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Repositorio Institucional en Ciencias de la Salud de la Región Murcia: Envíos recientes

  • The cervical microbiome of ewe breeds with known divergent fertility following artificial insemination with frozen-thawed semen 
    Norstebo, Simen-Foyn; Rodríguez-Campos, Sabrina; Umu, Ozgun-C-O; Abril-Parreño, Laura; Dalland, Marianne; Gilfillan, Gregor-Duncan; Fair, Sean; Krogenaes, Anette (NATURE PORTFOLIO, 2025-04-26)
    The use of artificial insemination (AI) with frozen-thawed semen in sheep is limited internationally due to low pregnancy rates. An exception is Norway, where high success rates routinely occur following vaginal deposition ...
  • Discovery of Z1362873773: a novel fascin inhibitor from a large chemical library for colorectal cancer 
    Rodríguez-Martínez, Alejandro; Giraldo-Ruiz, Lucía; Ramos, María-C; Luque, Irene; Ribeiro, Diogo; Postigo-Corrales, Fátima; Alburquerque-González, Begoña; Montoro-García, Silvia; Arroyo-Rodríguez, Ana-Belén; Conesa-Zamora, Pablo; Hurtado-López, Ana-María; Luengo-Gil, Ginés; Pérez-Sánchez, Horacio (NATURE PORTFOLIO, 2025-04-28)
    Metastasis is one of the leading causes of cancer-related death worldwide. Fascin, a protein that bundles actin filaments to produce protrusions in cancer cells, plays a significant role in the enhancement of cell migration. ...
  • Identifying risk factors and predicting long COVID in a Spanish cohort 
    Guillén-Teruel, Antonio; Mellina-Andreu, José-L; Reina, Gabriel; González-Billalabeitia, Enrique; Rodríguez-Iborra, Ramón; Palma, José; Botia, Juan-A; Cisterna-García, Alejandro (NATURE PORTFOLIO, 2025-03-28)
    Many studies have investigated symptoms, comorbidities, demographic factors, and vaccine effects in relation to long COVID (LC-19) across global populations. However, a number of these studies have shortcomings, such as ...
  • The Sarcoplasmic/Endoplasmic reticulum Ca2+-ATPase (SERCA) is present in pig sperm and modulates their physiology over liquid preservation 
    Garriga, Ferran; Martínez-Hernández, Jesús; Parra-Balaguer, Ainhoa; Llavanera, Marc; Yeste, Marc (NATURE PORTFOLIO, 2025-02-04)
    Liquid storage is the primary preservation method in the swine breeding industry because of its advantages over cryopreservation. Calcium (Ca(2+)), a key regulator of cell physiology, plays a crucial role during liquid ...
  • Pilot clinical comparison of three occlusal splint fabrication techniques: A preliminary study 
    Torne-Duran, Sergi; Marco-Martínez, Laura; Serrano-Belmonte, Ildefonso (NATURE PORTFOLIO, 2025-12-19)
    To compare laboratory production time, clinical adjustment time, and patient-reported comfort of three occlusal splint fabrication techniques (heat-cured acrylic, vacuum-adapted acrylic, and CAD-CAM 3D-printed splints) in ...
  • Epigenetic regulation of electromechanical continuity might determine phenotypic heterogeneity in SCN5A mutation carriers in Brugada syndrome 
    Moscoso, Isabel; Serrano-Cruz, Valentina; Cebro-Marquez, María; Vilar-Sánchez, Marta-E; Vidal-Abeijon, Iria; Brion, María; Blanco-Verea, Alejandro; Martínez-Campelo, Laura; Feijoo-Bandin, Sandra; Jiménez-Ramos, Victor; Gimeno-Blanes, Juan-Ramón; Sabater-Molina, María; Jiménez-Jaimez, Juan; González-Juanatey, José-Ramón; Rodríguez-Manero, Moises; Lage, Ricardo (NATURE PORTFOLIO, 2025-10-22)
    Brugada syndrome (BrS) is an inherited cardiac disorder characterized by electrical disturbances. Pathogenic variants in the SCN5A gene are implicated in 25-30% of probands. Although loss-of-function mutations in SCN5A ...
  • Distinct roles of amniotic membrane epithelial (hAEC) and mesenchymal stromal cells (hAMSC) in amniotic membrane-driven wound healing 
    Alcaraz, M; Hernández-Mármol, Isabel; Puente-Cuadrado, José-María; Rodríguez-Valiente, Mónica; Silini, A-R; Parolini, O; Nicolás, Francisco-José (NATURE PORTFOLIO, 2025-10-21)
    Human skin wound healing is a complex process involving sequential cellular events to restore skin integrity. Chronic wounds fail to heal due to impaired keratinocyte activation and dysregulated cytokine signaling. The ...
  • A machine learning approach to identify patients at risk for long-term consequences after pulmonary embolism 
    Nopp, Stephan; Spielvogel, Clemens; Bikdeli, Behnood; Alberich-Conesa, Ana; Hernández-Blasco, Luis; Peris, Ma-Luisa; Otero, Remedios; Jiménez, David; Monreal, Manuel; Ay, Cihan; Agudo-de-Blas, P; Aibar, J; Alberich-Conesa, Ana; Alda-Lozano, A; Alfonso, J; Alonso-Carrillo, J; Álvarez-Vega, P; Amado, C; Angelina-García, M; Arcelus, J-I; Ballaz, A; Barba, R; Barbagelata, C; Barron, M; Barron-Andres, B; Bascuñana, J; Blanco-Molina, A; Bustos-Carpio, J; Casado, I; Chasco, L; Claver, G; De-Juana-Izquierdo, C; Del-Toro, J; Demelo-Rodríguez, P; Díaz-Brasero, A-M; Díaz-Pedroche, M-C; Díaz-Peromingo, J-A; Dubois-Silva, A; Escribano, J-C; Fernández-Capitan, C; Fernández-Jiménez, B; Fernández-Reyes, J-L; Fidalgo, M-A; Francisco, I; Gabara, C; Galeano-Valle, F; García-Bragado, F; García-González, C; García-Ortega, A; Gavin-Sebastian, O; Gil-de-Gómez, M-A; Gil-Díaz, A; Gómez-Cepeda, C; Gómez-Cuervo, C; González-Martínez, J; González-Munera, A; Gorostidi, J; Grau, E; Guirado-Torrecillas, Leticia; Gutiérrez-Guisado, J; Hernández-Blasco, L; Jara-Palomares, L; Jiménez, D; Jou, I; Joya, M-D; Lainez-Justo, S; Lecumberri, R; Lobo, J-L; López-Jiménez, L; López-Miguel, P; López-Núñez, J-J; López-Ruiz, Alfonso; López-Sáez, J-B; Lorenzo, A; Madridano, O; Maestre, A; Marchena, P-J; Marcos, M; Martín-del-Pozo, M; Martin-Martos, Francisco; Maza, J-M; Mercado, M-I; Molino, A; Monreal, M; Monzon, L; Navas, M-S; Nieto, J-A; Núñez-Fernández, M-J; Ordieres, L; Ortiz, O; Otalora-Valderrama, Sonia; Otero, R; Pacheco-Gómez, N; Pagan, J; Parra-Caballero, P; Pedrajas, J-M; Pérez-Amoros, J; Pérez-Cabezas, A; Pérez-Ductor, C; Pérez-Pinar, M; Peris, M-L; Pesce, M-L; Porras, J-A; Puchades, R; Puche, G; Rivas, A; Rivera-Civico, F; Rodríguez-Cobo, A; Romero-Bruguera, M; Salgueiro, G; Sánchez-Juez, A; Sancho, T; Sendin, V; Siguenza, P; Soler, S; Sota-Yoldi, L-A; Suárez-Fernández, S; Tirado, R; Torrents-Vilar, A; Torres, M-I; Trujillo-Santos, Javier; Uresandi, F; Valle, R; Varona, J-F; Vázquez, E; Villalobos, A; Villarejo, C; Villares, P; Ay, C; Nopp, S; Pabinger, I; Vanassche, T; Verhamme, P; Verstraete, A; Rocha, A-T; Yoo, H-H-B; Montenegro, A-C; Morales, S-N; Roa, J; Hirmerova, J; Maly, R; Acassat, S; Bertoletti, L; Brehon, M; Bura-Riviere, A; Catella, J; Chopard, R; Couturaud, F; Espitia, O; Le-Mao, R; Leclercq, B; Mahe, I; Moustafa, F; Plaisance, L; Poenou, G; Quere, I; Sarlon-Bartoli, G; Suchon, P; Versini, E; Schellong, S; Rashidi, F; Sadeghipour, P; Tahmasbi, F; Brenner, B; Kennet, G; Tzoran, I; Barillari, G; Basaglia, M; Bilora, F; Bissacco, D; Brandolin, B; Casana, R; Ciammaichella, M-M; Colaizzo, D; Di-Micco, P; Giorgi-Pierfranceschi, M; Grandone, E; Lambertenghi-Deliliers, D; Marcon, C; Poz, A; Prandoni, P; Simioni, P; Siniscalchi, C; Taflaj, B; Tufano, A; Visona, A; Zalunardo, B; Skride, A; Tazi-Mezalek, Z; Fonseca, S; Marques, R; Meireles, J; Pinto, S; Bosevski, M; Zdraveska, M; Barco, S; Bounameaux, H; Keller, S; Mazzolai, L; Porceddu, E; Aujayeb, A; Angiolillo, D-J; Bikdeli, B; Caprini, J-A; Khalil, A; Ortega-Paz, L; Tafur, J; Weinberg, I; Bui, H-M (NATURE PORTFOLIO, 2025-09-24)
    Pulmonary embolism (PE) can result in long-term sequelae, such as post-PE syndrome, including persistent dyspnea and chronic thromboembolic pulmonary hypertension (CTEPH). Existing prediction tools for severe post-PE ...
  • Impact of the initial administration of an antiretroviral drug with latency reversal properties on the HIV reservoir size 
    de-la-Torre-Tarazona, Erick; Moraga, Elisa; Vaquer, Raúl; Sánchez-Palomino, Sonsoles; de-Lazzari, Elisa; Luna, Laura; Vicens-Artes, Sonia; García-Fraile, Lucio-Jesús; Peraire, Joaquim; García-Gasalla, Mercedes; Balsalobre, Luz; Guillén-Martínez, Sergio; López-Cortés, Luis-Fernando; Jarrin, Inma; Serrano-Villar, Sergio; Alcami, José; Moreno, Santiago (NATURE PORTFOLIO, 2025-07-13)
    The elimination of the latent viral reservoir remains the main barrier in the quest for a cure for people with HIV (PWH). The administration of latency reversal agents (LRA) at antiretroviral treatment (ART) initiation ...
  • Post-mortem human Alzheimer<acute accent>s brain metallome depends on Braak stages and brain regions 
    Parra-Martínez, Cecilio; Callejon-Leblic, Belén; Rodrigo-Lara, Héctor; Fernández-Vega, Iván; Guerrero-Marquez, Carmen; Rabano, Alberto; García-Barrera, Tamara (NATURE PORTFOLIO, 2025-07-01)
    Limited studies have evaluated the influence of redox-related metals on Alzheimer´s brain. We determined 15 metals in 241 human brain samples obtained from five biobanks. We examined the levels of metals in the frontal ...
  • Clinical and immunopathological evaluation and its comparison with IHC consensus molecular subtypes of colorectal cancer 
    Feliciangeli-Moreno, Eduardo; Albaladejo-González, Ana; García-Rodríguez, José; Lázaro-Sánchez, Antonio-David; Borg, Rosanna; Pimentel-Cáceres, Paola; Soriano-Polo, Diego; Rodríguez-Braun, Edith; Balsalobre-Yago, José; Martínez-Ortiz, María-José; Wikstrom-Fernández, Sofía; Murillo-Herrera, Andrés; García-García, Teresa; García-Solano, José; Conesa-Zamora, Pablo; Luengo-Gil, Ginés (NATURE PORTFOLIO, 2025-07-01)
    This study examined the prognostic significance of immunoscore within consensus molecular subtypes (CMS), tumour budding (TB), and macrophage infiltration in colorectal cancer (CRC). A retrospective series was analysed ...
  • Restorative potential of ciliary body cells in a retinal ganglion cell degeneration model 
    Lucas-Ruiz, Fernando; Fernández-Nogales, Marta; Valiente-Soriano, Francisco-Javier; Herrera, Macarena; Nadal-Nicolás, Francisco-M; Agudo-Barriuso, Marta; Herrera, Eloisa (NATURE PORTFOLIO, 2025-05-03)
    The ciliary body (CB) has been proposed as a niche of neural stem cells because, in vitro, cells from this area are able to form neurospheres, proliferate and differentiate. Here, we explore the potential of CB cells to ...
  • Genetics of monozygotic twins reveals the impact of environmental sensitivity on psychiatric and neurodevelopmental phenotypes 
    Assary, Elham; Coleman, Jonathan-R-I; Hemani, Gibran; van-de-Weijer, Margot-P; Howe, Laurence-J; Palviainen, Teemu; Grasby, Katrina-L; Ahlskog, Rafael; Nygaard, Marianne; Cheesman, Rosa; Lim, Kai; Reynolds, Chandra-A; Ordoñana, Juan-Ramón; Colodro-Conde, Lucía; Gordon, Scott; Madrid-Valero, Juan-José; Thalamuthu, Anbupalam; Hottenga, Jouke-Jan; Mengel-From, Jonas; Armstrong, Nicola-J; Sachdev, Perminder-S; Lee, Teresa; Brodaty, Henry; Trollor, Julian-N; Wright, Margaret; Ames, David; Catts, Vibeke-S; Latvala, Antti; Vuoksimaa, Eero; Mallard, Travis; Harden, K-Paige; Tucker-Drob, Elliot-M; Oskarsson, Sven; Hammond, Christopher-J; Christensen, Kaare; Taylor, Mark; Lundstrom, Sebastian; Larsson, Henrik; Karlsson, Robert; Pedersen, Nancy-L; Mather, Karen-A; Medland, Sarah-E; Boomsma, Dorret-I; Martin, Nicholas-G; Plomin, Robert; Bartels, Meike; Lichtenstein, Paul; Kaprio, Jaakko; Eley, Thalia-C; Davies, Neil-M; Munroe, Patricia-B; Keers, Robert (NATURE PORTFOLIO, 2025-06-10)
    Individual sensitivity to environmental exposures may be genetically influenced. This genotype-by-environment interplay implies differences in phenotypic variance across genotypes, but these variants have proven challenging ...
  • Maternal plasma cell-free RNA as a predictor of early and late-onset preeclampsia throughout pregnancy 
    Castillo-Marco, Nerea; Cordero, Teresa; Igual, Marina; Muñoz-Blat, Irene; Gómez-Álvarez, Carla; Bernat-González, Neus; Gaspar-Domenech, Ángela; Ortiz-Domingo, Erika; Vives, Alba; Ortega-Sanchis, Sheila; Monfort-Ortiz, Rogelio; Volkov, Petr; Delgado-Marín, Juan-Luis; Hernández-Hernández, Laura; Cánovas, Esther; Gil, María-del-Mar; Santacruz, Belén; González-González, Nieves-Luisa; Plasencia, Walter; Perales-Marin, Alfredo; Marcos-Puig, Beatriz; Palacios-Marqués, Ana-María; Melchor, Inigo; Martín-Martínez, Alicia; Benítez-Delgado, Taysa; Simon, Carlos; Garrido-Gómez, Tamara (NATURE PORTFOLIO, 2025-10-20)
    Early- and late-onset preeclampsia (EOPE and LOPE) pose serious maternal-fetal risks, yet non-invasive early prediction remains challenging. In a prospective cohort of 9,586 pregnancies, we analyze trimester-specific plasma ...
  • SETBP1 variants outside the degron disrupt DNA-binding, transcription and neuronal differentiation capacity to cause a heterogeneous neurodevelopmental disorder 
    Wong, Maggie-M-K; Kampen, Rosalie-A; Braden, Ruth-O; Alagoz, Gokberk; Hildebrand, Michael-S; Dingemans, Alexander-J-M; Corbally, Jean; den-Hoed, Joery; Mendoza, Ezequiel; Claassen, Willemijn-J-J; Barnett, Christopher; Barnett, Meghan; Brusco, Alfredo; Carli, Diana; de-Vries, Bert-B-A; Elmslie, Frances; Ferrero, Giovanni-Battista; Jansen, Nadieh-A; van-de-Laar, Ingrid-M-B-H; Moroni, Alice; Mowat, David; Murray, Lucinda; Novara, Francesca; Peron, Ángela; Scheffer, Ingrid-E; Sirchia, Fabio; Turner, Samantha-J; Vignoli, Aglaia; Vino, Arianna; Weber, Sacha; Chung, Wendy-K; Gerard, Marion; López-González, Vanesa; Palmer, Elizabeth; Morgan, Angela-T; van-Bon, Bregje-W; Fisher, Simon-E (NATURE PORTFOLIO, 2025-10-10)
    Different types of germline de novo SETBP1 variants cause clinically distinct and heterogeneous neurodevelopmental disorders: Schinzel-Giedion syndrome (SGS, via missense variants at a critical degron region) and ...
  • Programmed cell death pathways coordinate neutrophil and macrophage clearance in zebrafish and are differentially exploited by Salmonella Typhimurium 
    Lozano-Gil, Juan-Manuel; Pedoto, Annamaria; Conesa-Hernández, Ana-María; Ocañaa-Esparza, María; Mulero, Víctoriano; Tyrkalska, Sylwia-D (SPRINGERNATURE, 2025-12-08)
    Programmed cell death (PCD) is essential for immune cell homeostasis and host defense, yet its role in neutrophil and macrophage elimination during bacterial infections remains poorly understood. Using the zebrafish model, ...
  • Does perioperative FLOT increase cure rates in resectable esophageal adenocarcinoma? A mixture cure model analysis 
    Mateos, Lucía; Jiménez-Fonseca, Paula; Gallego, Javier; Lecumberri, Arturo; Custodio, Ana; Martínez-de-Castro, Eva; Hernández-San-Gil, Raquel; Fernández-Montes, Ana; Limon, María-Luisa; Vidal-Tocino, Rosario; Cano, Juana-María; López-Robles, Javier; Gil, Mireia; Acosta-Eyzaguirre, Daniel; Marín-Zafra, Gema-Rocío; Merida-García, Antonio-José; Francisco-Fernández, Alejandro; Ribera-Fernández, Paula; Hierro, Cinta; Riesco, María-Carmen; García-Araque, Montse; Ruiz-Martin, Maribel; Pimentel-Cáceres, Paola; Visa, Laura; Cerdá, Paula; Granja, Mónica; Ruperez-Blanco, Ana-Belén; Gutiérrez, Lourdes; Carmona-Bayonas, Alberto (SPRINGERNATURE, 2026-02-08)
    BACKGROUND: Translating trial findings to real-world cure rates for resectable oesophageal and gastroesophageal junction (GEJ) adenocarcinoma is critical. Standard endpoints like disease-free survival (DFS) may not distinguish ...
  • Real world outcomes of momelotinib in myelofibrosis patients with anemia: results from the MOMGEMFIN study 
    Pérez-Lamas, Lucía; Segura-Díaz, Adrián; García-Delgado, Regina; Álvarez-Larran, Alberto; Senin, María-Alicia; Mora, Elvira; Fox, María-Laura; Pastor-Galan, Irene; Azaceta, Gemma; Garrido-Paniagua, Sara; Pérez-López, Raúl; Trejos-Carvajal, Diana-Margarita; Angona, Anna; Albo-López, Carmen; Lorente-Alegre, Pablo; Vara, Miriam; Vera-Goni, Juan-Antonio; De-Miguel-Llorente, Dunia; Fernández-Rodríguez, Ángeles; Marín-Sánchez, Alberto; Hernando-Megido, Adriana; Gómez-Casares, María-Teresa; Stuckey, Ruth; Carreno-Tarragona, Gonzalo; De-Las-Heras-Rodríguez, Natalia; Xicoy, Blanca; Pérez-Encinas, Manuel; Mata-Serna, Raquel; Núñez-Martín-Buitrago, Lucía; Ferrer-Marín, Francisca; Amer-Salas, Neus; Guillén-Rienda, Carolina; Velez, Patricia; Lamarca-Eraso, Laura; Martin, Sandra; Luts-Khoroz, Iryna; De-Cabo-López, Erik; Gil, Ángela; Martín-Consuegra-Ramos, Sofia; Marco-de-Lucas, Fernando; Otero-Martínez-Fornes, María-José; Martín-Mateos, María-Luisa; Arquero, Teresa; Cabezudo-Pérez, Elena; López-Gómez, Luis-Antonio; Martínez-Hellin, Ángela; Tejedor-Gutiérrez, Aurelia; Herrera-de-Pablo, Esther; Mata-Vázquez, María-Isabel; Castillo-Valero, Inmaculada; Fernández, María-José; Aguilar, Carlos; Santaliestra, Marta; García-Menchon, Antonio; Navas-Elorza, Begoña; Durán, María-Antonia; Pérez-Sala, María; Hernández-Santamaria, Teresa; Muñoz-Jarreno, María-Ángeles; Dávila-Valls, Julio; Torres-Jiménez, Williana; Gonzalvez-Fernández, Joan-Alfons; Torres-Mantilla, Hugo-Alexander; Cobo-Rodríguez, Teresa; Abuin-Blanco, Aitor; Pérez, Francisco; Osorio-Prendes, Santiago; Beneit-Villena, Paola; Peralta, Raisa; Herrera, Federico; Canamero-Giro, Eloi; Jiménez-Barcenas, Reyes; Gasior-Kabat, Mercedes; González-de-Villambrosia, Sonia; Tercero-Mora-Rodríguez, Mariana-Teresa; Menéndez-Cuevas, Marina; Cuevas-Ruiz, Beatriz; Fonseca-Santos, Marta; Garces-Piquer, Sonia; de-la-Puerta, Rosalía; Lorenzo-Vizcaya, Álvaro; Hernández-Boluda, Juan-Carlos; García-Gutiérrez, Valentín (SPRINGERNATURE, 2025-04-17)
  • Allo-HCT refined ELN 2022 risk classification: validation of the Adverse-Plus risk group in AML patients undergoing allogeneic hematopoietic cell transplantation within the Spanish Group for Hematopoietic Cell Transplantation (GETH-TC) 
    Jiménez-Vicente, Carlos; Esteve, Jordi; Baile-González, Mónica; Pérez-López, Estefanía; Martín-Calvo, Carmen; Aparicio, Clara; Oiartzabal-Ormategi, Itziar; Esquirol, Albert; Peña-Muñoz, Felipe; Fernández-Luis, Sara; Heras-Fernando, Inmaculada; González-Rodríguez, Ana-Pilar; López-García, Alberto; López-Lorenzo, José-Luis; Torrado, Tamara; Sáez-Marin, Adolfo-Jesús; Acosta-Fleytas, Cynthia; García, Lucía; Villar, Sara; Filaferro, Silvia; Balsalobre, Pascual; Pascual-Cascon, María-Jesús; Queralt-Salas, María (SPRINGERNATURE, 2025-03-21)
    This multicenter retrospective study by GETH-TC validates the prognostic value of the Allo-HCT Refined ELN 2022 risk classification in allografted AML patients. The new classification refines the ELN 2022 risk classification, ...
  • CALRins5-mediated clonal hematopoiesis causes severe hemolytic anemia in a female PGK1Ser320Asn carrier 
    Morales, M-L; Cano, H; de-la-Morena-Barrio, Belén; Vives-Corrons, J-L; Cuenca-Zamora, E-J; Garrido-Rodríguez, P; Bento, C; Pereira, J; Martínez-Nieto, J; Chen-Liang, Tzu-Hua; Fuster-Soler, José-Luis; Caracena, S; Lozano-Almela, María-Luisa; Teruel-Montoya, Raúl; Corral, Javier; Ferrer-Marín, Francisca (SPRINGERNATURE, 2025-02-01)