Repositorio Dspace

Envíos recientes

02. Servicio Murciano de Salud (SMS): Envíos recientes

  • Real-World Use of COMT Inhibitors in the Management of Patients with Parkinson's Disease in Spain Who Present Early Motor Fluctuations: Interim Results from the REONPARK Study 
    López-Manzanares, Lydia; García-Caldentey, Juan; Mata-Álvarez-Santullano, Marina; Vilas-Rolan, Dolores; Herreros-Rodríguez, Jaime; Solano-Vila, Berta; Cerdán-Sánchez, María; Delgado-Ballestero, Tania; García-Ramos, Rocío; Rodríguez-Sanz, Ana; Olivares-Romero, Jesús; Blanco-Ameijeiras, José; Pijuan-Jiménez, Isabel; Tegel-Ayuela, Iciar (MDPI, 2025-05-21)
    OBJECTIVE: We aimed to analyze the real-world use of COMT inhibitors associated with levodopa in patients with Parkinson's disease (PD) who present early fluctuations and to explore whether early COMT inhibition optimizes ...
  • Exposure to Sulfur Hexafluoride Influences Viability in Cell Transplant Suspensions 
    Martínez-Alarcón, Laura; Liarte, Sergio; Abellaneda-Bernal, Juana-María; Quereda, Juan-J; Mendonca, Livia; Muñoz, Antonio; Ramírez, Pablo; Ramis-Vidal, Guillermo (MDPI, 2025-10-31)
    Cell transplantation is often performed with ultrasonographic guidance for accurate delivery through injection. In such procedures, using ultrasonographic contrast greatly improves target delivery. However, accumulating ...
  • Spinal Cord Stimulation in Painful Diabetic Neuropathy: Advances, Outcomes, and Future Directions 
    Gazzeri, Roberto; Mosca, Jacopo; Occhigrossi, Felice; Galarza, Marcelo; Schiaffini, Riccardo; Varrassi, Giustino; Mercieri, Marco; Leóni, Matteo-Luigi-Giuseppe (MDPI, 2025-12-12)
    Painful diabetic neuropathy (PDN) is a common complication of diabetes mellitus, often inadequately managed by conventional pharmacological therapies. Alternative interventions, including spinal cord stimulation (SCS), ...
  • The Long-Term Outcomes of Corticosteroid Use in COVID-19 Patients with Cardiovascular Disease: A Propensity-Matched Analysis from the Multi-Center International Prospective Registry (HOPE-2) 
    García-Onrubia, Jorge; Vazirani, Ravi; Feltes, Gisela; Sánchez-del-Hoyo, Rafael; Viana-Llamas, María-Carmen; Raposeiras-Roubin, Sergio; Romero, Rodolfo; Alfonso-Rodríguez, Emilio; Uribarri, Aitor; Santoro, Francesco; Becerra-Muñoz, Victor; Pepe, Martino; Castro-Mejia, Alex-F; Signes-Costa, Jaime; González, Adelina; Marín, Francisco; López-Pais, Javier; Cerrato, Enrico; Vázquez-Cancela, Olalla; Espejo-Paeres, Carolina; López-Masjuan, Álvaro; Velicki, Lazar; El-Battrawy, Ibrahim; Ramakrishna, Harish; Fernández-Ortiz, Antonio; Núñez-Gil, Ivan-J (MDPI, 2025-10-30)
    Introduction: Corticosteroid therapy has been demonstrated to improve prognosis and reduce mortality in patients with severe Coronavirus Disease 2019 (COVID-19) infection by attenuating the exaggerated inflammatory response ...
  • Ethylbenzene Exposure and Bronchoalveolar CD4/CD8 T Cells in Hypersensitivity Pneumonitis Development and Clinical Outcome 
    Minguela-Puras, Alfredo; Campillo, José-Antonio; Aguilar-Sanchis, María-Isabel; Baeza-Caracena, Antonia; Esquembre, Francisco; Novoa-Bolívar, Erika-M; González-López, Rosana; Otalora, Almudena; Ortuño-Hernández, Cristina; López-Hernández, Ruth; Gimeno-Arias, Lourdes; Ruiz-Lorente, Inmaculada; Ceballos, Diana; Solana-Martínez, Elena; Alcantara-Fructuoso, Juan; Muro-Amador, Manuel; Ros, José-A (MDPI, 2025-10-24)
    Background: Hypersensitivity pneumonitis (HP) is an interstitial lung disease (ILD) characterized by inflammation of the lung parenchyma, alveoli and bronchioles induced by inhalation of organic compounds. Bird-related-HP ...
  • Effectiveness and Safety of Sacituzumab Govitecan in Real-World Clinical Practice in Patients with Metastatic Triple-Negative and HR+/HER2-Negative Breast Cancer 
    Lago-Ballester, Fernando; Martínez-Orea, Adrian; Laorden-Carrasco, Ana; Díaz-Carrasco, María-Sacramento; Titos-Arcos, José-Carlos; Mira-Sirvent, María-del-Carmen; Luengo-Gil, Ginés; Martínez-Penella, Mónica (MDPI, 2025-08-23)
    Background/Objectives: Sacituzumab govitecan (SG) is an antibody-drug conjugate targeting Trop-2 that has demonstrated clinical benefits in randomised trials for patients with metastatic triple-negative breast cancer (mTNBC) ...
  • Donor-Derived Cell-Free DNA in Allograft Transplantation: Exaggerated Hope or Cautious Reality? 
    Fernández-González, Marina; Llorente-Vinas, Santiago; Botella-Martínez, Carmen; Galián, José-Antonio; González-López, Rosana; Alegría-Marcos, María-José; Hita-Ruiz, Alicia; Moya-Quiles, María-Rosa; Martínez-Banaclocha, Helios; Muro-Pérez, Manuel; Muro, Javier; Minguela-Puras, Alfredo; Legaz, Isabel; Muro-Amador, Manuel (MDPI, 2025-09-23)
    Nowadays, there have truly been spectacular advances in surgical techniques, the preservation of organs for transplants, the optimal and efficient selection of both donors and recipients, a more efficient diagnosis and ...
  • Pharmacogenomic Study of SARS-CoV-2 Treatments: Identifying Polymorphisms Associated with Treatment Response in COVID-19 Patients 
    Serra-Llovich, Alexandre; Cullell, Natalia; Maronas, Olalla; Jose-Herrero, María; Cruz, Raquel; Almoguera, Berta; Ayuso, Carmen; López-Rodríguez, Rosario; Domínguez-Garrido, Elena; Ortiz-López, Rocío; Barreda-Sánchez, María; Corton, Marta; Dalmau, David; Calbo, Esther; Boix-Palop, Lucía; Dietl, Beatriz; Sangil, Anna; Gil-Rodríguez, Almudena; Guillén-Navarro, Encarna; Mancebo, Esther; Lira-Albarran, Saul; Mínguez, Pablo; Paz-Artal, Estela; Olivera, Gladys-G; Recarey-Rama, Sheila; Sendra, Luis; Zucchet, Enrique-G; López-de-Heredia, Miguel; Flores, Carlos; Riancho, José-A; Rojas-Martínez, Augusto; Lapunzina, Pablo; Carracedo, Ángel; Arranz, María-J (MDPI, 2025-02-21)
    Background/Objectives: The COVID-19 pandemic resulted in 675 million cases and 6.9 million deaths by 2022. Despite substantial declines in case fatalities following widespread vaccination campaigns, the threat of future ...
  • Differential Role of NKG2A/HLA-E Interaction in the Outcomes of Bladder Cancer Patients Treated with M. bovis BCG or Other Therapies 
    Ruiz-Lorente, Inmaculada; Gimeno-Arias, Lourdes; López-Abad, Alicia; López-Cubillana, Pedro; Fernández-Aparicio, Tomás; Asensio-Egea, Lucas-Jesús; Moreno-Avilés, Juan; Doñate-Íñiguez, Gloria; Guzmán-Martínez-Valls, Pablo-Luis; Server, Gerardo; Ferri-Ñíguez, Belén; Campillo, José-Antonio; Martínez-Sánchez, María-Victoria; Minguela-Puras, Alfredo (MDPI, 2025-01-10)
    Background: Immunotherapy is gaining great relevance in both non-muscle-invasive bladder cancer (NMIBC), with the use of bacille Calmette-Guerin (BCG), and in muscle-invasive BC (MIBC) with anti-checkpoint therapies blocking ...
  • Characterization of Novel Variants in P2YRY12, GP6 and TBXAS1 in Patients with Lifelong History of Bleeding 
    Zamora-Cánovas, Ana; Marín-Quílez, Ana; Díaz-Ajenjo, Lorena; Sánchez-Fuentes, Ana; Gómez-González, Pedro-Luis; Crescente, Marilena; Fernández-Mosteirin, Nuria; Padilla, José; González-Porras, José-Ramón; Benito, Rocío; Lozano-Almela, María-Luisa; Bastida, José-María; Rivera-Pozo, José (MDPI, 2025-11-21)
    Inherited platelet function disorders (IPFDs) are rare diseases caused by defects in platelet surface receptors, enzymes, granules, or signaling proteins. In humans, GPVI and P2Y12 deficiency cause autosomal recessive ...
  • Molecular Pathogenesis of Inherited Platelet Dysfunction 
    Rodríguez-Alen, Agustin; Moscardo, Antonio; Bastida, José-María; Rivera, José (MDPI, 2025-10-30)
    Inherited platelet function disorders (IPFD) are characterized by normal platelet count and morphology but impaired function due to pathogenic variants in genes encoding membrane receptors, granule constituents, or ...
  • Defibrotide for Protecting Against and Managing Endothelial Injury in Hematologic Malignancies and COVID-19 
    Richardson, Edward; Mo, Clifton-C; Calabretta, ELeónora; Corrado, Francesco; Kocoglu, Mehmet-H; Baron, Rebecca-M; Connors, Jean-Marie; Iacobelli, Massimo; Wei, Lee-Jen; Benjamin, Emily-J; Rapoport, Aaron-P; Díaz-Ricart, Maribel; Martínez-Mellado, Antonio-José; Carlo-Stella, Carmelo; Richardson, Paul-G; Moraleda-Jiménez, José-María (MDPI, 2025-07-14)
    Defibrotide, which is approved for treating hepatic veno-occlusive disease (VOD)/sinusoidal obstruction syndrome (SOS), exhibits pleiotropic anti-inflammatory, anti-thrombotic, and fibrinolytic properties, conferring broad ...
  • Diagnosis of Inherited Platelet Disorders: Clinical Evaluation and Functional and Molecular Assays 
    Sánchez-Fuentes, Ana; Pérez-Botero, Juliana; Bastida, José-María; Rivera, José (MDPI, 2025-06-10)
    Inherited platelet disorders (IPDs) are a group of rare conditions affecting platelet number, function, or both. Clinical manifestations vary widely, from asymptomatic cases to patients with severe bleeding, syndromic ...
  • Examining the Effects of the RUNX1 p.Leu43Ser Variant on FPD/AML Phenotypes Using a CRISPR/Cas9-Generated Knock-In Murine Model 
    Marín-Quílez, Ana; García-Tunon, Ignacio; Benito, Rocío; Ordonez, José-Luis; Díaz-Ajenjo, Lorena; Lama-Villanueva, Ana; Guerrero, Carmen; Pérez-Losada, Jesús; González-Porras, José-Ramón; Hernández-Rivas, Jesús-María; del-Rey, Mónica; Bastida, José-María (MDPI, 2025-05-12)
    Germline heterozygous variants in RUNX1 lead to Familial Platelet Disorder with Myeloid Leukemia Predisposition (FPD/AML). Cellular and/or animal models are helpful to uncovering the role of a variant in disease progression. ...
  • Diagnostic Utility of Bronchoalveolar Lavage Flow Cytometric Leukocyte Profiling in Interstitial Lung Disease and Infection 
    Novoa-Bolívar, Erika-M; Ros, José-A; Pérez-Fernández, Sonia; Campillo, José-Antonio; López-Hernández, Ruth; González-López, Rosana; Ruiz-Lorente, Inmaculada; Otalora-Alcaraz, Almudena; Ortuño-Hernández, Cristina; Gimeno-Arias, Lourdes; Ceballos-Francisco, Diana; Muro-Amador, Manuel; Solana-Martínez, Elena; Martínez-Camblor, Pablo; Minguela-Puras, Alfredo (MDPI, 2025-04-17)
    Interstitial lung diseases (ILD) represent a diverse group of disorders that primarily affect the pulmonary interstitium and, less commonly, involve the alveolar and vascular epithelium. Overlapping clinical, radiological ...
  • Non-Invasive Redox Biomarkers Detected in Organ Preservation Outflow Solution Enable Early Prediction of Human Liver Allograft Dysfunction 
    Vidal-Correoso, Daniel; Caballero-Herrero, María-José; Muñoz-Morales, Ana-M; Mateo, Sandra-V; Jover-Aguilar, Marta; Alconchel-Gago, Felipe; Martínez-Alarcón, Laura; López-López, Víctor; Ríos-Zambudio, Antonio; Cascales-Campos, Pedro-Antonio; Pons-Miñano, José-Antonio; Ramírez, Pablo; Stromsnes, Kristine; Gambini, Juan; Cuevas, Santiago; Baroja-Mazo, Alberto (MDPI, 2025-09-10)
    Liver transplantation is commonly used for end-stage liver disease, but the demand for organs exceeds the supply, leading to the use of expanded criteria donors (ECDs). Organs from ECDs, especially from donors after ...
  • Preclinical Performance of Customized Polycaprolactone-Based Hybrid Bone Grafts 
    Serrano-Belmonte, Ildefonso; Montero, Javier; Roman-Macia, Ángel; Pérez-Fernández, Virginia; Rodríguez-Lorenzo, Luis-M; Cubo-Mateo, Nieves; Lara-Núñez, Angelica; Martínez-Cánovas, Ascensión (MDPI, 2025-07-04)
  • Uric Acid and Preeclampsia: Pathophysiological Interactions and the Emerging Role of Inflammasome Activation 
    Arias-Sánchez, Celia; Pérez-Olmos, Antonio; Reverte-Ribo, Virginia; Hernández, Isabel; Cuevas, Santiago; Llinas-Mas, María-Teresa (MDPI, 2025-07-29)
    Preeclampsia (PE) is a multifactorial hypertensive disorder unique to pregnancy and a leading cause of maternal and fetal morbidity and mortality worldwide. Its pathogenesis involves placental dysfunction and an exaggerated ...
  • Cardioprotective Peptides from Dry-Cured Ham in Primary Endothelial Cells and Human Plasma: An Omics Approach 
    Noguera-Navarro, Clara; Stelling, Javier; Orenes-Piñero, Esteban; Pipino, Caterina; Nicolás, Francisco-José; Montoro-García, Silvia (MDPI, 2025-06-24)
    Cardiovascular diseases are a leading cause of mortality, driving the search for alternative preventive strategies. This study investigates the antioxidant effects, among others, of a mixture of four bioactive peptides ...
  • Inflammasomes in Alzheimer's Progression: Nrf2 as a Preventive Target 
    López-Hernández, Rubén; de-la-Torre-Álamo, María-Magdalena; García-Bueno, Belén; Baroja-Mazo, Alberto; Fenoy, Francisco-José; Cuevas, Santiago (MDPI, 2025-01-21)
    Current knowledge about Alzheimer's disease highlights the accumulation of ?-amyloid plaques (A?1-42) and neurofibrillary tangles composed of hyperphosphorylated Tau, which lead to the loss of neuronal connections. Microglial ...

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