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Repositorio Institucional en Ciencias de la Salud de la Región Murcia: Envíos recientes

  • Combined Hyperthermic Intraperitoneal Chemotherapy and Normothermic Intraperitoneal Chemotherapy Long-Term After Interval Cytoreduction in Ovarian Cancer: A Phase I Clinical Trial (BICOV1) 
    González-Gil, Alida; Gil-Gómez, Elena; Olivares-Ripoll, Vicente; Cerezuela-Fernández-de-Palencia, Álvaro; Martínez-García, Jerónimo; Sánchez-Martínez, Domingo-Antonio; Guijarro-Campillo, Alberto-Rafael; Cascales-Campos, Pedro-Antonio (MDPI, 2025-06-12)
    Backgroud: Ovarian cancer is the deadliest gynecologic malignancy, with most patients presenting with peritoneal dissemination at diagnosis. Complete cytoreduction and sensitivity to platinum-based systemic chemotherapy ...
  • Diagnostic Delay in Soft Tissue Sarcomas: A Review 
    Fernández, Juan-Ángel; Gómez, Beatriz; Díaz-Gómez, Daniel; López, Irene; Lozano, Pablo; Muñoz, Paula; Muñoz-Casares, Francisco-Cristóbal; Olivares-Ripoll, Vicente; Vasques, Hugo; Asencio-Pascual, José-Manuel (MDPI, 2025-05-31)
    BACKGROUND/OBJECTIVES: To review the problem of diagnostic delay in soft tissue sarcomas with the aim of identifying its causes and consequences, understanding how to clinically suspect and refer them, and evaluating the ...
  • Challenges of Nontherapeutic Laparotomy in Patients with Peritoneal Surface Malignancies Selected for Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy 
    Gil-Gómez, Elena; González-Gil, Alida; Olivares-Ripoll, Vicente; Cerezuela-Fernández-de-Palencia, Álvaro; López-Hernández, Francisco; Martínez-Espí, Álvaro; Martínez-García, Jerónimo; Barcelo, Francisco; Guijarro-Campillo, Alberto-Rafael; Cascales-Campos, Pedro-Antonio (MDPI, 2025-04-25)
    BACKGROUND: This study aimed to analyze the morbidity, mortality, and survival outcomes in patients with peritoneal surface malignancies who were initially considered candidates for cytoreductive surgery (CRS) with ...
  • Ibero-American Consensus for the Management of Liver Metastases of Soft Tissue Sarcoma: Updated Review and Clinical Recommendations 
    Lopes-Bras, Raquel; Muñoz, Paula; Netto, Eduardo; Fernández, Juan-Ángel; Serradilla-Martin, Mario; Lozano, Pablo; Esperanca-Martins, Miguel; Blanco-Fernández, Gerardo; González-López, José-Antonio; Muñoz-Casares, Francisco-Cristóbal; Fernandes, Isabel; Asencio-Pascual, José-Manuel; Vasques, Hugo (MDPI, 2025-04-11)
    Liver metastases from soft tissue sarcoma (STS) (excluding gastrointestinal stromal tumors) are rare and more commonly arise from retroperitoneal and intra-abdominal primary sites. Chemotherapy remains the mainstay of ...
  • Conventional PCR Versus Next Generation Sequencing for Diagnosis of FLT3, IDH and NPM1 Mutations in Acute Myeloid Leukemia: Results of the PETHEMA PCR-LMA Study 
    Boluda, Blanca; Rodríguez-Veiga, Rebeca; Sargas, Claudia; Ayala, Rosa; Larrayoz, María-J; Chillon, María-Carmen; Soria-Saldise, Elena; Bilbao, Cristina; Prados-de-la-Torre, Esther; Navarro, Irene; Martínez-Cuadrón, David; Gil, Cristina; Bernal, Teresa; Bergua, Juan; Algarra, Lorenzo; Tormo, Mar; Martínez-Sánchez, Pilar; Carrillo-Cruz, Estrella; Serrano, Josefina; Alonso-Domínguez, Juan-Manuel; García, Raimundo; Amigo, María-Luz; Herrera-Puente, Pilar; Sayas, María-J; Lavilla-Rubira, Esperanza; García-Pérez, María-José; Moran, Julia; Pérez-Santaolalla, Esther; Alonso-Vence, Natalia; Oliva, Ana; López, Juan-Antonio; Barrios, Manuel; García-Fortes, María; Olave, María-Teresa; Labrador, Jorge; Martínez-López, Joaquín; Calasanz, María-J; García-Sanz, Ramón; Pérez-Simon, José-A; Gómez-Casares, María-Teresa; Sánchez-García, Joaquín; Mendizabal, Yolanda; Barragán, Eva; Montesinos, Pau; PETHEMA-Grp (MDPI, 2025-03-01)
    BACKGROUND/OBJECTIVES: This PETHEMA PCR-LMA study aimed to evaluate whether mutations detected by NGS (VAF cut-off of ?5%) correlate with NPM1, FLT3-ITD, FLT3-TKD, IDH1, and IDH2 mutations detected using conventional PCR ...
  • Optimizing Outcomes in Breast Reconstruction: The Role of Hormonal Therapy Management 
    Saorín-Gascón, Eduardo; Nova-Tayant, Óscar; Moreno-Villalba, Ramón-Andrés; García-Contreras, Juan-de-Dios; Fernandez-Pascual, Clemente-José; Mora-Ortiz, Asunción-M; Servet-Pérez-de-Lema, Carmen-María; Quiles-Hevia, Alba; Piñero-Madrona, Antonio (MDPI, 2025-02-17)
    BACKGROUND: Breast cancer comprises diverse subtypes with prognostic and therapeutic implications. Hormone therapy plays a crucial role in managing tumors expressing hormonal receptors, but its impact on breast reconstruction ...
  • Could microRNA Analysis Help in the Management of Medullary Thyroid Cancer? 
    Febrero, Beatriz; Ros-Madrid, Inmaculada; Revilla-Nuin, Beatriz; Abellan, Miriam; Ruiz-Manzanera, Juan-José; Gómez, Joaquín; Rodríguez-González, José-Manuel (MDPI, 2025-02-13)
    Introduction. In medullary thyroid carcinoma (MTC), calcitonin levels and TNM staging are established prognostic factors. However, the diagnostic accuracy of cytology in MTC is poor. In this context, microRNAs (miRNAs) may ...
  • Dose-Escalated SBRT for Borderline and Locally Advanced Pancreatic Cancer: Resectability Rate and Pathological Results of a Multicenter Prospective Study 
    Salas-Salas, Bárbara; Ferrera-Alayon, Laura; Espinosa-López, Alberto; Pérez-Rodríguez, María-Luisa; Alayon-Afonso, Antonio-Alayon; Vera-Rosas, Andrés; García-Plaza, Gabriel; Chicas-Sett, Rodolfo; Martínez-Martin, María-Soledad; Salcedo, Elisa; Kannemann, Andrea; Lloret-Sáez-Bravo, Marta; Lara, Pedro-C (MDPI, 2025-01-09)
    OBJECTIVE: We demonstrated for the first time the safety and feasibility of escalating up to 55 Gy/11 Gy/fr/5fr in borderline (BRPC)/unresectable locally advanced pancreatic cancer (LAPC), using the standard LINAC platform. ...
  • Disproportionate Cybersexual Victimization of Women from Adolescence into Midlife in Spain: Implications for Targeted Protection and Prevention 
    Mármol, Carlos-J; Luna-Maldonado, Aurelio; Legaz, Isabel (MDPI, 2025-11-17)
    Cybersexual victimization is a growing public health concern with severe psychosocial consequences, particularly for younger populations. Despite growing awareness of its prevalence, understanding how cybersexual victimization ...
  • Cyber-Sexual Crime and Social Inequality: Exploring Socioeconomic and Technological Determinants 
    Mármol, Carlos-J; Luna-Maldonado, Aurelio; Legaz, Isabel (MDPI, 2025-11-13)
    Cyber-sexual crimes have become a growing concern in the digital age, as rapid technological progress continues to create new forms of violence and victimization. These offenses affect society unevenly, striking more ...
  • Real-World Use of COMT Inhibitors in the Management of Patients with Parkinson's Disease in Spain Who Present Early Motor Fluctuations: Interim Results from the REONPARK Study (vol 15, 532, 2025) 
    López-Manzanares, Lydia; García-Caldentey, Juan; Mata-Álvarez-Santullano, Marina; Vilas-Rolan, Dolores; Herreros-Rodríguez, Jaime; Solano-Vila, Berta; Cerdán-Sánchez, María; Delgado-Ballestero, Tania; García-Ramos, Rocío; Rodríguez-Sanz, Ana; Olivares-Romero, Jesús; Blanco-Ameijeiras, José; Pijuan-Jiménez, Isabel; Tegel-Ayuela, Iciar (MDPI, 2025-11-14)
    There was an error in the original publication [...].
  • Improving Anxiety Related to Chronic Pain Through a Sleep Circadian Intervention Program: A Pilot Study 
    López-Monzoni, Sonia; Hernando-Benito, Gloria; Romero-Peralta, Sofia; Silgado-Martínez, Laura; Viejo-Ayuso, María-Esther; Álvarez-Balado, Leticia; Rodríguez-Matarranz, Enrique; Forne-Izquierdo, Carles; Sánchez-de-la-Torre, Manuel; Masa, Juan-Fernando; Barbe, Ferran; García-Río, Francisco; Martínez-Nicolas, Antonio; García-Mediano, Belén; Solano-Pérez, Esther; Mediano, Olga (MDPI, 2025-01-03)
    The limitations of pharmacological treatments for chronic pain have become increasingly evident: dependency, side effects, resistance, and diminishing efficacy. The urgent need for innovative solutions has become a compelling ...
  • Real-World Use of COMT Inhibitors in the Management of Patients with Parkinson's Disease in Spain Who Present Early Motor Fluctuations: Interim Results from the REONPARK Study 
    López-Manzanares, Lydia; García-Caldentey, Juan; Mata-Álvarez-Santullano, Marina; Vilas-Rolan, Dolores; Herreros-Rodríguez, Jaime; Solano-Vila, Berta; Cerdán-Sánchez, María; Delgado-Ballestero, Tania; García-Ramos, Rocío; Rodríguez-Sanz, Ana; Olivares-Romero, Jesús; Blanco-Ameijeiras, José; Pijuan-Jiménez, Isabel; Tegel-Ayuela, Iciar (MDPI, 2025-05-21)
    OBJECTIVE: We aimed to analyze the real-world use of COMT inhibitors associated with levodopa in patients with Parkinson's disease (PD) who present early fluctuations and to explore whether early COMT inhibition optimizes ...
  • Exposure to Sulfur Hexafluoride Influences Viability in Cell Transplant Suspensions 
    Martínez-Alarcón, Laura; Liarte, Sergio; Abellaneda-Bernal, Juana-María; Quereda, Juan-J; Mendonca, Livia; Muñoz, Antonio; Ramírez, Pablo; Ramis-Vidal, Guillermo (MDPI, 2025-10-31)
    Cell transplantation is often performed with ultrasonographic guidance for accurate delivery through injection. In such procedures, using ultrasonographic contrast greatly improves target delivery. However, accumulating ...
  • Collagen Formulation in Xenogeneic Bone Substitutes Influences Cellular Responses in Periodontal Regeneration: An In Vitro Study 
    Peláez-Cruz, Priscilla; López-Jornet, Pía; Pons-Fuster, Eduardo (MDPI, 2025-09-10)
    BACKGROUND: Bone regeneration is a key therapeutic objective in periodontology, particularly in the treatment of alveolar defects caused by periodontal disease, dentoalveolar trauma, or surgical interventions. Among current ...
  • Spinal Cord Stimulation in Painful Diabetic Neuropathy: Advances, Outcomes, and Future Directions 
    Gazzeri, Roberto; Mosca, Jacopo; Occhigrossi, Felice; Galarza, Marcelo; Schiaffini, Riccardo; Varrassi, Giustino; Mercieri, Marco; Leóni, Matteo-Luigi-Giuseppe (MDPI, 2025-12-12)
    Painful diabetic neuropathy (PDN) is a common complication of diabetes mellitus, often inadequately managed by conventional pharmacological therapies. Alternative interventions, including spinal cord stimulation (SCS), ...
  • The Long-Term Outcomes of Corticosteroid Use in COVID-19 Patients with Cardiovascular Disease: A Propensity-Matched Analysis from the Multi-Center International Prospective Registry (HOPE-2) 
    García-Onrubia, Jorge; Vazirani, Ravi; Feltes, Gisela; Sánchez-del-Hoyo, Rafael; Viana-Llamas, María-Carmen; Raposeiras-Roubin, Sergio; Romero, Rodolfo; Alfonso-Rodríguez, Emilio; Uribarri, Aitor; Santoro, Francesco; Becerra-Muñoz, Victor; Pepe, Martino; Castro-Mejia, Alex-F; Signes-Costa, Jaime; González, Adelina; Marín, Francisco; López-Pais, Javier; Cerrato, Enrico; Vázquez-Cancela, Olalla; Espejo-Paeres, Carolina; López-Masjuan, Álvaro; Velicki, Lazar; El-Battrawy, Ibrahim; Ramakrishna, Harish; Fernández-Ortiz, Antonio; Núñez-Gil, Ivan-J (MDPI, 2025-10-30)
    Introduction: Corticosteroid therapy has been demonstrated to improve prognosis and reduce mortality in patients with severe Coronavirus Disease 2019 (COVID-19) infection by attenuating the exaggerated inflammatory response ...
  • Ethylbenzene Exposure and Bronchoalveolar CD4/CD8 T Cells in Hypersensitivity Pneumonitis Development and Clinical Outcome 
    Minguela-Puras, Alfredo; Campillo, José-Antonio; Aguilar-Sanchis, María-Isabel; Baeza-Caracena, Antonia; Esquembre, Francisco; Novoa-Bolívar, Erika-M; González-López, Rosana; Otalora, Almudena; Ortuño-Hernández, Cristina; López-Hernández, Ruth; Gimeno-Arias, Lourdes; Ruiz-Lorente, Inmaculada; Ceballos, Diana; Solana-Martínez, Elena; Alcantara-Fructuoso, Juan; Muro-Amador, Manuel; Ros, José-A (MDPI, 2025-10-24)
    Background: Hypersensitivity pneumonitis (HP) is an interstitial lung disease (ILD) characterized by inflammation of the lung parenchyma, alveoli and bronchioles induced by inhalation of organic compounds. Bird-related-HP ...
  • Effectiveness and Safety of Sacituzumab Govitecan in Real-World Clinical Practice in Patients with Metastatic Triple-Negative and HR+/HER2-Negative Breast Cancer 
    Lago-Ballester, Fernando; Martínez-Orea, Adrian; Laorden-Carrasco, Ana; Díaz-Carrasco, María-Sacramento; Titos-Arcos, José-Carlos; Mira-Sirvent, María-del-Carmen; Luengo-Gil, Ginés; Martínez-Penella, Mónica (MDPI, 2025-08-23)
    Background/Objectives: Sacituzumab govitecan (SG) is an antibody-drug conjugate targeting Trop-2 that has demonstrated clinical benefits in randomised trials for patients with metastatic triple-negative breast cancer (mTNBC) ...
  • Donor-Derived Cell-Free DNA in Allograft Transplantation: Exaggerated Hope or Cautious Reality? 
    Fernández-González, Marina; Llorente-Vinas, Santiago; Botella-Martínez, Carmen; Galián, José-Antonio; González-López, Rosana; Alegría-Marcos, María-José; Hita-Ruiz, Alicia; Moya-Quiles, María-Rosa; Martínez-Banaclocha, Helios; Muro-Pérez, Manuel; Muro, Javier; Minguela-Puras, Alfredo; Legaz, Isabel; Muro-Amador, Manuel (MDPI, 2025-09-23)
    Nowadays, there have truly been spectacular advances in surgical techniques, the preservation of organs for transplants, the optimal and efficient selection of both donors and recipients, a more efficient diagnosis and ...