana, Juan-Ramón; Sánchez-Romera, Juan-F; Carrillo-Verdejo, Eduvigis; Franz, Carol-E; Kremen, William-S; Corley, Robin-P; Huibregtse, Brooke-M; Magnusson, Patrik-K-E; Karlsson, Ida-K; Aslan, Anna-K-Dahl; Lyons, Michael-J; Bartels, Meike; Ligthart, Lannie; de-Geus, Eco-J-C; Gatz, Margaret; Butler, David-A; Pool, Rene; Eriksson, Anders; Bruins, Susanne; Martin, Nicholas-G; Boomsma, Dorret-I; Kaprio, Jaakko; Silventoinen, Karri (SPRINGERNATURE, 2026-06-12)
    INTRODUCTION: Educational attainment (EA) is negatively associated with body mass index (BMI), but less is known about the association between EA and adult BMI change. We analysed the role of genetic and environmental ...
  • Impact-acceleration head injury results in optic neuropathy in the thirteen-lined ground squirrel. 
    Nadal-Nicolás, Francisco-M; Gold, Eve; Fu, Amanda; Kim, Yeonho; Gao, Yue; McCabe, Joseph; Miyagishima, Kiyoharu-J (SPRINGERNATURE, 2026-06-09)
    Traumatic brain injury (TBI) caused by rapid head acceleration produces visual impairments from damage to the optic nerve (ON), as well as widespread perturbations of the central visual system. Widely used mouse and rat ...
  • Worldwide Impact of Human Development and Inequality on the Prevalence of Asthma, Rhinoconjunctivitis and Eczema. Global Asthma Network's Ecological Study 
    García-Marcos, Luis; Chiang, Chen-Yuan; Asher, M-Innes; Marks, Guy-B; El-Sony, Asma; Masekela, Refiloe; Bissell, Karen; Ellwood, Eamon; Ellwood, Philippa; Pearce, Neil; Strachan, David-P; Martínez-Torres, A-Elena; Sánchez-Solís, Manuel; Mortimer, Kevin; Morales, Eva (WILEY, 2026-06-04)
    BACKGROUND: Lower-income countries have lower asthma prevalence. However, how differences in human development and inequality can explain changes in the prevalence of asthma and allergic diseases is not known. METHODS: The ...
  • The study of immunological markers in tuberculosis across animal models and its translation to human research 
    Díaz-Fernández, Sergio; Aleluia, Matilde; Saraiva, Margarida; Soldevilla, Pablo; Torrelles, Jordi-B; Sharan, Riti; Verreck, Frank-A-W; Izzo, Angelo; Vidal, María; Moreira, Ana-C; Pérez-de-Val, Bernat; Roca-Soler, Francisco-Jose; Preda, Madalina; Torrents, Eduard; Julian, Esther; Domínguez, José; Latorre, Irene (SPRINGERNATURE, 2026-07)
    Tuberculosis (TB), a disease caused by Mycobacterium tuberculosis, remains one of the major causes of death from infection worldwide, with over a million associated deaths each year. The study of biomarkers for TB is ...
  • Fingolimod increases cellular resistance to HIV-1 infection and limits viral reservoir size in peripheral CD4+ T-cells 
    Moraga, Elisa; Climent, Nuria; Sánchez-Molina, Alejandro; Vicens-Artes, Sonia; Maleno, María-José; Valero-López, Gabriel; Galera-Peñaranda, Carlos; Ambrosioni, Juan; Miro, José-M; Mallolas, Josep; Albendin-Iglesias, Helena; Alcami, José; Sánchez-Palomino, Sonsoles (PUBLIC LIBRARY SCIENCE, 2026-06-03)
    BACKGROUND: Fingolimod, a treatment for multiple sclerosis (MS), decreases autoreactive lymphocytes by lymph node sequestration. In vitro, fingolimod decreases HIV-1 infection and viral reservoir (VR) through SAMHD1 ...
  • A targeted combination therapy achieves effective pancreatic cancer regression and prevents tumor resistance 
    Liaki, Vasiliki; Barrambana, Sara; Kostopoulou, Myrto; Lechuga, Carmen-G; Zamorano-Domínguez, Elena; Acosta-Gallego, Domingo; Morales-Cacho, Lucía; Álvarez, Ruth; Sun, Pian; Rosas-Pérez, Blanca; Barrero, Rebeca; Jiménez-Parrado, Silvia; López-García, Alejandra; San-Roman, Marta; López-Gil, Juan-Carlos; Drosten, Matthias; Sainz, Bruno; Musteanu, Mónica; Caleiras, Eduardo; Dusetti, Nelson; Poli, Valeria; Sánchez-Bueno, Francisco; Guerra, Carmen; Barbacid, Mariano (NATL ACAD SCIENCES, 2026-06-09)
    Pancreatic ductal adenocarcinoma (PDAC) has one of the lowest cancer survival rates. Recent studies using RAS inhibitors have opened the door to more efficacious therapies although their beneficial effect is still limited ...
  • Midazolam prescription as a trigger for potential deceased donor identification outside the ICU: a prospective feasibility study. 
    Encarnación-Navarro, Juan-Antonio; Domínguez-Gil, B; Pellicer-Franco, Consuelo; Fernández, R; Moya, J; Ortin, A; Mansó-Murcia, Clara; Fernández, M; Lucas, C; Jimena-Pérez, Rocío; López, N; Alonso-Romero, José-Luis; Ruiz, P; Ortega-López, Nicolas; Royo-Villanova, Mario (SPRINGER, 2026-05-29)
    BACKGROUND: Systematic identification of potential deceased organ donors outside the intensive care unit (ICU) remains challenging. Patients receiving palliative sedation are rarely evaluated for donation, particularly in ...
  • Non-decameric NLRP3 reveals a TGN/MTOC-distal pathway of inflammasome activation 
    Mateo-Tortola, María; Hochheiser, Inga-V; Li, Gaopeng; Funk, Lukas; Hashemi, Atousa; Liu, Xiao; Torp, Jane; Erlebach, Lena; Szolek, Andras; Grga, Jelena; Bork, Francesca; Muller, Jana-S; Kronenberg-Versteeg, Deborah; Geyer, Matthias; Weber, Alexander-N-R; Tapia-Abellán, Ana (SPRINGERNATURE, 2026-05-30)
    The NLRP3 inflammasome contributes to a wide range of conditions from infections to Alzheimer's disease. NLRP3 forms an inactive decameric cage, that upon interaction with the trans-Golgi network (TGN) and microtubule ...

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