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Repositorio Institucional en Ciencias de la Salud de la Región Murcia: Envíos recientes

  • The Long-Term Outcomes of Corticosteroid Use in COVID-19 Patients with Cardiovascular Disease: A Propensity-Matched Analysis from the Multi-Center International Prospective Registry (HOPE-2) 
    García-Onrubia, Jorge; Vazirani, Ravi; Feltes, Gisela; Sánchez-del-Hoyo, Rafael; Viana-Llamas, María-Carmen; Raposeiras-Roubin, Sergio; Romero, Rodolfo; Alfonso-Rodríguez, Emilio; Uribarri, Aitor; Santoro, Francesco; Becerra-Muñoz, Victor; Pepe, Martino; Castro-Mejia, Alex-F; Signes-Costa, Jaime; González, Adelina; Marín, Francisco; López-Pais, Javier; Cerrato, Enrico; Vázquez-Cancela, Olalla; Espejo-Paeres, Carolina; López-Masjuan, Álvaro; Velicki, Lazar; El-Battrawy, Ibrahim; Ramakrishna, Harish; Fernández-Ortiz, Antonio; Núñez-Gil, Ivan-J (MDPI, 2025-10-30)
    Introduction: Corticosteroid therapy has been demonstrated to improve prognosis and reduce mortality in patients with severe Coronavirus Disease 2019 (COVID-19) infection by attenuating the exaggerated inflammatory response ...
  • Ethylbenzene Exposure and Bronchoalveolar CD4/CD8 T Cells in Hypersensitivity Pneumonitis Development and Clinical Outcome 
    Minguela-Puras, Alfredo; Campillo, José-Antonio; Aguilar-Sanchis, María-Isabel; Baeza-Caracena, Antonia; Esquembre, Francisco; Novoa-Bolívar, Erika-M; González-López, Rosana; Otalora, Almudena; Ortuño-Hernández, Cristina; López-Hernández, Ruth; Gimeno-Arias, Lourdes; Ruiz-Lorente, Inmaculada; Ceballos, Diana; Solana-Martínez, Elena; Alcantara-Fructuoso, Juan; Muro-Amador, Manuel; Ros, José-A (MDPI, 2025-10-24)
    Background: Hypersensitivity pneumonitis (HP) is an interstitial lung disease (ILD) characterized by inflammation of the lung parenchyma, alveoli and bronchioles induced by inhalation of organic compounds. Bird-related-HP ...
  • Effectiveness and Safety of Sacituzumab Govitecan in Real-World Clinical Practice in Patients with Metastatic Triple-Negative and HR+/HER2-Negative Breast Cancer 
    Lago-Ballester, Fernando; Martínez-Orea, Adrian; Laorden-Carrasco, Ana; Díaz-Carrasco, María-Sacramento; Titos-Arcos, José-Carlos; Mira-Sirvent, María-del-Carmen; Luengo-Gil, Ginés; Martínez-Penella, Mónica (MDPI, 2025-08-23)
    Background/Objectives: Sacituzumab govitecan (SG) is an antibody-drug conjugate targeting Trop-2 that has demonstrated clinical benefits in randomised trials for patients with metastatic triple-negative breast cancer (mTNBC) ...
  • Donor-Derived Cell-Free DNA in Allograft Transplantation: Exaggerated Hope or Cautious Reality? 
    Fernández-González, Marina; Llorente-Vinas, Santiago; Botella-Martínez, Carmen; Galián, José-Antonio; González-López, Rosana; Alegría-Marcos, María-José; Hita-Ruiz, Alicia; Moya-Quiles, María-Rosa; Martínez-Banaclocha, Helios; Muro-Pérez, Manuel; Muro, Javier; Minguela-Puras, Alfredo; Legaz, Isabel; Muro-Amador, Manuel (MDPI, 2025-09-23)
    Nowadays, there have truly been spectacular advances in surgical techniques, the preservation of organs for transplants, the optimal and efficient selection of both donors and recipients, a more efficient diagnosis and ...
  • The Efficacy of a Deproteinized Bovine Bone Mineral Graft for Alveolar Ridge Preservation: A Histologic Study in Humans 
    Sánchez-Pérez, Arturo; Rodríguez-Sánchez, Marcos; Martínez-Cáceres, Carlos-Manuel; Jornet-García, Alfonso; Moya-Villaescusa, María-José (MDPI, 2025-05-31)
    Background: Alveolar ridge preservation (ARP) following tooth extraction plays a vital role in maintaining ridge dimensions and supporting subsequent implant therapy. Objectives: This study histologically and radiographically ...
  • Pharmacogenomic Study of SARS-CoV-2 Treatments: Identifying Polymorphisms Associated with Treatment Response in COVID-19 Patients 
    Serra-Llovich, Alexandre; Cullell, Natalia; Maronas, Olalla; Jose-Herrero, María; Cruz, Raquel; Almoguera, Berta; Ayuso, Carmen; López-Rodríguez, Rosario; Domínguez-Garrido, Elena; Ortiz-López, Rocío; Barreda-Sánchez, María; Corton, Marta; Dalmau, David; Calbo, Esther; Boix-Palop, Lucía; Dietl, Beatriz; Sangil, Anna; Gil-Rodríguez, Almudena; Guillén-Navarro, Encarna; Mancebo, Esther; Lira-Albarran, Saul; Mínguez, Pablo; Paz-Artal, Estela; Olivera, Gladys-G; Recarey-Rama, Sheila; Sendra, Luis; Zucchet, Enrique-G; López-de-Heredia, Miguel; Flores, Carlos; Riancho, José-A; Rojas-Martínez, Augusto; Lapunzina, Pablo; Carracedo, Ángel; Arranz, María-J (MDPI, 2025-02-21)
    Background/Objectives: The COVID-19 pandemic resulted in 675 million cases and 6.9 million deaths by 2022. Despite substantial declines in case fatalities following widespread vaccination campaigns, the threat of future ...
  • Molecular Insights into the Interaction of Cathepsin D and Iron in Chronic Wound Healing: Exploring Therapeutic Potential and Mechanisms 
    Rodríguez-Moreno, María; Legaz, Isabel (MDPI, 2025-02-21)
    Background: Chronic wounds, such as diabetic ulcers, often fail to progress through healing due to persistent inflammation, infections, and extracellular matrix (ECM) imbalances. Cathepsin D, an aspartate protease active ...
  • SNX19 Interacts with Caveolin-1 and Flotillin-1 to Regulate D1R Endocytosis and Signaling 
    Amatya, Bibhas; Polzin, Jacob-Q-M; Villar, Van-A-M; Yang, Jiang; Konkalmatt, Prasad; Wang, Xiaoyan; Cadme, Raisha-C; Xu, Peng; Gildea, John-J; Cuevas, Santiago; Armando, Inés; Felder, Robin-A; Jose, Pedro-A; Lee, Hewang (MDPI, 2025-02-15)
    Background: Sorting nexin 19 (SNX19) is important in the localization and trafficking of the dopamine D(1) receptor (D(1)R) to lipid raft microdomains. However, the interaction between SNX19 and the lipid raft components ...
  • Differential Role of NKG2A/HLA-E Interaction in the Outcomes of Bladder Cancer Patients Treated with M. bovis BCG or Other Therapies 
    Ruiz-Lorente, Inmaculada; Gimeno-Arias, Lourdes; López-Abad, Alicia; López-Cubillana, Pedro; Fernández-Aparicio, Tomás; Asensio-Egea, Lucas-Jesús; Moreno-Avilés, Juan; Doñate-Íñiguez, Gloria; Guzmán-Martínez-Valls, Pablo-Luis; Server, Gerardo; Ferri-Ñíguez, Belén; Campillo, José-Antonio; Martínez-Sánchez, María-Victoria; Minguela-Puras, Alfredo (MDPI, 2025-01-10)
    Background: Immunotherapy is gaining great relevance in both non-muscle-invasive bladder cancer (NMIBC), with the use of bacille Calmette-Guerin (BCG), and in muscle-invasive BC (MIBC) with anti-checkpoint therapies blocking ...
  • Characterization of Novel Variants in P2YRY12, GP6 and TBXAS1 in Patients with Lifelong History of Bleeding 
    Zamora-Cánovas, Ana; Marín-Quílez, Ana; Díaz-Ajenjo, Lorena; Sánchez-Fuentes, Ana; Gómez-González, Pedro-Luis; Crescente, Marilena; Fernández-Mosteirin, Nuria; Padilla, José; González-Porras, José-Ramón; Benito, Rocío; Lozano-Almela, María-Luisa; Bastida, José-María; Rivera-Pozo, José (MDPI, 2025-11-21)
    Inherited platelet function disorders (IPFDs) are rare diseases caused by defects in platelet surface receptors, enzymes, granules, or signaling proteins. In humans, GPVI and P2Y12 deficiency cause autosomal recessive ...
  • Molecular Pathogenesis of Inherited Platelet Dysfunction 
    Rodríguez-Alen, Agustin; Moscardo, Antonio; Bastida, José-María; Rivera, José (MDPI, 2025-10-30)
    Inherited platelet function disorders (IPFD) are characterized by normal platelet count and morphology but impaired function due to pathogenic variants in genes encoding membrane receptors, granule constituents, or ...
  • Defibrotide for Protecting Against and Managing Endothelial Injury in Hematologic Malignancies and COVID-19 
    Richardson, Edward; Mo, Clifton-C; Calabretta, ELeónora; Corrado, Francesco; Kocoglu, Mehmet-H; Baron, Rebecca-M; Connors, Jean-Marie; Iacobelli, Massimo; Wei, Lee-Jen; Benjamin, Emily-J; Rapoport, Aaron-P; Díaz-Ricart, Maribel; Martínez-Mellado, Antonio-José; Carlo-Stella, Carmelo; Richardson, Paul-G; Moraleda-Jiménez, José-María (MDPI, 2025-07-14)
    Defibrotide, which is approved for treating hepatic veno-occlusive disease (VOD)/sinusoidal obstruction syndrome (SOS), exhibits pleiotropic anti-inflammatory, anti-thrombotic, and fibrinolytic properties, conferring broad ...
  • Transcriptomic Analysis Corroborates the New Radial Model of the Mouse Pallial Amygdala 
    Fernández, Gloria; López-González, Lara; Pons-Fuster, Eduardo; Puelles, Luis; García-Calero, Elena (MDPI, 2025-08-13)
    The mammalian amygdala is located in the temporal lobe of the telencephalon and plays a key role in limbic processing. Recently, our group proposed a radial morphological model to understand the glutamatergic (pallial) ...
  • Diagnosis of Inherited Platelet Disorders: Clinical Evaluation and Functional and Molecular Assays 
    Sánchez-Fuentes, Ana; Pérez-Botero, Juliana; Bastida, José-María; Rivera, José (MDPI, 2025-06-10)
    Inherited platelet disorders (IPDs) are a group of rare conditions affecting platelet number, function, or both. Clinical manifestations vary widely, from asymptomatic cases to patients with severe bleeding, syndromic ...
  • Examining the Effects of the RUNX1 p.Leu43Ser Variant on FPD/AML Phenotypes Using a CRISPR/Cas9-Generated Knock-In Murine Model 
    Marín-Quílez, Ana; García-Tunon, Ignacio; Benito, Rocío; Ordonez, José-Luis; Díaz-Ajenjo, Lorena; Lama-Villanueva, Ana; Guerrero, Carmen; Pérez-Losada, Jesús; González-Porras, José-Ramón; Hernández-Rivas, Jesús-María; del-Rey, Mónica; Bastida, José-María (MDPI, 2025-05-12)
    Germline heterozygous variants in RUNX1 lead to Familial Platelet Disorder with Myeloid Leukemia Predisposition (FPD/AML). Cellular and/or animal models are helpful to uncovering the role of a variant in disease progression. ...
  • Diagnostic Utility of Bronchoalveolar Lavage Flow Cytometric Leukocyte Profiling in Interstitial Lung Disease and Infection 
    Novoa-Bolívar, Erika-M; Ros, José-A; Pérez-Fernández, Sonia; Campillo, José-Antonio; López-Hernández, Ruth; González-López, Rosana; Ruiz-Lorente, Inmaculada; Otalora-Alcaraz, Almudena; Ortuño-Hernández, Cristina; Gimeno-Arias, Lourdes; Ceballos-Francisco, Diana; Muro-Amador, Manuel; Solana-Martínez, Elena; Martínez-Camblor, Pablo; Minguela-Puras, Alfredo (MDPI, 2025-04-17)
    Interstitial lung diseases (ILD) represent a diverse group of disorders that primarily affect the pulmonary interstitium and, less commonly, involve the alveolar and vascular epithelium. Overlapping clinical, radiological ...
  • Breath Analysis by Mass Spectrometry-Based Technologies for Biomonitoring Environmental Exposures 
    Sola-Martínez, Rosa-Alba; Porras-Guillen, Aurora; Lozano-Terol, Gema; Martínez-Vivancos, Adrián; Gallego-Jara, Julia; Ortega, Álvaro; de-Diego-Puente, Teresa (MDPI, 2025-11-18)
  • Machine Learning, Physiological Signals, and Emotional Stress/Anxiety: Pitfalls and Challenges 
    Liu, Yu; Itati-Palacio, María; Bikki, Taha; Toledo, César; Ouyang, Yu; Li, Zhongzheng; Wang, Zhengyi; Toledo, Francisco; Zeng, Hong; Herrero, María-Trinidad (MDPI, 2025-11-05)
  • Influence of the Type of Sauerkraut Fermentation with Probiotics Strains on Folate Content, Antioxidant Activity and Sensory Analysis 
    Jacome-Silva, Leslie-Gisella; Marín-Iniesta, Fulgencio; Tortosa-Díaz, Luis; Planes-Muñoz, David; López-Nicolás, Rubén (MDPI, 2025-09-11)
  • Non-Invasive Redox Biomarkers Detected in Organ Preservation Outflow Solution Enable Early Prediction of Human Liver Allograft Dysfunction 
    Vidal-Correoso, Daniel; Caballero-Herrero, María-José; Muñoz-Morales, Ana-M; Mateo, Sandra-V; Jover-Aguilar, Marta; Alconchel-Gago, Felipe; Martínez-Alarcón, Laura; López-López, Víctor; Ríos-Zambudio, Antonio; Cascales-Campos, Pedro-Antonio; Pons-Miñano, José-Antonio; Ramírez, Pablo; Stromsnes, Kristine; Gambini, Juan; Cuevas, Santiago; Baroja-Mazo, Alberto (MDPI, 2025-09-10)
    Liver transplantation is commonly used for end-stage liver disease, but the demand for organs exceeds the supply, leading to the use of expanded criteria donors (ECDs). Organs from ECDs, especially from donors after ...