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Repositorio Institucional en Ciencias de la Salud de la Región Murcia: Envíos recientes

  • Impact of an enhanced screening program on the detection of non-AIDS neoplasias in patients with human immunodeficiency virus infection 
    Masia, M; Padilla, S; Estan, G; Portu, J; Silva, A; Rivero, A; González-Cordon, A; García-Fraile, L; Martínez, O; Bernal, E; Galera, C; Martínez, VBoix; Macias, J; Montero, M; García-Rosado, D; Vivancos-Gallego, MJ; Llenas-García, J; Torralba, M; García, JA; Agullo, V; González-Fernández, M; Gutierrez, F; Martínez, E (BMC, 2021-11)
    BACKGROUND: The incidence of non-AIDS defining cancer (NADC) is higher in people living with HIV (PLWH) than in the general population, and it is already one of the leading causes of death in the HIV-infected population. ...
  • Seven-chain adaptive immune receptor repertoire analysis in rheumatoid arthritis reveals novel features associated with disease and clinically relevant phenotypes 
    Aterido, Adria; López-Lasanta, María; Blanco, Francisco; Juan-Mas, Antonio; García-Vivar, María-Luz; Erra, Alba; Pérez-García, Carolina; Sánchez-Fernández, Simon-Angel; Sanmarti, Raimon; Fernández-Nebro, Antonio; Alperi-López, Mercedes; Tornero, Jesus; Ortiz, Ana-María; Fernández-Cid, Carlos-Marras; Palau, Nuria; Pan, Wenjing; Byrne-Steele, Miranda; Starenki, Dmytro; Weber, Daniel; Rodríguez-Nunez, Ivan; Han, Jian; Myers, Richard-M; Marsal, Sara; Julia, Antonio (BMC, 2024-03)
    BACKGROUND: In rheumatoid arthritis (RA), the activation of T and B cell clones specific for self-antigens leads to the chronic inflammation of the synovium. Here, we perform an in-depth quantitative analysis of the seven ...
  • Efficacy and safety of intramuscular administration of allogeneic adipose tissue derived and expanded mesenchymal stromal cells in diabetic patients with critical limb ischemia with no possibility of revascularization: study protocol for a randomized cont 
    Soria-Juan, Barbara; García-Arranz, Maríano; Llanos-Jiménez, Lucia; Aparicio, Cesar; González, Alejandro; Mahillo-Fernández, Ignacio; Riera-del-Moral, Luis; Grochowicz, Lukasz; Andreu, Enrique-J; Marin, Pedro; Castellanos, Gregorio; Moraleda-Jiménez, José-María; García-Hernández, Ana-María; Lozano, Francisco-S; Sánchez-Guijo, Fermin; Villaron, Eva-María; Parra, Miriam-López; Yanez, Rosa-María; de-la-Cuesta-Diaz, Antonio; Tejedo, Juan-Rigoberto; Bedoya, Francisco-J; Martín, Franz; Miralles, Manuel; del-Rio-Sola, Lourdes; Fernández-Santos, María-Eugenia; Ligero, José-Manuel; Morant, Francisco; Hernández-Blasco, Luis; Andreu, Etelvina; Hmadcha, Abdelkrim; García-Olmo, Damian; Soria, Bernat (BMC, 2021-09)
    BACKGROUND: Chronic lower limb ischemia develops earlier and more frequently in patients with type 2 diabetes mellitus. Diabetes remains the main cause of lower-extremity non-traumatic amputations. Current medical treatment, ...
  • Characterization of an eutherian gene cluster generated after transposon domestication identifies Bex3 as relevant for advanced neurological functions 
    Navas-Pérez, Enrique; Vicente-García, Cristina; Mirra, Serena; Burguera, Demian; Fernández-Castillo, Noelia; Ferran, José-Luis; López-Mayorga, Macarena; Alaiz-Noya, Marta; Suárez-Pereira, Irene; Anton-Galindo, Ester; Ulloa, Fausto; Herrera-Ubeda, Carlos; Cusco, Pol; Falcon-Moya, Rafael; Rodríguez-Moreno, Antonio; D'Aniello, Salvatore; Cormand, Bru; Marfany, Gemma; Soriano, Eduardo; Carrion, Angel-M; Carvajal, Jaime-J; García-Fernández, Jordi (BMC, 2020-10)
    BACKGROUND: One of the most unusual sources of phylogenetically restricted genes is the molecular domestication of transposable elements into a host genome as functional genes. Although these kinds of events are sometimes ...
  • Implications of sedation during the use of noninvasive ventilation in children with acute respiratory failure (SEDANIV Study) 
    Bermudez-Barrezueta, Lorena; Mayordomo-Colunga, Juan; Minambres-Rodríguez, María; Reyes, Susana; Valencia-Ramos, Juan; López-Fernández, Yolanda-Margarita; Mendizabal-Diez, Mikel; Vivanco-Allende, Ana; Palacios-Cuesta, Alba; Oviedo-Melgares, Lidia; Unzueta-Roch, José-Luis; López-González, Jorge; Jiménez-Villalta, María-Teresa; Tejedor, Maite-Cuervas-Mons; González, Lourdes-Artacho; Olmos, Ainhoa-Jiménez; Pons-Odena, Marti (BMC, 2024-07)
    BACKGROUND: The objective of this study was to analyze the effects of sedation administration on clinical parameters, comfort status, intubation requirements, and the pediatric intensive care unit (PICU) length of stay ...
  • An updated HACOR score for predicting the failure of noninvasive ventilation: a multicenter prospective observational study 
    Duan, Jun; Chen, Lijuan; Liu, Xiaoyi; Bozbay, Suha; Liu, Yuliang; Wang, Ke; Esquinas-Rodríguez, Antonio; Shu, Weiwei; Yang, Fuxun; He, Dehua; Chen, Qimin; Wei, Bilin; Chen, Baixu; Li, Liucun; Tang, Manyun; Yuan, Guodan; Ding, Fei; Huang, Tao; Zhang, Zhongxing; Tang, ZhiJun; Han, Xiaoli; Jiang, Lei; Bai, Linfu; Hu, Wenhui; Zhang, Rui; Mina, Bushra (BMC, 2022-07)
    BACKGROUND: Heart rate, acidosis, consciousness, oxygenation, and respiratory rate (HACOR) have been used to predict noninvasive ventilation (NIV) failure. However, the HACOR score fails to consider baseline data. Here, ...
  • The TP53-activated E3 ligase RNF144B is a tumour suppressor that prevents genomic instability 
    Abad, Etna; Sandoz, Jeremy; Romero, Gerard; Zadra, Ivan; Urgel-Solas, Julia; Borredat, Pablo; Kourtis, Savvas; Ortet, Laura; Martínez, Carlos-M; Weghorn, Donate; Sdelci, Sara; Janic, Ana (BMC, 2024-04-29)
    BACKGROUND: TP53, the most frequently mutated gene in human cancers, orchestrates a complex transcriptional program crucial for cancer prevention. While certain TP53-dependent genes have been extensively studied, others, ...
  • Exploring association of melanoma-specific Bcl-xL with tumor immune microenvironment 
    Luciano, Anna-María; Di-Martile, Marta; Pérez-Oliva, Ana-B; Di-Caprio, Marica; Foddai, María-Laura; Buglioni, Simonetta; Mulero, Victoriano; Del-Bufalo, Donatella (BMC, 2023-07)
    BACKGROUND: Macrophages take center stage in the tumor microenvironment, a niche composed of extracellular matrix and a heterogeneous group of cells, including immune ones. They can evolve during tumor progression and ...
  • Anti-SARS-CoV-2-specific antibodies in human breast milk following SARS-CoV-2 infection during pregnancy: a prospective cohort study 
    Fernández-Buhigas, Irene; Rayo, Nieves; Silos, Julia-Cuesta; Serrano, Berta; Ocon-Hernández, Olga; Leung, Bo-Wah; Delgado, Juan-Luis; Fernández, David-Sánchez-Nieves; Valle, Silvia; De-Miguel, Laura; Silgado, Aroa; Tanoira, Ramon-Pérez; Rolle, Valeria; Santacruz, Belen; Gil, María-M; Poon, Liona-C (BMC, 2024-01-18)
    BACKGROUND: While the presence of SARS-CoV-2 in human breast milk is contentious, anti-SARS-CoV-2 antibodies have been consistently detected in human breast milk. However, it is uncertain when and how long the antibodies ...
  • MITF induces escape from innate immunity in melanoma 
    Sánchez-del-Campo, Luis; Marti-Diaz, Roman; Montenegro, María-F; González-Guerrero, Rebeca; Hernández-Caselles, Trinidad; Martínez-Barba, Enrique; Pinero-Madrona, Antonio; Cabezas-Herrera, Juan; Goding, Colin-R; Rodríguez-López, José-Neptuno (BMC, 2021-03)
    BACKGROUND: The application of immune-based therapies has revolutionized cancer treatment. Yet how the immune system responds to phenotypically heterogeneous populations within tumors is poorly understood. In melanoma, one ...
  • SARS-CoV-2 vaccine response and rate of breakthrough infection in patients with hematological disorders 
    Luis-Pinana, José; López-Corral, Lucia; Martíno, Rodrigo; Vazquez, Lourdes; Pérez, Ariadna; Martín-Martín, Gabriel; Gago, Beatriz; Sanz-Linares, Gabriela; Sánchez-Salinas, Andres; Villalon, Lucia; Conesa-García, Venancio; Olave, María-T; Corona, Magdalena; Marcos-Corrales, Sara; Tormo, Mar; Angel-Hernández-Rivas, José; Montoro, Juan; Rodríguez-Fernández, Alicia; Risco-Galvez, Irene; Rodríguez-Belenguer, Pablo; Carlos-Hernández-Boluda, Juan; García-Cadenas, Irene; Ruiz-García, Montserrat; Luis-Munoz-Bellido, Juan; Solano, Carlos; Cedillo, Angel; Sureda, Anna; Navarro, David (BMC, 2022-05)
    BACKGROUND: The clinical efficacy of SARS-CoV-2 vaccines according to antibody response in immunosuppressed patients such as hematological patients has not yet been established. PATIENTS AND METHODS: A prospective multicenter ...
  • Factors associated with satisfaction and perceived helpfulness of mental healthcare: a World Mental Health Surveys report 
    Harris, Meredith-G; Kazdin, Alan-E; Munthali, Richard-J; Vigo, Daniel-V; Stein, Dan-J; Viana, María-Carmen; Aguilar-Gaxiola, Sergio; Al-Hamzawi, Ali; Alonso, Jordi; Andrade, Laura-Helena; Bunting, Brendan; Chardoul, Stephanie; Gureje, Oye; Hu, Chiyi; Hwang, Irving; Karam, Elie-G; Navarro-Mateu, Fernando; Nishi, Daisuke; Orozco, Ricardo; Sampson, Nancy-A; Scott, Kate-M; Vladescu, Cristian; Wojtyniak, Bogdan; Xavier, Miguel; Zarkov, Zahari; Kessler, Ronald-C (BMC, 2024-03)
    BACKGROUND: Mental health service providers are increasingly interested in patient perspectives. We examined rates and predictors of patient-reported satisfaction and perceived helpfulness in a cross-national general ...
  • Determinants of effective treatment coverage for major depressive disorder in the WHO World Mental Health Surveys 
    Vigo, Daniel-V; Kazdin, Alan-E; Sampson, Nancy-A; Hwang, Irving; Alonso, Jordi; Andrade, Laura-Helena; Ayinde, Olatunde; Borges, Guilherme; Bruffaerts, Ronny; Bunting, Brendan; de-Girolamo, Giovanni; Florescu, Silvia; Gureje, Oye; Haro, Josep-María; Harris, Meredith-G; Karam, Elie-G; Karam, Georges; Kovess-Masfety, Viviane; Lee, Sing; Navarro-Mateu, Fernando; Posada-Villa, José; Scott, Kate; Stagnaro, Juan-Carlos; ten-Have, Margreet; Wu, Chi-Shin; Xavier, Miguel; Kessler, Ronald-C (BMC, 2022-06)
    BACKGROUND: Most individuals with major depressive disorder (MDD) receive either no care or inadequate care. The aims of this study is to investigate potential determinants of effective treatment coverage. METHODS: In order ...
  • Perceived helpfulness of service sectors used for mental and substance use disorders: Findings from the WHO World Mental Health Surveys 
    Harris, Meredith-G; Kazdin, Alan-E; Munthali, Richard-J; Vigo, Daniel-V; Hwang, Irving; Sampson, Nancy-A; Al-Hamzawi, Ali; Alonso, Jordi; Andrade, Laura-Helena; Borges, Guilherme; Bunting, Brendan; Florescu, Silvia; Gureje, Oye; Karam, Elie-G; Lee, Sing; Navarro-Mateu, Fernando; Nishi, Daisuke; Rapsey, Charlene; Scott, Kate-M; Stagnaro, Juan-Carlos; Viana, María-Carmen; Wojtyniak, Bogdan; Xavier, Miguel; Kessler, Ronald-C (BMC, 2022-01-29)
    BACKGROUND: Mental healthcare is delivered across service sectors that differ in level of specialization and intervention modalities typically offered. Little is known about the perceived helpfulness of the combinations ...
  • Real life data: follow-up assessment on Spanish Gaucher disease patients treated with eliglustat. TRAZELGA project 
    Serrano-Gonzalo, Irene; López-de-Frutos, Laura; Lahoz-Gil, Carlos; Delgado-Mateos, Francisco; Angeles-Fernández-Galan, María; Morales-Conejo, Montserrat; Victoria-Calle-Gordo, María; Ibarretxe-Gerediaga, Daiana; Madinaveitia-Ochoa, Andres; Albarracin-Arraigosa, Antonio; Balanzat-Munoz, José; Correcher-Medina, Patricia; Javier-García-Frade, Luis; María-Hernández-Rivas, Jesus; Labbadia, Francesca; Miguel-López-Dupla, Jesus; Luisa-Lozano-Almela, María; Mora-Castera, Elvira; Soledad-Noya-Pereira, María; Angeles-Ruiz-Guinaldo, María; del-Mar-Tormo-Diaz, María; Vitoria-Minana, Isidro; Arevalo-Vargas, Isidro; Andrade-Campos, Marcio; Giraldo, Pilar (BMC, 2023-12-15)
    BACKGROUND: The availability of multiple treatments for type 1 Gaucher disease increases the need for real-life studies to evaluate treatment efficacy and safety and provide clinicians with more information to choose the ...
  • Design of mobile and website health application devices for drug tolerability in hereditary fructose intolerance 
    Izquierdo-García, Elsa; Lazaro-Cebas, Andrea; Pastor, Berta-Montero; Diaz, Ana-Such; Alvaro-Alonso, Elena-Alba; Guerra, Laura-López; Escobar-Rodríguez, Ismael (BMC, 2024-01-05)
    BACKGROUND: Hereditary fructose intolerance (HFI) is a rare metabolic disease caused by aldolase B deficiency. The aim of our study was to analyse excipient tolerability in patients with HFI and other related diseases and ...
  • Validation of clinical exome sequencing in the diagnostic procedure of patients with intellectual disability in clinical practice 
    Ballesta-Martínez, María-Juliána; Pérez-Fernández, Virginia; López-González, Vanesa; Sánchez-Soler, María-José; Serrano-Anton, Ana-Teresa; Rodríguez-Pena, Lidia-Isolina; Barreda-Sánchez, María; Armengol-Dulcet, Lluis; Guillén-Navarro, Encarna (BMC, 2023-07)
    Intellectual disability (ID) has a prevalence of 1-3% and aproximately 30-50% of ID cases have a genetic cause. Development of next-generation sequencing has shown a high diagnostic potential. The aim of this work was to ...
  • European Achondroplasia Forum guiding principles for the detection and management of foramen magnum stenosis 
    Irving, Melita; AlSayed, Moeenaldeen; Arundel, Paul; Baujat, Genevieve; Ben-Omran, Tawfeg; Boero, Silvio; Cormier-Daire, Valerie; Fredwall, Svein; Guillén-Navarro, Encarna; Hoyer-Kuhn, Heike; Kunkel, Philip; Lampe, Christian; Maghnie, Mohamad; Mohnike, Klaus; Mortier, Geert; Sousa, Sergio-B (BMC, 2023-07)
    Foramen magnum stenosis is a serious, and potentially life-threatening complication of achondroplasia. The foramen magnum is smaller in infants with achondroplasia, compared with the general population, and both restricted ...
  • Real-world evidence in achondroplasia: considerations for a standardized data set 
    Alanay, Yasemin; Mohnike, Klaus; Nilsson, Ola; Alves, Ines; AlSayed, Moeenaldeen; Appelman-Dijkstra, Natasha-M; Baujat, Genevieve; Ben-Omran, Tawfeg; Breyer, Sandra; Cormier-Daire, Valerie; Gregersen, Pernille-Axel; Guillén-Navarro, Encarna; Hoegler, Wolfgang; Maghnie, Mohamad; Mukherjee, Swati; Cohen, Shelda; Pimenta, Jeanne; Selicorni, Angelo; Semler, JOliver; Sigaudy, Sabine; Popkov, Dmitry; Sabir, Ian; Noval, Susana; Sessa, Marco; Irving, Melita (BMC, 2023-06)
    BACKGROUND: Collection of real-world evidence (RWE) is important in achondroplasia. Development of a prospective, shared, international resource that follows the principles of findability, accessibility, interoperability, ...
  • Exploratory case-control study on childhood cancer near the Mar Menor lagoon Region of Murcia (Spain) 2000 to 2018 
    Ojeda-Sánchez, Carlos; Ramis-Prieto, Rebeca; Fernández-Aviles, Gema; Diaz-Martínez, Francisco; Orenes-Piñero, Esteban; Ortega-García, Juan-A (BMC, 2024-07)