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Repositorio Institucional en Ciencias de la Salud de la Región Murcia: Envíos recientes

  • Generation of Calpain-3 knock-out porcine embryos by CRISPR-Cas9 electroporation and intracytoplasmic microinjection of oocytes before insemination 
    Navarro-Serna, Sergio; Dehesa-Etxebeste, Martxel; Piñeiro-Silva, Celia; Romar, Raquel; Lopes, Jordana-S; López-de-Munain, Adolfo; Gadea, Joaquín (Elsevier Inc., 2022)
    Limb girdle muscular dystrophy type R1 (LGMDR1) is an autosomal recessive myopathy described in humans resulting from a deficiency of calpain-3 protein (CAPN3). This disease lacks effective treatment and an appropriate ...
  • Guía SEPAR de las terapias respiratorias domiciliarias, 2020 
    Peces-Barba-Romero, German; López-Campos, José-Luis; Mediano, Olga; Vaquero, Paz; Rios-Cortes, Antonio-Tomás (Elsevier Espana S.L.U, 2020)
  • Psychometric properties of the Spanish SABA Reliance Questionnaire (SRQ) among patients with asthma 
    Martínez, Mar; López, Juan-Carlos; Molina, Jesús; Sorribas, Mónica; Arancon, Mario; de-Simon, Raúl; Diaz, David; Trillo-Calvo, Eva; Gómez, José-Tomás; Fernández-Conde, Francisco; Alegria, Marta; Artes, Maite; Calle, Cristina; Foot, Holly; Sánchez-Covisa, Joaquín (Elsevier B.V., 2023)
  • Reductions in blood concentrations of persistent organic pollutants in the general population of Barcelona from 2006 to 2016 
    Porta, Miquel; Pumarega, José; Henriquez-Hernández, Luis-A; Gasull, Magda; Bartoll, Xavier; Arrebola, Juan-P; Morales, Eva; Ibarluzea, Jesús; Alguacil, Juan; Bilal, Usama; Luzardo, Octavio-P (ELSEVIER, 2021-07)
  • Outcome of treatment of MDR-TB or drug-resistant patients treated with bedaquiline and delamanid: Results from a large global cohort 
    Koirala, S; Borisov, S; Danila, E; Mariandyshev, A; Shrestha, B; Lukhele, N; Dalcolmo, M; Shakya, SR; Miliauskas, S; Kuksa, L; Manga, S; Aleksa, A; Denholm, JT; Khadka, HB; Skrahina, A; Diktanas, S; Ferrarese, M; Bruchfeld, J; Koleva, A; Piubello, A; Koirala, GS; Udwadia, ZF; Palmero, DJ; Muñoz-Torrico, M; Gc, R; Gualano, G; Grecu, VI; Motta, I; Papavasileiou, A; Li, Y; Hoefsloot, W; Kunst, H; Mazza-Stalder, J; Payen, M-c; Akkerman, OW; Bernal-Morell, Enrique; Manfrin, V; Matteelli, A; Mustafa-Hamdan, H; Nieto-Marcos, M; Cadinanos-Loidi, J; Cebrian-Gallardo, JJ; Duarte, R; Escobar-Salinas, N; Gómez-Rosso, R; Laniado-Laborin, R; Martínez-Robles, E; Quirós-Fernández, S; Rendon, A; Solovic, I; Tadolini, M; Viggiani, P; Belilovski, E; Boeree, MJ; Cai, Q; Davidaviciene, E; Forsman, LD; de-los-Rios, J; Draksiene, J; Duga, A; Elamin, SE; Filippov, A; García, A; Gaudiesiute, I; Gavazova, B; Gayoso, R; Gruslys, V; Jonsson, J; Khimova, E; Madonsela, G; Magis-Escurra, C; Marchese, V; Matei, M; Moschos, C; Nakceriene, B; Nicod, L; Palmieri, F; Pontarelli, A; Smite, A; Souleymane, MB; Vescovo, M; Zablockis, R; Zhurkin, D; Alffenaar, J-w; Caminero, JA; Codecasa, LR; García-García, J-m; Esposito, S; Saderi, L; Spanevello, A; Visca, D; Tiberi, S; Pontali, E; Centis, R; D'Ambrosio, L; van-den-Boom, M; Sotgiu, G; Migliori, GB (TAYLOR & FRANCIS LTD, 2021-09)
  • Patient and graft survival in pancreas transplant recipients: The EFISPAN study 
    Ventura-Aguiar, Pedro; Cabello, Mercedes; Beneyto, Isabel; Cabello, Dolores-Navarro; Tabernero, Guadalupe; Alonso, Ángel; Ruiz, Juan-Carlos; Llorente-Vinas, Santiago (SOC ESPANOLA NEFROLOGIA DR RAFAEL MATESANZ, 2023-01)
  • MYC-rearranged mature B-cell lymphomas in children and young adults are molecularly Burkitt Lymphoma 
    Mato, Sara; Castrejón-de-Anta, Natalia; Colmenero, Ariadna; Carita, Lorenzo; Salmerón-Villalobos, Julia; Ramis-Zaldivar, Joan-Enric; Nadeu, Ferrán; García, Noelia; Wang, Luojun; Verdu-Amoros, Jaime; Andrés, Mara; Conde, Nuria; Celis, Verónica; Ortega, María-José; Galera-Miñarro, Ana-María; Astigarraga, Itziar; Pérez-Alonso, Vanesa; Quiroga, Eduardo; Jiang, Aixiang; Scott, David-W; Campo, Elías; Balague, Olga; Salaverria, Itziar (SPRINGERNATURE, 2024-10)
    Aggressive B-cell non-Hodgkin lymphomas (NHL) in children, adolescents, and young adults (CAYA) include Burkitt lymphoma (BL), diffuse large B-cell lymphoma (DLBCL), and a subset of high-grade tumors with features intermediate ...
  • Prognostic role of pre-diagnostic circulating inflammatory biomarkers in breast cancer survival: evidence from the EPIC cohort study 
    Castro-Espín, Carlota; Cairat, Manon; Navionis, Anne-Sophie; Dahm, Christina-C; Antoniussen, Christian-S; Tjonneland, Anne; Mellemkjaer, Lene; Mancini, Francesca-Romana; Hajji-Louati, Mariem; Severi, Gianluca; Le-Cornet, Charlotte; Kaaks, Rudolf; Schulze, Matthias-B; Masala, Giovanna; Agnoli, Claudia; Sacerdote, Carlotta; Crous-Bou, Marta; Sánchez, María-José; Amiano, Pilar; Chirlaque-López, María-Dolores; Guevara, Marcela; Smith-Byrne, Karl; Heath, Alicia-K; Christakoudi, Sofía; Gunter, Marc-J; Rinaldi, Sabina; Agudo, Antonio; Dossus, Laure (SPRINGERNATURE, 2024-11)
    BACKGROUND: Inflammation influences tumour progression and cancer prognosis, but its role preceding breast cancer (BC) and its prognostic implications remain inconclusive. METHODS: We studied pre-diagnostic plasma inflammatory ...
  • Peds1 deficiency in zebrafish results in myeloid cell apoptosis and exacerbated inflammation 
    Arroyo, Ana-B; Tyrkalska, Sylwia-D; Bastida-Martínez, Eva; Monera-Girona, Antonio-J; Canton-Sandoval, Joaquín; Bernal-Carrión, Martín; García-Moreno, Diana; Elías-Arnanz, Montserrat; Mulero, Víctoriano (SPRINGERNATURE, 2024-08-29)
    Plasmalogens are glycerophospholipids with a vinyl ether bond that confers unique properties. Recent identification of the gene encoding PEDS1, the desaturase generating the vinyl ether bond, enables evaluation of the role ...
  • Pyroptosis leads to loss of centrosomal integrity in macrophages 
    Bai, Siyi; Martín-Sánchez, Fatima; Brough, David; López-Castejon, Gloria (SPRINGERNATURE, 2024-08-08)
    NLRP3 forms a multiprotein inflammasome complex to initiate the inflammatory response when macrophages sense infection or tissue damage, which leads to caspase-1 activation, maturation and release of the inflammatory ...
  • Estrogen receptor-? signaling in tanycytes lies at the crossroads of fertility and metabolism 
    Fernandois, Daniela; Rusidze, Maríam; Mueller-Fielitz, Helge; Sauve, Florent; Deligia, Eleonora; Silva, Mauro-SB; Evrard, Florence; Franco-García, Aurelio; Mazur, Daniele; Martínez-Corral, Inés; Jouy, Nathalie; Rasika, S; Maurage, Claude-Alain; Giacobini, Paolo; Nogueiras, Rubén; Dehouck, Benedicte; Schwaninger, Markus; Lenfant, Francoise; Prevot, Vincent (W B SAUNDERS CO-ELSEVIER INC, 2024-09)
    BACKGROUND: Estrogen secretion by the ovaries regulates the hypothalamic-pituitary-gonadal axis during the reproductive cycle, influencing gonadotropin-releasing hormone (GnRH) and luteinizing hormone (LH) secretion, and ...
  • Detection of inflammasome activation in liver tissue during the donation process as potential biomarker for liver transplantation 
    Mateo, Sandra-V; Vidal-Correoso, Daniel; Muñoz-Morales, Ana-M; Jover-Aguilar, Marta; Alconchel-Gago, Felipe; de-la-Peña, Jesús; Martínez-Alarcón, Laura; López-López, Víctor; Ríos-Zambudio, Antonio; Cascales, Pedro; Pons, José-A; Ramírez, Pablo; Pelegrín, Pablo; Baroja-Mazo, Alberto (SPRINGERNATURE, 2024-05)
    Deceased donor liver transplantation (LT) is a crucial lifesaving option for patients with end-stage liver diseases. Although donation after brain death (DBD) remains the main source of donated organs, exploration of ...
  • The genomic profiling of high-risk smoldering myeloma patients treated with an intensive strategy unveils potential markers of resistance and progression 
    Medina-Herrera, A; Vázquez, I; Cuenca, I; Rosa-Rosa, JM; Ariceta, B; Jiménez, C; Fernández-Mercado, M; Larrayoz, MJ; Gutiérrez, NC; Fernández-Guijarro, M; González-Calle, V; Rodríguez-Otero, P; Oriol, A; Rosiñol, L; Alegre, A; Escalante, F; de-la-Rubia, J; Teruel, AI; de-Arriba, F; Hernández, MT; López-Jiménez, J; Ocio, EM; Puig, N; Paiva, B; Lahuerta, JJ; Blade, J; San-Miguel, JF; Mateos, MV; Martínez-López, J; Calasanz, MJ; García-Sanz, R; Rios, R; Sureda, A; Blanchard, MJ; Martínez-Martínez, R; Moraleda, JM; Bargay, J; Gironella, M; Palomera, L; González-Montes, Y; Marti, JM; Krsnik, I; Arguinano, JM; González, ME; González, AP; Casado, LF (SPRINGERNATURE, 2024-04-29)
    Smoldering multiple myeloma (SMM) precedes multiple myeloma (MM). The risk of progression of SMM patients is not uniform, thus different progression-risk models have been developed, although they are mainly based on clinical ...
  • Penetrance of Dilated Cardiomyopathy in Genotype-Positive Relatives 
    Cabrera-Romero, Eva; Ochoa, Juan-Pablo; Barriales-Villa, Roberto; Bermúdez-Jiménez, Francisco-José; Climent-Paya, Vicente; Zorio, Esther; Espinosa, María-Ángeles; Gallego-Delgado, María; Navarro-Peñalver, Marina; Arana-Achaga, Xabier; Piqueras-Flores, Jesús; Espejo-Bares, Victoria; Rodríguez-Palomares, José-F; Lacuey-Lecumberri, Gemma; López, Javier; Tiron, Coloma; Pena-Pena, María-Luisa; García-Pinilla, José-M; Lorca, Rebeca; Ripoll-Vera, Tomás; Diez-López, Carles; Mogollon, María-Victoria; García-Álvarez, Ana; Martínez-Dolz, Luis; Brion, María; Larranaga-Moreira, José-María; Jiménez-Jaimez, Juan; García-Álvarez, María-Isabel; Vilches, Silvia; Villacorta, Eduardo; Sabater-Molina, María; Solla-Ruiz, Itziar; Royuela, Ana; Domínguez, Fernando; Mirelis, Jesús-G; García-Pavia, Pablo (ELSEVIER SCIENCE INC, 2024-04-30)
    BACKGROUND: Disease penetrance in genotype-positive (G+) relatives of families with dilated cardiomyopathy (DCM) and the characteristics associated with DCM onset in these individuals are unknown. OBJECTIVES: This study ...
  • Novel Re(I) Complexes as Potential Selective Theranostic Agents in Cancer Cells and In Vivo in Caenorhabditis elegans Tumoral Strains 
    Marco, Alicia; Ashoo, Pezhman; Hernández-García, Samanta; Martínez-Rodríguez, Pedro; Cutillas, Natalia; Vollrath, Annette; Jordan, Dustin; Janiak, Christoph; Gandía-Herrero, Fernando; Ruiz, José (AMER CHEMICAL SOC, 2024-03)
    A series of rhenium(I) complexes of the type fac-[Re(CO)(3)(N^N)L](0/+), Re1-Re9, was synthesized, where N^N = benzimidazole-derived bidentate ligand with an ester functionality and L = chloride or pyridine-type ligand. ...
  • Photoactivatable Ruthenium Complexes Containing Minimal Straining Benzothiazolyl-1,2,3-triazole Chelators for Cancer Treatment 
    Ballester, Francisco-J; Hernández-García, Alba; Santana, MDolores; Bautista, Delia; Ashoo, Pezhman; Ortega-Forte, Enrique; Barone, Giampaolo; Ruiz, José (AMER CHEMICAL SOC, 2024-02)
    Ruthenium(II) complexes containing diimine ligands have contributed to the development of agents for photoactivated chemotherapy. Several approaches have been used to obtain photolabile Ru(II) complexes. The two most ...
  • Oocyte electroporation prior to in vitro fertilization is an efficient method to generate single, double, and multiple knockout porcine embryos of interest in biomedicine and animal production 
    Navarro-Serna, Sergio; Piñeiro-Silva, Celia; Fernández-Martín, Irene; Dehesa-Etxebeste, Martxel; López-de-Munain, Adolfo; Gadea, Joaquín (ELSEVIER SCIENCE INC, 2024-04-01)
    Genetically modified pigs play a critical role in mimicking human diseases, xenotransplantation, and the development of pigs resistant to viral diseases. The use of programmable endonucleases, including the CRISPR/Cas9 ...
  • Novel 2-(5-Arylthiophen-2-yl)-benzoazole Cyclometalated Iridium(III) dppz Complexes Exhibit Selective Phototoxicity in Cancer Cells by Lysosomal Damage and Oncosis 
    Kasparkova, Jana; Hernández-García, Alba; Kostrhunova, Hana; Goicuria, Marta; Novohradsky, Vojtech; Bautista, Delia; Markova, Lenka; Santana, María-Dolores; Brabec, Viktor; Ruiz, José (AMER CHEMICAL SOC, 2023-12-23)
    A second-generation series of biscyclometalated 2-(5-aryl-thienyl)-benzimidazole and -benzothiazole Ir(III) dppz complexes [Ir(C^N)(2)(dppz)](+), Ir1-Ir4, were rationally designed and synthesized, where the aryl group ...
  • Urinary concentrations of bisphenol A, parabens and benzophenone-type ultra violet light filters in relation to sperm DNA fragmentation in young men: A chemical mixtures approach 
    Kiwitt-Cardenas, Jonathan; Arense-Gonzalo, Julián-J; Adoamnei, Evdochia; Sarabia-Cos, Laura; Vela-Soria, Fernando; Fernández, Mariana-F; Gosalvezi, Jaime; Mendiola, Jaime; Torres-Cantero, Alberto-M (ELSEVIER, 2024-02)
    People are daily exposed to multiple endocrine disruptor compounds (EDCs) that may interfere with different molecular and cellular processes, promoting a potential estrogenic, androgenic, or anti-androgenic state. However, ...
  • Targeting protein methylation in pancreatic cancer cells results in KRAS signaling imbalance and inhibition of autophagy 
    Montenegro, María-F; Marti-Diaz, Roman; Navarro, Ana; Tolivia, Jorge; Sánchez-del-Campo, Luis; Cabezas-Herrera, Juan; Rodríguez-López, José-Neptuno (SPRINGERNATURE, 2023-11)
    Pancreatic cancer cells with mutant KRAS require strong basal autophagy for viability and growth. Here, we observed that some processes that allow the maintenance of basal autophagy in pancreatic cancer cells are controlled ...