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Repositorio Institucional en Ciencias de la Salud de la Región Murcia: Envíos recientes

  • Antizyme Inhibitors in Polyamine Metabolism and Beyond: Physiopathological Implications 
    Ramos-Molina, Bruno; Lambertos, Ana; Peñafiel, Rafael (MDPI, 2018-10-09)
    The intracellular levels of polyamines, cationic molecules involved in a myriad of cellular functions ranging from cellular growth, differentiation and apoptosis, is precisely regulated by antizymes and antizyme inhibitors ...
  • Flavonoids and the Risk of Gastric Cancer: An Exploratory Case-Control Study in the MCC-Spain Study 
    Vitelli-Storelli, Facundo; Molina, Antonio-José; Zamora-Ros, Raul; Fernández-Villa, Tania; Roussou, Vasiliki; Romaguera, Dora; Aragonés, Nuria; Obon-Santacana, Mireia; Guevara, Marcela; Gómez-Acebo, Ines; Fernández-Tardon, Guillermo; Molina-Barceló, Ana; Olmedo-Requena, Rocío; Capelo, Rocío; Chirlaque-López, María-Dolores; Pérez-Gómez, Beatriz; Moreno, Victor; Castilla, Jesús; Rubin-García, María; Pollan, Marina; Kogevinas, Manolis; Barrio-Lera, Juan-Pablo; Martín, Vicente (MDPI, 2019-05)
    Several epidemiological studies have investigated the association between the dietary flavonoid intake and gastric cancer (GC) risk; however, the results remain inconclusive. Investigating the relationship between the ...
  • Melanopsin+RGCs Are fully Resistant to NMDA-Induced Excitotoxicity 
    Vidal-Villegas, Beatriz; Di-Pierdomenico, Johnny; Miralles-de-Imperial-Ollero, Juan-A; Ortin-Martínez, Arturo; Nadal-Nicolás, Francisco-M; Bernal-Garro, Jose-M; Cuenca-Navarro, Nicolas; Villegas-Pérez, María-Paz; Vidal-Sanz, Manuel (MDPI, 2019-06-02)
    We studied short- and long-term effects of intravitreal injection of N-methyl-d-aspartate (NMDA) on melanopsin-containing (m(+)) and non-melanopsin-containing (Brn3a(+)) retinal ganglion cells (RGCs). In adult SD-rats, the ...
  • A Proposed Methodology to Analyze Plant Growth and Movement from Phenomics Data 
    Victoria-Díaz-Galián, María; Pérez-Sanz, Fernando; David-Sánchez-Pagan, Jose; Weiss, Julia; Egea-Cortines, Marcos; Navarro, Pedro-J (MDPI, 2019-12-01)
  • Circulating Metabolites Associated with Alcohol Intake in the European Prospective Investigation into Cancer and Nutrition Cohort 
    van-Roekel, Eline-H; Trijsburg, Laura; Assi, Nada; Carayol, Marion; Achaintre, David; Murphy, Neil; Rinaldi, Sabina; Schmidt, Julie-A; Stepien, Magdalena; Kaaks, Rudolf; Kuehn, Tilman; Boeing, Heiner; Iqbal, Khalid; Palli, Domenico; Krogh, Vittorio; Tumino, Rosario; Ricceri, Fulvio; Panico, Salvatore; Peeters, Petra-H; Bueno-de-Mesquita, Bas; Ardanaz, Eva; Luján-Barroso, Leila; Quirós, J-Ramón; Huerta-Castaño, José-María; Molina-Portillo, Elena; Dorronsoro, Miren; Tsilidis, Konstantinos-K; Riboli, Elio; Rostgaard-Hansen, Agnetha-Linn; Tjonneland, Anne; Overvad, Kim; Weiderpass, Elisabete; Boutron-Ruault, Marie-Christine; Severi, Gianluca; Trichopoulou, Antonia; Karakatsani, Anna; Kotanidou, Anastasia; Hakansson, Anders; Malm, Johan; Weijenberg, Matty-P; Gunter, Marc-J; Jenab, Mazda; Johansson, Mattias; Travis, Ruth-C; Scalbert, Augustin; Ferrari, Pietro (MDPI, 2018-05)
    Identifying the metabolites associated with alcohol consumption may provide insights into the metabolic pathways through which alcohol may affect human health. We studied associations of alcohol consumption with circulating ...
  • The Snapdragon LATE ELONGATED HYPOCOTYL Plays A Dual Role in Activating Floral Growth and Scent Emission 
    I; Pérez-Sanz, Fernando; Navarro, Pedro-J; Weiss, Julia; Egea-Cortines, Marcos (MDPI, 2019-08)
    The plant circadian clock controls a large number of internal processes, including growth and metabolism. Scent emission displays a circadian pattern in many species such as the snapdragon. Here we show that knocking down ...
  • The Petunia CHANEL Gene is a ZEITLUPE Ortholog Coordinating Growth and Scent Profiles 
    Terry, Marta-I; Pérez-Sanz, Fernando; Victoria-Díaz-Galián, M; Pérez-de-los-Cobos, Felipe; Navarro, Pedro-J; Egea-Cortines, Marcos; Weiss, Julia (MDPI, 2019-04)
    The floral perianth, comprising sepals and petals, conceals the sexual organs and attracts pollinators. The coordination of growth and scent emission is not fully understood. We have analyzed the effect of knocking down ...
  • Melanin and Melanin-Related Polymers as Materials with Biomedical and Biotechnological Applications-Cuttlefish Ink and Mussel Foot Proteins as Inspired Biomolecules 
    Solano, Francisco (MDPI, 2017-07)
    The huge development of bioengineering during the last years has boosted the search for new bioinspired materials, with tunable chemical, mechanical, and optoelectronic properties for the design of semiconductors, batteries, ...
  • On the Metal Cofactor in the Tyrosinase Family 
    Solano, Francisco (MDPI, 2018-02)
    The production of pigment in mammalian melanocytes requires the contribution of at least three melanogenic enzymes, tyrosinase and two other accessory enzymes called the tyrosinase-related proteins (Trp1 and Trp2), which ...
  • An Interoperable System toward Cardiac Risk Stratification from ECG Monitoring 
    Soguero-Ruiz, Cristina; Mora-Jiménez, Inmaculada; Ramos-López, Javier; Quintanilla-Fernández, Teresa; García-García, Antonio; Díez-Mazuela, Daniel; García-Alberola, Arcadio; Rojo-Álvarez, José-Luis (MDPI, 2018-03)
    Many indices have been proposed for cardiovascular risk stratification from electrocardiogram signal processing, still with limited use in clinical practice. We created a system integrating the clinical definition of cardiac ...
  • Biomarkers and polymorphisms in pancreatic neuroendocrine tumors treated with sunitinib 
    Jiménez-Fonseca, Paula; Martín, Miguel-Navarro; Carmona-Bayonas, Alberto; Calvo, Alfonso; Fernández-Mateos, Javier; Redrado, Miriam; Capdevila, Jaume; Martínez-Lago, Nieves; Lacasta, Adelaida; Muñarriz, Javier; Segura, Ángel; Fuster, Josep; Barón, Francisco; Llanos, Marta; Serrano, Raquel; Castillo, Alfredo; Cruz-Hernández, Juan-Jesús; Grande, Enrique (IMPACT JOURNALS LLC, 2018-12-11)
    Several circulating biomarkers and single nucleotide polymorphisms (SNPs) have been correlated with efficacy and tolerability to antiangiogenic agents. These associations remain unexplored in well-differentiated, metastatic ...
  • Biochemical and cellular consequences of the antithrombin p.Met1? mutation identified in a severe thrombophilic family 
    Navarro-Fernández, José; de-la-Morena-Barrio, María-Eugenia; Martínez-Alonso, Emma; Dybedal, Ingunn; Toderici, Mara; Bohdan, Natalia; Miñano, Antonia; Heimdal, Ketil; Abildgaard, Ulrich; Martínez-Menárguez, José-Ángel; Corral, Javier; Vicente, Vicente (IMPACT JOURNALS LLC, 2018-09-04)
    Nature is always the best inspiration for basic research. A family with severe thrombosis and antithrombin deficiency, the strongest anticoagulant, carried a new mutation affecting the translation-start codon of SERPINC1, ...
  • Tourniquet-ALPPS is a promising treatment for very large hepatocellular carcinoma and intrahepatic cholangiocarcinoma 
    López-López, Víctor; Robles-Campos, Ricardo; Brusadin, Roberto; López-Conesa, Asunción; Navarro, Álvaro; Arévalo-Pérez, Julio; Gil, Pedro-José; Parrilla-Paricio, Pascual (IMPACT JOURNALS LLC, 2018-06-15)
    When very large hepatocellular carcinomas (HCCs) and intrahepatic cholangiocarcinoma (IHCCs) with insufficient future liver remnants are treated using associating liver partition and portal vein ligation for staged hepatectomy ...
  • Genome-wide significant risk factors on chromosome 19 and the APOE locus 
    Moreno-Grau, Sonia; Hernández, Isabel; Heilmann-Heimbach, Stefanie; Ruiz, Susana; Rosende-Roca, Maitée; Mauleón, Ana; Vargas, Liliana; Rodríguez-Gómez, Octavio; Alegret, Montserrat; Espínosa, Ana; Ortega, Gemma; Aguilera, Nuria; Abdelnour, Carla; Neuroimaging-Initiative, Alzheimer's-Disease; Gil, Silvia; Maier, Wolfgang; Sotolongo-Grau, Oscar; Tárraga, Lluís; Ramírez, Alfredo; López-Arrrieta, Jesús; Antúnez-Almagro, Carmen; Serrano-Ríos, Manuel; Boada, Mercè; Ruiz, Agustín (IMPACT JOURNALS LLC, 2018-05-15)
    The apolipoprotein E (APOE) gene on chromosome 19q13.32, was the first, and remains the strongest, genetic risk factor for Alzheimer's disease (AD). Additional signals associated with AD have been located in chromosome 19, ...
  • Recurrent mutations in a SERPINC1 hotspot associate with venous thrombosis without apparent antithrombin deficiency 
    Zeng, Wei; Hu, Bei; Tang, Liang; You, Yan-Yan; Toderici, Mara; de-la-Morena-Barrio, María-Eugenia; Corral, Javier; Hu, Yu (IMPACT JOURNALS LLC, 2017-10-13)
    Despite the essential anticoagulant function of antithrombin and the high risk of thrombosis associated with its deficiency, the prevalence of antithrombin deficiency among patients with venous thromboembolism (VTE) is ...
  • Glioblastoma progression is assisted by induction of immunosuppressive function of pericytes through interaction with tumor cells 
    Valdor, Rut; García-Bernal, David; Bueno, Carlos; Ródenas, Mónica; Moraleda-Jiménez, José-María; Macian, Fernando; Martínez, Salvador (IMPACT JOURNALS LLC, 2017-09-15)
    The establishment of immune tolerance during Glioblastoma Multiforme (GBM) progression, is characterized by high levels expression of anti-inflammatory cytokines, which suppress the function of tumor assocciated myeloid ...
  • Verapamil Parameter- and Dose-Dependently Impairs Memory Consolidation in Open Field Habituation Task in Rats 
    Popovi?, Natalija; Giménez-de-Béjar, Verónica; Caballero-Bleda, María; Popovi?, Miroljub (FRONTIERS MEDIA SA, 2017)
    The purpose of the present study was to examine the effects of the phenylalkylamine class of the L-type voltage-dependent calcium channel antagonist, verapamil (1.0, 2.5, 5.0, or 10 mg/kg i.p.), administered immediately ...
  • Barriers to Radiation-induced In Situ Tumor vaccination 
    Wennerberg, Erik; Lhuillier, Claire; Vanpouille-Box, Claire; Pilones, Karsten-A; García-Martínez, Elena; Rudqvist, Nils-Petter; Formenti, Silvia-C; Demaria, Sandra (FRONTIERS MEDIA SA, 2017-03-13)
    The immunostimulatory properties of radiation therapy (RT) have recently generated widespread interest due to preclinical and clinical evidence that tumor-localized RT can sometimes induce antitumor immune responses mediating ...
  • Time for Radical Changes in Brain Stem Nomenclature-Applying the Lessons From Developmental Gene Patterns 
    Watson, Charles; Bartholomaeus, Caitlin; Puelles, Luis (FRONTIERS MEDIA SA, 2019-02-12)
    The traditional subdivision of the brain stem into midbrain, pons, and medulla oblongata is based purely on the external appearance of the human brain stem. There is an urgent need to update the names of brain stem structures ...
  • Shared and Differential Retinal Responses against Optic Nerve Injury and Ocular Hypertension 
    Vidal-Sanz, Manuel; Galindo-Romero, Caridad; Valiente-Soriano, Francisco-Javier; Nadal-Nicolás, Francisco-M; Ortin-Martínez, Arturo; Rovere, Giuseppe; Salinas-Navarro, Manuel; Lucas-Ruiz, Fernando; Sánchez-Migallón, María-C; Sobrado-Calvo, Paloma; Avilés-Trigueros, Marcelino; Villegas-Pérez, María-Paz; Agudo-Barriuso, Marta (FRONTIERS MEDIA SA, 2017-04-26)
    Glaucoma, one of the leading causes of blindness worldwide, affects primarily retinal ganglion cells (RGCs) and their axons. The pathophysiology of glaucoma is not fully understood, but it is currently believed that damage ...