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Repositorio Institucional en Ciencias de la Salud de la Región Murcia: Envíos recientes

  • Representation of chemistry transport models simulations using knowledge graphs 
    Illueca-Fernández, Eduardo; Jara-Valera, Antonio-Jesús; Fernández-Breis, Jesualdo-Tomás (BMC, 2025-05-31)
    Persistent air quality pollution poses a serious threat to human health, and is one of the action points that policy makers should monitor according to the Directive 2008/50/EC. While deploying a massive network of hyperlocal ...
  • Probable chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids syndrome: management with corticosteroids and intravenous immunoglobulin-a case report 
    Encarnación-Navarro, Juan-Antonio; León-Hernández, Adelaida; Litrán-López, Guillermo; Alonso-Romero, José-Luis; de-la-Fuente-Muñoz, Isabel; Cárdenas-Cánovas, Enrique; Ruiz-Carreño, Paula; Royo-Villanova, Mario; Mansó-Murcia, Clara (BMC, 2025-07-17)
    BACKGROUND: Chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids is a rare, subacute inflammatory disorder of the central nervous system with an unknown etiology. It is characterized ...
  • Hypomethylation of the MEG8:Int2-DMR in patients with pathogenic PLAG1 variants suggests new role of the chr14q32 imprinting cluster in Silver-Russell syndrome 
    D'angelo, Emilia; Pignata, Laura; Cecere, Francesco; Vimercati, Alessandro; Cubellis, María-Vittoria; Saadat, Abu; Giaccari, Carlo; Thibaud, Nathalie; Eggermann, Thomas; Fernández-Fructuoso, Jose-Ramón; Russo, Silvia; Netchine, Irene; Cerrato, Flavia; Riccio, Andrea; Brioude, Frederic (BMC, 2025-11-23)
    BACKGROUND: Silver-Russell syndrome (SRS) is a clinically and genetically heterogeneous imprinting disorder. The most common molecular defects are loss of methylation of the H19/IGF2:IG-DMR on chromosome 11p15.5, followed ...
  • Gender differences in clinical and prescribing characteristics of biologic and targeted synthetic drugs in naïve patients with rheumatoid arthritis: Data from BIOBADASER III registry 
    Vela-Casasempere, Paloma; Otero-Varela, Lucía; Gómez-Sabater, Silvia; Alameda, Rocio-Cano; Campos-Fernández, Cristina; Calvo-Gutiérrez, Jerusalen; Pérez-Vera, Yanira; Manrique-Arija, Sara; Bustabad, Sagrario; Manero-Ruiz, Javier; Ruiz-Montesino, María-Dolores; Gutiérrez, Lucía-Ruiz; Mera-Varela, Antonio; Moreno-Ramos, Manuel-José; Sánchez-Alonso, Fernando; Castrejon, Isabel (BMC, 2025-05-14)
    BACKGROUND: Rheumatoid arthritis (RA) is a chronic systemic inflammatory autoimmune disease that can lead to progressive joint damage and irreversible disability when inadequately treated. RA is more common in women than ...
  • Disease activity in patients with idiopathic inflammatory myopathy according to time since diagnosis and positivity to antisynthetase autoantibodies: data from the Myo-Spain registry 
    Cobo-Ibáñez, Tatiana; Castellvi, Iván; Pros, Ana; Domínguez-Álvaro, Marta; Nuno-Nuno, Laura; Martínez-Barrio, Julia; Jovani, Vega; Romero-Bueno, Fredeswinda; Ruiz-Lucea, Esther; Tomero, Eva; Trallero-Araguas, Ernesto; Narváez, Javier; Camins-Fabregas, Jordi; Ruiz-Roman, Alberto; Loarce-Martos, Jesús; Holgado-Pérez, Susana; Flores-Rodríguez, V-Miguel; Sivera, Francisca; Merino-Argumanez, Carolina; Juan-Mas, Antonio; Altabas-González, Irene; Martín-López, María; Belzunegui-Otano, Joaquín-María; Carrasco-Cubero, Carmen; Freire-González, Mercedes; Rua-Figueroa, Íñigo-Jesús; Lozano-Rivas, Nuria; Suárez-Cuba, Julio-David; Martínez, Olga; Ortega-Castro, Rafaela; Alcocer, Patricia; Gómez-Gómez, Alejandro; Sánchez-Pernaute, Olga; Tandaipan, José-Luis; Carrion-Barbera, Irene; Plasencia-Rodríguez, Chamaida; Ibarguengoitia-Barrena, Oihane; Vidal-Montal, Paola; Ortiz-Santamaria, Vera; Garrido-Puñal, Noemi; Riveros, Anne; Delgado-Frias, Esmeralda; López-Gómez, Juan-Miguel; Barbadillo, Carmen; Pego-Reigosa, José-María; Joven-Ibáñez, Beatriz-E; Valero-Jaimes, Jesús-Alejandro; Naveda, Elena; Turrion-Nieves, Ana-Isabel; Seoane-Mato, Daniel; Prado-Galbarro, Francisco-Javier; Puche-Larrubia, M-angeles (BMC, 2025-01-08)
    OBJECTIVE: To evaluate the main outcomes of disease activity and their association with other measures of activity, damage, and quality of life in patients with idiopathic inflammatory myopathy (IIM) according to time since ...
  • Randomized clinical trial of the use of Propofol as a sedative agent versus spinal analgesia with bupivacaine in External Cephalic Version (PropoSpinECV): study protocol for a randomized clinical trial 
    Sánchez-Romero, Javier; Falcón-Arana, Luis; Blanco-Carnero, José-Eliseo; García-Fulgueiras, Ana; Herrera-Giménez, Javier; Fuentes-García, Diego; Araico-Rodríguez, Fernando; Gallego-Pozuelo, rosa-María; Nieto-Díaz, Anibal; de-Paco-Matallana, Catalina (BMC, 2025-10-09)
    BACKGROUND: External Cephalic Version (ECV) is an effective procedure for modifying fetal position to achieve a cephalic presentation. ECV is usually performed with tocolysis and spinal anesthesia. Recently, propofol has ...
  • Transcriptional analysis of metastatic hormone-naïve prostate cancer primary tumor biopsies reveals a relevant role for SOX11 in prostate cancer cell dissemination 
    Martín-Martin, Natalia; García-Longarte, Saioa; Corres-Mendizabal, Jon; Lazcano, Uxue; Astobiza, Ianire; Bozal-Basterra, Laura; Herranz, Nicolas; van-Splunder, Hielke; Carlevaris, Onintza; Pujana-Vaquerizo, Mikel; Blasco, María-Teresa; Aransay, Ana-M; Rosino-Sánchez, Antonio; Tudela-Pallarés, Julián; Jiménez, Daniel; Martínez, Alberto; Salca, Andrei; Santos-Martin, Aida; Rey, Sofia; Ugalde-Olano, Aitziber; Gonzalo, David; Graupera, Mariona; Gomis, Roger-R; Mateo, Joaquín; Unda, Miguel; González-Billalabeitia, Enrique; Loizaga-Iriarte, Ana; Mendizabal, Isabel; Carracedo, Arkaitz (BMC, 2025-06-03)
    BACKGROUND: Metastatic hormone-naïve prostate cancer (mHNPC) is an infrequent form of this tumor type that is characterized by metastasis at the time of diagnosis and accounts for up to 50% of prostate cancer-related deaths. ...
  • Lifestyle changes and postmenopausal breast cancer risk in women from the European Prospective Investigation into Cancer and Nutrition 
    Vasson, Fanelie; Matta, Komodo; Biessy, Carine; S-Antoniussen, Christian; Fournier, Agnes; Marques, Chloe; Cadeau, Claire; Le-Cornet, Charlotte; T-Fortner, Renee; Schulze, Matthias-B; Sieri, Sabina; Panico, Salvatore; Tumino, Rosario; Ricceri, Fulvio; Masala, Giovanna; Hiensch, Anouk-E; Monninkhof, Evelyn-M; Agudo, Antonio; Guevara, Marcela; Colorado-Yohar, Sandra; Sánchez, María-José; Llorente, Adrián; Tin-Tin, Sandar; Jackson, Isobel-G; Gunter, Marc-J; Botteri, Edoardo; Ferrari, Pietro; Dossus, Laure (BMC, 2025-10-29)
    BACKGROUND: The risk of breast cancer has been associated with various lifestyle factors, yet the evidence regarding how lifestyle modifications affect this risk remains limited. This study examines the relationship between ...
  • Ipatasertib combined with non-taxane chemotherapy for patients with previously treated advanced triple-negative breast cancer: the PATHFINDER phase IIa trial 
    López-Miranda, Elena; Pérez-García, José-Manuel; Gion, María; Ribelles, Nuria; Cortez-Castedo, Patricia; Alonso-Romero, José-Luis; Martínez-García, María; González-Santiago, Santiago; Bermejo, Begoña; Morales, Serafin; Caranana, Vicente; Garrigos, Laia; Fernández-Pinto, Melissa; García-Vicente, Silvia; García-Sanz, Alicia; Mena-Molina, Arnau; Boix, Olga; Alcalá-López, Daniel; Llombart-Cussac, Antonio; Cortés, Javier (BMC, 2025-08-06)
    BACKGROUND: The PI3K/AKT pathway is frequently altered in advanced triple-negative breast cancer (aTNBC), representing a promising target. Ipatasertib, a pan-AKT inhibitor, has shown activity with taxane-based chemotherapy ...
  • Evaluating the effect of heart and respiratory rate measurement errors on the ability to predict the outcome of high flow nasal cannula therapy: a multi-centre study 
    Yu, Hang; Saffaran, Sina; Tonelli, Roberto; Laffey, John-G; Zhang, Qingchen; Esquinas-Rodríguez, Antonio; Martins-de-Lima, Lucas; Kawano-Dourado, Leticia; Maia, Israel-S; Cavalcanti, Alexandre-Biasi; Clini, Enrico; Bates, Declan-G (BMC, 2025-11-22)
    BACKGROUND: The respiratory rate oxygenation (ROX) index, and machine learning (ML) models, are promising approaches to help clinicians identify earlier those patients at risk of failing high flow nasal cannula (HFNC) ...
  • Machine learning models compared with current clinical indices to predict the outcome of high flow nasal cannula therapy in acute hypoxemic respiratory failure 
    Yu, Hang; Saffaran, Sina; Tonelli, Roberto; Laffey, John-G; Esquinas-Rodríguez, Antonio; Martins-de-Lima, Lucas; Kawano-Dourado, Leticia; Maia, Israel-S; Cavalcanti, Alexandre-Biasi; Clini, Enrico; Bates, Declan-G (BMC, 2025-03-07)
    BACKGROUND: Early identification of patients with acute hypoxemic respiratory failure (AHRF) who are at risk of failing high-flow nasal cannula (HFNC) therapy could facilitate closer monitoring, and timely adjustment/escalation ...
  • CAR-T cells targeting CCR9 and CD1a for the treatment of T cell acute lymphoblastic leukemia 
    Tirado, Nestor; Fidyt, Klaudyna; Mansilla, María-José; García-Pérez, Alba-María; Martínez-Moreno, Alba; Vinyoles, Meritxell; Alcain, Juan; García-Peydro, Marina; Roca-Ho, Heleia; Fernández-Fuentes, Narcis; Guerrero-Murillo, Mercedes; Falgas, Aida; Velasco-Hernández, Talia; Bueno, Clara; Panelli, Patrizio; Mulens-Arias, Vladimir; Apostolov, Apostol; Engel, Pablo; González-Navarro, Europa-Azucena; Vick, Binje; Jeremias, Irmela; Caye-Eude, Aurelie; Baruchel, Andre; Cave, Helene; Genesca, Eulalia; Ribera, Jordi; Díaz-Beya, Marina; Martínez-Sánchez, María-Victoria; Fuster-Soler, José-Luis; Escudero-López, Adela; Minguillon, Jordi; Pérez-Martínez, Antonio; Ramírez-Orellana, Manuel; Torrebadell, Montserrat; Díaz, Víctor-M; Toribio, María-L; Sánchez-Martínez, Diego; Menéndez, Pablo (BMC, 2025-07-01)
    T cell acute lymphoblastic leukemia (T-ALL) is an aggressive malignancy characterized by high rates of induction failure and relapse, and effective targeted immunotherapies are lacking. Despite promising clinical progress ...
  • Predictors and barriers to minimally adequate treatment among treated individuals with mental disorders: results from the World Mental Health Surveys. 
    Pozuelo, Julia-R; Vigo, Daniel-V; Kazdin, Alan-E; Harris, Meredith-G; Stein, Dan-J; Viana-Llamas, María-Carmen; Hwang, Irving; Kessler, Timothy-L; Manoukian, Sophie-M; Sampson, Nancy-A; Aguilar-Gaxiola, Sergio; Alonso, Jordi; Andrade, Laura-Helena; Ayinde, Olatunde-O; Bruffaerts, Ronny; Bunting, Brendan; Caldas-de-Almeida, José-Miguel; Chardoul, Stephanie; de-Girolamo, Giovanni; Domenech, Cristina; Gureje, Oye; Karam, Elie-G; Kiejna, Andrzej; Kovess-Masfety, Viviane; Medina-Mora, María-Elena; Moskalewicz, Jacek; Navarro-Mateu, Fernando; Nishi, Daisuke; Piazza, Marina; Posada-Villa, José; Scott, Kate-M; Ten-Have, Margreet; Torres, Yolanda; Vladescu, Cristian; Kessler, Ronald-C (BMC, 2025-12-18)
    BACKGROUND: Treatments for mental disorders vary widely in type and quality, with many patients failing to receive treatments that meet even minimally adequate standards. We use data from the World Mental Health (WMH) ...
  • Pathway to effective treatment for common mental and substance use disorders in the World Mental Health Surveys: Perceived need for treatment 
    Harris, Meredith-G; Kazdin, Alan-E; Hwang, Irving; Manoukian, Sophie-M; Sampson, Nancy-A; Stein, Dan-J; Viana-Llamas, María-Carmen; Vigo, Daniel-V; Alonso, Jordi; Andrade, Laura-Helena; Bruffaerts, Ronny; Bunting, Brendan; Caldas-de-Almeida, José-Miguel; Chardoul, Stephanie; de-Girolamo, Giovanni; Gureje, Oye; Haro, Josep-María; Karam, Elie-G; Kovess-Masfety, Viviane; Medina-Mora, María-Elena; Navarro-Mateu, Fernando; Nishi, Daisuke; Posada-Villa, José; Rapsey, Charlene; Stagnaro, Juan-Carlos; ten-Have, Margreet; Wciorka, Jacek; Zarkov, Zahari; Kessler, Ronald-C (BMC, 2025-05-23)
    BACKGROUND: Perceived need for treatment is a first step along the pathway to effective mental health treatment. Perceived need encompasses a person's recognition that they have a problem and their belief that professional ...
  • Patterns and predictors of 12-month treatment of common anxiety, mood, and substance use disorders in the World Mental Health (WMH) surveys: treatment in the context of perceived need 
    Stein, Dan-J; Vigo, Daniel-V; Harris, Meredith-G; Kazdin, Alan-E; Viana-Llamas, María-Carmen; Hwang, Irving; Kessler, Timothy-L; Manoukian, Sophie-M; Sampson, Nancy-A; Alonso, Jordi; Andrade, Laura-Helena; Benjet, Corina; Bruffaerts, Ronny; Bunting, Brendan; Cardoso, Graca; Chardoul, Stephanie; de-Girolamo, Giovanni; de-Jonge, Peter; Gureje, Oye; Haro, Josep-María; Karam, Elie-G; Kovess-Masfety, Viviane; Moskalewicz, Jacek; Navarro-Mateu, Fernando; Nishi, Daisuke; Posada-Villa, José; Scott, Kate; Stagnaro, Juan-Carlos; Vladescu, Cristian; Wciorka, Jacek; Zarkov, Zahari; Kessler, Ronald-C; Aguilar-Gaxiola, Sergio; Al-Hamzawi, Ali; Altwaijri, Yasmin-A; Atwoli, Lukoye; Borges, Guilherme; Bromet, Evelyn-J; Caldas-de-Almeida, José-Miguel; Cia, Alfredo-H; Degenhardt, Louisa; de-Guzmán, Ma-Lourdes-Rosanna-E; Hinkov, Hristo; Hu, Chi-yi; Karam, Aimee-Nasser; Karam, Georges; Kawakami, Norito; Khaled, Salma; Kiejna, Andrzej; Mcgrath, John-J; Medina-Mora, María-Elena; Piazza, Marina; Scott, Kate-M; ten-Have, Margreet; Torres, Yolanda; Williams, David-R; Wojtyniak, Bogdan; Woodruff, Peter; Xavier, Miguel; Zaslavsky, Alan-M (BMC, 2025-03-14)
    BACKGROUND: Data from the World Mental Health (WMH) surveys on the coverage cascade has underscored the importance of perceived need for seeking treatment of mental disorders. However, little research has focused on treatment ...
  • Barriers to 12-month treatment of common anxiety, mood, and substance use disorders in the World Mental Health (WMH) surveys 
    Viana-Llamas, María-Carmen; Kazdin, Alan-E; Harris, Meredith-G; Stein, Dan-J; Vigo, Daniel-V; Hwang, Irving; Manoukian, Sophie-M; Sampson, Nancy-A; Alonso, Jordi; Andrade, Laura-Helena; Borges, Guilherme; Bunting, Brendan; Caldas-de-Almeida, José-Miguel; de-Girolamo, Giovanni; de-Jonge, Peter; Gureje, Oye; Haro, Josep-María; Karam, Elie-G; Kovess-Masfety, Viviane; Moskalewicz, Jacek; Navarro-Mateu, Fernando; Nishi, Daisuke; Piazza, Marina; Posada-Villa, José; Scott, Kate-M; Vladescu, Cristian; Wojtyniak, Bogdan; Zarkov, Zahari; Kessler, Ronald-C; Kessler, Timothy; World-Mental-Hlth-Survey-collaborators, Sergio (BMC, 2025-02-09)
    BACKGROUND: High unmet need for treatment of mental disorders exists throughout the world. An understanding of barriers to treatment is needed to develop effective programs to address this problem. METHODS: Data on barriers ...
  • Management of sleep-disordered breathing in achondroplasia: guiding principles of the European Achondroplasia Forum 
    Fauroux, Brigitte; Alsayed, Moeenaldeen; Ben-Omran, Tawfeg; Boero, Silvio; Boon, Mieke; Cormier-Daire, Valerie; Fredwall, Svein; Guillén-Navarro, Encarna; Irving, Melita; Kunkel, Philip; Madureira, Nuria; Maghnie, Mohamad; Milerad, Josef; Mohnike, Klaus; Mortier, Geert; Nobili, Lino; Pejin, Zagorka; Sessa, Marco; Sousa, Sergio-B (BMC, 2025-05-15)
    Due to the craniofacial anatomy of people with achondroplasia, sleep-disordered breathing (SDB) occurs more frequently than in the average stature population. SDB, which comprises obstructive sleep apnoea (OSA), more rarely ...
  • Evolution of mobility, pain/discomfort, self-care, and mental health in patients with alpha-mannosidosis: an international caregiver and patient survey 
    Stepien, Karolina-M; Thomas, Sophie; Hennermann, Julia-B; Lampe, Christina; Muschol, Nicole-M; Ballesta-Martínez, María-Juliana; Cruz, Jordi; López-Rodríguez, Mónica; Barth, Anneliese; Magner, Martin; Lund, Allan-M; Plaiasu, Vasilica; Ballabeni, Andrea; Dona, Francesca; Morgan, Heather-M; Guffon, Nathalie (BMC, 2025-05-07)
    BACKGROUND: Alpha-mannosidosis is a rare recessive lysosomal storage disorder with progressive multi-systemic impacts. In the absence of standardized monitoring protocols, there is insufficient understanding of disease ...
  • Recommendations for management of infants and young children with achondroplasia: Does clinical practice align? 
    Guillén-Navarro, Encarna; Alsayed, Moeenaldeen; Alves, Inés; Ben-Omran, Tawfeg; Boero, Silvio; Cormier-Daire, Valerie; Fauroux, Brigitte; Fredwall, Svein; Irving, Melita; Kunkel, Philip; Lampe, Christian; Lausch, Ekkehart; Maghnie, Mohamad; Mohnike, Klaus; Mortier, Geert; Pejin, Zagorka; Sessa, Marco; Sousa, Sergio-B (BMC, 2025-03-11)
    BACKGROUND: Achondroplasia is one of the most prevalent forms of skeletal dysplasia. Lifelong follow-up by an experienced multidisciplinary team is required, particularly during the first 2 years. In 2021, international ...
  • Regulation of glial markers expression in the rat basolateral amygdala and hippocampus during morphine aversive memory retrieval and its extinction 
    Franco-García, Aurelio; Gómez-Murcia, Victoria; Nuñez, Cristina (BMC, 2025-12-14)
    BACKGROUND: Opioid use disorder is driven by neurobehavioral adaptations where environmental cues trigger relapse. Consequently, extinction therapy (ET) aims to modify drug-associated memories but has limited long-term ...